Articles tagged with Arthritis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Patient-centered medical homes in Ontario's Family Health Team Model show high patient satisfaction and improved income for primary care physicians. Additionally, a novel approach to detecting white-coat hypertension using automated serial blood pressure measurements is found to be valid and useful.
Researchers believe ADAM-12 gene could be important in fighting cancer, arthritis and cardiac hypertrophy. The gene's regulation pathway could lead to new treatment plans.
Modified-release sildenafil reduced the frequency of Raynaud's phenomenon in patients with limited cutaneous systemic sclerosis by 44%, according to a recent clinical trial. The treatment was well-tolerated, with only minor or moderate side effects reported.
Researchers found that IFN-a priming promotes lipid uptake and foam cell formation in lupus patients, increasing the risk of premature plaque build-up. This activation of the IFN signaling pathway may be linked to the increased cardiovascular risk in SLE patients.
A national survey found that 76% of people would take a predictive test to learn about their future health risks, with willingness to pay varying by disease type and accuracy. Respondents were more likely to pay for tests related to breast and prostate cancer, and were willing to alter lifestyle choices after receiving positive results.
Researchers have identified seven genetic variations associated with both ankylosing spondylitis and Crohn's disease, highlighting a potential new understanding of how AS develops. The study suggests that these immune cells may play a key role in the development of AS.
Researchers found that etanercept treatment significantly increased mean height, weight, and body mass index (BMI) percentiles in patients with juvenile idiopathic arthritis (JIA). Growth improvements were observed in both etanercept alone and combined with methotrexate treatments.
A study published in Arthritis Care & Research found that narcotics and diagnostic tests are overused in treating chronic neck pain, with only 53% of subjects prescribed therapeutic exercise. The researchers suggest that evidence supports the effectiveness of rehabilitation conditioning and acupuncture as treatments for chronic neck pain.
Research from Utrecht University reveals that anger and sadness amplify pain equally in both women with and without fibromyalgia. The study also found that emotional sensitization of pain may be especially detrimental in people who already have high pain levels.
Researchers have identified Gαq as a key protein that determines the fate of damaging cells, leading to autoimmune disorders like arthritis. The discovery offers new hope for treatments and personalized therapy for patients.
A recent study found significant racial disparities in the age of systemic lupus erythematosus (SLE) patients at the time of hospital admission for cardiovascular disease (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD.
A study by FDA researchers found a higher incidence of malignancy in children using TNF blockers like infliximab and etanercept. The reporting rate for U.S. cases of malignancy in children was 4-18 times the estimated background rate for the general pediatric population.
A recent study found a link between elevated intrinsic brain connectivity and spontaneous pain intensity in fibromyalgia patients. The research shows an interaction of multiple brain networks, providing insights into how pain arises in these individuals.
A new study finds that patients with arthritic back pain can experience significant pain relief after radiofrequency denervation without diagnostic nerve blocks. The procedure is safer and more cost-effective, allowing patients to return to work sooner.
A Spanish Centre for Pharmacoepidemiological Research study found that slow-release NSAIDs increase the risk of gastrointestinal complications, including GI bleeding and perforation. Long half-life or slow-release formulations were associated with a greater risk.
Researchers found a combination of antibiotics to be an effective treatment for Chlamydia-induced reactive arthritis, with significant improvements seen in patients receiving a 6-month course of combination antibiotics. The results suggest potential for eradication of the persistent infection and improvement in clinical sequelae.
Research found an association between leisure time physical exercise and a future risk of developing fibromyalgia. Women who exercised regularly had a lower risk of developing the condition compared to inactive women. High BMI is also identified as an independent risk factor for future development of FM.
A 52-year follow-up study found that higher serum uric acid levels increase gout risk in women, with the risk being 46 times higher among those above 8mg/dl. Other factors such as age, obesity, and hypertension also contribute to the risk of developing gout.
A new study published in Arthritis Research & Therapy found that lifestyle physical activity can help people with fibromyalgia improve their symptoms. Participants who engaged in short bursts of physical activity took 54% more steps per day, experienced reduced perceived functional deficits, and reported less pain compared to those in ...
Researchers found that SLE patients with high disease activity have higher levels of anti-Apo A-I, anti-HDL, and anti-CRP antibodies, contributing to the development of atherosclerosis. This association may place SLE patients at risk for cardiovascular disease.
