Articles tagged with Arthritis
Research finds that nocturnal gout attacks are 2.4 times higher at night and 1.3 times higher in the evening compared to daytime hours. Prophylactic measures may be more effective in preventing flares, especially at night.
Research finds fibromyalgia patients exhibit reduced activation in primary sensory regions and increased activation in sensory integration areas. This abnormal brain response may contribute to the condition's characteristic hypersensitivity to daily visual, auditory, and tactile stimulation.
Researchers discovered that GILZ protein can reduce bone loss and inflammation associated with arthritis, potentially replacing synthetic glucocorticoids as a treatment option. The study used mice bred with overexpressed tumor necrosis factor alpha and GILZ to demonstrate the protein's protective effects.
A panel of experts has called for improved screening and treatment of psoriatic arthritis (PsA) to help millions worldwide. The condition causes painful joint inflammation and can lead to irreversible joint damage if left untreated.
A new class of anti-arthritic drugs, DTrp, has been shown to effectively treat both arthritic joint inflammation and periodontitis without exacerbating other conditions. This finding offers a promising alternative to existing medications with unwanted side effects.
A new study by University of Toronto researchers found that adult children with arthritis are more likely to have had a parent addicted to drugs or alcohol during childhood. The study associated parental addictions with a 58% higher odds of developing arthritis, despite controlling for other factors.
Researchers have identified a key protein called TL1A that drives chronic inflammation, leading to diseases like arthritis. The discovery provides hope for developing targeted biological medicines to halt disease progression and alleviate symptoms.
A new study from Johns Hopkins Bloomberg School of Public Health reveals substantial discrepancies among mid-life and late-life adults in reporting past mental health disorders compared to physical disorders. The study found that lifetime estimates of mental disorders ascertained by retrospective versus cumulative evaluations were sign...
A novel study reveals a severe shortage of rheumatologists in smaller micropolitan US regions, where patients often have to travel over 200 miles for care. The research highlights the need for interventions to increase the supply of rheumatologists in underserved areas.
Research suggests that fibromyalgia is associated with disrupted brain signals for reward and punishment, contributing to hyperalgesia. Fibromyalgia patients exhibit altered brain responses to pain anticipation and relief, which may explain the heightened sensitivity to pain and lack of effectiveness of pain medications.
A new study published in Arthritis & Rheumatism found that headaches in lupus patients are not linked to disease activity or specific autoantibodies. The study of over 1,700 lupus patients showed that nearly all headache episodes resolved on their own without treatment.
A large observational study found that only 43% of patients with gout achieved the recommended serum uric acid level after taking allopurinol. The study showed no new safety signals with the commonly used treatment.
New findings show STELARA significantly inhibits structural damage progression at week 24 and maintains effect through two years. Treatment with STELARA results in reduced total psoriatic arthritis modified vdH-S scores compared to placebo.
The 2013 classification criteria for systemic sclerosis are more sensitive than the 1980 measures, enabling earlier identification and treatment of this autoimmune disease. The new criteria improve the classification of systemic sclerosis by clustering items and simplifying the weighting of different criteria.
The American College of Rheumatology has released new guidelines for the treatment of systemic juvenile idiopathic arthritis (JIA). The update includes over 1,200 clinical scenarios and covers various medication options, including biologics. The new recommendations aim to enhance care for children with this disabling disease.
Researchers discover STING's critical role in treating autoimmune diseases by evoking expression of enzyme IDO, which blocks immune attack on healthy body constituents. Mice with STING deficiency had no response to DNA nanoparticles, highlighting the protein's essential role in recognizing the molecule that senses DNA.
A novel study in Arthritis Care & Research examines the medical response and imaging technologies used to treat Boston Marathon bombing victims. The study found that radiology resources should be used liberally to save lives and limbs in urgent situations like the Boston Marathon bombing.
A study of 115 children with juvenile arthritis found that changes in prostanoid levels may predict disease activity and help provide individualized treatment. The discovery could lead to more effective treatment options and reduce the physical, emotional, and financial burden of childhood arthritis.
The National Psoriasis Foundation has awarded the inaugural Dr. Mark G. Lebwohl Medical Dermatology Fellowship to Zelma Chiesa, a third-year dermatology resident. Through this one-year fellowship, Chiesa will investigate treatments and health risks of psoriasis, aiming to predict skin clearance and cardiovascular events.
A new study has revealed that the COX-2 enzyme is largely absent from major blood vessels, instead found in brain, kidney, thymus, and gut. This knowledge paves the way for the development of safer, more targeted drugs for arthritis patients with fewer side effects.
