Articles tagged with Protein Coding Genes
The Reactome project has released its 10,000th human protein, marking a significant milestone in its annotation and expansion. This achievement enables researchers to better understand genomic variation leading to diseases like cancer and develop more effective treatments.
Researchers have developed a novel toolkit based on modified yeast cells to tease out how plant genes and proteins respond to auxin, the most ubiquitous plant hormone. The system revealed the basic 'code' of auxin signaling, including how specific combinations of repressing or activating proteins can bind to auxin, DNA, and one another.
Scientists at CNIO deconstructed alternative splicing as a source of protein production, finding it secondary to gene dominance. The study reveals that most human genes produce a single dominant protein, calling for rethinking biological innovation.
The discovery of POLD3's critical role in DNA replication reveals its necessity for both tumor and healthy cells, casting doubt on its use as a therapeutic target for cancer treatment. The study used genetic engineering to eliminate the gene in mice, showing its essential function in cell division and survival.
Researchers developed a novel simulation technique called eBDIMS to predict protein movements, which can be done on standard PCs. This approach uses low-resolution models, simplifying the structure of proteins, allowing for precise predictions in minutes, not months.
Researchers have discovered how the Doa10 ligase complex forms a ubiquitin chain to mark faulty proteins for degradation. This process is crucial for maintaining cellular homeostasis and preventing diseases like Alzheimer's and Parkinson's. The study sheds light on the importance of protein quality control in cells.
A study at The University of Texas MD Anderson Cancer Center reveals protein ZMYND8's ability to block metastasis-linked gene expression in prostate cancer. ZMYND8 cooperates with histone mark eraser JARID1D to suppress metastasis-linked genes.
Researchers have identified two proteins that safeguard skin stem cells, which are essential for skin renewal and regeneration. The study reveals that without these proteins, skin stem cells collapse and disappear from the tissue.
A new study found a strong association between red meat intake and increased risk of end-stage renal disease (ESRD), with soy and legumes appearing slightly protective. Substituting one serving of red meat with other protein sources can significantly reduce the risk of ESRD by up to 62%.
Scientists have developed a new technique to selectively block the disease-causing protein in mice with spinocerbellar ataxia type 6 (SCA6). The method uses a modified virus to deliver micro RNA that prevents SCA6 from developing, offering a potential treatment for other diseases caused by mutations in bicistronic genes.
Researchers studied Euplotes focardii's genes and proteins for survival in cold, oxygen-rich waters. The organism produces protective proteins against oxidative stress and adapts quickly through flexible RNA decoding.
Researchers analyzed firefly flash signals to understand how new mating signals arise through evolution. They found variations in luciferase and opsin genes didn't correlate with signal color changes, suggesting natural selection may be acting on unknown DNA sequences.
Researchers found a vast array of previously unknown RNA transcripts and alternative splicing patterns, revealing new functional parts of the maize gene. This discovery has great importance for agriculture, as it can help breed corn to adapt to climate changes.
A study published in Epigenetics & Chromatin identified a critical role for methyl-CpG-binding protein 2 (MeCP2) in regulating gene expression involved in pain perception. MeCP2 was found to be increased after nerve injury, leading to changes in downstream genes that can cause pain.
Geneticists at KU Leuven have discovered that tumour protein TP53 can autonomously locate and bind to specific DNA sequences, activating the right genes to repair damaged cells. This finding sheds light on the mechanisms controlling gene expression and holds promise for future cancer therapies.
The study reveals that genetic variants can affect protein levels through post-transcriptional effects, including direct protein-protein interactions. By combining quantitative proteomics and transcriptomics, researchers can infer the proteome-wide effects of a specific genetic variant.
Research reveals snoRNAs control ribosome modification and regulate alternative splicing, leading to wrong protein variants. This discovery explains the cause of diseases like Prader-Willi syndrome and cancer, and offers a possible therapy for genetic hyperphagia.
Researchers at Kyoto University have identified a genetic mechanism that could predict effectiveness of cure for certain cancers. Genetic alterations affecting the PD-L1 protein allow cancer cells to escape immune detection, but these abnormalities were found in many common cancer types.
A UMass Amherst research team discovered the folding mechanism of serpin antithrombin III, a key protein in the blood coagulation pathway. They found that this protein folds to a higher-energy state, allowing it to function as a 'molecular mousetrap' and generate the work required for physiological functions.
Researchers discovered a crucial connection between protein structures and molecular functions by analyzing ancient genetic sequences. They found that tiny gene segments determine the formation of active sites in proteins, enabling them to perform specific functions.
