Articles tagged with Arthritis
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A recent study found that 55.0% of individuals aged 50+, 62.9% with moderate depression, and 67.8% with severe depression had arthritis. The study highlights the importance of treating arthritis-related pain in older adults with depressive symptoms.
A study published in Arthritis & Rheumatology found that people with obstructive sleep apnea have a higher risk of developing gout. The risk was highest one to two years after diagnosis and was seen in patients with normal body mass index, regardless of weight status.
Scientists have identified a molecular handle that chikungunya virus uses to get inside cells, which could lead to ways to prevent or treat disease caused by the virus. The researchers found that blocking this handle reduces chikungunya infection and signs of arthritis.
A large study published in CMAJ found that gout is not associated with an increased risk of fracture. Researchers from Keele University studied over 31,000 patients with gout and their matched controls, finding a similar rate of fractures in both groups.
A new Phase III clinical trial found that belimumab, a monoclonal antibody therapy, significantly reduces SLE disease activity and incidence of severe flares. The treatment's subcutaneous formulation offers an alternative to intravenous administration, making it more accessible to patients.
A recent study found that celecoxib, an NSAID, had better gastrointestinal safety than ibuprofen or naproxen when co-prescribed with esomeprazole. The medication was associated with infrequent gastrointestinal side effects in arthritis patients, making it a safer option for those taking these medications.
Researchers from the University of Liverpool and Alder Hey will join a UK-wide effort to drive the development of new, targeted treatments for children and young people with juvenile idiopathic arthritis (JIA) and its associated eye-inflammation condition, uveitis. The CLUSTER Consortium aims to improve the lives of children living wit...
Researchers at University of Utah Health identified a mechanism that activates T cells, a key component of the immune system, in patients with persistent Lyme arthritis. This activation mechanism triggers inflammation and arthritis by producing inflammatory molecules that accumulate around the joints.
A new review article examines efforts to address variability in treating rare pediatric rheumatic diseases. Consensus treatment plans are a potential alternative to randomized clinical trials, and the Childhood Arthritis and Rheumatology Research Alliance is pioneering their use.
A large cohort study found that 25% of chikungunya-infected individuals experienced chronic joint pain two years after initial infection. The researchers also identified several predictors of persistent joint pain, including being a college graduate and having severe initial symptoms.
A new study found that community screening for osteoporosis reduced hip fractures by 28% in older women. Screening identified those at risk and led to targeted treatment, resulting in a significant decrease in hip fractures.
Research suggests that US arthritis prevalence is much higher than current estimates, especially among younger adults. The study found that 91.2 million US adults are affected by arthritis, with a significant impact on healthcare costs and productivity.
Researchers have discovered a new marker, Ratiometric thrombin-Activatable Cell Penetrating Peptide, to identify joints with established arthritis and predict subsequent swelling. This imaging tool may help clinicians monitor arthritis development and progression, enabling early intervention.
The new American College of Rheumatology/National Psoriasis Foundation treatment guideline provides pharmacologic and non-pharmacologic recommendations for treating adult patients with active psoriatic arthritis. The guideline development team used the GRADE methodology to evaluate evidence and create therapy options.
A new online education tool has been developed to improve accessibility and disease self-management for teens with juvenile idiopathic arthritis. The tool, which includes monthly calls with health coaches, improved health-related quality of life for participating teens compared to those who received standard disease education only.
Febuxostat reduced gout flares and synovitis in a 2-year study of adults with early gout. Urate-lowering therapy may benefit people after one or two prior gout flares.
New research reveals striking racial and ethnic disparities in lupus incidence and prevalence, with higher rates found in Black, Hispanic, and Asian populations. The findings emphasize the need for vigilant diagnosis and prompt care for these groups, particularly in cases of arthritis, rashes, and kidney disease symptoms.
New research finds that temperature rises and increasing physical activity levels, not weather conditions, drive online searches for knee and hip pain. Temperatures peaked at 73 and 83 degrees Fahrenheit respectively.
Researchers from Florida Atlantic University caution that copaiba's potential benefits for treating inflammatory arthritis are unproven due to limited evidence. Despite this, sales of the essential oil continue to increase, presenting clinical challenges.
Research suggests that vitamin D levels combined with good sleep quality can effectively manage conditions like arthritis, menstrual cramps, and chronic back pain. This review highlights the potential benefits of vitamin D supplementation in pain management, offering a new approach to alleviate suffering.
