Articles tagged with Transcriptional Elongation
Researchers uncover pivotal role of ZmCCT2 in regulating maize mesocotyl length and adapting to high altitudes. Significant associations between genetic variations and mesocotyl lengths were found, highlighting the essential function of ZmCCT2 in promoting cell elongation.
Researchers have developed fresh tomatoes with improved stress tolerance and elongated fruit shapes, suitable for mechanized harvesting. The study identified the FS8.1 gene responsible for this trait, which promotes cell proliferation in the ovary wall, resulting in longer fruit shapes.
As organisms age, gene transcription speed increases but accuracy decreases, leading to lower-quality proteins. However, researchers found that dietary restrictions and certain interventions can reverse this process, revealing a potential molecular mechanism for healthy aging.
Scientists from Tokyo Institute of Technology have developed a genetically encoded probe to visualize active transcription sites in living cells. The probe successfully identified phosphorylated Ser2 in RNA polymerase II, allowing for the localization of elongation phase transcription sites in real-time.
Researchers have identified a novel mechanism that coordinates the assembly of components inside cells that control gene expression, revealing a widespread role for disordered protein interactions. The findings suggest that disrupting these interactions can lead to impaired gene expression, providing potential new targets for treatment.
The study reveals that gene transcription is equally important to DNA damage response, with activated transcription facilitating DNA repair and limiting abnormal transcripts. Cells become hypersensitive to DNA damage-inducing agents when the RBM7-P-TEFb axis is interfered with.
Researchers at Ohio State University suggest new ways to treat cancer by inhibiting overactive cancer-promoting genes and enhancing sluggish tumor-suppressor genes. The findings, published in Nature Communications and Nature Genetics, provide insights into the role of glucocorticoid receptors and epigenetic marks in cancer development.
A new study led by Stowers Institute researchers reveals the Little Elongation Complex (LEC) as a critical component of small nuclear RNA (snRNA) transcription. LEC's unique 'Swiss Army knife' function is required for both initiation and elongation phases of snRNA transcription, shedding light on gene expression and regulation.
Researchers at National University of Singapore have identified a novel double-stranded DNA structure, dubbed S-DNA, which has sparked a 16-year scientific debate. The team's findings suggest that S-DNA may be a potential binding substrate for DNA intercalators and proteins.
Stowers researchers find that each class of genes transcribed by RNA polymerase II has a specific class of elongation factors, controlling which genes are transcriptionally regulated. This discovery adds a new dimension to transcriptional elongation control and has significant implications for understanding gene expression.
The Stowers Institute's Workman Lab has made a groundbreaking discovery of a novel histone demethylase protein complex, which plays a crucial role in regulating transcription elongation. The research reveals that this protein complex associates with the heterochromatin protein 1a and stimulates its histone demethylation activity.