Articles tagged with Arthritis
Researchers found Bartonella infection in 62% of patients with conditions like arthritis, chronic fatigue, and Lyme disease. The study suggests a possible link between Bartonella bacterium and rheumatoid illnesses in humans.
Researchers at the University of Sheffield have identified three new ways to tackle bone diseases like osteoporosis. By understanding how individual cells respond to mechanical loading and stress, they've discovered that controlling ATP release during exercise could help build stronger bones.
Researchers have identified a rare gene mutation in the CARD14 gene that is directly linked to plaque psoriasis, accounting for 80% of all cases. The discovery may lead to more effective treatments and sheds light on the genetic pathway underlying the condition.
Research finds that children with JIA have a significantly increased cancer risk, with rates 3.9 times higher for methotrexate-only patients and 4.4 times higher overall compared to peers without the disease. The study suggests that treatment, including TNF inhibitors, may not be directly linked to this increased risk.
A large study found that overweight and obese adults are more likely to have disc degeneration than those with a normal body mass index. Disc degeneration was associated with an increased number of levels of degenerated disks and greater severity of disc degeneration, including narrowing of the disc space.
A phase II clinical trial demonstrated that rilonacept significantly reduced acute gout flares by 81% compared to a placebo. The treatment was found to be well-tolerated with no serious infections or adverse events reported.
A study published in the American Association for Cancer Research found that women who underwent bilateral oophorectomy before age 45 had lower bone mineral density and a higher prevalence of arthritis. The research suggests that clinicians should be aware of this association to provide early intervention if needed.
A longitudinal study published in Arthritis & Rheumatism found a strong association between poor sleep habits and the risk of developing fibromyalgia in women. The study, which followed over 12,000 women for ten years, found that women with severe sleep problems were at increased risk of developing fibromyalgia.
A randomized controlled trial found that telephone-delivered cognitive behavioral therapy and an exercise program were associated with short-term positive outcomes for patients with chronic widespread pain. The combined intervention showed improvements in physical component score and reduced passive coping strategies.
A study found that patients with juvenile idiopathic arthritis who responded well to etanercept treatment had lower disability scores, younger age at onset, and fewer disease-modifying antirheumatic drugs used before treatment. These factors are associated with a better long-term outcome.
A new study finds that gout prevalence has risen significantly in the US adult population, affecting 8.3 million people, while hyperuricemia affects 43.3 million adults. The study suggests that managing modifiable risk factors like obesity and hypertension could help prevent further escalation of gout and hyperuricemia.
A study by Columbia University's Mailman School of Public Health found that blue collar workers are more likely to suffer from arthritis and reduce their quality of life due to health conditions. The research highlights the need for enhanced federal programs, including disability and health insurance, to support these workers.
Researchers discovered seven new genes linked to Ankylosing Spondylitis, bringing the total to thirteen known predisposing genes. The study also revealed an interaction between genetic mutations HLA-B27 and ERAP1, providing insight into the disease's cause.
Research shows that African Americans with systemic lupus erythematosus (SLE) have a higher antibody response to the influenza vaccine compared to European American patients. Treatment with prednisone and history of hemolytic anemia are linked to low antibody responses in SLE patients.
Researchers found PCR testing for Borrelia burgdorferi DNA in joint fluid confirms diagnosis but is not a reliable indicator of active joint infection. Patients with persistent arthritis require more intensive antibiotic and DMARD therapy.
A UBC study found that a strong relationship with a primary healthcare provider is key to managing chronic conditions. Patients who felt connected to their provider reported better health outcomes and self-management skills.
A new study reveals that adults with arthritis experience poorer health-related quality of life compared to those without the condition. The analysis found significant associations between low HRQOL, factors such as income, employment, access to care, diabetes, and physical inactivity.
The new guidelines provide evidence-based guidance for the initiation and safety monitoring of multiple medications used in treating JIA, including biologic therapies. The recommendations aim to improve short- and medium-term outcomes for children with JIA.
Research published in Arthritis Care & Research found that traffic accidents increase the likelihood of developing chronic widespread pain by 84%. Individuals with poorer health or psychological issues may be more prone to developing this type of pain following a traumatic event.
Patient-centered medical homes in Ontario's Family Health Team Model show high patient satisfaction and improved income for primary care physicians. Additionally, a novel approach to detecting white-coat hypertension using automated serial blood pressure measurements is found to be valid and useful.
