Articles tagged with Rna
A cross-sectional study found that men from disadvantaged neighborhoods had higher stress-related gene expression in their prostate tumors. This association suggests a potential link between neighborhood factors and aggressive prostate cancer.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
This study found that lowering the fecal immunochemical test positivity threshold can achieve comparable sensitivity and specificity to the multitarget stool RNA test without additional testing. The findings are similar to previous observations with multitarget stool DNA testing, suggesting a potentially simpler screening method.
The Penn researchers developed an mRNA vaccine targeting a specific subtype of the H5N1 virus, which elicited strong antibody and T cell responses in mice and ferrets. Vaccinated animals also cleared the virus more rapidly and displayed fewer symptoms than unvaccinated controls.
Researchers at the University of Leeds identified a surge in rare autoimmune cases linked to MDA5 autoimmunity, affecting mainly white men and women. The condition, characterized by skin rashes, pneumonia, and interstitial lung disease, has proven fatal in some cases.
Researchers at IOCB Prague have developed a novel method for preparing ribonucleic acid (RNA) containing modified bases using engineered DNA polymerases. This opens the door to applications in chemical biology and therapeutic applications, including mRNA drugs.
A new study reveals that a specific RNA chemical modification, m6A, is crucial for HIV-1 virus replication and production. The research found that targeting this modification could lead to the development of new treatments for HIV infection.
A recent study by Martin Hetzer and colleagues shows that RNA molecules, crucial for cellular function, remain stable for two years in nerve cells of mice. These long-lived RNAs play a significant role in maintaining cellular longevity and protecting the genome.
Research reveals a mechanism by which daughter cells safeguard themselves against UV-damaged RNA inherited from mother cells. DHX9 stress granules, a special type of stress granule, trap and neutralize damaged RNA to prevent harm.
Researchers have discovered why some RNA-splicing drugs work better than others, revealing a key factor that impacts treatment efficacy. By analyzing the interactions between drugs and RNA, they found that combining splice-modifying drugs targeting the same gene segment can lead to greater therapeutic effects.
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers have discovered the atomic structure of an RNA replicase using cryogenic electron microscopy, shedding light on a primordial 'RNA world' that kick-started evolution. The study provides structural insight into an ancient RNA machine thought to reside at the origin of life.
The American Society for Biochemistry and Molecular Biology is offering complimentary press passes for its annual meeting, Discover BMB, taking place in San Antonio from March 23-26. Qualifying journalists can register to attend the event or access press materials electronically.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
A team of researchers at Hokkaido University has discovered a new role for 4.5 SH RNA in mice, which plays a crucial role in regulating alternative splicing and may be the first identified member of a new class of regulatory RNAs.
Researchers from Japan have discovered a novel targeted molecular therapy using microRNA-451a to suppress the progression of gemcitabine-resistant biliary tract cancers. The study found that miR-451a significantly diminished cell proliferation, induced cell death, and reduced chemoresistance in cancer cells.
Researchers aim to validate noninvasive screening test using exosomal microRNAs for early detection of pancreatic ductal adenocarcinoma. The goal is to reduce unnecessary surgeries and improve health equity by including diverse populations in the study.
A new multitarget stool RNA test, ColoSense, has been shown to detect colorectal neoplasia with high sensitivity and comparable specificity to existing molecular diagnostic tests. The test also demonstrated significant improvement in sensitivity relative to the fecal immunochemical test.
A new study reveals the critical importance of post-transcriptional processes in regulating circadian rhythms and their impact on sleep. Researchers identified a structure in the circadian mRNA Period2 that alters the amplitude of circadian rhythms and disrupts sleep patterns, particularly during transitions between light and dark.
Rice University scientists developed a tiny CRISPR-Cas13 system to shred viruses by targeting RNA. The system's unique mechanism and three-dimensional structure were mapped using cryo-electron microscopy, allowing researchers to engineer it for improved precision and specificity.
