Articles tagged with Arthritis
Researchers at the University of Missouri have completed a comprehensive analysis of bioactive lipids in an inflammatory response triggered by Lyme disease. The study found correlations between eicosanoid levels and arthritis severity, paving the way for diagnostic tools, personalized therapies, and more effective treatments.
Researchers found that screening all babies with a physical clinical exam and ultrasound can significantly decrease the chance of developing early arthritis. Infants with hip dysplasia are at risk of long-term complications if left untreated, emphasizing the importance of early detection and treatment.
Researchers analyzed joint fluid samples from patients with Lyme arthritis, identifying bacterial strains and finding correlations between OspC typing and clinical outcomes. The study suggests that certain B. burgdorferi genotypes, particularly RST1, may induce a more marked immune response leading to persistent joint inflammation.
A new study by The George Institute for International Health found Tai Chi to have positive effects on improving pain and disability among arthritis sufferers. Researchers are now conducting a trial to establish if similar benefits can be seen in people with chronic low back pain.
The study found that canakinumab significantly improved symptoms of systemic juvenile idiopathic arthritis (sJIA) in children, achieving an ACR Pedi 50 score within 15 days. Steroid tapering was also observed in the majority of responders, and 'inactive' disease status was reached in 4 cases.
Three studies confirm etanercept's effectiveness in treating JIA, with improved HRQoL and reduced disease activity. The treatment showed a good safety profile, with most patients experiencing mild adverse events.
A systematic review and meta-analysis found that Tai Chi decreases pain in people with arthritis, improving physical function and quality of life. Additionally, it is an inexpensive, convenient, and enjoyable form of exercise that conveys psychological and social benefits.
Researchers have developed DNA-like compounds that effectively inhibit cells responsible for chronic autoimmune condition lupus. The compounds, known as class R inhibitory oligonucleotides (INH-ODNs), selectively reduce the activity of autoreactive B cells and dendritic cells, delaying death and reducing kidney damage in mice with lupus.
Women suffer up to two and a half times more disabilities than men in their senior years, largely due to higher rates of obesity and arthritis. The study found that these chronic health conditions explain up to 48 percent of the gender gap in disability.
A new study found that women with arthritis are more likely to leave the workforce, while men may be more likely to remain working and report negative experiences. The study analyzed data from over 9,000 individuals aged 25-64 and found that greater education was associated with being in the labor force for both men and women.
A study published in the Journal of Leukocyte Biology found that bacterial remnants and genetics contribute to arthritis. The NOD2 gene is activated by muramyl dipeptide, leading to inflammation and disease progression. Researchers hope to find treatments that can either eliminate or mask this inflammatory signal.
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
Men with higher vitamin C intake appear less likely to develop gout, a painful type of arthritis. Vitamin C may reduce levels of uric acid in the blood and affect kidney function, leading to a lower risk of gout.
Researchers at MU College of Veterinary Medicine found that blocking specific proteins, AP-1 and SAF-1, may prevent cartilage breakdown in arthritis patients by inhibiting inflammation. This could lead to new therapeutic targets for treating the disease.
Researchers found that ustekinumab significantly improves symptoms of psoriatic arthritis and diminishes skin lesions in patients. The treatment, which targets interleukins 12 and 23, showed good tolerability and a benign safety profile.
A randomized, double-blind study found ustekinumab to be effective in treating moderate-to-severe psoriatic arthritis, with significant improvements in pain and stiffness. The treatment showed sustained benefits up to 36 weeks after initial dosing.
A new study found that nearly three-quarters of adolescents with arthritis were encouraged to take responsibility for their health care needs, but only half discussed how their needs might change as adults. The results highlight the need for more information and support to facilitate a successful transition.
A study published in Proceedings of the National Academy of Sciences shows that natural killer (NK) T cells play a crucial role in preventing chronic inflammatory infection and clearing Borrelia burgdorferi bacteria, which cause Lyme disease. The research demonstrates that NK T cells are central to reducing arthritis symptoms.
A study of 130 children with suspected musculoskeletal infections found that pre-treatment MRI can avoid unnecessary diagnostic or surgical procedures. Early MRI evaluation can reduce the need for procedures, even if there's a delay in diagnosis or sedation required.
A new study led by Georgetown University Medical Center researchers finds that sinusitis can cause severe bodily pain, often misdiagnosed as other conditions. Endoscopic sinus surgery has been shown to provide significant pain relief for these patients.
