Articles tagged with Genomic Dna
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Salk scientists discover that maternal behavior changes brain cells in mice by altering L1 gene copy number and methylation. This correlation suggests a unique role for the jumping gene L1 in shaping brain development.
Researchers from the University of Seville have discovered that genes located near nuclear pores contribute to maintaining genome stability. The study found that anchoring DNA to the pore during transcription prevents DNA-RNA hybrids, a natural source of genome instability.
Scientists have identified a novel mechanism safeguarding mitochondrial DNA, which encodes for essential parts of cellular respiration machinery. The study reveals that an unusual enzyme called PrimPol can re-initiate replication after damage, helping to prevent double-strand breaks and mitochondrial dysfunction.
A study has characterized all of the circular DNA in the worm <em>C. elegans</em> and three human cell types, revealing different sets of circles in different cell varieties. The researchers used a 50-year-old lab technique called density gradient centrifugation to separate and purify the circular DNA.
Researchers developed a new imaging approach called ChromEMT to visualize the three-dimensional structure of chromatin, resolving long-standing debates about its organization. The study reveals that local nucleosome structure combined with global 3D organization determines gene expression and cell fate.
The study found that the red vizcacha rat's genome grew quickly due to the expansion of highly repetitive elements, rather than whole genome duplication. This mechanism is also thought to contribute to 'genomic baggage' in humans, influencing disease susceptibility.
Researchers have identified the KMT2A gene translocations as a common underlying cause of infant and treatment-related leukemias. The Penn/CHOP team has also found that topoisomerase II cleavage clusters in specific regions of the genome, which may play a role in DNA damage repair and cancer development.
A study by the University of Edinburgh reveals that dynamic DNA properties can ward off gene damage and promote genome organization. The research highlights the importance of scaffold attachment factor A in forming a protective chromatin mesh that allows for flexible and responsive cell signals.
A team of researchers used computational modeling to understand DNA knotting in nanochannels, a challenge in genome mapping. They found that experimental results are not consistent with simulations, but the data may come from other sources.
Scientists have determined the first 3D structures of intact mammalian genomes from individual cells, showing how chromosomes fold together inside cell nuclei. This knowledge can help study gene interactions, regulation, and development, with potential applications in understanding diseases.
Researchers have developed a new method of genetic engineering that creates artificial restriction enzymes with enhanced sequence specificity and defined sticky ends. This technology has the potential to revolutionize genomic research and gene editing by improving precision and reducing obstacles posed by existing restriction enzymes.
Researchers from the University of Granada have discovered 62 satellite DNA families in the migratory locust, a species with no previously known satellite DNA. This discovery expands the genetic information available to date about the species, revealing new insights into its genome and potential applications for chromosome identification.
A team of researchers has successfully developed a genome editing technique that induces target point mutation without cutting the DNA. This technique offers high-level editing operations with reduced cytotoxicity, making it suitable for gene therapy, disease research, and organism breeding.
A new type of transposable element was discovered in certain bird genomes, which also occurred in nematode worms that are human parasites. The finding reveals that these modern human parasite species were birds from 25-17 million years ago.
A team co-led by Penn Medicine researcher discovers that a mysterious lncRNA has no obvious function in regulating its neighbor's gene expression, but the DNA from which it originates does. The study reveals a new mechanism for enhancer functions in the genome, pointing to a broader role of non-coding DNA and RNA.
Researchers at CNIO have discovered a code of signals that regulates the concentration of proteins involved in genome duplication. The USP7 protein acts as a traffic officer, eliminating ubiquitin marks to favor protein accumulation and DNA copying. This balance is essential for accurate genome replication.
New study confirms Neanderthal DNA has a subtle but significant impact on modern human biology, including associations with skin lesions, nicotine addiction, depression, and blood coagulation. The research uses anonymized electronic health records and genomes to test the effects of archaic genetic variants on clinical traits.
Researchers at IBS created multiplex Digenome-seq to detect errors in CRISPR-Cas9 processes. The tool uses cell-free genomic DNA and sgRNA to identify on- and off-target sites, providing precise analysis results.
Two studies on yeast reveal that gene expression among tandem DNA repeats varies substantially depending on position within the array. These findings provide key information about DNA architecture in cells, highlighting the central role of chromosome architecture in regulating these sequences.
Scientists at the University of Minnesota and BioNano Genomics have developed a new method to analyze DNA sequences in nanochannels, enabling more accurate genome mapping. By analyzing the probability distributions of DNA barcode label separations, researchers can identify structural oddities and improve the accuracy of genome maps.
