Articles tagged with Rna
Researchers at the University of Würzburg have discovered a new degradation process for mRNA that targets proteins involved in cell differentiation. This process, triggered by the m6A modification, is significantly faster and more efficient than previously known mechanisms.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Scientists have captured 3D snapshots of individual RNA nanoparticles in motion, showcasing the dynamic and intricate folding process. This breakthrough uses advanced electron microscopy to study RNA's flexibility, enabling new insights into its structure and potential applications in molecular medicine.
A groundbreaking microscopy method called TRISCO has enabled detailed three-dimensional RNA analysis at cellular resolution in whole intact mouse brains. The new method allows for the study of complex brain anatomy without sectioning, providing a powerful tool for brain research.
Exposure to multiple environmental stressors simultaneously impairs the ability of herring larvae to react at a molecular level, reducing their capacity for acclimatization. This can lead to increased protein damage and cell injury, potentially affecting growth and survival.
A team of researchers has identified a mechanism that interferes with the splicing process in a more subtle way, leading to cell death. The study reveals that spliceosome subunits U4, U5, and U6 are normally stabilized by protein USP39, but when mutated or absent, stability is compromised, causing incorrect connections during splicing.
A team of biologists at UT Arlington has discovered a new species of gecko, Pseudogonatodes fuscofortunatus, with distinct skeletal features and genetic data. The discovery highlights the unique characteristics of this tiny lizard, found in the Paria Peninsula of Venezuela.
A team at Penn State developed an experimental pipeline called Cleavage High-Throughput Assay (CHiTA) that can test the activity of thousands of predicted twister ribozymes. The study identified approximately 94% of tested ribozymes as active, revealing their function can persist even with slight imperfections.
Researchers have found that Alzheimer's disease and alcohol use disorder are associated with similar gene expression changes in the brain, including inflammation and disrupted cell signaling. This study may inform future targeted treatments for Alzheimer's and highlight the importance of considering alcohol use as a risk factor.
Researchers demonstrate the first cross-chiral exponential amplification of an RNA enzyme, potentially leading to the development of cross-chiral therapeutics and biotechnologies. The discovery suggests that a bioengineer can create a new form of biochemical evolution by using both left- and right-handed molecules.
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. This new approach provides a less toxic and quickly reversible alternative to hydroxyurea, allowing for better insight into cell cycle arrest mechanisms.
A new study reveals a connection between NF-κB signaling pathways and X chromosome inactivation in T cells, which has implications for understanding sex-based immune responses. Researchers found that the maintenance of X chromosome inactivation depends on nuclear factor kappa B (NF-κB), a transcription factor.
A new study found that 5-fluorouracil kills cells by interfering with RNA synthesis, not DNA damage. The findings suggest that combining 5-FU with drugs affecting RNA synthesis could make it more effective in patients with gastrointestinal cancers.
Researchers identify a plausible geological environment where nucleic acids can replicate and potentially lead to life. The study reveals a circular fluid flow at the gas-water interface drives strand separation, allowing replication to occur.
Researchers at Boston University discovered a new method to harness self-amplifying RNA to create more effective vaccines. The modified saRNA vaccine protected mice from severe COVID-19 disease with a lower dose than current mRNA vaccines. Longer duration of protein expression and reduced inflammation were also observed.
Researchers from Japan have discovered that Exportin-5 interacts with a broader spectrum of RNAs, including tRNAs, miRNAs, lncRNAs, and specific mRNAs. This study sheds light on the unique roles of Exp5 in RNA export within Drosophila cells.
A team of international researchers has discovered a surprising genetic mechanism that influences the vibrant patterns on butterfly wings. An RNA molecule controls where dark pigments are made during butterfly metamorphosis, shaping the butterfly's color patterns in a way previously unforeseen.
Researchers at Osaka Metropolitan University found compounds in nucleic acids from salmon DNA and torula yeast RNA inhibit cancer cell growth. These compounds may prevent cancer by stopping cell replication.
A team led by Harvard's Ryan Flynn has discovered the mechanism of how RNA is chemically linked to N-glycans, proving the existence of glycoRNAs. This finding broadens the scope of known glycoconjugates and opens new avenues for research into glycoRNA biology.
Researchers at TUM discovered a mechanism that enables double-stranded RNA molecules to form and remain stable in the primordial soup. This discovery has significant implications for understanding the origin of life and could lead to breakthroughs in medicine, particularly in vaccine development.
Researchers predict that circular RNAs will play a crucial role in cancer diagnosis and treatment, enabling innovative diagnostic and therapeutic developments. The study highlights the potential of circRNAs as biomarkers, therapy targets, and even immune response inducers against cancer cells.
A cross-sectional study found that men from disadvantaged neighborhoods had higher stress-related gene expression in their prostate tumors. This association suggests a potential link between neighborhood factors and aggressive prostate cancer.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
This study found that lowering the fecal immunochemical test positivity threshold can achieve comparable sensitivity and specificity to the multitarget stool RNA test without additional testing. The findings are similar to previous observations with multitarget stool DNA testing, suggesting a potentially simpler screening method.
Researchers at the University of Leeds identified a surge in rare autoimmune cases linked to MDA5 autoimmunity, affecting mainly white men and women. The condition, characterized by skin rashes, pneumonia, and interstitial lung disease, has proven fatal in some cases.
The Penn researchers developed an mRNA vaccine targeting a specific subtype of the H5N1 virus, which elicited strong antibody and T cell responses in mice and ferrets. Vaccinated animals also cleared the virus more rapidly and displayed fewer symptoms than unvaccinated controls.
Researchers at IOCB Prague have developed a novel method for preparing ribonucleic acid (RNA) containing modified bases using engineered DNA polymerases. This opens the door to applications in chemical biology and therapeutic applications, including mRNA drugs.