The National Psoriasis Foundation has awarded twelve fellowships totaling nearly half a million dollars to researchers working to cure psoriasis and psoriatic arthritis. The fellowships will support studies on the impact of diet, exercise, and lifestyle on psoriasis severity and treatment outcomes.
A randomized trial found that the MMR booster vaccination did not worsen disease activity in patients with juvenile idiopathic arthritis. The researchers also observed higher antibody concentrations and seroprotection rates after vaccination.
A new study by McGill University researchers suggests that the nervous system and nerve-growth factor (NGF) play a major role in arthritis. The findings support the idea that reducing elevated NGF levels may be an important strategy for developing treatment of arthritis pain.
Apremilast administered to patients with psoriatic arthritis showed significant clinical responses beyond 24 weeks, with up to 65% achieving ACR20 response rates at week 52. The novel PDE-4 inhibitor was well-tolerated with an acceptable long-term safety profile.
The CHERISH trial demonstrates the effectiveness of tocilizumab in reducing symptoms and signs of juvenile idiopathic arthritis. Patients with polyarticular JIA achieved significant clinical responses, including ACR30/50/70 responses, with as many as 65% attaining an ACR70 response.
A study of 333 female patients with fibromyalgia found that weather conditions had no significant impact on their pain and fatigue symptoms. Individual patients may still experience some sensitivity to certain weather conditions, but this is not associated with demographic or mental health status.
Six top scientists received funding for projects aiming to discover new treatments and a cure for psoriasis and psoriatic arthritis. The National Psoriasis Foundation awarded $450,000 in research grants to support promising research projects.
A new study has found that bunions and lesser toe deformities are highly inheritable in Caucasian men and women of European descent. The Framingham Foot Study estimated heritability using genetic analyses of familial data, confirming the prevalence of these foot conditions is higher in older adults with a European ancestry.
New research published in Arthritis & Rheumatism found that vitamin C supplementation had a weak effect on lowering uric acid levels in gout patients. The study suggests that vitamin C may not be a viable therapy for reducing uric acid levels in patients with established gout.
Scientists have discovered 14 new genes associated with childhood arthritis, which could lead to more effective treatments and improved outcomes. The study's findings may also enable clinicians to identify children who require specific therapy earlier, ultimately reducing the impact of the disease on their quality of life.
Research suggests that low to moderate drinkers of alcohol may experience lower severity of fibromyalgia symptoms, including chronic pain, fatigue, and sleep problems. Moderate drinking has also been found to improve quality of life, with benefits seen in physical function, ability to work, and overall well-being.
Research finds fibromyalgia is a spectrum disorder with nearly 40% of patients meeting criteria for physical symptom disorder. The prevalence is 2.1%, higher in women than men.
A new study published in Arthritis Research & Therapy shows lenalidomide to be a safe and effective alternative treatment for refractory cutaneous lupus erythematosus, with significant clinical improvement in most patients. The treatment's efficacy is comparable to thalidomide but with lower toxicity.
Researchers identified molecular pathways involved in both systemic and arthritic components of SJIA, revealing differences in affected organs. The study found that glucocorticoid signalling was more heavily involved in inflammation associated with SJIA, highlighting the need for tailored treatment plans.
Researchers found vitamin D supplementation improved SLE symptoms by increasing beneficial CD4+ cells, Treg cells, and decreasing effector Th1 and Th17 cells. Vitamin D also reduced memory B cell and anti-DNA antibodies in patients.
The newly approved guidelines educate patients on effective methods to prevent gout attacks, including dietary recommendations and lifestyle choices. The guidelines also provide recommended therapies for long-term management of gout, such as xanthine oxidase inhibitors and non-drug treatments.
A new study found that cherry consumption lowered gout attack risk by 35% compared to non-consumers, while combined with allopurinol it decreased risk by 75%. The findings suggest cherries may be a preventive option for patients with gout.
Researchers found that antibiotic treatment reduced the number of live spirochetes in infected mice but left behind fluorescent bacterial debris. This debris triggered an inflammatory immune response and may contribute to arthritis-like symptoms in some patients.
Research suggests that functional disability in juvenile idiopathic arthritis (JIA) patients affects their ability to achieve educational success and secure employment. Patients with JIA often experience joint damage, disability, and lowered quality of life, leading to higher rates of unemployment compared to healthy counterparts.
Research shows that adult JIA patients with higher functional disability have lower educational achievement and job stability, while those with oligoarticular JIA perform better. Education is key to success for these individuals, suggesting that career guidance and disease management are crucial for employment outcomes.
