Articles tagged with Arthritis
A major new report suggests that children's chronic pain is often ignored or undertreated, with up to 10% of young people experiencing disabling conditions. The Lancet Child and Adolescent Health Commission recommends four key goals: making childhood pain matter, understanding it, making it visible, and managing it effectively.
A new study reveals that stem cells contribute to the formation of osteophytes, or pathological bone spurs, in arthritis patients. The researchers identified a specific type of stem cell with activity in the Sox9 gene as the major culprit behind this process.
A study of search and rescue dogs found that dogs at the disaster site lived a similar length of time as those in a control group, with no discernable difference in cause of death. The most common cause of death was age-related conditions such as arthritis and cancer.
Researchers have identified a specific receptor in immune cells from psoriatic arthritis patients, suggesting a single cause for the disease. This finding could lead to developing targeted treatments and offers new insights into the intricate mechanisms behind psoriatic arthritis.
The prevalence of gout increased worldwide between 1990 and 2017, reaching approximately 41.2 million cases in 2017. High body mass index and impaired kidney function were identified as key risk factors for the disease.
Researchers discovered an overabundance of KLK6 protein can produce skin inflammation in psoriasis, while normalizing its level can eliminate it. They also found that KLK6 plays a key role in damaging joints and bones in people with the disorder.
BIOCAD presents results of clinical trial showing netakimab decreases disease activity and reduces skin manifestation of psoriatic arthritis through 24 weeks of therapy. The treatment was well-tolerated, with significant improvement in skin manifestations and quality of life.
Researchers at Baylor College of Medicine found that CBD significantly reduces inflammatory molecules and immune cells associated with arthritis in dogs. The study showed that CBD treatment improved quality of life in 90% of the dogs, supporting future scientific evaluation of CBD for human arthritis.
Lyme disease is the most reported vector-borne disease in the country, with a dramatic increase in cases over the past 20 years. The research aims to understand how the bacterium Borrelia burgdorferi causes sustained inflammation and Lyme arthritis symptoms.
Researchers at Washington State University have identified a key protein in Borrelia burgdorferi that shields the immune system from fighting Lyme disease. By understanding this 'VlsE' protein, they hope to develop effective vaccines against the disease.
A study published in Arthritis & Rheumatology found a significant increase in autoimmunity prevalence in the US population between 1988 and 2012. The prevalence of antinuclear antibodies (ANA) rose from 11.0% in 1988 to 15.9% in 2011-2012, affecting an estimated 41 million individuals.
Scientists at Fred Hutchinson Cancer Center discovered a mini-protein in scorpion venom that rapidly accumulates in joint cartilage, allowing it to deliver steroids and other drugs directly to the affected area. This approach may potentially improve the safety of arthritis treatment by reducing systemic side effects.
This observational study analyzed 112 studies to examine the association between cancer risk in patients with psoriasis or psoriatic arthritis. The findings suggest that these patients may be at higher risk of specific cancers, including melanoma and non-melanoma skin cancers.
A new study finds that married couples with multiple chronic conditions experience rising depression symptoms, with husbands faring worse when their conditions differ from their wives. The study highlights the importance of recognizing and addressing these dynamics to maintain mental and physical health.
A study found that children with Down syndrome are at an increased risk of developing inflammatory and erosive arthritis. Researchers estimate that around 20 per 1,000 children with Down syndrome have this condition.
Researchers found that psoriasis onset age determines whether arthritis starts first, with a 65-month delay for arthritis onset after psoriasis. Early-onset psoriasis is strongly associated with arthritis onset, suggesting a different subgroup of PsA patients.
A study of 14,624 US adults found that four modifiable risk factors--body mass index, diet, alcohol consumption, and diuretic use--contribute to hyperuricemia. Promoting healthy diets and preventing obesity can help reduce the frequency of hyperuricemia and gout.
Researchers have developed a way to detect cells infected with chikungunya virus that survive the infection, shedding light on the cause of chronic viral arthritis. The study found that the virus can persist in muscle and connective tissue cells for up to 114 days after infection.
A study of 456 acute gout patients found that over 28% received opioid prescriptions, with many lasting longer than the typical gout attack. Diabetes and prior opioid use increased the likelihood of receiving opioids.
Researchers have discovered a cellular component called peptidoglycan that contributes to Lyme arthritis, a debilitating condition. The presence of peptidoglycan in synovial fluid may explain why some people experience symptoms despite no obvious infection, and could lead to new treatments.