This review summarizes six common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing, which play crucial roles in various human diseases. The authors discuss the mechanisms of these modifications and their targeting by small molecule inhibitors.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
Scientists have identified specific long noncoding RNAs that regulate gene expression and life cycle progression of the deadly Plasmodium falciparum malaria parasite. The discovery could lead to new therapeutic strategies against malaria.
Researchers have identified an essential stage in the takeover of rice cells by a fungus, which could accelerate treatment or prevention of rice blast disease. The discovery involves a modification in tRNA molecules that aid in protein construction, and its absence leads to reduced virulence.
Researchers from Osaka University have shed light on how certain proteins contribute to the formation of piRNAs, a type of RNA that protects the genome. Tejas plays a key role in recruiting Vas and Spn-E, facilitating nuage formation and piRNA processing.
Researchers investigate how bacteria modify host RNA using effector proteins to ensure their survival, a process previously unknown in eukaryotes. The team aims to decipher the mechanisms behind this process and its benefits for the bacteria.
A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
A study published in Hepatology reveals that abnormal pre-mRNA splicing is associated with liver disease caused by excessive alcohol consumption. The researchers propose targeting specific splicing factors as a novel approach to mitigate the disease.
A recent publication in Molecular Therapy unveiled the promise of HDT Bio Corp.’s AMPLIFY vaccine platform combining self-replicating RNA (repRNA) with its localizing cationic nanocarrier (LION™) formulation. The preclinical data showcased a more favorable safety profile and increased efficacy of repRNA vaccines delivery with LION tech...
Molecular biologists Ruslan Afasizhev and Inna Afasizheva have discovered the architecture of molecular machines involved in RNA editing in a disease-causing parasite. This understanding could potentially help treat African sleeping sickness, which is usually fatal and has limited treatment options.
The study identifies 1,074 semi-extractable RNAs potentially involved in phase-separated membraneless organelles. These RNAs are enriched in repressed heterochromatin regions and act as hubs for RNA-RNA interactions.
Scientists at Rockefeller University identified distinct RNA changes in the brains of deceased patients with Parkinson's disease, which were also found in their living counterparts' blood. These changes are associated with various clinical symptoms, such as dementia and levodopa-induced dyskinesia.
A new study by researchers at NYU and the New York Genome Center combines deep learning with CRISPR screens to control human gene expression. The model predicts on- and off-target activity of RNA-targeting CRISPRs, enabling precise gene controls for developing new therapies.
A German federal funding program will support a five-year research collaboration to develop specialty lipids and auxiliaries for mRNA vaccines. The project aims to enhance production capacities and improve the resilience of supply chains for future mRNA therapeutics.
Researchers have created an RNA nanoparticle therapy that disables the pathways through which multiple myeloma cells travel, stopping their spread. The therapy targets the microenvironment of the cancer and prevents the production of a protein that attracts cancer cells to blood vessels.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Researchers have identified a new group of mitochondrial viruses confined to arbuscular mycorrhizal fungi Glomeromycotina, which may represent an ancestral lineage of mitoviruses. These large duamitoviruses possess distinct characteristics and are globally distributed in ecological niches occupied by glomeromycotinian fungi.
Scientists at Tohoku University found that boric acid catalyzes polypeptide synthesis under neutral and acidic conditions, producing up to 39 monomer-long glycine polypeptides. This discovery challenges previous studies suggesting neutral conditions hinder peptide synthesis.
Researchers at Cold Spring Harbor Laboratory have developed a potential therapeutic for diffuse intrinsic pontine glioma (DIPG) using antisense oligonucleotide technology. The treatment has slowed tumor growth, reversed changes in cancer cells, and increased survival rates in mice with DIPG.
James Chappell, a Rice University bioscientist, has won a National Science Foundation CAREER Award to create RNA programming methods for microbial communities in natural habitats. His research aims to improve human health and the environment by genetically manipulating microbial communities.
