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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Genomic survey of elephants reveals recurring genetic admixture

A genomic survey of living and extinct elephants reveals recurring genetic admixture, suggesting a more complex evolutionary history. The study confirms the distinctness of African savanna and forest elephants, while also uncovering signs of admixture among other elephant family members.

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Why are there so many types of lizards?

An ASU study has shed light on the biodiversity of anole lizard family trees by comparing their genomes with those of other animals. The research found that genes involved in interbrain development, color vision, and hormones may contribute to species boundaries.

You are what you eat: Diet-specific adaptations in vampire bats

The vampire bat's unique blood-based diet requires specific genetic and microbial adaptations, including enhanced iron assimilation and immunity, to tackle nutritional and non-nutritional challenges posed by blood meals. The findings suggest that the bats' microbiome plays a crucial role in their defense against viral infections.

Duplicate genes help animals resolve sexual conflict

A study by researchers at the University of Chicago found that duplicate copies of a gene in fruit flies evolved separate male- and female-specific functions, resolving competing demands between sexes. These changes occurred rapidly, with the genes specializing relatively quickly.

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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

New software helps detect adaptive genetic mutations

Researchers from Brown University have developed a new method, SWIF(r), to detect adaptive genetic mutations. The technique combines multiple statistical tests into a single machine-learning framework, allowing for more accurate identification of beneficial mutations and shedding light on the evolutionary history of populations.

No sex for all-female fish species

The Amazon molly fish species has defied extinction predictions by maintaining its all-female population through asexually reproduced offspring. Its unique genetic variability, particularly in immune system genes, contributes to its survival, allowing it to rapidly grow and adapt to environmental changes.

Despite odds, fish species that bypasses sexual reproduction is thriving

The Amazon molly's unique reproductive method has allowed it to thrive for millennia, defying expectations that asexual reproduction would lead to extinction. The fish's hybrid genome and high genetic diversity have enabled it to adapt to environmental changes without accumulating harmful mutations.

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Researchers raise a 170-million-year question over mysterious moss gene

Researchers have identified a fused gene in moss that provides insight into how cells build their external walls through the exocytosis process. The discovery raises questions about the unique arrangement of genes that have been retained for millions of years, with potential benefits for cell shape and structure.

The social evolution of termites

Researchers compared termites' genetic features to those of ants and bees, discovering similar molecular mechanisms for eusocial lifestyles. They found evidence of convergent evolution in chemoreceptor families and genes involved in pheromone recognition.

A clonal crayfish from nature as a model for tumors

The marbled crayfish, a single female ancestor of all Marmorkrebs specimens, exhibits epigenetic mechanisms that enable rapid adaptation to various environments without genetic variation. This clonal genome evolution shares similarities with tumor development, where environmental factors influence gene regulation and adaptation.

Solving the puzzle of multicellularity

A Wits University PhD student has solved part of the evolutionary puzzle of multicellularity by studying the genomic sequence of a four-celled algae. The research identified the ubiquitin proteasomal pathway as a process controlling cell division, which played a key role in the evolution of multicellularity.

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House dust mites evolved a new way to protect their genome

A genetic study found that house dust mites replaced the traditional Piwi pathway with a new small RNA mechanism to control transposable elements, affecting up to 1.2 billion people worldwide. The discovery provides insights into the evolutionary history of these common indoor pests.

Colorado potato beetle genome gives insight into major agricultural pest

The Colorado potato beetle's genome provides insights into its ability to rapidly develop resistance to insecticides and spread to new climates. Researchers have discovered genes that enable the beetle to thrive on different plant hosts and tolerate toxins, but not new genes explaining rapid pesticide evolution.

Gene enhancers are important despite apparent redundancy

Researchers investigated ultraconserved elements and found that deleting individual enhancers does not cause major defects, but some subtle brain abnormalities persist. A second study on limb enhancers showed functional redundancy, highlighting the importance of these regulatory elements.

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Coral lifestyles reflected in their genes

A comparative genome study between two corals, Stylophora pistillata and Acropora digitifera, reveals significant genetic disparities. The findings suggest that corals exhibit high levels of genetic variation within the same species, affecting their resilience to climate change.

Decoding the axolotl genome

Researchers have sequenced the axolotl genome, the largest genome ever to be decoded, to study molecular basis of regrowing limbs and other forms of regeneration. The analysis discovered several genes that are expressed in regenerating limb tissue and revealed key roles for PAX3 and PAX7 genes in muscle and neural development.

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Scientists explore mysteries behind diversity of DNA composition among species

A study published in Nature Ecology and Evolution reveals that G+C composition is generally strongly favored across different species, regardless of genome size or location. The researchers used large-scale DNA sequencing data to demonstrate a correlation between G+C content and the expectations based on neutral mutations.

When one reference genome is not enough

Researchers have created a plant pan-genome using Brachypodium distachyon, revealing nearly twice the number of genes found in any individual line. This new estimate enables breeders to tap into genetic variability for traits like yield and disease resistance.

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CLOCK gene may hold answers to human brain evolution

A new study provides insight into the CLOCK gene's vital role in regulating human-specific genes important to brain evolution. The findings suggest that CLOCK regulates genes linked to cognitive disorders and has an important role in human neuronal migration, a process crucial for brain development.

