Articles tagged with Targeted Genome Editing
A Baylor College of Medicine team has reported the first successful genome surgery, changing how the human genome is folded inside the cell nucleus. By manipulating specific DNA motifs, the team was able to destroy, move, and create new loops in the genome.
A highly efficient CRISPR/Cas system has been developed for targeted long cassette insertion into the mouse genome, achieving efficiency of up to 50%. This breakthrough technology enables the creation of humanized mice for modeling genetic diseases and improving gene therapy safety.
A team of scientists, led by Harvard University's David Liu, has developed an engineered form of the genome-editing protein Cas9 that can be turned on with a small drug-like molecule. This approach achieves up to 25-fold higher specificity in genome editing than the standard form of Cas9.
Researchers have developed a CRISPR-Cas system to edit the genome of Candida albicans, a pathogen resistant to antifungal drugs. This system enables efficient targeting of essential genes, offering new hope for developing therapies against deadly fungal infections.