Articles tagged with Arthritis
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A team of researchers from Aarhus University has developed interdisciplinary guidelines to optimise the treatment of patients with juvenile arthritis, focusing on early diagnosis and screening. The guidelines aim to improve treatment outcomes by promoting a more timely initiation of treatment.
Scientists have identified WASH protein complex as a gatekeeper of neutrophil-driven inflammation, potentially leading to new treatments for conditions like sepsis and arthritis. The study reveals that WASH regulates the release of antimicrobial molecules, which can harm healthy cells if released excessively.
A new study found that gout patients who suffered from a heart attack or stroke were twice as likely to have had a gout flare in the 60 days prior to the event. Gout flares are also associated with a transient increase in cardiovascular events, particularly among those with pre-existing heart disease.
A study by University of Toronto researchers found that childhood physical abuse is associated with chronic pain, diabetes, cancer, migraines, arthritis, and heart disease in later life. The trauma can influence both physical and mental health many decades after the event.
A Michigan Medicine study found that people with cerebral palsy and spina bifida are prescribed opioids at a rate up to five times higher than those without the conditions. Chronic pain is the most commonly reported symptom among these individuals, raising concerns over addiction and overdose issues.
A recent study found that older adults in later-born generations are more likely to have multiple chronic health conditions than prior generations. This trend may lead to increased strain on the well-being of older adults and medical insurance systems, particularly as the US population ages. The researchers suggest that sociodemographi...
A study published in Cell reveals that individuals with gum disease are more susceptible to developing arthritis due to alterations in immune cell precursors in the bone marrow. The researchers also found that this association may prompt a reconsideration of how bone marrow donors are selected.
A new study has identified a strong predictor for the development of clinically important liver problems in people with Hemochromatosis. Researchers found that 84% of those with advanced liver fibrosis also had arthritis, highlighting the importance of early detection and monitoring.
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
A new study published in the Chinese Medical Journal assessed mortality risk in middle-aged and older Chinese individuals with multiple diseases. The study identified four multimorbidity patterns, with cardiometabolic being the most common, and found that individuals with these patterns had a significantly increased mortality risk.
Researchers at MD Anderson have made significant advancements in treating neuroendocrine tumors with combination therapy, identified consensus subtypes for hepatocellular carcinoma to improve treatment selection, and found a targetable vulnerability in urothelial cancer due to MTAP loss.
Researchers found that elevated blood levels of two cardiovascular markers are associated with higher risks of cardiovascular problems in psoriatic disease patients. The study suggests a potential clinical tool for assessing heart health, but ordering tests is not recommended for asymptomatic patients.
A new study predicts rheumatoid arthritis progression using a polygenic risk score. The score, generated from genetic variants associated with the disease, significantly differed between severe and non-severe progression groups. Higher scores were linked to higher risks of severe progression, particularly among younger patients.
A recent study by Éric Boilard at Université Laval has established a link between the gut microbiota and chronic inflammatory diseases such as arthritis. The research reveals that phospholipase A2-IIA, a protein naturally present in the gut, alters the bacterial lipid profile and promotes inflammation. This finding suggests that local ...
The Tennessee AgrAbility Project has received new funding from the USDA, bolstering its impact and success into 2022. The program, a collaboration between the University of Tennessee Extension and NIFA, assists farmers and farm workers with disabilities by providing support, resources, and equipment to enhance their quality of life.
A new study found that telephone cognitive behavioral therapy can effectively improve sleeplessness and pain in older adults with osteoarthritis-related insomnia, reducing clinical and financial burdens. The study showed that telephone CBT reduced healthcare costs without increasing them.
A study published in PAIN found that weather-related factors can affect pain tolerance, particularly for cold-induced pain. Temperature, barometric pressure, and humidity were associated with changes in pain tolerance tests, suggesting a dynamic and non-linear relationship between weather and pain.
Researchers at WashU Medicine have identified two antibodies that protect animals from disease caused by alphaviruses, which could form the basis of treatments or serve as a template for a universal vaccine. The antibodies worked against all tested alphaviruses and prevented arthritis and brain infections in animals.
Research found that men diagnosed with inflammatory arthritis before their peak reproductive years have lower fertility rates, fewer pregnancies, and poor sperm quality compared to those diagnosed at older ages. Inflammatory arthritis is linked to male infertility, erectile dysfunction, and insufficient testosterone production.
Research presents alarming rate of glenohumeral arthritis progression after arthroscopic posterior stabilization in active-duty servicemembers. The study found that 12.7% of patients developed arthritis within seven years of surgery.