Researchers believe ADAM-12 gene could be important in fighting cancer, arthritis and cardiac hypertrophy. The gene's regulation pathway could lead to new treatment plans.
Modified-release sildenafil reduced the frequency of Raynaud's phenomenon in patients with limited cutaneous systemic sclerosis by 44%, according to a recent clinical trial. The treatment was well-tolerated, with only minor or moderate side effects reported.
Researchers found that IFN-a priming promotes lipid uptake and foam cell formation in lupus patients, increasing the risk of premature plaque build-up. This activation of the IFN signaling pathway may be linked to the increased cardiovascular risk in SLE patients.
A national survey found that 76% of people would take a predictive test to learn about their future health risks, with willingness to pay varying by disease type and accuracy. Respondents were more likely to pay for tests related to breast and prostate cancer, and were willing to alter lifestyle choices after receiving positive results.
Researchers have identified seven genetic variations associated with both ankylosing spondylitis and Crohn's disease, highlighting a potential new understanding of how AS develops. The study suggests that these immune cells may play a key role in the development of AS.
Researchers found that etanercept treatment significantly increased mean height, weight, and body mass index (BMI) percentiles in patients with juvenile idiopathic arthritis (JIA). Growth improvements were observed in both etanercept alone and combined with methotrexate treatments.
A study published in Arthritis Care & Research found that narcotics and diagnostic tests are overused in treating chronic neck pain, with only 53% of subjects prescribed therapeutic exercise. The researchers suggest that evidence supports the effectiveness of rehabilitation conditioning and acupuncture as treatments for chronic neck pain.
Research from Utrecht University reveals that anger and sadness amplify pain equally in both women with and without fibromyalgia. The study also found that emotional sensitization of pain may be especially detrimental in people who already have high pain levels.
Researchers have identified Gαq as a key protein that determines the fate of damaging cells, leading to autoimmune disorders like arthritis. The discovery offers new hope for treatments and personalized therapy for patients.
A recent study found significant racial disparities in the age of systemic lupus erythematosus (SLE) patients at the time of hospital admission for cardiovascular disease (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD.
A recent study found a link between elevated intrinsic brain connectivity and spontaneous pain intensity in fibromyalgia patients. The research shows an interaction of multiple brain networks, providing insights into how pain arises in these individuals.
A study by FDA researchers found a higher incidence of malignancy in children using TNF blockers like infliximab and etanercept. The reporting rate for U.S. cases of malignancy in children was 4-18 times the estimated background rate for the general pediatric population.
A new study finds that patients with arthritic back pain can experience significant pain relief after radiofrequency denervation without diagnostic nerve blocks. The procedure is safer and more cost-effective, allowing patients to return to work sooner.
A Spanish Centre for Pharmacoepidemiological Research study found that slow-release NSAIDs increase the risk of gastrointestinal complications, including GI bleeding and perforation. Long half-life or slow-release formulations were associated with a greater risk.
Researchers found a combination of antibiotics to be an effective treatment for Chlamydia-induced reactive arthritis, with significant improvements seen in patients receiving a 6-month course of combination antibiotics. The results suggest potential for eradication of the persistent infection and improvement in clinical sequelae.
Research found an association between leisure time physical exercise and a future risk of developing fibromyalgia. Women who exercised regularly had a lower risk of developing the condition compared to inactive women. High BMI is also identified as an independent risk factor for future development of FM.
A 52-year follow-up study found that higher serum uric acid levels increase gout risk in women, with the risk being 46 times higher among those above 8mg/dl. Other factors such as age, obesity, and hypertension also contribute to the risk of developing gout.
A new study published in Arthritis Research & Therapy found that lifestyle physical activity can help people with fibromyalgia improve their symptoms. Participants who engaged in short bursts of physical activity took 54% more steps per day, experienced reduced perceived functional deficits, and reported less pain compared to those in ...
Researchers found that SLE patients with high disease activity have higher levels of anti-Apo A-I, anti-HDL, and anti-CRP antibodies, contributing to the development of atherosclerosis. This association may place SLE patients at risk for cardiovascular disease.
A study published in Arthritis Care & Research found that obesity and physical inactivity contribute to a higher prevalence of arthritis and activity limitations in the US compared to Canada. Women are particularly vulnerable, with a higher incidence of arthritis and activity limitations in both countries.
