Articles tagged with Immune Response
A recent study published in The Open Sports Sciences Journal found that Ascorbic acid supplementation reduced exercise-induced oxidative stress and inflammation in healthy women. The supplement also increased plasma ascorbic acid levels and reduced post-exercise MDA levels, suggesting a potential protective effect against muscle injury.
A recent study suggests that inhibiting epigenetic control enzymes in immune cells, specifically HDAC1, improves anti-tumor immunity and tumor surveillance. This finding could lead to new therapeutic strategies in cancer immunotherapy.
Researchers at Uppsala University found that macrophages in injured muscle tissues transform into cells resembling mural cells, promoting restoration of blood flow and healing. This finding highlights the potential for immunotherapies to enhance vascular integrity and tissue repair.
Researchers found that tumor-associated macrophages respond to physical properties of fibrosis by synthesizing injury-associated collagens, resulting in metabolic changes that suppress CTL function. This provides an alternative explanation for why anti-tumor immunity is impaired in fibrotic solid tumors.
Researchers found that Werner syndrome mice experience age-dependent and sex-specific changes in their livers and immune systems, including fatty liver accumulation and altered lipid metabolism. These findings suggest a potential link between immunoglobulin variants and fatty liver progression in the disorder.
Researchers at University of Turku have discovered a novel RNA that controls the development and function of regulatory T cells. This finding may enable the development of precision medicine treatments for autoimmune diseases and cancer.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers explore nanoparticle-based therapies to specifically target lymphatic metastasis in breast cancer, providing a promising solution for patient treatment. Nanoparticles deliver drugs directly to tumors, targeting cancer cells to destroy them or slow their growth, while also enhancing the immune response.
Researchers at Harvard University have identified a specific cell type in the mouse embryonic brain that responds to an immune response in the mother, altering gene regulation and persisting in juvenile mice. This study provides new insights into how maternal immune responses might influence brain development in embryos, potentially sh...
Researchers from Osaka University found that Csk inhibits germinal center B cell signaling, decreasing reactive oxygen species production and promoting affinity maturation. This study reveals the crucial role of Csk tyrosine kinase in regulating B cell development.
The study investigates the anticancer potential of CLK kinase inhibitors 1C8 and GPS167, which inhibit CLOCK kinases and affect cancer cell proliferation. The compounds also alter the expression and alternative splicing of transcripts involved in EMT and antiviral immune response.
Researchers found that repeat COVID-19 vaccinations elicit cross-reactive neutralizing antibodies capable of targeting multiple SARS-CoV-2 variants and distantly related coronaviruses. The findings suggest periodic re-vaccination may help build a stock of protective antibodies against emerging variants.
Researchers found that ARID1A mutation renders tumors sensitive to immunotherapy by triggering an antiviral immune response. This could lead to improved patient outcomes and the development of targeted therapies.
Researchers found a significant association between neighborhood deprivation and DNA methylation in brain tissue, which may be linked to immune response. The study identified one CpG site (cg26514961, PLXNC1 gene) significantly associated with neighborhood deprivation after controlling for covariates.
A third Covid vaccine dose has been shown to improve defensive antibody responses in some clinically extremely vulnerable patients. The trial found that 90% of patients who received a booster dose developed significant antibodies, but more than half of those with low initial responses saw no improvement.
Researchers have identified new cellular targets for a vaccine to treat eczema in children, which may limit the severity of symptoms and reduce antibiotic use. The study uncovered specific immune signatures in children with infected flares of eczema, providing a potential blueprint for future therapies.
A new Cochrane review suggests that taking zinc may reduce the duration of common cold symptoms by around two days, but the evidence is not conclusive. Common side-effects include bowel problems, nausea, and unpleasant taste.
Researchers found that inflammatory proteins peak at different times of day based on whether new mothers breastfeed or formula-feed their babies. The study's findings suggest a unique immune profile for lactating mothers and highlight the need for further research into postpartum breastfeeding.
Researchers developed a new 'proactive vaccinology' approach to build vaccines before disease-causing pathogens emerge. The Quartet Nanocage vaccine trains the immune system to target specific regions of eight coronaviruses, providing broad protection against known and unknown strains.