Researchers at Imperial College London have created a computer simulation of gene expression interactions, revealing the sequence of events that lead to genes being switched on. This breakthrough could lead to the design of molecules that interfere with or disrupt the process, potentially tackling diseases.
Research reveals gene expression is a two-way communication between nucleus and cytoplasm, controlled by the Ccr4-Not complex. This protein complex acts as a messenger to ensure transcription and translation levels are well-balanced.
Researchers at CSU have made a groundbreaking discovery by imaging RNA translation in real time, shedding light on the fundamental cellular process. They observed proteins forming and maturing at a rate of 10 amino acids per second, and found polysomes to be globular rather than elongated.
A study by IRB Barcelona reveals the genetic code stopped evolving at 20 amino acids due to limitations in tRNA molecules. The researchers explain that new amino acids can't be introduced without causing problems with protein synthesis and translation.
A study found that FOXO proteins regulate 46 conserved genes across four species, including metabolism and DNA repair processes. This research provides new guidance on understanding the biology of aging and could lead to the development of interventions to promote health and longevity in humans.
Researchers have identified six newly discovered proteins that may help prevent diabetes, Alzheimer's disease, cancer, and other age-related illnesses. The tiny proteins are produced in the mitochondria of cells and play a significant role in metabolism and cell survival.
A team co-led by Penn Medicine researcher discovers that a mysterious lncRNA has no obvious function in regulating its neighbor's gene expression, but the DNA from which it originates does. The study reveals a new mechanism for enhancer functions in the genome, pointing to a broader role of non-coding DNA and RNA.
Researchers have found that suppressing the nuclear receptor protein ROR-γ with small-molecule compounds can reduce androgen receptor levels in castration-resistant prostate cancer, stopping tumor growth. This novel approach targets the root cause of the problem - the overexpression of the AR gene and its protein.
A study led by Michigan State University reveals that the retinoblastoma tumor suppressor protein controls cell migration in fruit flies and humans, contributing to cancer metastasis. The researchers also found that this protein regulates polarity genes important for maintaining proper cell organization and specialized functions.
Researchers have made a major breakthrough in understanding how cells find the right DNA to copy, revealing the role of TFIID and its ability to recognize different sequences for different genes. This finding paves the way for understanding and treating various malignancies.
A study published in The Plant Cell reveals that clock genes produced during the evening are regulated by clock proteins produced in the morning. This discovery sheds light on how plants adapt to their environment through a complex biological clock system.
Researchers at Princeton University discovered how a synthetic protein called SynSerB promotes cell growth in serine-depleted E. coli cells. By inducing overexpression of a protein called HisB, SynSerB enables the production of essential amino acid serine, allowing cells to survive.
The 2016 Protein Society Awards recognized Dr. Gary Pielak, Dr. Rachel Klevit, Dr. H. Eric Xu, and Dr. Andreas Plückthun for their groundbreaking contributions to protein science. The winners received prestigious awards sponsored by Rigaku Corporation, Genentech, The Neurath Foundation, and The Protein Society.
Researchers have discovered alternative protein versions, known as proteoforms, which are stable and tightly regulated, challenging the single gene-single protein theory. This study adds an extra dimension to the human protein landscape, potentially affecting gene editing techniques.
Researchers from Kumamoto University have identified the protein p53, which plays a crucial role in slowing down the progression of Alport syndrome. The study suggests that recovering the function of the p53 gene could help inhibit symptom progression and develop new treatment strategies for genetic diseases.
A study published in Neurology found that individuals with higher BDNF protein levels had slower cognitive decline than those with lower levels. The researchers discovered a 50% reduction in cognitive decline for those in the highest 10% of protein expression compared to the lowest 10%.
A team of scientists has uncovered greater intricacy in protein signaling than previously understood, shedding light on the nature of genetic production. The research found that both protein synthesis and mRNA production are highly regulated processes, with different patterns and responses to outside stimuli.
Rice University researchers found that a master regulator's activity is determined by kinetics, not thermodynamics. The study revealed the 'molecular stripping' process, which quickly stops protein production.
A new method called RiboTaper helps to clarify the function of unknown genes by analyzing sequencing data. By filtering out background noise, researchers can determine which genes are actively producing proteins and identify specific points on RNA where significant events occur.
A recent study published in Oncogene reveals that alterations in an intermediate molecule called RNA can lead to protein mutations without DNA damage. This discovery highlights the importance of RNA editing enzyme ADAR1 in regulating gene expression and contributing to tumor growth.
