Articles tagged with Genomic Dna
A massive global study of diverse populations has significantly advanced the understanding of type 2 diabetes by identifying 117 genes that contribute to the disease. The research used genetic data from almost 181,000 people with type 2 diabetes and 1.16 million without it.
Researchers at Karolinska Institutet have mapped the formation of hybrid strains in Trypanosoma cruzi, a parasite causing chronic infection and severe symptoms. These hybrids are more effective at evading the immune system and causing disease, but understanding their formation can help develop new diagnostic and treatment methods.
A new study documents multiple small regions of DNA from domestic cattle in North American bison genomes, revealing a shared genetic ancestry. The research reveals that even historically isolated herds contain low levels of cattle genomic introgression, with implications for bison conservation efforts.
Researchers have mapped the connections between DNA and blood proteins in two large populations, providing insights into disease causes and potential treatment targets. The study's findings could shed light on health disparities and help develop new therapies.
Researchers at WFIRM have developed a novel method to refine CRISPR/Cas9 gene editing, increasing efficiency and decreasing large DNA deletions. The technique, which fuses DNA polymerase I or the Klenow fragment to Cas9, improves safety and functional editing outcomes.
A team of researchers at UC Riverside has discovered that a protein complex called CAF-1 controls genome organization to maintain lineage fidelity in blood stem cells. The study found that CAF-1 keeps specific genomic sites compacted and inaccessible to transcription factors, ensuring the expression of lineage-specific genes.
Researchers found that somatic mutations accumulated at a faster rate in Alzheimer's disease patients' brain cells, leading to DNA damage and dysfunction. This discovery provides a window into the molecular events of AD pathogenesis, potentially leading to novel treatments targeting these pathways.
A new study from MIT suggests that genome loops, which were believed to play a crucial role in controlling gene expression, are actually short-lived and fleeting. The researchers found that these loops only exist for about 3-6% of the time and last for only 10-30 minutes.
A new study has shown that increasing genetic diversity can improve researchers' ability to identify important genetic markers for health conditions. The study, which analyzed data from over 470,000 Hispanic/Latino individuals, identified 42 previously unidentified regions of the human genome related to BMI, height, and waist-to-hip ra...
A large-scale genetic study has identified 287 genomic regions associated with schizophrenia and 120 specific genes linked to the disorder. These findings provide new insights into the biological processes underlying schizophrenia, offering potential avenues for novel therapies.
Researchers at the University of Otago have developed a new method for obtaining ancient genomic data from small vertebrate remains, causing no visible damage to the underlying bone. The study presents a breakthrough in analyzing materials in museum collections and rare, valuable specimens.
Scientists have successfully sequenced an entire human genome, filling in gaps that were previously unknown or difficult to read. The achievement marks a major breakthrough in understanding the complexities of human genetics and has the potential to reveal new insights into evolution, disease, and adaptation.
The T2T consortium's completed human genome has shown significant improvements in DNA sequencing accuracy, correcting tens of thousands of errors and revealing millions of genetic variations. This new reference genome can support the analysis of over 200 genes of medical relevance, potentially propelling research into genetic disorders.
A new Brazilian database of whole-genome sequences brings diverse genetic information to international databases, shedding light on the genetics of aging and disease in Brazil's elderly population. The study identified over 2 million novel genetic variants, providing insights into the health and well-being of older adults.
A new study from Mayo Clinic and Baylor College of Medicine found that targeted genomic information can significantly impact drug prescribing practices. By applying drug-gene testing, clinicians can identify nearly every patient as a potential candidate for preemptive testing, particularly for drugs with unknown genetic influences.
Researchers developed a new genomic technology to analyze DNA, RNA and chromatin from a single cell, providing a comprehensive database for better understanding of brain diseases. The technology helped identify 63 cell types in the human frontal cortex region.
Aging egg cells accumulate damage to genetic material, preventing maturation and fertilization. Researchers have identified a key process causing this damage and found that anti-viral drugs can reverse it.
A team of scientists has identified hundreds of new genomic loci associated with brain structure, shedding light on how the human brain is shaped. The study used genetically informed brain atlases to uncover the largest number of genetic variants linked to cortex size and thickness.
The Sanford Children's Genomic Medicine Consortium has initiated a whole genome sequencing research project to investigate undiagnosed illnesses in children with suspected inborn errors of immunity. The study aims to sequence the genomes of up to 25 patient genomes and learn information that can benefit patients and others.