Borrelia peptidoglycan, a component of the Lyme disease bacterium, is detected in patients' synovial fluid and stimulates proinflammatory cytokines. The finding suggests that Borrelia peptidoglycan contributes to inflammation in Lyme arthritis.
The phase 2B study demonstrated superior efficacy of tildrakizumab versus placebo in patients with psoriatic arthritis, achieving high response rates for PASI 90 and ACR 50. The treatment was generally safe, with minor adverse events reported.
A systematic review of 55 studies found that people with inflammatory arthritis experience higher rates of sexual dysfunction compared to others, primarily due to disease-related factors such as pain and mobility restrictions. This highlights the importance of considering the impact of inflammatory arthritis on sexual health and intima...
A team of scientists developed a machine learning algorithm that identifies children with juvenile arthritis with nearly 90% accuracy from a simple blood test. The new findings pave the way for improving diagnosis and predicting which patients respond best to different treatment options.
Researchers developed a machine learning tool to classify children with arthritis into seven distinct groups based on joint patterns. This allowed them to predict which children will go into remission faster or develop more severe disease, enabling doctors to tailor treatment and spare patients unnecessary medication side effects.
Researchers at VIB-KU Leuven discovered a genetic mutation that can cause a juvenile form of inflammatory joint disease. The study used next-generation sequencing and immunology approaches to unravel the disease mechanism, providing insights into the development of targeted therapies.
A study published in Geriatrics found that 3D-printed adaptive aids for arthritis patients can offer significant cost savings, with some items costing as little as 45 cents. The customized designs can also improve the quality of life for these individuals, enabling them to perform daily tasks independently.
A trial revealed that nurse-led care significantly improves gout treatment outcomes, including higher ULT adoption and better patient adherence. Patients receiving nurse-led care had lower urate levels, reduced flare-ups, and improved quality of life.
A new study reveals the effect of vitamin E is often based on luck due to its metabolite, alpha-carboxychromanol, which has a promising anti-inflammatory effect. Personalized medicine could be improved with this discovery, as the level of alpha-carboxychromanol in patients varies greatly.
Patients undergoing elective hip surgery may experience new health issues such as mental health disorders, chronic pain, and cardiovascular ailments up to two years after the procedure. The study found that these hidden complications can have a significant impact on patients' quality of life.
A recent study found that 55.0% of individuals aged 50+, 62.9% with moderate depression, and 67.8% with severe depression had arthritis. The study highlights the importance of treating arthritis-related pain in older adults with depressive symptoms.
A study published in Arthritis & Rheumatology found that people with obstructive sleep apnea have a higher risk of developing gout. The risk was highest one to two years after diagnosis and was seen in patients with normal body mass index, regardless of weight status.
Scientists have identified a molecular handle that chikungunya virus uses to get inside cells, which could lead to ways to prevent or treat disease caused by the virus. The researchers found that blocking this handle reduces chikungunya infection and signs of arthritis.
A large study published in CMAJ found that gout is not associated with an increased risk of fracture. Researchers from Keele University studied over 31,000 patients with gout and their matched controls, finding a similar rate of fractures in both groups.
A new Phase III clinical trial found that belimumab, a monoclonal antibody therapy, significantly reduces SLE disease activity and incidence of severe flares. The treatment's subcutaneous formulation offers an alternative to intravenous administration, making it more accessible to patients.
A recent study found that celecoxib, an NSAID, had better gastrointestinal safety than ibuprofen or naproxen when co-prescribed with esomeprazole. The medication was associated with infrequent gastrointestinal side effects in arthritis patients, making it a safer option for those taking these medications.
Researchers from the University of Liverpool and Alder Hey will join a UK-wide effort to drive the development of new, targeted treatments for children and young people with juvenile idiopathic arthritis (JIA) and its associated eye-inflammation condition, uveitis. The CLUSTER Consortium aims to improve the lives of children living wit...
Researchers at University of Utah Health identified a mechanism that activates T cells, a key component of the immune system, in patients with persistent Lyme arthritis. This activation mechanism triggers inflammation and arthritis by producing inflammatory molecules that accumulate around the joints.
A new review article examines efforts to address variability in treating rare pediatric rheumatic diseases. Consensus treatment plans are a potential alternative to randomized clinical trials, and the Childhood Arthritis and Rheumatology Research Alliance is pioneering their use.