Researchers at Rockefeller University found that mRNA components are expressed unevenly, with some regions carrying coding sequences and others not. This skewed expression may regulate protein production, particularly during embryonic development, and could provide new insights into gene function.
Researchers mapped the topological structure of the human genome, revealing how proteins like CTCF and cohesin organize genes for proper transcription. The findings provide new insights into the relationship between genome architecture and gene regulation, with potential implications for understanding genetic diseases.
Protein seekers can find genetic targets faster with obstacles in some cases, according to Rice University scientists. The study resolves conflicts between other research on protein interactions with DNA.
Scientists from Switzerland and the Netherlands have identified over 2,300 bacterial proteins in 22 different growth conditions, representing half of the bacterial genes. The dataset provides insight into protein function, expression levels, and post-translational adaptations.
Researchers have invented a technique to dramatically accelerate protein evolution, allowing them to test millions of variants in hours or days. The technology, called µSCALE, enables the identification of promising variants and their DNA sequences, paving the way for breakthroughs in medicine, industry, and biosensors.
Researchers found that certain proteins undergo a transition from liquid droplets to toxic, fibrous solids on their way to becoming harmful. Cells may use this liquid state for normal physiology, but under certain conditions the proteins can transition again.
Researchers have identified ORF0 sequences in human and chimp DNA that may produce hundreds of previously unknown proteins. The discovery suggests a new mechanism for generating novel proteins, which could be beneficial or disease-causing, depending on the evolutionary context.
Flexible, spaghetti-like proteins can bind to their receptor within billionths of a second, retaining high specificity. This discovery explains the transport paradox in cellular communication, enabling efficient proof-reading while maintaining speed.
Scientists at Rockefeller University uncover new insights into mechanical forces governing mitotic spindle formation. They describe how kinesin-5 acts as a molecular motor to organize the spindle, generating forces that tune its balance. This research has medical implications for cancer therapies and understanding cell division.
Researchers found a previously unknown code within the genetic code that affects protein assembly speed, leading to different functions of identical proteins. This discovery has significant implications for understanding human disease-causing mutations.
A new study by the Scripps Research Institute has identified a specific molecule called RGS7 that controls morphine receptor signaling in brain cells. Without this protein, animals were more prone to morphine addiction. The findings suggest that RGS7 could be a potential drug target for developing less-addictive pain medications.
Researchers at NIAID can detect infectious prion protein in mouse brains within a week of inoculation, surpassing prior detection times of six weeks. The study found that the protein was generated outside blood vessels in a specific brain region where drug treatment could be targeted.
Researchers at Duke University have deciphered the genetic code that instructs proteins to assemble or disassemble in response to environmental stimuli. This discovery provides a new platform for designer proteins and investigations into nanotechnology, biotechnology, and medical treatments.
A study of Inuit DNA reveals how their unique genetic makeup helps them thrive on a high-fat diet, with genes associated with fat metabolism, height and weight, and cholesterol playing key roles. The research suggests that the Inuit population has undergone significant adaptation to its extreme climate environment.
A new study from the University of Pennsylvania reveals that disruptions in splicing proteins cause facial and skin barrier defects in mice. The research highlights the importance of these genes in normal development, particularly in the formation of epithelial tissues.
Researchers at Harvard and MIT have developed a new approach that allows for both genome editing and gene regulation to be achieved using the same Cas9 protein, opening up possibilities for understanding diseases and designing synthetic gene circuits. The method uses engineered guide RNAs to control gene expression.
Scientists have successfully used gene therapy to fully restore vision in a mouse model of Leber congenital amaurosis-1, a genetic disorder causing severe visual impairment. The treatment, which replaced the deficient retGC1 protein, showed long-lasting results and supports clinical testing for human patients.
Researchers at Rockefeller University identified a protein that recognizes a chemical instruction tag on RNA molecules. This 'reader' molecule determines the fate of RNA by recognizing m6A tags, influencing gene expression and splicing processes.
A team led by Carnegie Mellon University physicists has discovered the structure of PTEN, a key tumor-suppressing protein. The findings reveal how PTEN regulates cell growth and suppresses tumor formation through dimerization, providing new insights into cancer development and potential therapeutics.
A team of scientists at Scripps Research Institute has devised an improved method to engineer therapeutic proteins into antibodies, which can persist long enough to be useful. The technique mimics evolution and harnesses the power of large numbers to select rare junction segments that allow inserted proteins to fold and function normally.