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Worm genomes reveal a link between ourselves and our distant relatives

Researchers decoded two worm genomes and found genetic similarities with vertebrates, including humans. They share genes involved in multicellularity and head development with deuterostomes, despite being distantly related. This discovery highlights the dynamic nature of animal genome evolution and our connection to ancient ancestors.

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Evolutionary history of Staphylococcus aureus

Researchers analyzed 224 ST8 isolates and found that the ancestor likely emerged in Central Europe during the mid-19th century. The lineage then spread globally, acquiring characteristics of USA300 and becoming widespread in North America by the early 20th century.

Passenger pigeon genome shows effects of natural selection in a huge population

A new study analyzes DNA from museum specimens and finds that passenger pigeons' low genetic diversity was caused by natural selection, which spread beneficial mutations rapidly and eliminated deleterious ones. The research suggests that the species' adaptation to large flocks may have become a liability when their population declined.

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'Left-handed' fish and asymmetrical brains

Biologists have found that cichlid fish with a distinct preference for one side of their bodies exhibit corresponding asymmetry in brain structure and gene expression. The study reveals a functional relationship between brain shape and behavioral laterality, suggesting an evolutionary link to handedness in humans.

In the fight against viral infection, spelling counts

Researchers find that certain spellings in HIV and other viruses' genetic codes are critical for replication and infection. The discovery highlights a potential avenue for vaccine development by exploiting this variation.

Sifting gold from the data deluge

Researchers develop new data mining technique to extract genetic information from large sequence data sets. The method, tested on a plant family with unique floral structures, retrieves useful sequences from genes influencing flower shape and symmetry.

Key to better asparagus identified in evolution of sex chromosomes

Researchers at the University of Georgia sequenced the genome of garden asparagus, shedding light on sex chromosome evolution and aiding breeding efforts. They identified genetic markers that allow breeders to efficiently distinguish male and female plants, paving the way for more efficient development and production of valuable hybrid...

The secret lives of ancient land plants

The study of Marchantia polymorpha's genome sheds light on land plant evolution, showing liverworts possess ancestral characteristics. The findings have significant implications for molecular and genetic studies, providing insights into future agricultural applications.

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An early Christmas present: Scientists have unwrapped the reindeer genome

A team of Chinese researchers has sequenced and analyzed the reindeer genome, revealing unique features such as a smaller genome size and 335 genes specific to the species. The findings provide valuable resources for understanding the processes of evolution, domestication, and adaptation to extreme environments.

Landmark discovery turns marathon of evolution into a sprint

A research team has discovered a technique called Accelerated Evolution that rapidly generates valuable natural products by mimicking bacterial evolution processes. This breakthrough could lead to hundreds of new compounds and revolutionize natural product drug discovery.

Pumpkin genomes sequenced, revealing uncommon evolutionary history

Scientists have sequenced the genomes of two pumpkin species, Cucurbita maxima and Cucurbita moschata, to understand their contrasting desirable traits. The study reveals an interesting evolutionary history, with pumpkins being a paleotetraploid resulting from the combination of two ancient genomes.

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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

Crops evolving 10 millennia before experts thought

Research reveals that humans systemically affected crop evolution up to 30,000 years ago, triggering domestication of rice, wheat, and barley. This discovery proves the existence of dense populations and challenges previous understanding of agriculture's origins.

Saguaro and other towering cacti have a scrambled history

The study found that the giant saguaro, organ pipe, senita, and cardón have scrambled family relationships due to long generation times. However, some similarities like succulent flesh were retained by some cacti through ancient genes.

Pioneering discovery of an odor-detecting receptor enhancer

Researchers discovered an evolutionary conserved sequence motif in mammalian genomes that regulates class I odorant receptor genes, a novel mechanism of expression. The J element controls the selective expression of these genes, highlighting its importance in understanding gene regulation and disease.

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The sea cucumber genome points to genes for tissue regeneration

The sea cucumber genome provides new insights into its ability to regenerate damaged body parts, including viscera, which can be regrown within weeks. The study identified specific genes that may contribute to this ability, offering potential avenues for regenerative medicine research.

Liverwort genes and land plant evolution

The liverwort's genome has provided insight into the transition from algae to land plants, identifying genes critical for plant growth and development. The study also found that early plants developed strategies for water retention and distribution, which are still employed by modern plants.

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$1.1 million DOE grant will help beef up biofuels through evolutionary approaches

Michigan State University researchers will use a $1.1 million grant to identify disease-resistant regions in switchgrass, aiming to produce more resilient crops for the emerging bio-based economy. The study's findings will provide valuable insights for breeders to improve switchgrass' viability and provide a consistent source of biofuels.

Lightning-fast trappers

Researchers discovered that bladderwort traps suck in prey like water fleas at incredible speeds, decelerating them before trapping. Comparative analyses of different species revealed unique trap entrance structures and movement patterns adapted to various habitats.

American oaks share a common northern ancestor

Researchers have solved the mystery of the geographic origins of American oaks by finding that red and white oaks diverged simultaneously from a single species 45 million years ago. This common ancestor gave rise to two distinct lineages, which then radiated into different ecological spaces across North America.