Articles tagged with Arthritis
A recent University of Toronto study found that individuals with arthritis are more likely to attempt suicide compared to those without the condition. The study also identified childhood adversities such as parental domestic violence and sexual abuse as key risk factors for suicide attempts among adults with arthritis.
A newly developed PsA-comorbidity index (PsACI) can identify PsA patients at greater risk of hospitalisation and premature death. The index is expected to improve patient outcomes and reduce costs.
A new study has identified four symptoms that predict septic arthritis in children with swollen, painful knees. The study found that patients with these characteristics were more likely to have septic arthritis than Lyme disease.
Young arthritis patients experience physical, emotional, social, and vocational consequences from treatment, emphasizing the importance of discussing concerns with healthcare providers. Active encouragement is necessary to achieve balance between disease control and treatment burden.
Researchers at Einstein College of Medicine have identified a human protein called transthyretin (TTR) that causes an autoimmune reaction in the joints of Juvenile Idiopathic Arthritis (JIA) patients. Tafamidis, a drug targeting TTR, may be a potential treatment for JIA.
A recent study identified transthyretin (TTR) as an antigen that stimulates B and T cell immune responses in patients with juvenile idiopathic arthritis (JIA). Elevated levels of TTR in synovial joint fluid were found in some patients, leading to increased TTR autoantibodies.
Scientists discovered that PAD4 works with BRD4 to switch E2F-1 from promoting cell growth to inducing inflammation in cancers. Inhibiting both proteins reduced arthritis symptoms and decreased inflammatory products in mice.
A recent study published in JAMA Network reveals that adults with cerebral palsy (CP) are more likely to develop chronic health conditions such as asthma, hypertension, and arthritis. The study found significant differences in age-adjusted prevalence rates of these conditions between adults with CP and those without CP.
Researchers at NYU Langone Health found that bariatric surgery significantly reduced psoriasis and psoriatic arthritis symptoms in patients who lost excess weight. The study suggests that obesity contributes to the development of these conditions through systemic inflammation.
A new study shows that patients with sleep apnea are at a higher risk of developing gout. The incidence rate of gout was found to be 60% higher among those with sleep apnea compared to similar-weight comparators.
Women with arthritis face a 87% higher risk of multidimensional poverty compared to nonarthritic females. Arthritis also affects men, increasing their poverty risk by 22% and 29% for multidimensional poverty, respectively.
Research shows that past use of oral contraceptives can reduce problems related to functioning, mood and disease activity in women with early inflammatory arthritis. Currently using them also reports benefits.
A study of high-intensity interval training in women with rheumatic disease found significant reductions in arthritic inflammation and improvements in cardiovascular health. Participants experienced less inflammation, increased oxygen intake, and a small reduction in BMI after ten weeks of twice-weekly sessions.
Research conducted by King's College London found a 50% increase in females reaching age 100 between 1990 and 2013, with women four times more likely to reach this milestone than men. Centenarian men, on the other hand, tend to be healthier, experiencing fewer chronic illnesses and disabilities compared to their female counterparts.
A new iPad app, 'This Feeling!', has been shown to be preferred by 95% of children with Juvenile Idiopathic Arthritis (JIA) over conventional tools. The app uses interactive technology to help children describe their pain experiences, improving communication and support for long-term management.
The National Psoriasis Foundation has awarded five Translational Research Grants to researchers investigating the causes of psoriasis and psoriatic arthritis. The grants will support studies on genetic risk factors, gut bacteria, and targeted treatments for these conditions.
The National Psoriasis Foundation has awarded eight researchers $75,000 each to study the causes of psoriasis and develop new treatments. The grants will support research into various aspects of psoriasis, including genetic mutations, skin stem cells, and inflammatory proteins.
A study of 14,348 Swiss individuals found that those with depressive symptoms have a higher risk of developing physical diseases, especially arthrosis and arthritis. The researchers suggest that lack of interest in physical activity or inflammatory processes may be key factors in this association.
A new study found that women have better outcomes than men following total knee and hip replacement surgeries, with lower rates of complications and revision surgeries. Men are more likely to experience heart attacks, infections, and require revisions after surgery.
A recent study found that men have higher levels of function before and after total knee replacement (TKR) surgery compared to women. At five years post-surgery, implant survival was nearly identical between genders, with men having a slightly higher functional score.
Prolonged work at the World Trade Center site after 9/11 linked to increased risk of autoimmune diseases like arthritis and lupus. Individuals worked 10 months at the site face 3-times greater risk of developing an autoimmune disease compared to those who worked for only a month.