Researchers at Columbia University's Zuckerman Institute have identified a new brain circuit in mice that regulates the body's inflammatory reactions. The discovery reveals a previously unknown pathway between the brain and body, which may lead to innovative treatments for various immune disorders.
Researchers uncovered Bcl6's importance for certain dendritic cell formation and its impact on T-cell responses. Bcl6 deficiency leads to impaired antibody production and weakened immunity.
New research reveals updated vaccines provide a strong immune response against previous strains and emerging variants of COVID-19. Regular vaccinations are recommended for older people or those with underlying medical conditions to combat the virus.
University of Bonn researchers found that harmless particles improve immune responses and enhance lung function in mice. The study used beta-glucan to stimulate the immune system, resulting in a modified response to pathogenic bacteria.
Researchers at University of Kansas discover a new compound that inhibits SARS-CoV-2 replication in cell models by targeting the 'Mac-1' protein. This finding offers hope for developing new treatments and preventing future pandemics.
Researchers at TUM have uncovered a mechanism by which tumor cells prevent the formation of immune responses, including cytotoxic T cells. This discovery provides rationales for new cancer immunotherapies and could enhance existing treatments.
A new study reveals that aspirin boosts certain aspects of the immune system to detect and target cancer cells, reducing cancer spread to lymph nodes. Aspirin also increases expression of a protein called CD80 on immune cells, enhancing their ability to alert other immune cells of tumor-associated proteins.
A specific protein, TRBP, regulates the balance between apoptosis and interferon response to suppress viral replication. This study sheds light on a previously unclear mechanism of defense against viruses in mammalian cells.
A York University-led study found that COVID-19 booster shots provide significantly longer-lasting immunity than the primary vaccine series. The researchers used health data from over 150 individuals to model the immune response and controlled for factors like age, sex, and comorbidities.
Researchers at UC Riverside demonstrate a new vaccine strategy targeting a common viral genome part, eliminating the need for annual booster shots. The vaccine uses small RNA molecules to boost the immune system, making it safe for babies and those with weakened immunity.
A new murine model of dermatomyositis reveals the underlying immune system involvement in this highly progressive disease. The study identifies key components of the immune system responsible for disease development and suggests potential treatments targeting interleukin-6.
A newly developed compound called UH15-38 has been shown to safely and efficiently block necroptosis, a key receptor in lung cells causing excessive inflammation and lung damage. The study demonstrates that UH15-38 can prevent influenza deaths even when administered late in the course of an infection.
Researchers identified a gene mutation associated with impaired natural killer cell function, leading to increased susceptibility to viral infections in people with a rare genetic condition. Oleic acid supplementation shows promise as a potential therapy for these patients.
A new study found that high-dose influenza vaccine significantly improved humoral response in patients with heart failure or prior myocardial infarction. Vaccination remains crucial in preventing influenza-related complications in high-risk populations.
Researchers at Butantan Institute used phage display to screen 12,000 proteins from Schistosoma mansoni, identifying key parasite peptides targeted by macaque antibodies. This approach has potential for developing candidate vaccines against the disease.
Researchers have identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery and reducing bacterial burden in tuberculosis-infected rabbits. The study leverages decades of cancer research to study tuberculosis-affected lung tissue and improves treatment.
Researchers found that ageing reduces the ability of regulatory T cells to enhance myelin regeneration, which can have profound consequences for neurological functions. The study suggests that the loss of function may be reversible, and two new molecules, ITGA2 and MCAM, have been identified as potential therapeutic targets.
Researchers have identified a potential path to eliminate the viral reservoir that prevents people from being completely cured of HIV. A new drug candidate, called a proteolysis targeting chimeras (PROTAC) molecule, triggers the degradation of the Nef protein, which suppresses HIV replication and restores immune system detection. This ...
Scientists have created a new approach for treating tendon-bone injuries by combining manganese silicate nanoparticles with cells to create an immunomodulatory scaffold. This innovation promotes integrated regeneration and functional recovery in patients, offering a promising solution for improving life quality.
A new study published in PLOS Medicine found distinct patterns of antimicrobial resistance prevalence by age and sex across Europe. The study analyzed data from nearly one million people in 29 European countries, revealing that peaks in resistance varied by bacterial species and often occurred at the youngest and oldest ages.