Researchers used long-read sequencing to identify novel mutational patterns and complex genomic rearrangements in cancer genomes, including those associated with liposarcoma. This approach offers a more comprehensive understanding of DNA mutations and their impact on cell function.
A new method for global profiling of in-situ RNA–RNA contacts associated with specific RBP has been developed, revealing positional mechanisms by which PTBP1-associated RNA loops regulate cassette exon splicing. The study found that PTBP1 can modulate cassette exon splicing via mediating specific RNA loops in a position-dependent manner.
Scientists have detected uracil and nicotinic acid in asteroid Ryugu samples collected by the Hayabusa2 spacecraft. The discovery suggests that important building blocks for life were created in space and delivered to Earth via meteorites, supporting current theories on the source of nucleobases.
Researchers discovered that jewel beetles have duplicated genes allowing them to see new colors, including ultraviolet and blue light. This evolution likely occurred after the loss of blue vision in beetle ancestors around 300 million years ago.
Researchers discovered ADAR2 dysregulation contributes to CBF-AML leukemogenesis through downregulation of the gene. Re-expressing ADAR2 suppressed leukaemogenesis in CBF-AML cells, highlighting its functional relevance.
Researchers have discovered a surprising mechanism by which the molecular machine Dis3L2 unwinds and destroys RNA molecules. By changing shape, Dis3L2 reveals an RNA-splitting wedge, allowing it to execute its tasks in a more dynamic and versatile way.
A team of researchers developed an AI-based method called m6Anet to accurately predict chemical modifications of RNA molecules from genomic data. This enables the detection of RNA modifications in clinical samples and understanding their role in diseases such as cancer.
A new method for rapid and specific antibody detection has been introduced, using programmable gene circuits, cell-free transcription, and electrochemical detection. The system can detect antibodies in complex samples such as blood serum and is adaptable for a wide variety of other antibodies.
Researchers at the University of Tokyo have developed artificial DNA that can target and kill cancer cells by binding to microRNA molecules. The DNA triggers an immune response that not only kills cancer cells but also prevents further growth of cancerous tissue.
A study published in Aging-US reveals changes in gene expression associated with age-related muscle loss and frailty. Researchers identified unique cellular subpopulations in aged and sarcopenic skeletal muscle, which may facilitate the development of new treatments for age-related frailty.
In a complex process, germ cells produce GRIF-1 protein to mark and degrade maternal RNA molecules, gaining access to their own genetic material. This allows for the development of an entire organism without maternal control.
The new CRC 1551 will study the polymer properties of DNA, RNA, and proteins to understand their interaction in cells. The researchers aim to describe and understand nonequilibrium processes in cells triggered by complex interplay of cellular polymers.
The German Research Foundation renewed CRC 1361 for an additional four years to explore mechanisms of DNA repair and genome stability. The consortium aims to elucidate how cells safeguard genetic information and promote human health by understanding DNA damage signaling pathways.
Johannes Gutenberg University Mainz has been awarded funding for three Collaborative Research Centers in the life sciences, including CRC 1551 and CRC/Transregio 355. The centers will focus on investigating polymer concepts in cellular function and heterogeneity of regulatory T cells in distinct microenvironments.
Experts in RNA biology and drug design will gather for a two-day symposium on the state of the science that is changing preventive medicine. The event features confirmed speakers known for their advances in RNA biology and drug discovery, including mRNA vaccine success against COVID-19.
Current sequencing methods miss gene fusions in many non-small cell lung cancer patients, denying them access to targeted therapies. Novel genomic technology ASPYRE provides ultra-sensitive detection of gene fusions from RNA.
Researchers at Aarhus University use RNA origami sponges and CRISPR technology to regulate protein production levels and gene expression in bacteria and yeast. This approach generates stable, interactive molecules for synthetic biology-based regulation, enabling unique applications in industrial, diagnostic, and therapeutic fields.