An international research team has mapped the current global landscape for musculoskeletal health and developed an action plan to address the growing global burden of disability. The blueprint prioritizes eight key areas, including community education, leadership, and research, to guide health systems reform and promote integrated care.
A £14 million investment from UKRI and Versus Arthritis will massively scale up research into chronic pain, with a focus on the psychosocial aspect. The project aims to understand how psychological and social factors influence pain development and maintenance, and will work with people living with pain every step of the way.
A double-blind trial found that faecal microbiota transplantation did not improve treatment outcomes or reduce symptoms in patients with active peripheral PsA. The study suggests that FMT may not be an effective treatment option for this condition, and future research is needed to explore its potential benefits.
A global review of diagnosis delays in axial spondyloarthritis reveals common challenges, including inadequate patient access to rheumatologists and poorly defined referral pathways. The report aims to empower stakeholders to reduce this delay and improve patient outcomes.
Children with juvenile idiopathic arthritis (JIA) are at high risk for uveitis relapses after discontinuing disease-modifying antirheumatic drugs (DMARDs). The study found that patients are more likely to experience uveitis events within the first 3-24 months after DMARD withdrawal.
A novel chemical blocker targeting chemokine proteins significantly reduces skin and joint inflammation in a mouse model with psoriasis and psoriatic arthritis. The study identifies CCR6 as a critical agent for joint inflammation, making it an attractive target for arthritis therapy.
A study published in The Journal of Bone & Joint Surgery found that total ankle replacement (TAA) provides better long-term function than ankle arthrodesis (AA) for patients with severe ankle arthritis. TAA resulted in improved patient-reported outcomes, including reduced pain and enhanced quality of life.
The study reveals a significant disparity in lupus prevalence across racial and ethnic groups, with female rates significantly higher than male rates. The analysis estimates that approximately 204,295 individuals in the US have been diagnosed with lupus as of 2018.
A major register-based study demonstrates a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. The risk was found to be 35% higher in men who were rated as the least fit compared to those who were fittest.
The new guideline recommends increased use of biologic drugs, reduced steroid treatment, and regular immunizations for infectious diseases. Disease-modifying treatments are now more rapidly escalated in JIA patients, reducing the need for oral or intravenous steroids.
A major new report suggests that children's chronic pain is often ignored or undertreated, with up to 10% of young people experiencing disabling conditions. The Lancet Child and Adolescent Health Commission recommends four key goals: making childhood pain matter, understanding it, making it visible, and managing it effectively.
A new study reveals that stem cells contribute to the formation of osteophytes, or pathological bone spurs, in arthritis patients. The researchers identified a specific type of stem cell with activity in the Sox9 gene as the major culprit behind this process.
Researchers have identified a specific receptor in immune cells from psoriatic arthritis patients, suggesting a single cause for the disease. This finding could lead to developing targeted treatments and offers new insights into the intricate mechanisms behind psoriatic arthritis.
A study of search and rescue dogs found that dogs at the disaster site lived a similar length of time as those in a control group, with no discernable difference in cause of death. The most common cause of death was age-related conditions such as arthritis and cancer.
The prevalence of gout increased worldwide between 1990 and 2017, reaching approximately 41.2 million cases in 2017. High body mass index and impaired kidney function were identified as key risk factors for the disease.
Researchers discovered an overabundance of KLK6 protein can produce skin inflammation in psoriasis, while normalizing its level can eliminate it. They also found that KLK6 plays a key role in damaging joints and bones in people with the disorder.
BIOCAD presents results of clinical trial showing netakimab decreases disease activity and reduces skin manifestation of psoriatic arthritis through 24 weeks of therapy. The treatment was well-tolerated, with significant improvement in skin manifestations and quality of life.
Researchers at Baylor College of Medicine found that CBD significantly reduces inflammatory molecules and immune cells associated with arthritis in dogs. The study showed that CBD treatment improved quality of life in 90% of the dogs, supporting future scientific evaluation of CBD for human arthritis.
Lyme disease is the most reported vector-borne disease in the country, with a dramatic increase in cases over the past 20 years. The research aims to understand how the bacterium Borrelia burgdorferi causes sustained inflammation and Lyme arthritis symptoms.
Researchers at Washington State University have identified a key protein in Borrelia burgdorferi that shields the immune system from fighting Lyme disease. By understanding this 'VlsE' protein, they hope to develop effective vaccines against the disease.
