Articles tagged with Rna
Scientists discovered queuine and preQ1, produced by gut bacteria, regulate protein synthesis in human cells. These bacterial metabolites promote cell growth and halt it, respectively. The study suggests using diet or microbiome composition to balance cell growth in cancer and prevent autoimmune diseases.
Researchers at the University of Connecticut have developed two fast tests for early markers of Alzheimer's disease using CRISPR technology. The tests recognize microRNA molecules associated with Alzheimer's, allowing for quick identification in doctor's offices.
Researchers at Hebrew University of Jerusalem have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule helping certain cancer cells survive. The discovery paves the way for a new generation of RNA-based cancer treatments targeting genetic roots rather than symptoms.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
Researchers at UMass Amherst have developed a new tool, iConRNA, that provides an unrivaled look inside cells and can help solve the mystery of how devastating diseases develop. The tool resolves the balance of physical driving forces of phase separation and predicts how this balance is tuned under different cellular situations.
Researchers developed a new diagnostic test, CAARRD, to detect ribonucleic acid (RNA) at room temperature, increasing sensitivity and reducing complexity. The test uses special 'anti-tag' CRISPR sequences to block the activity of the Cas13a enzyme, allowing for faster and more affordable detection of viral RNAs such as HIV.
Researchers have developed a new mRNA vaccine technology using albumin-recruiting lipid nanoparticles to deliver vaccines precisely to lymph nodes, avoiding liver toxicity. The approach outperformed traditional delivery systems in laboratory tests, producing strong antitumor T-cell responses and high levels of neutralizing antibodies.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
A new mRNA vaccine has stopped allergens from causing immune reactions and inflammation in mice, instructing the immune system to respond more appropriately. The vaccine is tailored to encode proteins from different allergens, offering a flexible solution to treat seasonal pollen allergies, food sensitivities, and asthma.
Scientists have created a novel method to synthesize all 21 types of transfer RNA (tRNA) simultaneously in a test tube using the tRNA array method. This breakthrough allows for precise control over protein synthesis and has significant implications for the development of artificial molecular systems with self-reproducing capabilities.
Researchers developed an mRNA vaccine that suppresses abnormal blood vessel growth in mouse models of age-related macular degeneration. The vaccine is as effective as current therapies and offers a convenient alternative to frequent eye injections.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers have developed a system to selectively switch off the key molecule of NMD, allowing them to observe its function in human cells with unprecedented precision. The study reveals that NMD not only prevents errors but also acts as an important regulator of gene activity.
Researchers have devised a method to safely and temporarily 'switch off' and then 'turn on' ribonucleic acid (RNA) inside cells using disulfide-containing chemical groups. This strategy could potentially open new avenues in more precise RNA-based therapeutics and gene editing.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Researchers discovered that disordered regions enhance specific RNA interactions in FUS protein-RNA complexes, revealing a breakthrough strategy for nucleic acid binding. The study suggests that intrinsically disordered regions actively contribute to the RNA-binding mechanism.
Cells use a stopwatch-like mechanism to measure the length of messenger RNA (mRNA) tails, achieving molecular accuracy in vital processes like gene expression. The discovery reveals that two proteins, CPAC and Nab2, set the tail's length by timing their interaction, with the final length determined by a race between their speeds.
Scientists have developed a new approach to analyze proteins in individual cells during blood cell formation, bypassing mRNA intermediates. This study reveals the correlation between mRNA levels and protein expression, shedding light on the role of essential proteins in maintaining stem cell populations.
Researchers at the University of Waterloo have developed a novel method using modified M13 bacteria to deliver targeted gene therapies for genetic disorders. This approach shows promise as a cost-effective alternative to current methods, which can be expensive and trigger toxic side effects.
Researchers have identified a previously unknown molecular mechanism behind chemoresistance in acute myeloid leukemia (AML), a type of blood cancer. The study found that a protein called RUNX1C plays a key role in this process, and blocking its activity with RNA-targeting tools can improve chemotherapy's effectiveness.
Researchers used machine-learning models to design nanoparticles that can deliver RNA to cells more efficiently. The approach accelerated the identification of optimal ingredient mixtures in lipid nanoparticles, leading to better delivery vehicles for RNA vaccines and mRNA therapies. This could dramatically speed up the development of ...
