Articles tagged with Rna
Current sequencing methods miss gene fusions in many non-small cell lung cancer patients, denying them access to targeted therapies. Novel genomic technology ASPYRE provides ultra-sensitive detection of gene fusions from RNA.
Researchers at Aarhus University use RNA origami sponges and CRISPR technology to regulate protein production levels and gene expression in bacteria and yeast. This approach generates stable, interactive molecules for synthetic biology-based regulation, enabling unique applications in industrial, diagnostic, and therapeutic fields.
Researchers investigate how motor proteins transport vital proteins and RNAs to the right location within cells, where they can cause or prevent genetic neurological diseases. By understanding these highly regulated transport systems, scientists hope to develop new treatments for conditions like spinal muscular atrophy and Charcot-Mari...
A new method, EPISENS-S, has been developed to measure SARS-CoV-2 in wastewater with high sensitivity. This allows for the estimation of COVID-19 prevalence, including asymptomatic cases. The method was found to be approximately 100 times more sensitive than existing methods.
Researchers at OIST Graduate University have experimentally shown the concept of a neutral network, vital for increasing diversity, by designing and testing over 120,000 RNA variants. They found a large number of accessible pathways between two variants, challenging previous theoretical predictions.
Coronavirus levels in wastewater accurately predicted hospitalization peaks and healthcare pressure, enabling timely forecasting. The study's results demonstrate the value of virus surveillance in monitoring ongoing outbreaks.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
A study by Osaka University researchers comprehensively analyzed mRNA and microRNA expression patterns in the blood of patients with severe COVID-19, revealing specific mRNAs and microRNAs associated with the immune response pathway. The findings suggest that interferon-β plays a crucial role in COVID-19 severity.
A study by Hokkaido University scientists found a close association between clinical cases of COVID-19 and viral loads in wastewater, with the viral loads picking up to two days before the cases were detected. The researchers used wastewater-based epidemiology to track the spread of SARS-CoV-2 in the Tokyo 2020 Olympics and Paralympics.
A new study has identified the genes that become active in carotid arteries when plaque rupture causes a stroke. The researchers sequenced the RNAs in plaques from patients who had experienced a stroke within two to five days, revealing increased inflammation and loss of protective cap.
A team of scientists has discovered the genetic mechanism behind the emergence of highly resistant fungal strains, such as Cryptococcus neoformans. The researchers found that transposon mobility is controlled by small interfering RNA (siRNA), and that disabling siRNA can lead to resistance.
A study reveals that an ADAR1 gene mutation activates ZBP1 protein, leading to programmed cell death and inflammatory responses. This causes damage to organs like the kidneys and liver in genetically modified mouse models.
A team of scientists has discovered a key link between the protein αSyn and Parkinson's disease, finding that it interacts with immune responses in neurons. This interaction may play a critical role in the development of the disease, suggesting a potential new approach for treatments by targeting inflammatory pathways.
A UNC Charlotte-led team has invented a new biomolecular anticoagulant platform that holds promise as a revolutionary advancement over current blood thinners. The technology uses programmable RNA-DNA fibers to prevent blood clotting as needed, then be swiftly eliminated from the body.
A team of researchers has discovered a wide range of nitriles, key molecular precursors for life, in the interstellar molecular cloud G+0.693-0.027 near the Milky Way center. The study provides important insights into the chemical ingredients available in the nebula that give rise to our planetary system.
A new statistical method called Association Plot facilitates the determination and analysis of marker genes in single-cell data. This allows researchers to trace back RNA molecules to their cell of origin, providing insights into cell-type specific genes.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A new study published in mSystems demonstrates that a surface sampling method can detect SARS-CoV-2 RNA on surfaces, improving environmental surveillance in public health labs.
Researchers developed a simple physical model to explain DNA deformations caused by ions and temperature changes. The model reveals that salt-induced twist changes are driven by electrostatic interactions, while temperature-induced changes are related to DNA diameter variation. These findings provide new insights into the molecular mec...
A new type of RNA structure targeting tool has been developed to specifically recognise unusual four-strand RNA structures associated with diseases such as cancer and neurological disorders. The L-RNA aptamer-based rG4 targeting approach shows promise for developing new therapeutic tools.
Assistant professor David Knowles at Columbia University wins a $500,000 NSF CAREER Award to develop a new framework and tools for analyzing alternative splicing in diseases such as ALS and cancer. The project aims to create more accurate algorithms for single-cell and long-read RNA-seq analysis.