A streamlined PITCh system enables efficient genome editing for inserting foreign DNA into targeted genomic loci. This method can aid rapid research progress in fields like drug screening and human disease modeling.
Researchers have developed a new technique that maps genomic contact points to shed light on the parts of the genome involved in autoimmune diseases. This approach identified novel candidate genes relating to the risk of developing conditions like rheumatoid arthritis and type 1 diabetes.
Researchers found that tardigrades have a massive amount of foreign DNA, with around 17.5% coming from non-tardigrade sources, primarily bacteria. This challenges conventional views on how DNA is inherited and raises new questions about the connection between foreign DNA and extreme environment survival.
Scientists classify all gene promoters into two distinct types differing in nucleosome stability, with one type found at highly expressed growth-related genes and the other at less frequently expressed genes. The study reveals the role of dynamic nucleosomes in increasing access to promoter DNA for transcription initiation.
The sequenced ancient human genome from Africa reveals a significant wave of migration back into the continent around 3,000 years ago, affecting all populations across the African continent. This migration predates the 'Eurasian backflow' event and shares genetic similarities with Early Neolithic farmers who brought agriculture to Europe.
Researchers analyzed copy number variation across 236 genomes from 125 populations to identify patterns of ancestry and genetic subpopulations. DNA deletions are more reflective of selection, while duplications highlight these variations.
A team of researchers from the University of Cambridge and the Babraham Institute has discovered that a naturally occurring modified DNA base, 5-formylcytosine (5fC), is stably incorporated in the DNA of many mammalian tissues. This rare 'extra' base may play a key role in regulating gene activity.
Australian researchers discovered that a single genetic change in Smchd1 affects its function in the cell, leading to debilitating muscle wasting in FSHD. This fundamental understanding could help develop future treatments for the currently untreatable disease.
Researchers developed coupled microcantilevers that can measure mass on the order of nanograms in a liquid environment with only a 1 percent margin of error. This enables weighing individual molecules, ideal for biological processes such as DNA hybridization and protein characterization.
A genome-wide study found that malnutrition in the first 10 weeks of pregnancy is associated with changes in DNA methylation, which can suppress genes involved in growth, development, and metabolism. These findings have significant implications for understanding the long-term effects of prenatal nutrition on health outcomes.
A new study reveals that carnivorous bladderwort Utricularia gibba packs an impressive number of genes into its tiny genome, outperforming well-known plant species. The plant's unique genetic architecture allows it to thrive in aquatic environments, boasting floating branches and miniature traps that capture prey using vacuum pressure.
Researchers found that C2H2-ZF transcription factors evolved to defend the genome from self-replicating parasitic DNA, known as selfish DNA. These proteins eventually took control of genes, including those involved in brain and heart development.
A genomic test helped doctors solve a medical mystery for a boy with painful spasms. Whole exome sequencing identified the rare condition Episodic ataxia type 1, allowing for targeted treatment and symptom relief. The patient's motor and cognitive functioning have improved since medication was started.
Researchers have identified widespread incorporation of ribonucleotides in genomic DNA, with hotspots found in nuclear and mitochondrial DNA. The Ribose-seq technique allows for the precise location of ribonucleotides, which can affect genome stability and function.
A new computational method can identify positions in the human genome that play a role in cell function, revealing insights into genetic regulation and potential applications in personalized medicine. The study found that 4.2 to 7.5 percent of nucleotides in the human genome have influenced fitness since humans diverged from chimpanzees.
A new study using DNA barcoding confirms that most Ginkgo biloba supplements contain the expected species, while others may be adulterated or contain incorrect materials. The research provides a validated method for supplement manufacturers to ensure quality control and may help consumers avoid toxic or ineffective products.
Researchers at Harvard University have developed a method to efficiently deliver genome-editing proteins into cells, bypassing the need for DNA delivery. The new system uses commercially-available cationic lipids to introduce proteins into cells, offering hope for treating genetic diseases, including deafness.
Scientists have developed a new method to isolate plant nuclear DNA from organellar DNA using the human methyl-binding domain. This approach enables rapid and simple separation of genome sequences, reducing wasted data and increasing efficiency in genomic studies.
Researchers found that only 8.2% of human DNA has a clear function, with most being 'junk' DNA. This figure challenges the previous claim of 80% functional DNA, highlighting the need for a more precise definition of 'function'.
Researchers at Duke University mapped fragile sites across the entire yeast genome, finding they occur in areas where DNA replication slows or stalls. These sites are linked to genetic abnormalities seen in solid tumors and can lead to chromosome instability.