A case-crossover study found that engaging in manual tasks with awkward positions, being distracted during activities, or feeling fatigued significantly increases the risk of acute low back pain. The study, published in Arthritis Care & Research, identified 12 modifiable triggers for an episode of low back pain.
Research finds that nocturnal gout attacks are 2.4 times higher at night and 1.3 times higher in the evening compared to daytime hours. Prophylactic measures may be more effective in preventing flares, especially at night.
Research finds fibromyalgia patients exhibit reduced activation in primary sensory regions and increased activation in sensory integration areas. This abnormal brain response may contribute to the condition's characteristic hypersensitivity to daily visual, auditory, and tactile stimulation.
Researchers discovered that GILZ protein can reduce bone loss and inflammation associated with arthritis, potentially replacing synthetic glucocorticoids as a treatment option. The study used mice bred with overexpressed tumor necrosis factor alpha and GILZ to demonstrate the protein's protective effects.
A panel of experts has called for improved screening and treatment of psoriatic arthritis (PsA) to help millions worldwide. The condition causes painful joint inflammation and can lead to irreversible joint damage if left untreated.
A new class of anti-arthritic drugs, DTrp, has been shown to effectively treat both arthritic joint inflammation and periodontitis without exacerbating other conditions. This finding offers a promising alternative to existing medications with unwanted side effects.
A new study by University of Toronto researchers found that adult children with arthritis are more likely to have had a parent addicted to drugs or alcohol during childhood. The study associated parental addictions with a 58% higher odds of developing arthritis, despite controlling for other factors.
Researchers have identified a key protein called TL1A that drives chronic inflammation, leading to diseases like arthritis. The discovery provides hope for developing targeted biological medicines to halt disease progression and alleviate symptoms.
A new study from Johns Hopkins Bloomberg School of Public Health reveals substantial discrepancies among mid-life and late-life adults in reporting past mental health disorders compared to physical disorders. The study found that lifetime estimates of mental disorders ascertained by retrospective versus cumulative evaluations were sign...
A novel study reveals a severe shortage of rheumatologists in smaller micropolitan US regions, where patients often have to travel over 200 miles for care. The research highlights the need for interventions to increase the supply of rheumatologists in underserved areas.
Research suggests that fibromyalgia is associated with disrupted brain signals for reward and punishment, contributing to hyperalgesia. Fibromyalgia patients exhibit altered brain responses to pain anticipation and relief, which may explain the heightened sensitivity to pain and lack of effectiveness of pain medications.
A new study published in Arthritis & Rheumatism found that headaches in lupus patients are not linked to disease activity or specific autoantibodies. The study of over 1,700 lupus patients showed that nearly all headache episodes resolved on their own without treatment.
A large observational study found that only 43% of patients with gout achieved the recommended serum uric acid level after taking allopurinol. The study showed no new safety signals with the commonly used treatment.
New findings show STELARA significantly inhibits structural damage progression at week 24 and maintains effect through two years. Treatment with STELARA results in reduced total psoriatic arthritis modified vdH-S scores compared to placebo.
The 2013 classification criteria for systemic sclerosis are more sensitive than the 1980 measures, enabling earlier identification and treatment of this autoimmune disease. The new criteria improve the classification of systemic sclerosis by clustering items and simplifying the weighting of different criteria.
The American College of Rheumatology has released new guidelines for the treatment of systemic juvenile idiopathic arthritis (JIA). The update includes over 1,200 clinical scenarios and covers various medication options, including biologics. The new recommendations aim to enhance care for children with this disabling disease.
Researchers discover STING's critical role in treating autoimmune diseases by evoking expression of enzyme IDO, which blocks immune attack on healthy body constituents. Mice with STING deficiency had no response to DNA nanoparticles, highlighting the protein's essential role in recognizing the molecule that senses DNA.
A novel study in Arthritis Care & Research examines the medical response and imaging technologies used to treat Boston Marathon bombing victims. The study found that radiology resources should be used liberally to save lives and limbs in urgent situations like the Boston Marathon bombing.
A study of 115 children with juvenile arthritis found that changes in prostanoid levels may predict disease activity and help provide individualized treatment. The discovery could lead to more effective treatment options and reduce the physical, emotional, and financial burden of childhood arthritis.