A new study reveals that a specific RNA chemical modification, m6A, is crucial for HIV-1 virus replication and production. The research found that targeting this modification could lead to the development of new treatments for HIV infection.
A recent study by Martin Hetzer and colleagues shows that RNA molecules, crucial for cellular function, remain stable for two years in nerve cells of mice. These long-lived RNAs play a significant role in maintaining cellular longevity and protecting the genome.
Research reveals a mechanism by which daughter cells safeguard themselves against UV-damaged RNA inherited from mother cells. DHX9 stress granules, a special type of stress granule, trap and neutralize damaged RNA to prevent harm.
Researchers have discovered why some RNA-splicing drugs work better than others, revealing a key factor that impacts treatment efficacy. By analyzing the interactions between drugs and RNA, they found that combining splice-modifying drugs targeting the same gene segment can lead to greater therapeutic effects.
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers have discovered the atomic structure of an RNA replicase using cryogenic electron microscopy, shedding light on a primordial 'RNA world' that kick-started evolution. The study provides structural insight into an ancient RNA machine thought to reside at the origin of life.
The American Society for Biochemistry and Molecular Biology is offering complimentary press passes for its annual meeting, Discover BMB, taking place in San Antonio from March 23-26. Qualifying journalists can register to attend the event or access press materials electronically.
A team of researchers at Hokkaido University has discovered a new role for 4.5 SH RNA in mice, which plays a crucial role in regulating alternative splicing and may be the first identified member of a new class of regulatory RNAs.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Researchers from Japan have discovered a novel targeted molecular therapy using microRNA-451a to suppress the progression of gemcitabine-resistant biliary tract cancers. The study found that miR-451a significantly diminished cell proliferation, induced cell death, and reduced chemoresistance in cancer cells.
Researchers aim to validate noninvasive screening test using exosomal microRNAs for early detection of pancreatic ductal adenocarcinoma. The goal is to reduce unnecessary surgeries and improve health equity by including diverse populations in the study.
A new multitarget stool RNA test, ColoSense, has been shown to detect colorectal neoplasia with high sensitivity and comparable specificity to existing molecular diagnostic tests. The test also demonstrated significant improvement in sensitivity relative to the fecal immunochemical test.
A new study reveals the critical importance of post-transcriptional processes in regulating circadian rhythms and their impact on sleep. Researchers identified a structure in the circadian mRNA Period2 that alters the amplitude of circadian rhythms and disrupts sleep patterns, particularly during transitions between light and dark.
Rice University scientists developed a tiny CRISPR-Cas13 system to shred viruses by targeting RNA. The system's unique mechanism and three-dimensional structure were mapped using cryo-electron microscopy, allowing researchers to engineer it for improved precision and specificity.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
This review summarizes six common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing, which play crucial roles in various human diseases. The authors discuss the mechanisms of these modifications and their targeting by small molecule inhibitors.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
Scientists have identified specific long noncoding RNAs that regulate gene expression and life cycle progression of the deadly Plasmodium falciparum malaria parasite. The discovery could lead to new therapeutic strategies against malaria.
Researchers have identified an essential stage in the takeover of rice cells by a fungus, which could accelerate treatment or prevention of rice blast disease. The discovery involves a modification in tRNA molecules that aid in protein construction, and its absence leads to reduced virulence.
Researchers from Osaka University have shed light on how certain proteins contribute to the formation of piRNAs, a type of RNA that protects the genome. Tejas plays a key role in recruiting Vas and Spn-E, facilitating nuage formation and piRNA processing.
A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
Researchers investigate how bacteria modify host RNA using effector proteins to ensure their survival, a process previously unknown in eukaryotes. The team aims to decipher the mechanisms behind this process and its benefits for the bacteria.
A study published in Hepatology reveals that abnormal pre-mRNA splicing is associated with liver disease caused by excessive alcohol consumption. The researchers propose targeting specific splicing factors as a novel approach to mitigate the disease.
A recent publication in Molecular Therapy unveiled the promise of HDT Bio Corp.’s AMPLIFY vaccine platform combining self-replicating RNA (repRNA) with its localizing cationic nanocarrier (LION™) formulation. The preclinical data showcased a more favorable safety profile and increased efficacy of repRNA vaccines delivery with LION tech...
Molecular biologists Ruslan Afasizhev and Inna Afasizheva have discovered the architecture of molecular machines involved in RNA editing in a disease-causing parasite. This understanding could potentially help treat African sleeping sickness, which is usually fatal and has limited treatment options.
The study identifies 1,074 semi-extractable RNAs potentially involved in phase-separated membraneless organelles. These RNAs are enriched in repressed heterochromatin regions and act as hubs for RNA-RNA interactions.
Scientists at Rockefeller University identified distinct RNA changes in the brains of deceased patients with Parkinson's disease, which were also found in their living counterparts' blood. These changes are associated with various clinical symptoms, such as dementia and levodopa-induced dyskinesia.
A new study by researchers at NYU and the New York Genome Center combines deep learning with CRISPR screens to control human gene expression. The model predicts on- and off-target activity of RNA-targeting CRISPRs, enabling precise gene controls for developing new therapies.
A German federal funding program will support a five-year research collaboration to develop specialty lipids and auxiliaries for mRNA vaccines. The project aims to enhance production capacities and improve the resilience of supply chains for future mRNA therapeutics.
Researchers have created an RNA nanoparticle therapy that disables the pathways through which multiple myeloma cells travel, stopping their spread. The therapy targets the microenvironment of the cancer and prevents the production of a protein that attracts cancer cells to blood vessels.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.