A study found that abatacept reduced flare events and improved symptoms in children with juvenile idiopathic arthritis, but its design raised questions about its true effectiveness. The treatment was well-tolerated, but the study's limitations highlighted the need for further research to establish its role in treating this condition.
The new book provides facts about various types of JA and information on new treatments such as biologic drugs. It also offers practical advice on managing daily activities without pain and navigating the education system.
A randomized clinical trial found that oral prednisolone is clinically equivalent to naproxen in reducing pain and inflammation in patients with gout. The study suggests that prednisolone could be a safer alternative for treating gout, with potential economic benefits due to reduced healthcare costs.
A recent study published in Arthritis Care and Research journal found that regular exercise, specifically the Arthritis Foundation Exercise Program, significantly improves and manages arthritis pain. Participants reported a decrease in pain and fatigue, an increase in upper and lower extremity function, and increased strength after par...
A recent study published in Arthritis Research & Therapy found that patients with fibromyalgia who participated in supervised training exercises in warm water experienced reduced symptoms and improved health-related quality of life. This cost-effective approach may offer a promising alternative to traditional treatments.
The study evaluated the Arthritis Foundation Exercise Program's effects on managing arthritis through exercise. The results showed significant improvements in pain, fatigue, and physical function, with continued benefits when participants maintained program participation at home.
Researchers found that joint inflammation persists in patients with antibiotic-refractory Lyme arthritis, despite the spirochetes being killed. Antibody titers declined to similar levels after 4-6 months of antibiotic therapy, regardless of treatment response.
Depression produces the greatest decrement in health compared to chronic diseases like angina, arthritis, and asthma. People with depression and one or more chronic diseases have the worst health scores, according to a study of 245,404 people.
Research found knee monoarthritis in 296 patients (4.4%) with rheumatic disorders, a rare condition associated with operable non-small cell lung cancer. The disease is challenging to treat unless caught early, and the discovery provides new insights into potential early warning signs.
A new study found that hip and knee replacements are rarely performed in patients over 100 due to concerns about short-term life expectancy. However, the research suggests that these procedures should not be denied solely based on age and that the benefits may outweigh the risks.
A new study found that racial disparities play a significant role in the development of disability among older adults with arthritis. The study, which included over 7,200 respondents, showed that African Americans and Hispanic/Spanish groups experienced significantly higher rates of disability compared to whites.
A new study shows surgery significantly improves results for patients with degenerative spondylolisthesis and spinal stenosis compared to non-surgical alternatives. Surgery provides quick relief from symptoms and improved function, especially within six weeks after the procedure.
A recent study published in Arthritis & Rheumatism found gabapentin to be an effective treatment for fibromyalgia pain, with patients reporting significantly less pain and improved sleep. The medication was well-tolerated, with mild side effects such as dizziness and sedation.
A long-term study found that drinking 4 or more cups of coffee per day dramatically reduces the risk of gout in men. The study, which followed 45,869 men for 12 years, showed a 59% lower risk of gout among those who drank 6 or more cups of coffee daily.
The cost of treating arthritis in the US has more than doubled between 1998 and 2003 due to the increasing number of people with the disease and inflation-adjusted prescription costs. Total medical care expenditures for arthritis patients increased by $88 billion annually, with estimated incremental costs reaching $81 billion.
The study found a significant increase in arthritis prevalence from 36.8 million to 46.1 million adults between 1997 and 2003. Medical expenditures for prescription drugs almost doubled during this period, while inpatient expenditures declined, resulting in stable total medical care spending for individuals with arthritis.
A new study estimates that 6.9 million US adults have arthritis-attributable work limitation (AAWL), with 1 in 20 working age adults reporting AAWL, and 1 in 3 among those with arthritis. Adults with AAWL have poor physical health and function, including high body mass index, joint pain, and frequent doctor's office visits.
Women in their 70s who engage in moderate physical activity may reduce their risk of developing frequent arthritis symptoms. The study found that increasing exercise to 2 ½ hours per week can further decrease the likelihood of these symptoms appearing.
A trial comparison found that COX-2 inhibitors like etoricoxib are associated with fewer upper gastrointestinal clinical events in patients with arthritis, compared to traditional NSAIDs like diclofenac. The study suggests that COX-2 inhibitors may be a safer alternative for pain management.
A study found that children with juvenile idiopathic arthritis had significant direct medical costs, including $1,686 per year. The study also highlighted the importance of long-term medical and social costs in resource allocation.