A study published in Arthritis Care & Research found that obesity and physical inactivity contribute to a higher prevalence of arthritis and activity limitations in the US compared to Canada. Women are particularly vulnerable, with a higher incidence of arthritis and activity limitations in both countries.
Researchers at UT Health Science Center at Houston identify two new genes implicated in ankylosing spondylitis and pinpoint areas regulating gene activity associated with the condition. The study brings the scientific community closer to understanding AS, a chronic form of arthritis affecting millions worldwide.
A recent study found that increasing patient responsibility for medical decisions decreases their willingness to accept risky treatments. Patients who were presented with choices reported higher worry about risks and lower uptake of treatment.
A study found that rural Medicare beneficiaries were 27% more likely to undergo total knee or hip replacement surgeries compared to urban recipients. Women and minorities showed significant disparities in both rural and urban areas. The study used the 2005 Medicare data and included over 6 million rural and nearly 38 million urban part...
The National Institutes of Health has awarded grants to further develop and test the Patient Reported Outcomes Measurement Information System (PROMIS), a tool that assesses pain, fatigue, and other aspects of quality of life in a standardized manner. The second phase of PROMIS aims to strengthen assessment of patient-reported outcomes ...
Research found a higher incidence of chronic rhinosinusitis among patients with other chronic diseases, particularly asthma. The study suggests that some chronic diseases may share common mechanisms of how they arise or progress, highlighting the need for further investigation into the relationship between CRS and other conditions.
Researchers found that PCPs can effectively screen for serious diseases like vertebral fractures and cancer using red flag clinical features. The study identified a diagnostic rule containing four variables, which can increase the probability of vertebral fracture when multiple flags are present.
Researchers at the University of Missouri have completed a comprehensive analysis of bioactive lipids in an inflammatory response triggered by Lyme disease. The study found correlations between eicosanoid levels and arthritis severity, paving the way for diagnostic tools, personalized therapies, and more effective treatments.
Researchers found that screening all babies with a physical clinical exam and ultrasound can significantly decrease the chance of developing early arthritis. Infants with hip dysplasia are at risk of long-term complications if left untreated, emphasizing the importance of early detection and treatment.
Researchers analyzed joint fluid samples from patients with Lyme arthritis, identifying bacterial strains and finding correlations between OspC typing and clinical outcomes. The study suggests that certain B. burgdorferi genotypes, particularly RST1, may induce a more marked immune response leading to persistent joint inflammation.
A new study by The George Institute for International Health found Tai Chi to have positive effects on improving pain and disability among arthritis sufferers. Researchers are now conducting a trial to establish if similar benefits can be seen in people with chronic low back pain.
The study found that canakinumab significantly improved symptoms of systemic juvenile idiopathic arthritis (sJIA) in children, achieving an ACR Pedi 50 score within 15 days. Steroid tapering was also observed in the majority of responders, and 'inactive' disease status was reached in 4 cases.
Three studies confirm etanercept's effectiveness in treating JIA, with improved HRQoL and reduced disease activity. The treatment showed a good safety profile, with most patients experiencing mild adverse events.
A systematic review and meta-analysis found that Tai Chi decreases pain in people with arthritis, improving physical function and quality of life. Additionally, it is an inexpensive, convenient, and enjoyable form of exercise that conveys psychological and social benefits.
Researchers have developed DNA-like compounds that effectively inhibit cells responsible for chronic autoimmune condition lupus. The compounds, known as class R inhibitory oligonucleotides (INH-ODNs), selectively reduce the activity of autoreactive B cells and dendritic cells, delaying death and reducing kidney damage in mice with lupus.
Women suffer up to two and a half times more disabilities than men in their senior years, largely due to higher rates of obesity and arthritis. The study found that these chronic health conditions explain up to 48 percent of the gender gap in disability.
A new study found that women with arthritis are more likely to leave the workforce, while men may be more likely to remain working and report negative experiences. The study analyzed data from over 9,000 individuals aged 25-64 and found that greater education was associated with being in the labor force for both men and women.
A study published in the Journal of Leukocyte Biology found that bacterial remnants and genetics contribute to arthritis. The NOD2 gene is activated by muramyl dipeptide, leading to inflammation and disease progression. Researchers hope to find treatments that can either eliminate or mask this inflammatory signal.
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
Men with higher vitamin C intake appear less likely to develop gout, a painful type of arthritis. Vitamin C may reduce levels of uric acid in the blood and affect kidney function, leading to a lower risk of gout.