The National Psoriasis Foundation has awarded the inaugural Dr. Mark G. Lebwohl Medical Dermatology Fellowship to Zelma Chiesa, a third-year dermatology resident. Through this one-year fellowship, Chiesa will investigate treatments and health risks of psoriasis, aiming to predict skin clearance and cardiovascular events.
A new study has revealed that the COX-2 enzyme is largely absent from major blood vessels, instead found in brain, kidney, thymus, and gut. This knowledge paves the way for the development of safer, more targeted drugs for arthritis patients with fewer side effects.
The National Psoriasis Foundation has awarded twelve fellowships totaling nearly half a million dollars to researchers working to cure psoriasis and psoriatic arthritis. The fellowships will support studies on the impact of diet, exercise, and lifestyle on psoriasis severity and treatment outcomes.
A randomized trial found that the MMR booster vaccination did not worsen disease activity in patients with juvenile idiopathic arthritis. The researchers also observed higher antibody concentrations and seroprotection rates after vaccination.
A new study by McGill University researchers suggests that the nervous system and nerve-growth factor (NGF) play a major role in arthritis. The findings support the idea that reducing elevated NGF levels may be an important strategy for developing treatment of arthritis pain.
The CHERISH trial demonstrates the effectiveness of tocilizumab in reducing symptoms and signs of juvenile idiopathic arthritis. Patients with polyarticular JIA achieved significant clinical responses, including ACR30/50/70 responses, with as many as 65% attaining an ACR70 response.
Apremilast administered to patients with psoriatic arthritis showed significant clinical responses beyond 24 weeks, with up to 65% achieving ACR20 response rates at week 52. The novel PDE-4 inhibitor was well-tolerated with an acceptable long-term safety profile.
A study of 333 female patients with fibromyalgia found that weather conditions had no significant impact on their pain and fatigue symptoms. Individual patients may still experience some sensitivity to certain weather conditions, but this is not associated with demographic or mental health status.
Six top scientists received funding for projects aiming to discover new treatments and a cure for psoriasis and psoriatic arthritis. The National Psoriasis Foundation awarded $450,000 in research grants to support promising research projects.
A new study has found that bunions and lesser toe deformities are highly inheritable in Caucasian men and women of European descent. The Framingham Foot Study estimated heritability using genetic analyses of familial data, confirming the prevalence of these foot conditions is higher in older adults with a European ancestry.
New research published in Arthritis & Rheumatism found that vitamin C supplementation had a weak effect on lowering uric acid levels in gout patients. The study suggests that vitamin C may not be a viable therapy for reducing uric acid levels in patients with established gout.
Scientists have discovered 14 new genes associated with childhood arthritis, which could lead to more effective treatments and improved outcomes. The study's findings may also enable clinicians to identify children who require specific therapy earlier, ultimately reducing the impact of the disease on their quality of life.
Research suggests that low to moderate drinkers of alcohol may experience lower severity of fibromyalgia symptoms, including chronic pain, fatigue, and sleep problems. Moderate drinking has also been found to improve quality of life, with benefits seen in physical function, ability to work, and overall well-being.
Research finds fibromyalgia is a spectrum disorder with nearly 40% of patients meeting criteria for physical symptom disorder. The prevalence is 2.1%, higher in women than men.
A new study published in Arthritis Research & Therapy shows lenalidomide to be a safe and effective alternative treatment for refractory cutaneous lupus erythematosus, with significant clinical improvement in most patients. The treatment's efficacy is comparable to thalidomide but with lower toxicity.
Researchers identified molecular pathways involved in both systemic and arthritic components of SJIA, revealing differences in affected organs. The study found that glucocorticoid signalling was more heavily involved in inflammation associated with SJIA, highlighting the need for tailored treatment plans.
Researchers found vitamin D supplementation improved SLE symptoms by increasing beneficial CD4+ cells, Treg cells, and decreasing effector Th1 and Th17 cells. Vitamin D also reduced memory B cell and anti-DNA antibodies in patients.
The newly approved guidelines educate patients on effective methods to prevent gout attacks, including dietary recommendations and lifestyle choices. The guidelines also provide recommended therapies for long-term management of gout, such as xanthine oxidase inhibitors and non-drug treatments.
A new study found that cherry consumption lowered gout attack risk by 35% compared to non-consumers, while combined with allopurinol it decreased risk by 75%. The findings suggest cherries may be a preventive option for patients with gout.
Researchers found that antibiotic treatment reduced the number of live spirochetes in infected mice but left behind fluorescent bacterial debris. This debris triggered an inflammatory immune response and may contribute to arthritis-like symptoms in some patients.