Researchers found that etanercept, a TNF inhibitor, had no impact on new cartilage or bone formation in mice with spontaneous arthritis. The study suggests that joint fusion and joint inflammation are separate processes, which should be considered as distinct therapeutic targets.
Scientists at NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases have successfully imaged the influenza virus using electron tomography, revealing five distinct types of particles. This breakthrough provides insight into the virus's structure and potential targets for vaccine development.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has funded four new Centers of Research Translation (CORTs) to translate basic discoveries into new treatments for arthritis and related diseases. The CORTs will focus on lupus, X-linked hypophosphatemic rickets, scleroderma, and other conditions.
A University of Pittsburgh School of Medicine study found that gout is an independent risk factor for myocardial infarction (heart attack) in men with no previous history of coronary artery disease. Gouty arthritis was associated with modest elevations in blood pressure, age, and body mass index.
Despite well-documented exercise benefits, individuals with arthritis face various barriers, including pain, lack of support, and limited facilities. To overcome these challenges, healthcare professionals can prescribe exercise, expand arthritis-specific programs, and emphasize adaptations for physical limitations.
Researchers argue that COX-2 inhibitors, including Vioxx, are as effective as traditional NSAIDs but carry fewer gastric side effects. They suggest these drugs may be the best option for some patients without cardiovascular risk factors who cannot tolerate traditional NSAIDs.
Researchers found that leptin blockade improved clinical symptoms of disease, slowed progression, reduced relapses, and reduced antigen-specific T cells in experimental autoimmune encephalomyelitis. Additionally, the study suggests that leptin neutralization may be a potential way to treat multiple sclerosis.
The new CD-ROM provides a wide range of resources, including patient education brochures, professional educational materials, and web links to numerous useful resources. The CD-ROM has been overwhelmingly approved by healthcare professionals, who will use it to better understand and manage childhood rheumatic diseases.
Research shows that Viagra reduced demand for seals, sea horses, and tigers used in TCM treatments. The study surveyed 256 Chinese men aged 50-76, finding more men previously used TCM treatments than current users.
Researchers found that endomorphin 1, a natural painkiller, had no effect on chronic arthritis pain. The study suggests the need for alternative pain management strategies for long-term arthritis sufferers.
A study published in the American Journal of Public Health found that baby boomers' obesity rates grew substantially compared to previous generations, leading to a surge in arthritis cases attributed to obesity. The researchers suggest that public health strategies could have a major impact on the lives of aging baby-boomers.
A life impact study found that adults with childhood onset ankylosing spondylitis experience more serious physical deformity and work-related disability than those who develop the disease as adults. Early diagnosis and treatment can significantly improve symptoms and prevent long-term effects.
Researchers from Imperial College London identified an enzyme called IKKá, which acts as a 'brake' on immune cell pathways. By inhibiting IKKa activity, the body's ability to fight off infection increased, but also led to higher inflammatory responses.
A long-term study found that lack of regular vigorous physical activity was the strongest predictor of functional decline in older adults with arthritis. Engaging in exercise or physical activity can reduce functional deterioration by up to 32 percent, according to researchers.
Researchers identified phenolic compounds in pine bark extract with high biological activity, including potent inhibition of nitric oxide and prostaglandin production. The study suggests that consuming pine bark-based food supplements may help alleviate arthritis symptoms.
A new study led by McGill University aims to collect data on the safety of medical cannabis use in Canada. The COMPASS study will follow patients with chronic pain and assess various safety issues, including adverse events and cognitive function.
Researchers at Cornell University Institute for Health and Productivity Studies estimate that presenteeism costs companies up to 60% of total worker illness expenses. Common conditions such as allergies, headaches, and mental health problems incur significant on-the-job productivity losses.
Researchers question current disease treatment theory, suggesting new treatments targeting neutrophil leukocytes instead. The study's findings could lead to a re-evaluation of antioxidant therapies and a shift in medical practice.
A new study published in the New England Journal of Medicine found that people with lupus are more likely to develop fatty deposits in their arteries, accelerating atherosclerosis. The risk is higher in patients who have had the disease longer and those who have used less immunosuppressive treatment.
Labral tears in hip cartilage have been identified as a common injury among professional golfers, with MRI scans revealing significant damage. Eight pro golfers underwent successful arthroscopic surgery to repair labral injuries, marking a significant shift towards earlier diagnosis and treatment of hip pain.