Researchers at MU College of Veterinary Medicine found that blocking specific proteins, AP-1 and SAF-1, may prevent cartilage breakdown in arthritis patients by inhibiting inflammation. This could lead to new therapeutic targets for treating the disease.
Researchers found that ustekinumab significantly improves symptoms of psoriatic arthritis and diminishes skin lesions in patients. The treatment, which targets interleukins 12 and 23, showed good tolerability and a benign safety profile.
A randomized, double-blind study found ustekinumab to be effective in treating moderate-to-severe psoriatic arthritis, with significant improvements in pain and stiffness. The treatment showed sustained benefits up to 36 weeks after initial dosing.
A new study found that nearly three-quarters of adolescents with arthritis were encouraged to take responsibility for their health care needs, but only half discussed how their needs might change as adults. The results highlight the need for more information and support to facilitate a successful transition.
A study published in Proceedings of the National Academy of Sciences shows that natural killer (NK) T cells play a crucial role in preventing chronic inflammatory infection and clearing Borrelia burgdorferi bacteria, which cause Lyme disease. The research demonstrates that NK T cells are central to reducing arthritis symptoms.
A study of 130 children with suspected musculoskeletal infections found that pre-treatment MRI can avoid unnecessary diagnostic or surgical procedures. Early MRI evaluation can reduce the need for procedures, even if there's a delay in diagnosis or sedation required.
A new study led by Georgetown University Medical Center researchers finds that sinusitis can cause severe bodily pain, often misdiagnosed as other conditions. Endoscopic sinus surgery has been shown to provide significant pain relief for these patients.
A study found that abatacept reduced flare events and improved symptoms in children with juvenile idiopathic arthritis, but its design raised questions about its true effectiveness. The treatment was well-tolerated, but the study's limitations highlighted the need for further research to establish its role in treating this condition.
The new book provides facts about various types of JA and information on new treatments such as biologic drugs. It also offers practical advice on managing daily activities without pain and navigating the education system.
A randomized clinical trial found that oral prednisolone is clinically equivalent to naproxen in reducing pain and inflammation in patients with gout. The study suggests that prednisolone could be a safer alternative for treating gout, with potential economic benefits due to reduced healthcare costs.
A recent study published in Arthritis Care and Research journal found that regular exercise, specifically the Arthritis Foundation Exercise Program, significantly improves and manages arthritis pain. Participants reported a decrease in pain and fatigue, an increase in upper and lower extremity function, and increased strength after par...
A recent study published in Arthritis Research & Therapy found that patients with fibromyalgia who participated in supervised training exercises in warm water experienced reduced symptoms and improved health-related quality of life. This cost-effective approach may offer a promising alternative to traditional treatments.
The study evaluated the Arthritis Foundation Exercise Program's effects on managing arthritis through exercise. The results showed significant improvements in pain, fatigue, and physical function, with continued benefits when participants maintained program participation at home.
Researchers found that joint inflammation persists in patients with antibiotic-refractory Lyme arthritis, despite the spirochetes being killed. Antibody titers declined to similar levels after 4-6 months of antibiotic therapy, regardless of treatment response.
Depression produces the greatest decrement in health compared to chronic diseases like angina, arthritis, and asthma. People with depression and one or more chronic diseases have the worst health scores, according to a study of 245,404 people.
Research found knee monoarthritis in 296 patients (4.4%) with rheumatic disorders, a rare condition associated with operable non-small cell lung cancer. The disease is challenging to treat unless caught early, and the discovery provides new insights into potential early warning signs.
A new study found that racial disparities play a significant role in the development of disability among older adults with arthritis. The study, which included over 7,200 respondents, showed that African Americans and Hispanic/Spanish groups experienced significantly higher rates of disability compared to whites.
A new study found that hip and knee replacements are rarely performed in patients over 100 due to concerns about short-term life expectancy. However, the research suggests that these procedures should not be denied solely based on age and that the benefits may outweigh the risks.
A new study shows surgery significantly improves results for patients with degenerative spondylolisthesis and spinal stenosis compared to non-surgical alternatives. Surgery provides quick relief from symptoms and improved function, especially within six weeks after the procedure.
A recent study published in Arthritis & Rheumatism found gabapentin to be an effective treatment for fibromyalgia pain, with patients reporting significantly less pain and improved sleep. The medication was well-tolerated, with mild side effects such as dizziness and sedation.