Articles tagged with Antibodies
Scientists designed a novel approach to create stable and predictable antibody drug conjugates (ADCs) using computational docking molecular simulations. The new therapy, called MAGNET-ADC, can deliver cancer drugs specifically to tumor tissue with reduced toxicity.
Researchers at Boston Medical Center identified specific virus characteristics that can help predict the efficacy of HIV-1 treatments using antibody-based treatments. These findings will enable physicians to make better-informed decisions on treatment plans for patients with HIV-1, ultimately treating the virus to slow it down earlier.
A study published in Pediatric Allergy and Immunology found that 17% of children with food allergies are also allergic to sesame. The researchers developed a mathematical model to predict sesame allergy in children with food allergies, which could help clinicians identify this common allergy.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
Researchers found filovirus antibodies in 5.9% of human samples and up to 13.3% of bat species, including those with Ebola virus, Bundibugyo virus, Sudan virus, Marburg virus, and Mengla virus antibodies. The study highlights the need for surveillance at the human-animal interface.
A recent study published in Science reveals that measles virus infection can eliminate up to 73% of a child's protective antibodies, rendering them defenseless against other viruses. The discovery underscores the importance of widespread vaccination and highlights the potential consequences of measles infection on the immune system.
In unvaccinated children, measles infection can cause a significant weakening of the immune system, leading to impaired immunity against viruses and bacteria for months or even years. This phenomenon, known as 'immune amnesia,' was observed in two separate studies published in Science Immunology and Science.
Researchers at Scripps Research have found an antibody that protects against a wide range of influenza viruses by targeting the neuraminidase protein. The discovery could lead to the development of a universal flu vaccine that offers broad protection against human, swine, and avian strains.
A newly discovered antibody protects mice against a wide range of lethal influenza viruses, representing human, swine, and avian strains. The antibody could serve as a template to design a universal flu vaccine and treat severe cases of flu.
Scientists demonstrate flaws in protein detection tools and outline a solution to improve antibody validation. The study highlights the need for accurate standard processes to test antibody quality.
Scientists have decoded the immune response to the Ebola vaccine, revealing a broad range of antibodies against the virus. The research, led by Prof. Klein, found that different sites on the envelope protein of the virus were recognized and many antibodies exhibited high neutralising activity.
A UK-wide collaboration has identified a genetic variant carried by 40% of the population that explains why some patients develop antibodies against anti-TNF drugs and lose response. This discovery could lead to individualized treatment strategies for patients with Crohn's disease.
Researchers at the Hubrecht Institute have created a new method called GateID that allows for the purification of cell types to high purity without using antibodies or genetic reporters. This enables the detailed study of individual cell types, such as stem cells and tumor cells, which are crucial for understanding their properties and...
Researchers found that blocking interleukin-11 protein with therapeutic antibodies can reverse lung fibrosis in a mouse model. This discovery holds promise for treating idiopathic pulmonary fibrosis (IPF), a life-threatening lung disease. Clinical trials are expected to begin by 2021.
Researchers have developed a laser incubator for blood that can slash incubation time to just 40 seconds, improving pre-transfusion testing and saving lives. This technology has the potential to prevent fatal blood transfusions in critically ill patients and detect antibodies in pregnant women.
A new study in Nature explores the role of chromatin loops in V(D)J recombination, a gene assembly process that generates diverse antibodies. The research reveals how cells exploit loop formation to mix and match genetic code, leading to the creation of new antibodies.
Researchers have developed a technique to make sheep produce new antibodies by injecting DNA building blocks, offering a cheaper and more efficient approach than industrial production. This breakthrough brings the study of antibody gene therapy closer to clinical use.
Researchers at U of T have developed growth factor-mimicking antibodies that can induce tissue repair in the body. The antibodies, called FLAgs, mimic key proteins called Wnt that normally instruct stem cells to form tissue.
Researchers have identified key immunological changes in people who develop a meat allergy triggered by tick bites, which can lead to mild hives or life-threatening anaphylaxis. The study provides important insights into why otherwise healthy individuals can suddenly become allergic to mammalian meat.
New research suggests that the risk of developing microcephaly due to Zika virus infection depends on the types of antibodies produced by pregnant mothers. Antibodies from mothers of babies with microcephaly are more effective at neutralizing the virus, but also show enhanced ability to boost viral entry into human cells.