Researchers at Boston Children's Hospital have developed a new approach to lengthening telomeres using synthetic RNA. The technique, known as eTERC, has been shown to increase telomere length in human stem cells and leave normal cell mechanisms intact. Additionally, polygenic scores have been developed to estimate the combined effect o...
HTGAnalyzer is an automated tool simplifying complex transcriptomic workflows, enabling clinicians without bioinformatics expertise to perform essential analyses in precision medicine. The tool has been validated using multiple datasets and identified differentially expressed genes linked to cancer diagnosis, treatment, and prognosis.
Researchers discovered that CRISPR-Cas13a can activate even in the absence of a target, leading to unforeseen bystander RNA cleavage. This 'RINCA' activity has implications for cancer therapy and diagnostic tools, with engineered variants showing promise.
Emerging evidence highlights the involvement of extracellular RNAs in the antiviral defense process, with microRNAs binding viral genomes via base-pairing interactions to inhibit expression. RNA immunity represents a complementary arm of the mammalian immune system, functionally independent of traditional protein-based defenses.
Researchers have discovered a natural mechanism by which RNA modifications prevent innate immune activation, raising questions about their potential link to autoimmune disorders. The study found that N-glycans on glycoRNAs block hypermodified RNA bases from inducing immune responses.
Researchers discovered that our bodies add sugars to RNA, shielding it from the immune system. This 'sugarcoating' prevents inflammation and helps clean up dead cells.
Researchers at the University of Illinois Chicago have uncovered the detailed chemical mechanism behind preventing premature protein release. The discovery sheds light on how cells execute protein production, one of life's most essential processes, and clarifies the role of the release factor.
Scientists have identified a previously unknown virus in Pacific oysters linked to annual mass die-offs, highlighting the importance of disease prevention measures. The discovery also underscores the need for further research into the causes of mortality in oyster populations.
Researchers validated panels of antibodies targeting clinically relevant nucleic acid modifications to visualize antisense oligonucleotides in both in vitro and in vivo studies. The tools enable detection of modified nucleic acids irrespective of sequence, facilitating multiple clinical and pre-clinical workflows.
Researchers developed TraMA, an RNA-based measure of biological aging that predicts health risks and mortality. It captures distinct aspects of aging and health decline, including inflammation, immune function, and kidney and brain health.
Researchers found that ribose binds to phosphate more quickly and effectively than other sugar molecules, which could have helped select it for inclusion in RNA development. The study also showed that ribose produces a five-member ring form, similar to the forms seen in RNA and DNA today.
Researchers at the University of Pennsylvania designed a new recipe for mRNA vaccines by adding phenol groups, which reduce inflammation and improve vaccine effectiveness. The modified lipids improved vaccine performance in various diseases, including COVID-19, cancer, and genetic diseases, with enhanced efficacy and reduced side effects.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
A 1,000-patient clinical study will use RNA-based stool and saliva tests to detect colon polyps, enabling early prevention of colorectal cancer. The study aims to develop an at-home RNA test that empowers people to take action before cancer takes hold.
Researchers identified a family of RNA molecules, B2-SINEs, that stimulate growth in peripheral nerves and brain neurons after injury. These findings may lead to new treatments for nerve injuries and neurodegenerative diseases.
Bentham Science Publishers announces that MicroRNA has been awarded an Impact Factor ranking for 2024. The journal continues to lead the list with a 2024 impact factor of 5.3, followed by Recent Patents on Anti-Cancer Drug Discovery and Current Medicinal Chemistry.
A team from Kyushu University has discovered that the smallest known protein-based tRNA-processing enzyme, HARP, forms a star-shaped complex to cut both ends of tRNA. This finding sheds light on how HARP processes the 5' leader sequence and reveals a new mechanism for RNA processing.
A new technology, Toti-N-Seq, harnesses the presence of N-glycans to tag cells and nuclei, achieving precise sample multiplexing without cell-type or species restrictions. This enables accurate single-cell profiling, preserving rare cell populations and reducing doublet rates.
AIMP3 is essential to avoiding mistakes in protein synthesis, not affecting protein production, according to Brown University researchers. The discovery could lead to new treatments for heart diseases linked to homocysteine buildup and has implications beyond the heart.