Researchers at UT Health Science Center at Houston identify two new genes implicated in ankylosing spondylitis and pinpoint areas regulating gene activity associated with the condition. The study brings the scientific community closer to understanding AS, a chronic form of arthritis affecting millions worldwide.
A recent study found that increasing patient responsibility for medical decisions decreases their willingness to accept risky treatments. Patients who were presented with choices reported higher worry about risks and lower uptake of treatment.
A study found that rural Medicare beneficiaries were 27% more likely to undergo total knee or hip replacement surgeries compared to urban recipients. Women and minorities showed significant disparities in both rural and urban areas. The study used the 2005 Medicare data and included over 6 million rural and nearly 38 million urban part...
The National Institutes of Health has awarded grants to further develop and test the Patient Reported Outcomes Measurement Information System (PROMIS), a tool that assesses pain, fatigue, and other aspects of quality of life in a standardized manner. The second phase of PROMIS aims to strengthen assessment of patient-reported outcomes ...
Research found a higher incidence of chronic rhinosinusitis among patients with other chronic diseases, particularly asthma. The study suggests that some chronic diseases may share common mechanisms of how they arise or progress, highlighting the need for further investigation into the relationship between CRS and other conditions.
Researchers found that PCPs can effectively screen for serious diseases like vertebral fractures and cancer using red flag clinical features. The study identified a diagnostic rule containing four variables, which can increase the probability of vertebral fracture when multiple flags are present.
Researchers at the University of Missouri have completed a comprehensive analysis of bioactive lipids in an inflammatory response triggered by Lyme disease. The study found correlations between eicosanoid levels and arthritis severity, paving the way for diagnostic tools, personalized therapies, and more effective treatments.
Researchers found that screening all babies with a physical clinical exam and ultrasound can significantly decrease the chance of developing early arthritis. Infants with hip dysplasia are at risk of long-term complications if left untreated, emphasizing the importance of early detection and treatment.
Researchers analyzed joint fluid samples from patients with Lyme arthritis, identifying bacterial strains and finding correlations between OspC typing and clinical outcomes. The study suggests that certain B. burgdorferi genotypes, particularly RST1, may induce a more marked immune response leading to persistent joint inflammation.
A new study by The George Institute for International Health found Tai Chi to have positive effects on improving pain and disability among arthritis sufferers. Researchers are now conducting a trial to establish if similar benefits can be seen in people with chronic low back pain.
The study found that canakinumab significantly improved symptoms of systemic juvenile idiopathic arthritis (sJIA) in children, achieving an ACR Pedi 50 score within 15 days. Steroid tapering was also observed in the majority of responders, and 'inactive' disease status was reached in 4 cases.
Three studies confirm etanercept's effectiveness in treating JIA, with improved HRQoL and reduced disease activity. The treatment showed a good safety profile, with most patients experiencing mild adverse events.
A systematic review and meta-analysis found that Tai Chi decreases pain in people with arthritis, improving physical function and quality of life. Additionally, it is an inexpensive, convenient, and enjoyable form of exercise that conveys psychological and social benefits.
Researchers have developed DNA-like compounds that effectively inhibit cells responsible for chronic autoimmune condition lupus. The compounds, known as class R inhibitory oligonucleotides (INH-ODNs), selectively reduce the activity of autoreactive B cells and dendritic cells, delaying death and reducing kidney damage in mice with lupus.
Women suffer up to two and a half times more disabilities than men in their senior years, largely due to higher rates of obesity and arthritis. The study found that these chronic health conditions explain up to 48 percent of the gender gap in disability.
A new study found that women with arthritis are more likely to leave the workforce, while men may be more likely to remain working and report negative experiences. The study analyzed data from over 9,000 individuals aged 25-64 and found that greater education was associated with being in the labor force for both men and women.
A study published in the Journal of Leukocyte Biology found that bacterial remnants and genetics contribute to arthritis. The NOD2 gene is activated by muramyl dipeptide, leading to inflammation and disease progression. Researchers hope to find treatments that can either eliminate or mask this inflammatory signal.
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
Men with higher vitamin C intake appear less likely to develop gout, a painful type of arthritis. Vitamin C may reduce levels of uric acid in the blood and affect kidney function, leading to a lower risk of gout.
Researchers at MU College of Veterinary Medicine found that blocking specific proteins, AP-1 and SAF-1, may prevent cartilage breakdown in arthritis patients by inhibiting inflammation. This could lead to new therapeutic targets for treating the disease.