A panel of international experts recommends against knee arthroscopy for almost all patients with degenerative knee disease, citing limited evidence of long-term pain relief and function improvement. Non-use of knee arthroscopy can be used as a performance measure to reduce unnecessary surgery.
A clinical trial has discovered a drug combination that significantly reduces eye inflammation in children with Juvenile Idiopathic Arthritis (JIA). The therapy, Adalimumab plus Methotrexate, showed a 75% reduction in eye inflammation and prevented treatment failure.
Dr. Scott Wolfe's research has significantly advanced the understanding of wrist kinematics and its applications to treating arthritis and wrist injuries. His work has led to the development of new implants for total and partial wrist replacements, enabling better movement and reduced pain for patients.
Each succeeding generation shows a higher prevalence of arthritis, particularly among obese individuals. The study highlights the impact of obesity and concurrent lifestyle changes on arthritis rates over time.
A new study found that psoriasis patients who developed depression were 37% more likely to develop psoriatic arthritis compared to those without depression. This highlights the need for early detection and prevention of depression in psoriasis patients.
Misdiagnosing six common foot and ankle injuries can result in poor long-term patient outcomes, including arthritis and disability. Clinicians are advised to be suspicious and obtain additional imaging or a second opinion from an orthopedic surgeon to confirm the initial diagnosis.
Researchers investigated the use of abatacept, an immune cell modulator, in treating two rare forms of vasculitis: giant cell arteritis (GCA) and Takayasu's arteritis. The studies found promising results for GCA patients, with improved relapse-free survival rates and longer duration of remission compared to placebo.
A novel study at the University of Warwick aims to design a package of care and support for people with chronic pain to overcome obstacles to returning to work. The study will use Individual Placement Support (IPS) and provide work placements, aiming to improve health outcomes and quality of life.
A recent study published in Science Advances found that over 85% of pain-sensing neurons are sensitive to one specific type of painful stimulus. This challenges previous findings suggesting most neurons respond to all types of pain.
A new study from McMaster University finds that chronic conditions like arthritis, depression, and diabetes can lead to disability and reduced social participation in middle-aged adults. The research highlights the importance of targeting treatment strategies for patients and developing preventative health plans.
A new study published in Arthritis & Rheumatology suggests that the DASH diet can effectively lower blood levels of uric acid, a known trigger of gout. The DASH diet, which emphasizes fruits, vegetables, and whole grains, was found to lower uric acid by an average of 0.35 mg/dL.
A study published in The FASEB Journal found that the CRYPTOCHROME protein represses inflammatory pathways during nighttime sleep, leading to increased inflammation symptoms upon waking. This discovery offers new opportunities for developing anti-inflammatory treatments for conditions like arthritis.
A new study from Ohio State University finds that women who work long hours over three decades triple the risk of diabetes, cancer, heart trouble, and arthritis. Long hours above 50 per week also increases the risk of life-threatening illnesses.
A recent University of Toronto study found that individuals with arthritis are more likely to attempt suicide compared to those without the condition. The study also identified childhood adversities such as parental domestic violence and sexual abuse as key risk factors for suicide attempts among adults with arthritis.
A newly developed PsA-comorbidity index (PsACI) can identify PsA patients at greater risk of hospitalisation and premature death. The index is expected to improve patient outcomes and reduce costs.
A new study has identified four symptoms that predict septic arthritis in children with swollen, painful knees. The study found that patients with these characteristics were more likely to have septic arthritis than Lyme disease.
Young arthritis patients experience physical, emotional, social, and vocational consequences from treatment, emphasizing the importance of discussing concerns with healthcare providers. Active encouragement is necessary to achieve balance between disease control and treatment burden.
Researchers at Einstein College of Medicine have identified a human protein called transthyretin (TTR) that causes an autoimmune reaction in the joints of Juvenile Idiopathic Arthritis (JIA) patients. Tafamidis, a drug targeting TTR, may be a potential treatment for JIA.
A recent study identified transthyretin (TTR) as an antigen that stimulates B and T cell immune responses in patients with juvenile idiopathic arthritis (JIA). Elevated levels of TTR in synovial joint fluid were found in some patients, leading to increased TTR autoantibodies.
Scientists discovered that PAD4 works with BRD4 to switch E2F-1 from promoting cell growth to inducing inflammation in cancers. Inhibiting both proteins reduced arthritis symptoms and decreased inflammatory products in mice.