Researchers have unveiled a biological process that explains how DNA can be damaged during genome replication, which relies on protein RPA. Cells use this protein as 'band aids' to protect DNA temporarily during replication, but if they run out, DNA breaks severely and cells cannot divide.
Researchers at Salk Institute discovered a patchwork of genetic variation in individual brain neurons, contrary to the long-held belief that each cell possesses identical DNA code. The study found that up to 41% of neurons have unique, massive copy number variations (CNVs) that arose spontaneously.
Scientists at Ludwig-Maximilians-Universität München discovered a mechanism that allows chromosomal DNA to be locally displaced from nucleosomes for transcription. The FACT complex interacts with histone subunits and detaches stretches of packaged DNA from the nucleosome core, releasing it from its tight wrapping.
Researchers have developed a new method for precisely altering the genomes of living cells, enabling targeted gene insertion and deletion with increased accuracy. This breakthrough technology has far-reaching potential applications in biofuel production, disease research, and therapy development.
A new study by Ohio State University researchers found that mobile DNA elements, called transposons, can significantly disrupt gene expression and cause biological variation in mice. The study discovered that these elements can influence gene expression even when located far away from the affected gene.
A new study reveals two mechanisms by which cells remove embedded ribonucleotides from DNA: the mismatch repair system and RNase H. This research provides insights into how cells maintain genomic integrity and potentially opens up new avenues for understanding RNA-driven DNA evolution.
Researchers at RIKEN have uncovered a key epigenetic mechanism by which Arabidopsis protects cells from harmful DNA elements. The discovery sheds light on the complex interplay between DNA methylation and histone modification, revealing how plants silence transposons and prevent gene disruption.
Researchers at IDIBELL have identified a small molecule called enoxacin that inhibits tumor growth by activating the 'dark genome' and microRNA molecules, offering new potential for cancer treatment. The study's findings open up new directions for anti-tumor therapy targeting microRNA as a therapeutic target.
The modENCODE project has made significant breakthroughs in understanding the epigenome, a complex system that regulates gene expression in eukaryotic organisms. By analyzing the epigenetics of fruit flies and round worms, researchers have gained insights into how DNA packaging affects organism development.
Scientists at the University of Liverpool have sequenced the entire wheat genome, providing key genetic tools for breeding. The data will help select traits for a healthy yield, addressing global food shortages driven by climate change and population growth.
Researchers have discovered a near complete catalog of DNA segments that copy themselves, move around, and insert themselves in the human genome. These transposon insertion locations help determine physical traits and disease risks, and may lead to new disease gene discoveries.
A study of copy number variations in the genome found no significant link between these changes and common diseases. However, rare genetic variants and epigenetic factors are believed to play a role in disease susceptibility. The research suggests that focusing on other genetic variations may lead to important advances in human health.
Research reveals that a DNA interval in chromosome 9p21 increases the risk for coronary artery disease by regulating cell division genes, which can lead to vascular cell proliferation and narrowed coronary arteries. The study's findings suggest potential therapies targeting these genes could combat the disease.
Researchers found that a master regulatory protein called KAP1 orchestrates silencing of viral sequences, preventing harm to the host. The discovery provides insights into evolution and suggests potential new therapies for fighting AIDS.
The company's proprietary platform enables efficient imaging with low reagent consumption, generating high-quality diploid base calls in up to 95% of the genomes sequenced. The approach identifies 3.2 million to 4.5 million sequence variants per genome processed.
The human genome is organized into two separate compartments, with active genes separated from inactive DNA. The fractal globule architecture enables cells to pack DNA densely while avoiding knots, allowing for efficient gene expression and replication.
Scientists have successfully mapped the melon genome with hundreds of DNA markers, allowing for the identification of desirable genes for higher sugar content, disease resistance, and drought tolerance. This breakthrough will aid in developing new melon varieties for future summer picnics.
Researchers at Baylor College of Medicine have created a comprehensive library of clones covering most of the Drosophila melanogaster genome using the P[acman] tool. This new resource enables scientists to study large chunks of DNA in living flies, facilitating genetic research and discovery.
The American Society of Human Genetics hosted its fourth annual DNA Day essay contest to educate students and teachers about genetic science. The contest challenged high school students to write original essays on the genetic basis of various traits, including health and disease. ASHG received over 300 submissions from around the world.
Researchers have successfully sequenced the genomes of two uncultured flavobacteria using a novel single-cell approach. This technique allows for the analysis of minute quantities of DNA and has potential applications in biotechnology and understanding microbial communities.