Researchers studied peptide bond formation between tRNA molecules and a ribosomal RNA segment, revealing the potential for minihelices to bind to the primordial peptidyl transferase center. The study suggests that functional interactions between tRNA and PTC could have been 'revised' in evolution.
Researchers developed a virus that infects cancer cells, killing them while sending signals to nearby uninfected cells for viral attack. This approach shrinks tumors and enhances cancer-killing efficacy in various models, including pancreatic and ovarian cancers.
New research from Rutgers University sheds light on the genetic mechanisms of reproductive disorders, including infertility and miscarriage. The study reveals how the RNA helicase YTHDC2 regulates meiosis, a critical step in egg and sperm development.
A study compared the antibody response in human milk after vaccination with four COVID-19 vaccines, revealing differences in immune system activation. The findings provide valuable insights into vaccine effectiveness and potential impact on infant health.
Scientists at Karolinska Institutet have developed a new high-precision tool to identify the function of noncoding DNA sequences, which may eventually contribute to the development of targeted drugs. The study reveals that these noncoding parts of patients' DNA are linked to genetic changes in diseases.
Researchers at Johns Hopkins Medicine discovered 110 genes, circular RNAs, lipids and metabolites that differ between medulloblastoma patients' cerebrospinal fluid and healthy controls. These findings provide proof of principle for novel biomarkers to detect and track the disease.
A new method called DisCo enhances the efficiency of single-cell RNA sequencing by actively detecting and capturing cells using machine-vision. This approach allows for continuous operation and high capture efficiency, making it suitable for processing small cell samples such as tissues or patient biopsies.
Researchers at the University of Gothenburg mapped SARS-CoV-2 mutation patterns and found that ADAR1-induced mutations weaken the virus. These mutations are more common than other types of mutations, suggesting a protective mechanism against COVID-19.
A Rutgers study found measurable airborne SARS-CoV-2 RNA in the air of most homes where COVID-19 infected individuals were isolating, suggesting airborne transmission beyond isolation rooms poses a risk to other occupants. The study also showed that infected individuals often did not strictly adhere to self-isolation protocols.
Researchers at Cold Spring Harbor Laboratory develop a novel method to modify the CFTR gene, allowing for the production of functional protein in patients with certain mutations. The technique involves using antisense oligonucleotides to skip over the mutation and produce a partially functional protein.
A recent study published in Pediatric Research found no SARS-CoV-2 genetic material in breastmilk from mothers infected with COVID-19, ruling out transmission to infants. The authors analyzed 110 lactating women and did not find any clinical evidence of infection in breastfeeding infants.
Plant cells use RNA signals to coordinate growth, but these signals require a special escort protein to reach the right cells. Without this protein, plants fail to develop properly, highlights a crucial step in understanding how information is exchanged between cells.
Researchers at Karolinska Institutet have identified a specific connection between a protein and an lncRNA molecule that can help decrease fat depots in tumor cells, leading to cell division cessation and cancer cell death. The study contributes to increased knowledge of liver cancer diagnosis and future treatments.
Researchers developed a novel strategy to deliver siRNA therapeutics directly to the brain, reversing Huntington's disease symptoms and improving behavioral deficits. The approach utilizes exosomes to facilitate siRNA delivery, avoiding invasive procedures and safety concerns.
Researchers developed a new technique to analyze brain cell development, finding that cells of similar types are often unrelated and can converge from different progenitors. Conversely, different cell types can diverge from the same progenitor, determining their fate during differentiation.
A Yale team has discovered an RNA molecule, SLR14, that stimulates the body's early antiviral defense system to protect against SARS-CoV-2 variants. This therapy holds promise as a new class of RNA therapeutics for treating COVID-19 in immunocompromised patients.
Researchers developed a biodegradable polymer called polylactide (PLA) with RNA-inspired breaking points, which can break down faster in seawater. The degradation rate of the polymer can be tailored depending on the amount of breaking points, offering a potential solution to marine pollution.
Alicia Angelbello and Professor Matthew Disney developed an RNA-targeting medication strategy to treat a type of muscular dystrophy. Their technology destroys toxic RNA genetic repeats, impacting about 200,000 people in the US, and may lead to first-ever oral medications.
A research group at Osaka University has developed a new tool for sequencing various types of RNA base modifications, including microRNA modifications. They successfully detected two types of chemical base modifications simultaneously using a single-molecule quantum sequencer.