A recent study published in JAMA Network reveals that adults with cerebral palsy (CP) are more likely to develop chronic health conditions such as asthma, hypertension, and arthritis. The study found significant differences in age-adjusted prevalence rates of these conditions between adults with CP and those without CP.
Researchers at NYU Langone Health found that bariatric surgery significantly reduced psoriasis and psoriatic arthritis symptoms in patients who lost excess weight. The study suggests that obesity contributes to the development of these conditions through systemic inflammation.
A new study shows that patients with sleep apnea are at a higher risk of developing gout. The incidence rate of gout was found to be 60% higher among those with sleep apnea compared to similar-weight comparators.
Women with arthritis face a 87% higher risk of multidimensional poverty compared to nonarthritic females. Arthritis also affects men, increasing their poverty risk by 22% and 29% for multidimensional poverty, respectively.
Research shows that past use of oral contraceptives can reduce problems related to functioning, mood and disease activity in women with early inflammatory arthritis. Currently using them also reports benefits.
A study of high-intensity interval training in women with rheumatic disease found significant reductions in arthritic inflammation and improvements in cardiovascular health. Participants experienced less inflammation, increased oxygen intake, and a small reduction in BMI after ten weeks of twice-weekly sessions.
Research conducted by King's College London found a 50% increase in females reaching age 100 between 1990 and 2013, with women four times more likely to reach this milestone than men. Centenarian men, on the other hand, tend to be healthier, experiencing fewer chronic illnesses and disabilities compared to their female counterparts.
A new iPad app, 'This Feeling!', has been shown to be preferred by 95% of children with Juvenile Idiopathic Arthritis (JIA) over conventional tools. The app uses interactive technology to help children describe their pain experiences, improving communication and support for long-term management.
The National Psoriasis Foundation has awarded five Translational Research Grants to researchers investigating the causes of psoriasis and psoriatic arthritis. The grants will support studies on genetic risk factors, gut bacteria, and targeted treatments for these conditions.
The National Psoriasis Foundation has awarded eight researchers $75,000 each to study the causes of psoriasis and develop new treatments. The grants will support research into various aspects of psoriasis, including genetic mutations, skin stem cells, and inflammatory proteins.
A study of 14,348 Swiss individuals found that those with depressive symptoms have a higher risk of developing physical diseases, especially arthrosis and arthritis. The researchers suggest that lack of interest in physical activity or inflammatory processes may be key factors in this association.
A new study found that women have better outcomes than men following total knee and hip replacement surgeries, with lower rates of complications and revision surgeries. Men are more likely to experience heart attacks, infections, and require revisions after surgery.
A recent study found that men have higher levels of function before and after total knee replacement (TKR) surgery compared to women. At five years post-surgery, implant survival was nearly identical between genders, with men having a slightly higher functional score.
Prolonged work at the World Trade Center site after 9/11 linked to increased risk of autoimmune diseases like arthritis and lupus. Individuals worked 10 months at the site face 3-times greater risk of developing an autoimmune disease compared to those who worked for only a month.
A case-crossover study found that engaging in manual tasks with awkward positions, being distracted during activities, or feeling fatigued significantly increases the risk of acute low back pain. The study, published in Arthritis Care & Research, identified 12 modifiable triggers for an episode of low back pain.
Research finds that nocturnal gout attacks are 2.4 times higher at night and 1.3 times higher in the evening compared to daytime hours. Prophylactic measures may be more effective in preventing flares, especially at night.
Research finds fibromyalgia patients exhibit reduced activation in primary sensory regions and increased activation in sensory integration areas. This abnormal brain response may contribute to the condition's characteristic hypersensitivity to daily visual, auditory, and tactile stimulation.
Researchers discovered that GILZ protein can reduce bone loss and inflammation associated with arthritis, potentially replacing synthetic glucocorticoids as a treatment option. The study used mice bred with overexpressed tumor necrosis factor alpha and GILZ to demonstrate the protein's protective effects.
A panel of experts has called for improved screening and treatment of psoriatic arthritis (PsA) to help millions worldwide. The condition causes painful joint inflammation and can lead to irreversible joint damage if left untreated.
A new class of anti-arthritic drugs, DTrp, has been shown to effectively treat both arthritic joint inflammation and periodontitis without exacerbating other conditions. This finding offers a promising alternative to existing medications with unwanted side effects.