A retrospective analysis found that methotrexate injection was not more effective than oral therapy in treating juvenile idiopathic arthritis. The study suggests that the oral approach may be a more suitable option for pediatric patients, sparing them from the pain of injections.
The National Psoriasis Foundation has awarded a record $2.06 million in grants to 26 scientists studying psoriasis and psoriatic arthritis, aiming to advance knowledge and lead to new treatments. The foundation's mission is to find a cure for these autoimmune diseases through research, advocacy, and education.
Researchers studied a giant pliosaur specimen from the Upper Jurassic and discovered signs of an arthritis-like disease that eroded its left jaw joint. The animal, believed to be an old female, lived with a crooked jaw for many years, still able to hunt despite its condition.
African Americans with systemic sclerosis have higher frequencies of certain autoantibodies, associated with increased frequency and severity of pulmonary fibrosis and decreased survival. The study highlights the need for more aggressive treatment for African-American patients with severe lung disease.
Researchers at Queen Mary University of London have identified primary cilia as a crucial regulator of inflammation. The discovery could lead to novel therapies for millions suffering from arthritis and other inflammatory conditions.
A study found that children with juvenile idiopathic arthritis have a higher risk of hospitalized bacterial infections than children without the condition. High-dose steroids significantly increased this risk, while methotrexate and tumor necrosis factor inhibitors did not.
Researchers found Bartonella infection in 62% of patients with conditions like arthritis, chronic fatigue, and Lyme disease. The study suggests a possible link between Bartonella bacterium and rheumatoid illnesses in humans.
Researchers have identified a rare gene mutation in the CARD14 gene that is directly linked to plaque psoriasis, accounting for 80% of all cases. The discovery may lead to more effective treatments and sheds light on the genetic pathway underlying the condition.
Researchers at the University of Sheffield have identified three new ways to tackle bone diseases like osteoporosis. By understanding how individual cells respond to mechanical loading and stress, they've discovered that controlling ATP release during exercise could help build stronger bones.
Research finds that children with JIA have a significantly increased cancer risk, with rates 3.9 times higher for methotrexate-only patients and 4.4 times higher overall compared to peers without the disease. The study suggests that treatment, including TNF inhibitors, may not be directly linked to this increased risk.
A large study found that overweight and obese adults are more likely to have disc degeneration than those with a normal body mass index. Disc degeneration was associated with an increased number of levels of degenerated disks and greater severity of disc degeneration, including narrowing of the disc space.
A phase II clinical trial demonstrated that rilonacept significantly reduced acute gout flares by 81% compared to a placebo. The treatment was found to be well-tolerated with no serious infections or adverse events reported.
A study published in the American Association for Cancer Research found that women who underwent bilateral oophorectomy before age 45 had lower bone mineral density and a higher prevalence of arthritis. The research suggests that clinicians should be aware of this association to provide early intervention if needed.
A randomized controlled trial found that telephone-delivered cognitive behavioral therapy and an exercise program were associated with short-term positive outcomes for patients with chronic widespread pain. The combined intervention showed improvements in physical component score and reduced passive coping strategies.
A longitudinal study published in Arthritis & Rheumatism found a strong association between poor sleep habits and the risk of developing fibromyalgia in women. The study, which followed over 12,000 women for ten years, found that women with severe sleep problems were at increased risk of developing fibromyalgia.
A study found that patients with juvenile idiopathic arthritis who responded well to etanercept treatment had lower disability scores, younger age at onset, and fewer disease-modifying antirheumatic drugs used before treatment. These factors are associated with a better long-term outcome.
A new study finds that gout prevalence has risen significantly in the US adult population, affecting 8.3 million people, while hyperuricemia affects 43.3 million adults. The study suggests that managing modifiable risk factors like obesity and hypertension could help prevent further escalation of gout and hyperuricemia.
A study by Columbia University's Mailman School of Public Health found that blue collar workers are more likely to suffer from arthritis and reduce their quality of life due to health conditions. The research highlights the need for enhanced federal programs, including disability and health insurance, to support these workers.
Researchers discovered seven new genes linked to Ankylosing Spondylitis, bringing the total to thirteen known predisposing genes. The study also revealed an interaction between genetic mutations HLA-B27 and ERAP1, providing insight into the disease's cause.
Research shows that African Americans with systemic lupus erythematosus (SLE) have a higher antibody response to the influenza vaccine compared to European American patients. Treatment with prednisone and history of hemolytic anemia are linked to low antibody responses in SLE patients.