A large cohort study found that 25% of chikungunya-infected individuals experienced chronic joint pain two years after initial infection. The researchers also identified several predictors of persistent joint pain, including being a college graduate and having severe initial symptoms.
A new study found that community screening for osteoporosis reduced hip fractures by 28% in older women. Screening identified those at risk and led to targeted treatment, resulting in a significant decrease in hip fractures.
Research suggests that US arthritis prevalence is much higher than current estimates, especially among younger adults. The study found that 91.2 million US adults are affected by arthritis, with a significant impact on healthcare costs and productivity.
Researchers have discovered a new marker, Ratiometric thrombin-Activatable Cell Penetrating Peptide, to identify joints with established arthritis and predict subsequent swelling. This imaging tool may help clinicians monitor arthritis development and progression, enabling early intervention.
The new American College of Rheumatology/National Psoriasis Foundation treatment guideline provides pharmacologic and non-pharmacologic recommendations for treating adult patients with active psoriatic arthritis. The guideline development team used the GRADE methodology to evaluate evidence and create therapy options.
A new online education tool has been developed to improve accessibility and disease self-management for teens with juvenile idiopathic arthritis. The tool, which includes monthly calls with health coaches, improved health-related quality of life for participating teens compared to those who received standard disease education only.
Febuxostat reduced gout flares and synovitis in a 2-year study of adults with early gout. Urate-lowering therapy may benefit people after one or two prior gout flares.
New research reveals striking racial and ethnic disparities in lupus incidence and prevalence, with higher rates found in Black, Hispanic, and Asian populations. The findings emphasize the need for vigilant diagnosis and prompt care for these groups, particularly in cases of arthritis, rashes, and kidney disease symptoms.
New research finds that temperature rises and increasing physical activity levels, not weather conditions, drive online searches for knee and hip pain. Temperatures peaked at 73 and 83 degrees Fahrenheit respectively.
Researchers from Florida Atlantic University caution that copaiba's potential benefits for treating inflammatory arthritis are unproven due to limited evidence. Despite this, sales of the essential oil continue to increase, presenting clinical challenges.
Research suggests that vitamin D levels combined with good sleep quality can effectively manage conditions like arthritis, menstrual cramps, and chronic back pain. This review highlights the potential benefits of vitamin D supplementation in pain management, offering a new approach to alleviate suffering.
A panel of international experts recommends against knee arthroscopy for almost all patients with degenerative knee disease, citing limited evidence of long-term pain relief and function improvement. Non-use of knee arthroscopy can be used as a performance measure to reduce unnecessary surgery.
A clinical trial has discovered a drug combination that significantly reduces eye inflammation in children with Juvenile Idiopathic Arthritis (JIA). The therapy, Adalimumab plus Methotrexate, showed a 75% reduction in eye inflammation and prevented treatment failure.
Dr. Scott Wolfe's research has significantly advanced the understanding of wrist kinematics and its applications to treating arthritis and wrist injuries. His work has led to the development of new implants for total and partial wrist replacements, enabling better movement and reduced pain for patients.
Each succeeding generation shows a higher prevalence of arthritis, particularly among obese individuals. The study highlights the impact of obesity and concurrent lifestyle changes on arthritis rates over time.
A new study found that psoriasis patients who developed depression were 37% more likely to develop psoriatic arthritis compared to those without depression. This highlights the need for early detection and prevention of depression in psoriasis patients.
Misdiagnosing six common foot and ankle injuries can result in poor long-term patient outcomes, including arthritis and disability. Clinicians are advised to be suspicious and obtain additional imaging or a second opinion from an orthopedic surgeon to confirm the initial diagnosis.
Researchers investigated the use of abatacept, an immune cell modulator, in treating two rare forms of vasculitis: giant cell arteritis (GCA) and Takayasu's arteritis. The studies found promising results for GCA patients, with improved relapse-free survival rates and longer duration of remission compared to placebo.
A novel study at the University of Warwick aims to design a package of care and support for people with chronic pain to overcome obstacles to returning to work. The study will use Individual Placement Support (IPS) and provide work placements, aiming to improve health outcomes and quality of life.
A recent study published in Science Advances found that over 85% of pain-sensing neurons are sensitive to one specific type of painful stimulus. This challenges previous findings suggesting most neurons respond to all types of pain.
A new study from McMaster University finds that chronic conditions like arthritis, depression, and diabetes can lead to disability and reduced social participation in middle-aged adults. The research highlights the importance of targeting treatment strategies for patients and developing preventative health plans.