Researchers found that antibodies generated against the Zika virus itself may contribute to birth defects in some pregnancies. The study suggests that a safe vaccine would need to induce protective antibodies while avoiding those that increase the risk of microcephaly.
A study led by ISGlobal found that vaccination with RTS,S increases levels of antibodies recognizing 'P. falciparum' antigens not included in the vaccine, potentially leading to natural immunity. This effect was observed mainly in regions with low to moderate transmission levels.
Consuming more gluten during early childhood is associated with higher risk of celiac disease and autoimmunity among genetically predisposed children. The study found a significant increase in risk for every 1-gram per day increase in gluten consumption.
A new study finds that enterovirus antibodies were detected in the cerebrospinal fluid of most patients with acute flaccid myelitis, suggesting a possible link between the two conditions. The research provides further evidence that enterovirus infection may be a factor in AFM.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
A new combination treatment regimen enhances the immune system's ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to attract natural killer immune cells to cancer cells, resulting in increased killing of acute lymphoblastic leukemia cells by up to 35%.
Mount Sinai researchers have developed a novel vaccine consisting of DNA and recombinant proteins, which was tested in monkeys and induced antibodies similar to those associated with protection from HIV. The vaccine targets the V1V2 loop of the gp120 envelope protein and showed strong protective effects against HIV infection.
A novel microfluidics-based system detects clinically significant IL-6 levels for sepsis diagnosis in about 25 minutes using less than a finger prick of blood. This device provides a more sensitive and efficient alternative to traditional assays.
Scientists developed a tumor-activatable antibody nanoparticle to overcome immunological tolerance in tumors. The nanoparticle releases PD-L1, triggering tumor antigen release and CTL infiltration, leading to efficient antitumor immunity and long-term immune memory effects.
Scientists have developed a novel nanoparticle formulation targeting PD-L1 with high specificity, allowing for improved infiltration of T cells into tumors and increased sensitivity to checkpoint blockade. This approach achieved an 80% mouse survival rate over 70 days, outperforming traditional antibody therapies.
A new antibody treatment for high-frequency migraines has been found to be ineffective in reducing headache frequency among patients. Only six out of 28 patients reported a reduction of at least 25 percent in headache days, with none achieving a 50 percent reduction.
Researchers have identified a new pathological mechanism responsible for 10-20% of unexplained anaphylactic cases involving IgG antibodies that activate neutrophils, releasing harmful vasodilating mediators. This discovery may help improve diagnosis and treatment for patients with anaphylactic shock.
A recent study has discovered that IgG antibodies can contribute to drug-induced anaphylactic shock by activating neutrophils, leading to high doses of vasodilating mediators. This finding explains up to 10-20% of previously unexplained cases and may help improve diagnosis and treatment for patients with this condition.
Scientists have discovered a newly found function of the US11 protein that impairs antibody immunity, allowing human cytomegalovirus (HCMV) to evade white blood cells and potentially leading to birth defects and immune system dysfunction. This breakthrough has significant therapeutic prospects for treating autoimmune diseases like lupus.
Scientists have identified a novel pathway allowing subcutaneously administered antibodies to bypass the immune system's traditional route. This breakthrough discovery enables targeted delivery of antibodies to the draining lymph node, potentially revolutionizing treatments for inflammatory diseases and cancers.
Blocking Nogo-A increases newly formed blood vessels and improves motor tasks, neuronal survival, dopamine levels, and nerve fiber density after ischemic stroke. Anti-Nogo-A antibodies may represent a therapeutic strategy for ischemic stroke recovery.
A new therapy has shown promise in promoting vascular repair following a stroke, leading to improved motor functions and regeneration of damaged blood vessels. Researchers used anti-Nogo-A antibodies in mice and found better recovery and reduced motor function impairment compared to control groups.
Research found associations between serum antibodies against P. gingivalis and A. actinomycetemcomitans with altered metabolite levels, including lipoprotein particles and fatty acids. These findings suggest exposure to periodontal pathogens may contribute to a proatherogenic state.
Researchers at the University of Oxford have identified protective antibodies against malaria, which may lead to a highly effective vaccine. The study found that specific antibodies can block the malaria parasite's ability to bind to red blood cells.
Researchers identified factors contributing to placental transfer of antibodies, including a preference for NK-activating antibodies that activate natural killer cells. This knowledge can be used to develop more effective maternal vaccines and deliver them during pregnancy to protect newborns from serious diseases like polio.