A study published in Arthritis & Rheumatology found a significant increase in autoimmunity prevalence in the US population between 1988 and 2012. The prevalence of antinuclear antibodies (ANA) rose from 11.0% in 1988 to 15.9% in 2011-2012, affecting an estimated 41 million individuals.
Scientists at Fred Hutchinson Cancer Center discovered a mini-protein in scorpion venom that rapidly accumulates in joint cartilage, allowing it to deliver steroids and other drugs directly to the affected area. This approach may potentially improve the safety of arthritis treatment by reducing systemic side effects.
This observational study analyzed 112 studies to examine the association between cancer risk in patients with psoriasis or psoriatic arthritis. The findings suggest that these patients may be at higher risk of specific cancers, including melanoma and non-melanoma skin cancers.
A new study finds that married couples with multiple chronic conditions experience rising depression symptoms, with husbands faring worse when their conditions differ from their wives. The study highlights the importance of recognizing and addressing these dynamics to maintain mental and physical health.
Researchers found that psoriasis onset age determines whether arthritis starts first, with a 65-month delay for arthritis onset after psoriasis. Early-onset psoriasis is strongly associated with arthritis onset, suggesting a different subgroup of PsA patients.
A study found that children with Down syndrome are at an increased risk of developing inflammatory and erosive arthritis. Researchers estimate that around 20 per 1,000 children with Down syndrome have this condition.
A study of 14,624 US adults found that four modifiable risk factors--body mass index, diet, alcohol consumption, and diuretic use--contribute to hyperuricemia. Promoting healthy diets and preventing obesity can help reduce the frequency of hyperuricemia and gout.
Researchers have developed a way to detect cells infected with chikungunya virus that survive the infection, shedding light on the cause of chronic viral arthritis. The study found that the virus can persist in muscle and connective tissue cells for up to 114 days after infection.
A study of 456 acute gout patients found that over 28% received opioid prescriptions, with many lasting longer than the typical gout attack. Diabetes and prior opioid use increased the likelihood of receiving opioids.
Borrelia peptidoglycan, a component of the Lyme disease bacterium, is detected in patients' synovial fluid and stimulates proinflammatory cytokines. The finding suggests that Borrelia peptidoglycan contributes to inflammation in Lyme arthritis.
Researchers have discovered a cellular component called peptidoglycan that contributes to Lyme arthritis, a debilitating condition. The presence of peptidoglycan in synovial fluid may explain why some people experience symptoms despite no obvious infection, and could lead to new treatments.
The phase 2B study demonstrated superior efficacy of tildrakizumab versus placebo in patients with psoriatic arthritis, achieving high response rates for PASI 90 and ACR 50. The treatment was generally safe, with minor adverse events reported.
A systematic review of 55 studies found that people with inflammatory arthritis experience higher rates of sexual dysfunction compared to others, primarily due to disease-related factors such as pain and mobility restrictions. This highlights the importance of considering the impact of inflammatory arthritis on sexual health and intima...
A team of scientists developed a machine learning algorithm that identifies children with juvenile arthritis with nearly 90% accuracy from a simple blood test. The new findings pave the way for improving diagnosis and predicting which patients respond best to different treatment options.
Researchers developed a machine learning tool to classify children with arthritis into seven distinct groups based on joint patterns. This allowed them to predict which children will go into remission faster or develop more severe disease, enabling doctors to tailor treatment and spare patients unnecessary medication side effects.
Researchers at VIB-KU Leuven discovered a genetic mutation that can cause a juvenile form of inflammatory joint disease. The study used next-generation sequencing and immunology approaches to unravel the disease mechanism, providing insights into the development of targeted therapies.
A study published in Geriatrics found that 3D-printed adaptive aids for arthritis patients can offer significant cost savings, with some items costing as little as 45 cents. The customized designs can also improve the quality of life for these individuals, enabling them to perform daily tasks independently.
A trial revealed that nurse-led care significantly improves gout treatment outcomes, including higher ULT adoption and better patient adherence. Patients receiving nurse-led care had lower urate levels, reduced flare-ups, and improved quality of life.
A new study reveals the effect of vitamin E is often based on luck due to its metabolite, alpha-carboxychromanol, which has a promising anti-inflammatory effect. Personalized medicine could be improved with this discovery, as the level of alpha-carboxychromanol in patients varies greatly.
Patients undergoing elective hip surgery may experience new health issues such as mental health disorders, chronic pain, and cardiovascular ailments up to two years after the procedure. The study found that these hidden complications can have a significant impact on patients' quality of life.