Researchers used time-restricted feeding to restore microbial rhythms in mice fed a high-fat diet, identifying bile salt hydrolase as a key enzyme protecting metabolic health. Engineered gut bacteria showed improved glucose control and reduced body fat in mice, suggesting potential targeted therapies for obesity and diabetes.
Researchers at KAIST have developed a groundbreaking technology capable of selectively acetylating specific RNA molecules within the human body using the CRISPR-Cas13 system. This breakthrough enables precise, programmable control of RNA function and is expected to open new avenues in RNA-based therapeutic development.
Researchers found that amino acids can actively promote RNA polymerization under mild, prebiotic conditions, increasing formation by up to 100-fold. This process is driven by acid-base catalysis, enabling the shuttle of protons in the reaction. The study suggests a mutual dependence between RNA and amino acids, reshaping our understand...
A Chinese Medical Journal study investigates the role of non-coding RNAs in pancreatic cancer, revealing how dysregulation of these molecules contributes to tumor growth and treatment resistance. The research highlights potential therapeutic targets for this devastating disease.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
Researchers at Stanford University have developed a new CRISPR technology called CRISPR-TO that can transport RNA molecules to specific locations within neurons, enabling repair and regeneration. The technology has shown promising results in increasing neurite growth by up to 50% in mouse brain neurons.
Researchers at UC San Francisco have identified potential protein markers for frontotemporal dementia (FTD), a form of dementia affecting middle age. The study found changes in RNA regulation and brain connections that could lead to early diagnosis and targeted treatments.
A UC San Francisco-led study found that delivering medicine for spinal muscular atrophy (SMA) via the amniotic fluid was safe and helped prevent damage to nerve cells. The therapy used molecules called antisense oligonucleotides (ASOs), which can alter gene expression, and was tested in mice and sheep with promising results.
Researchers discovered that METTL3, an oncogene, regulates the expression of SMAD4 via miR-146a-5p in OSCC. This pathway can potentially have therapeutic implications for treating oral squamous cell carcinoma.
The study found that mRNA-1083 induced higher immune responses than standard care influenza and COVID-19 vaccines, with an acceptable tolerability and safety profile. The vaccine met noninferiority criteria for all 4 influenza strains and SARS-CoV-2 across various age groups.
Researchers found that a chemical modification on messenger RNAs triggers disposal while being read by the ribosome, but during cell stress, this process is halted, allowing stress-response proteins to accumulate and help cells recover. The study may have implications for cancer therapies targeting m6A modifications.
Researchers will gather in Italy to review a decade of work on promoting healthy aging and extreme longevity. The study aims to identify key factors that contribute to the remarkable health of residents over 100 years old.
A centralized and accessible database aims to integrate molecular simulation data, ensuring findability, accessibility, interoperability, and reusability. This will amplify the impact of these data and avoid duplication.
Researchers from Scripps Research and Georgia Institute of Technology have found that the formose reaction can only produce branched sugars, contradicting the widely-held hypothesis. This discovery may help scientists understand how life arose on Earth and lead to better biofuel production.
The Phytovirome Focus Issue addresses fundamental and translational aspects of phytovirome science, highlighting the transformative role of high-throughput sequencing technologies. Researchers discovered a remarkable diversity of viruses in plants, with complex communities interacting with hosts in both pathogenic and beneficial ways.
NuFold, a computational solution developed by Purdue University researchers, uses machine learning techniques to predict the 3D structures of RNA from its sequence. This breakthrough has wide-ranging potential applications in understanding RNA mechanisms and drug development for diseases involving RNA.
Biologists have identified a new type of regulation that influences the expression of about half of all human genes by targeting specific introns. This discovery adds complexity to the process of gene expression and suggests potential therapeutic targets for diseases such as blood cancers and spinal muscular atrophy.
Researchers developed a breakthrough technology using Mirvie's RNA platform to identify unique molecular signals in unborn babies. This innovation enables prediction of severe fetal growth restriction, a leading cause of stillbirth.
A University of Oklahoma research team has developed a breakthrough method of adding a single nitrogen atom to bioactive molecules, transforming them into new pharmacophores. This process, called skeletal editing, could open up uncharted regions of chemical space in drug discovery, making existing drugs cheaper and more accessible.
Researchers have identified three distinct subtypes of osteosarcoma using advanced mathematical modeling and machine learning. This breakthrough could transform clinical trials and patient care by enabling targeted treatment personalized to individual cancer subtypes.