Researchers developed a new method to complete genetic data gaps using haplotype blocks, improving breeding efficiency in plants. The approach has shown comparable quality to collecting more information from DNA strands, reducing costs in animal and plant breeding.
Researchers at the University of Missouri have developed a free online resource that speeds up data analysis of human genomes three times faster than current methods. This enables scientists to see how an individual's genome makes them susceptible to different diseases in different ways, ultimately reducing associated costs and increas...
A special form of four-stranded DNA has been found to interact with the gene that causes Cockayne Syndrome when faulty. G-quadruplexes, which form knot-like structures in DNA, specifically bind to a protein called CSB, affecting its function and potentially leading to premature ageing.
Despite making progress, genome sequencing of 1.66 million animal species remains incomplete, with vertebrates accounting for 54% of current sequences. Invertebrates, including insects and spiders, comprise only 34% despite representing 78.5% of all species.
A study by University of Seville researchers reveals that messenger RNA modifying factors play a crucial role in the repair of DNA breaks. The discovery could lead to better understanding of rare diseases and cancer. Messenger RNA editing facilitates the removal of trapped RNA molecules, allowing for proper DNA repair.
Researchers at JGI have developed a new protocol to study the effects of genetic variations on traits, using DNA affinity purification sequencing technology. The protocol allows for rapid capture of transcription factor binding locations in the genome, providing insights into gene regulation and function.
Scientists successfully induce gene expression from a synthetic DNA and evolution through continuous replication using cell-free materials. They also improve the DNA to increase its replication efficiency by up to 10-fold in just 60 days.
A new study led by scientists at Mount Sinai highlights the role of rare genomic differences in obsessive-compulsive disorder (OCD) risk. The research found that about 10% of the risk for OCD is attributed to rare genomic variations, which were not seen in previous studies.
Researchers identified ALRs as key genetic factors influencing treatment response to radiation and chemotherapy. Cells deficient in ALRs are more resistant to radiation and chemotherapy, while those with higher ALR levels are more sensitive.
Researchers developed an integrated framework combining single-cell and metagenomics to characterize microbes. The approach showed higher accuracy and precise binning, revealing more bacterial genera and intra-species diversity.
A new research center will use genomic data and socioeconomic factors to better predict health outcomes in individuals of diverse ancestry. The center aims to develop computational tools to combine large datasets and analyze them for consistent relationships among admixed populations.
Three new species of freshwater goby fish have been identified in Japan and the Philippines, with distinct color patterns indicating separate lineages. The researchers believe that different color patterns play a crucial role in maintaining these separate lineages during courtship and mate selection.
Researchers at DTU Health Tech have invented a one-pot assay, NISDA, for rapid detection of SARS-CoV-2 RNA without the need for enzyme-based methods. The assay detects low concentrations of RNA in 30 minutes and has shown high accuracy and sensitivity.
Researchers reveal stable phosphatidylglycerol-DNA complex formation with strong van der Waals and hydrophobic interactions. The complex's structural parameters are determined, providing insight into the differences between DNA-phospholipid interaction and fatty acid binding.
New study finds that modern Japanese populations have a tripartite genetic origin, with contributions from Jomon hunter-gatherers, Yayoi farmers, and Kofun peoples. The analysis reveals a complex history of population dynamics, including assimilation rather than replacement during the agricultural transition.
Researchers found that viral fossils in Australian marsupials are used to make non-coding RNAs that protect against outside infection. The study suggests that these viral fossils may be helping to immunize animals, potentially providing a mechanism similar to vaccination.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
Yang Gao's lab has received a $1.9 million NIH grant to investigate the mechanisms of proteins that produce copies of genomic DNA, with potential implications for cancer treatment. The research aims to understand how DNA replication and repair processes can be targeted to develop new therapies.
Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.
The center will provide a one-stop shop for custom DNA constructs, accelerating cancer research through access to state-of-the-art tools. The facility will enable transformative, large-scale experimental projects that were previously impossible for individual labs.
MIT researchers have created a new DNA writing technique called HiSCRIBE that can record interactions between cells and store spatial information. This approach offers a way to edit genes in the human microbiome, potentially revolutionizing the field of genome editing.