Researchers discovered that plant immune proteins condense into droplets to become activated and protect against infections. Phase separation plays a crucial role in the activation of TIR domain proteins, a class of important immune receptors.
Researchers developed a protein-based vaccine candidate called SpyCage that induces an immune response in rodent models, clearing COVID-19 infections more quickly than controls. The platform has the potential to prevent infection and transmission of respiratory viruses like SARS-CoV-2 by inducing a mucosal immune response.
Researchers found that viral infections like adenovirus create conditions for arrhythmias by disrupting gap junctions and ion channels in the heart. This discovery opens new directions to diagnose and treat viral infections affecting the heart, particularly for individuals with acute infections.
Researchers found that rapamycin extends lifespan by regulating the activity of protein S6K, which influences the endolysosomal system. This leads to improved immune function and clearance of bacterial infections at old age.
Researchers created Elenagen, a novel DNA immunotherapy for deadly ovarian cancer, which significantly enhances standard chemotherapy and provides clinical benefits. The study shows that Elenagen delays disease progression in patients with stage III and IV platinum-resistant ovarian cancer.
Rumbaugh's lab aims to understand the effects of dispersing bacteria from a biofilm on their susceptibility to antibiotics and on the host. They will use enzymes as tools to break up biofilms, allowing researchers to better comprehend the relationship between bacterial dispersal and infection outcomes.
Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
Scientists discovered a novel mechanism for removing mtDNA from mitochondria, which can initiate an immune response promoting inflammation. The discovery reveals new targets for therapeutics to disrupt the inflammatory pathway and mitigate inflammation during aging and diseases.
Researchers have found that alterations in the blood immune system increase cancer risk, and identified over 1,000 genes influencing this regulation. The study also discovered protective roles of certain immune cells against common cancers.
Researchers found a four-fold increase in immune response when people alternate arms during two-dose vaccinations. The study showed improved immunity to the original and omicron variants after three weeks and persisted beyond 13 months.
Researchers have discovered that immune cells can form memories of pathogens at multiple phases during an infection, with the ability to switch between memory and effector cell fates. This flexibility enables individuals to better adapt to uncertain situations and respond effectively to different threats.
Researchers found XRCC1 to have both positive and negative correlations with prognosis across different tumors. The study also revealed associations between XRCC1 expression and DNA methylation patterns, TMB, MSI, immune cell infiltration levels, and immune checkpoint gene expression.
Researchers have unraveled the activation mechanism of GBP1, a protein that encapsulates bacterial pathogens with an antimicrobial coat. The study reveals how GBP1 forms a protein coat around invaders, destroying their membrane and preventing multiplication.
A new study finds that infants born full-term to mothers infected with COVID-19 during pregnancy are three times more likely to develop respiratory distress compared to uninfected infants. Vaccination prior to infection was found to be protective, reducing the risk by half.
Researchers analyzed LTBR expression levels in various cancers, finding it associated with low patient survival and immune cell infiltration. The study identified LTBR as a potential target for cancer immunotherapy and marker of poor prognosis.
Researchers found that the complement system remains activated in Long Covid patients, causing cell damage and tissue destruction. This abnormal activity can lead to thromboinflammation and other symptoms of the condition.
A new vaccine design has been developed by a UC Riverside-led research team, which uses preexisting immunity to the influenza virus to help kickstart the production of antibodies against SARS-CoV-2. The vaccine aims to speed up the immune response and provide better protection for people who still lack immunity to the coronavirus.
Researchers at UC San Diego School of Medicine found that the immune system's response to Staphylococcus aureus bacteria can be tricked into producing non-protective antibodies, making vaccines ineffective. The study suggests targeting subdominant antigens for future vaccine development.
Researchers at Karolinska Institutet have developed a nasal spray with IgA antibodies that can protect mice from SARS-CoV-2 infection. The treatment significantly diminished virus load in infected mice and showed stronger binding to the spike protein compared to original IgG antibodies.
Research suggests that structural changes in upper motor neurons send a signal to immune cells, leading to toxic effects on neurons and reduced synaptic connections. Blocking inflammation with a semi-synthetic drug can restore synaptic connections and improve ALS symptoms.