A genome-wide search has revealed genetic variants linked to varying antibody levels after childhood vaccines, potentially informing personalized vaccine strategies. The study identifies two genetic loci associated with the persistence of vaccine-induced immunity.
A study published in Nature Medicine finds that targeting the stalk of the flu virus provides protection against infection. Researchers analyzed naturally occurring influenza cases and found that individuals with higher levels of stalk antibodies had a reduced risk of getting sick, correlating with a 42% reduction in influenza infection.
Researchers discovered Charcot-Leyden Crystals are abundant in airway mucus, stimulate immune system and promote inflammation, which can be treated with newly developed antibodies. These antibodies can dissolve the crystals to reduce asthma features.
Researchers developed a 3D-printed pipette-tip test that leverages the enzyme-linked immunosorbent assay (ELISA) method. The new technology significantly reduces testing costs and time, allowing for faster diagnosis and potentially making medical testing available in rural or remote areas.
Researchers have discovered a human antibody that recognizes and disrupts a vulnerable region on the hemagglutinin protein of the influenza virus. This breakthrough could lead to the development of effective vaccines against multiple strains of the virus, potentially eliminating the need for annual seasonal flu vaccination.
A study by ISGlobal and colleagues found that the RTS,S vaccine's protective effect increases with the strength of antibodies, not just their quantity. Children tend to have better protection due to higher avidity responses.
Researchers found widespread inconsistencies in antibody use, causing unreliable results and wasting $2 billion per year. They call for industry-wide standards to validate antibodies, especially in human tissue research.
Researchers used VirScan to detect antibodies against viruses in kidney transplant recipients and found results concordant with conventional viral screening. Antibody responses remained largely unchanged one year after transplantation, suggesting a safe and reproducible approach to monitor post-transplant viral infections.
Researchers at Aarhus University and Novo Nordisk have developed a novel method for connecting proteins to DNA structures, enabling the assembly of large multi-antibody-like nanostructures. This innovation has potential applications in enhancing traditional therapies and understanding biological mechanisms.
Researchers have generated two antibodies that potentially could be used in a simple filter paper test to detect Ebola virus. The study, published in the American Journal of Tropical Medicine & Hygiene, marks a breakthrough in diagnosing Ebola and Marburg viruses, which can cause severe bleeding and organ failure with high fatality rates.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Researchers developed protein catalyzed capture technology to improve receptor stability and manufacturability for wearable sensor applications. The technology enables real-time monitoring of Soldier health and performance, as well as sensing environmental threats.
Researchers developed a statistical method to quantify changes in environmental systems, finding La Nina winters favor mountain snowpack. Scientists also invented synthetic antibodies that could improve disease detection and toxin identification.
Researchers at the University of Zurich have developed a simple and fast method for radiolabelling antibodies against breast cancer using UV light. The new procedure allows for the production of radioactive drugs and diagnostic agents in under 20 minutes, making it a game-changer for PET imaging and targeted radioimmunotherapy.
Researchers at the NIH have made progress toward developing an EBV vaccine by identifying key antibodies that block infection. The new vaccine candidates elicited potent anti-EBV antibody responses in animals, offering potential protection against EBV-associated cancers and infectious mononucleosis.
Researchers at Colorado State University developed a technology that can detect extremely small amounts of antibodies in a person's blood, allowing for faster diagnosis and treatment. The new sensor can detect as few as 10 antibody molecules within 20 minutes, making it more sensitive than current medical testing methods.
A joint team from Hokkaido University and Keio University has identified a key player in the gut defense mechanism of infants, a protein called Sox8. This discovery could help understand how infants develop their own intestinal immune systems after weaning.
A Stanford University School of Medicine study found that blocking a specific protein's activity improved cognitive behavior in aging mice. The researchers identified a gene called CD22, which is involved in microglial phagocytosis and is upregulated with age.
Scientists have discovered that white blood cells enter the spleen primarily via vessels in the red pulp and migrate to other structures. The Clever-1 molecule controls this process, also regulating antibody-producing white blood cell expression.
Scientists have developed edible antibodies that can survive digestion and reach the gut, offering an alternative to traditional treatments. The technology has potential applications in fighting gut infections, treating inflammatory disorders, and preventing diarrhea in pigs and humans.