A new study published in Journal of the American Heart Association found a correlation between high cell-free DNA concentrations and markers of preeclampsia severity. Increasing amounts of circulating cell-free DNA were associated with earlier gestational age at delivery, worse systolic blood pressure, and maternal tissue injury.
Researchers developed a direct cloning method, CAPTURE, to accelerate large-scale discovery of novel natural products. The method allows for efficient cloning of large genomic fragments, including those with high-GC content or sequence repeats.
Research reveals that regions of the human genome with unusual DNA folding tend to have higher mutation rates than others. The study found that non-B DNA sequences, which can fold into different conformations, play a major role in determining regional variation in mutation rates across the genome.
University of Alberta researchers found that chromatin is neither solid nor liquid but rather a gel-like substance. This discovery could lead to better understanding of diseases like cancer and improve gene regulation.
Scientists identify a 34,000-year-old Early East Asian fossil with mixed Eurasian descent, showing a quarter of its ancestry came from western Eurasians. The study found that the individual's DNA contained segments from extinct hominins, including Denisovans and Neandertals.
Scientists have developed a method to create high-resolution maps of contact points between replicated chromosomes, providing insights into the molecular machinery regulating DNA conformation and repair. This breakthrough could shed light on the mechanics underlying genome transport during cell division.
Researchers developed polymeric carriers that can load multiple types of genetic material, improving efficiency and reducing toxicity compared to existing analogues. The technology has the potential to revolutionize gene therapy by delivering two RNA and DNA molecules through a single carrier.
A comprehensive catalogue of human genome's molecular elements has been produced by the ENCODE collaboration, providing insights into potential regulatory regions. The resource will help all human biology research moving forward, particularly in understanding genetic variants and their functions.
Researchers identified nearly 1 million potential functional genomic elements in the human genome, which control gene expression and promote health or disease. The UMMS team's registry of these elements can be used to study links between regulatory switches and genetic diseases.
Scientists discovered that Neurospora crassa, a type of bread mould, actively mutates its own DNA to fight virus-like infections. The fungus uses a process called Repeat-Induced Point mutation (RIP) to rapidly degrade transposable elements, but this comes at a cost of considerable collateral damage.
Researchers screened 163,000 DNA mutations in C. elegans roundworms to understand the interplay between DNA damage and faulty repair systems. The study found that multiple DNA repair pathways work together to prevent mutagenesis, and a single mutagen can leave varying mutational signatures depending on the faulty repair system.
Researchers discovered that bacteria employ a strategy of adding new DNA while shedding unused genes, allowing them to avoid overloading their genomes. This process helps the bacteria outgrow competitors and potentially infect other organisms more easily.
Researchers from CNIO and Cabimer reveal DNA topological problems cause endogenous DNA breaks leading to lymphoma development. The study highlights a strong causal relationship between topological problems and cancer development in ATM-deficient lymphoid malignancies.
Researchers successfully used CRISPR to make targeted cuts in human breast cancer genes, allowing for efficient sequencing of critical alterations. The technique has the potential to streamline cancer treatment selection and use of targeted therapies.
Max Planck researchers have successfully developed a self-replicating genome, enabling the regeneration of proteins and DNA. The artificial system, assembled from modular DNA pieces, can produce its own translation factors and maintain chemical systems.
Researchers found that linker histone H1 undergoes liquid-liquid phase separation in the nucleus, forming droplets with densely packed DNA and enriching with protein HP1α. This process segregates heterochromatin from euchromatin, revealing a new function of histones in gene regulation.
A team of scientists has identified the tools for repairing damaged DNA molecules, revealing new insights into how the human genome works. The study found that damaged DNA undergoes a unique packing state during repair, moving faster than healthy DNA but depending on its size.
The study observed changes in A/B compartments of mouse embryonic stem cells, correlating with gene expression and replication timing changes. Chromosome conformation changes preceded gene expression changes, suggesting a physical mechanism for transcriptional regulation.
Yale scientists identify two proteins P300 and Brd4 as essential for activating the zebrafish genome after fertilization, allowing embryonic development to proceed. The discovery provides new insights into how life begins at a molecular level.
Researchers have discovered that DNA base editors can induce tens of thousands of off-target RNA single nucleotide variants (SNVs). To address this issue, they engineered deaminases to eliminate the off-target effects, providing a solution for the clinical application of these methods.