Stanford researchers have developed a mini CRISPR genome editing system that is smaller and more efficient than existing versions. The new system, called CasMINI, has been successfully tested in human cells and shows promise for treating various diseases, including eye disease, organ degeneration, and genetic diseases.
Scientists have found that misfolded tau protein accumulates RNA tags called N6-Methyladenosine (m6A) in nerve cells, leading to neurodegeneration. Inhibiting this RNA-tagging pathway shows promise as a potential approach to treat Alzheimer's disease.
Researchers have developed an approach that predicts accurate structures computationally, overcoming the problem of determining molecular shapes. The algorithm succeeds even when learning from only a few known structures, making it applicable to difficult-to-determine molecules.
Researchers found that a chemical modification called m6A may offer protection against non-alcoholic fatty liver by slowing down the accumulation of fat in the liver. The study also suggested that this modification occurs at a different rate in females than males, potentially explaining sex differences in liver fat content.
The study found a significant association between SARS-CoV-2 RNA levels and symptom severity in patients with the virus. Researchers discovered that higher RNA levels were linked to more severe symptoms, suggesting a possible correlation between viral load and disease progression.
UC Riverside researchers have decoded the genome of a benign infection, potentially sending medicine into citrus trees. The discovery could harness its unique properties to deliver antibacterial and antiviral agents into plants' vascular systems.
A team of Colorado State University scientists detected Zika virus RNA in free-ranging African bats, shedding light on the ecology of flaviviruses and potential natural transmission routes. The findings suggest that bats may be incidental hosts of Zika virus infection, rather than amplifying hosts or reservoir hosts.
The Skoltech team created a genome-wide atlas of developmental alternative splicing changes in seven organs across six mammal species and chicken. Alternative splicing plays a crucial role in forming organs like the brain, heart, and testes, but is less significant for others like the liver and kidneys.
A Z-RNA nanoswitch that switches from a right-handed A-RNA state to a left-handed Z-RNA state regulates immune responses against self RNAs. The switch is encoded by 'junk DNA' and protects normal cells from inflammatory diseases, while malfunctioning causes diseases like Aicardi-Goutieres disease.
Researchers developed a new method to test AI algorithms' decision-making processes by presenting them with carefully designed synthetic data. The technique, called Global Importance Analysis, revealed that AI models consider more factors beyond just sequence length, such as RNA folding and motif proximity.
Researchers found that GS-441524, a metabolite of remdesivir, inhibits the nsP3 protein's activity, which is important for virus replication and suppressing host cell defense. This discovery could lead to the development of new antiviral drugs effective against multiple viruses
Researchers found that a chemical modification of RNA, influenced by diet, plays a key role in polycystic kidney disease. Limiting methionine in the diet may partially control cyst formation, and identifying chemicals that stem Mettl3 activity may lead to new drug treatments.
Scientists have developed a technology that allows pinpointing millions of RNA molecules mapped inside tissues with nanoscale resolution. This breakthrough enables researchers to advance treatment of complex diseases and Alzheimer's research by analyzing RNA molecules in 3D tissue samples.
The study reveals that many virus-like insertions may remain undiscovered in animal genomes, highlighting the need for further research on endogenous RNA viruses. Machine learning was used to detect sequence patterns characteristic of endogenous RNA viruses in the human genome.
Researchers discovered SARS-CoV-2 RNA in human corneas of patients with COVID-19, shedding light on the virus's presence beyond respiratory sites. The study suggests potential implications for eye care and infection transmission.
Chemists at Scripps Research Institute demonstrate a simple compound called diamidophosphate can assemble DNA building blocks into primordial DNA strands. This finding supports the theory that DNA and RNA arose together as products of similar chemical reactions.
A systematic review of SARS-CoV-2 air contamination in hospitals revealed frequent viral RNA presence but low viable virus rates. High viral loads were detected in toilets, bathrooms, and public areas, emphasizing the importance of careful cleaning and disinfection.
A study examines SARS-CoV-2 RNA test results in patients who recovered from COVID-19 with prior negative results. Researchers found that some patients tested positive for the virus after recovery, highlighting the need for continued monitoring and testing.
Membraneless compartments, known as complex coacervates, respond predictably to wet-dry cycling, a process likely common during the early development of life on Earth. The behavior informs current applications of the droplets found in household items and has implications for the evolution of life.
Researchers from Aarhus University discovered that a circular RNA molecule, ciRS-7, is actually not found in cancer cells but contributes to cancer development through the tumor's microenvironment. This finding challenges previous conclusions and highlights the importance of spatial analyses of patient tumors.