Articles tagged with Inflammatory Response
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A study of 50 COVID-19 patients revealed a distinctive 'hallmark' of severe disease, characterized by interferon deficiency and exacerbated inflammation. This signature may inform therapeutic approaches combining interferon supplementation with anti-inflammatory treatments.
A new single-cell RNA sequencing analysis of over 59,000 cells from COVID-19 patients and influenza patients reveals distinct immune responses to both diseases. The study suggests targeting the IFN-I signaling pathway as a potential treatment strategy for severe COVID-19.
Researchers found that bats' ability to control inflammation may hold clues to developing new treatments for diseases in humans. By understanding the mechanisms underlying bats' unique abilities, scientists may be able to develop therapies to fight diseases like COVID-19.
New research from Saarland University suggests that low levels of the stress hormone cortisol and protein GILZ can trigger chronic inflammatory responses in the body. This leads to macrophage ageing, which impairs immune cells' ability to control inflammation, resulting in increased pro-inflammatory signalling molecules.
Researchers found an immune system cell called interleukin-6 (IL-6) triggers inflammation in times of stress, worsening health problems such as diabetes and autoimmune disease. Blocking IL-6 production protects stressed mice from inflammation and alleviates symptoms of depression.
The study found that female neutrophils have enhanced proinflammatory genes and responses to inflammatory stimuli compared to male neutrophils. Sex hormones may drive these differences, with males exhibiting increased mitochondrial metabolism in their neutrophils.
A recent study published in Nature Medicine found that healthy adults exhibit a wide range of metabolic responses to food, with inflammation triggered by eating varying up to ten-fold. This suggests personalized diets can help reduce inflammation and improve health.
Research published in Nature Genetics found that the three-dimensional structure of the human genome is essential for a rapid and robust inflammatory response. The discovery sheds light on the fundamental relationship between genome folding and cell function, highlighting the importance of architectural proteins like CTCF.
Researchers find that repositioning the spleen during surgery can lead to physical changes and altered immune responses, suggesting a key role of mesothelial cells in modulating inflammation. The study suggests that breaking connections between these cells and the spleen may have consequences for immune function.
A new study finds that e-cigarettes cause a proinflammatory response in the oral microbiome, coating commensal bacteria with slime and disrupting healthy colonization. The glycerol/glycol vehicle in e-cigarettes appears to drive these changes, according to researchers who analyzed bacterial genes in plaque samples from e-cigarette users.
Researchers have discovered that increasing levels of lipid mediators derived from omega-3 fatty acids can turn off inflammation caused by SARS-CoV-2, a hallmark symptom of severe COVID-19 illness. This approach may be as important as antiviral therapies or vaccines in reducing associated organ damage and mortality.
Researchers at Monash University have discovered the mechanism behind one of two signalling arms involved in the cGAS-STING pathway. The findings reveal that a closely related TBK1 homologue, IKK-epsilon, plays a crucial role in cytokine production, leading to new understanding of autoimmune diseases and cancer treatment.
Researchers found that a commonly used drug, ursodiol, can reduce inflammation in mice infected with C. difficile and inhibit the life cycle of the bacteria. The study suggests that ursodiol may be a viable alternative to antibiotic treatments for C. diff infections.
Activated platelets attach to vessel walls and interact with mast cells, triggering a powerful inflammatory response that can lead to organ damage and death after heart surgery. Inhibiting platelet activation may prevent or minimize this response, according to a study published in Science Advances.
A study published in Immunity identifies an enzyme that blocks self-healing in blood vessels during inflammation, hindering regeneration. Removing this enzyme allows cells to fully regenerate, suggesting a potential therapeutic target for improving endogenous regeneration.
Research suggests that inflammation-related genes are associated with biobehavioral factors like body mass index and smoking, while interferon-related genes are linked to individual demographic factors such as sex and race/ethnicity. The study's findings could help explain social disparities in chronic diseases that emerge decades later.
Researchers have developed injectable hydrogels that can tune the body's inflammatory response, promoting or reducing inflammation as needed. The study found that positively charged hydrogels triggered stronger responses for wound-healing and cancer treatment, while negatively charged gels were better suited for drug delivery.
A recent study published in the Journal of Nutritional Biochemistry found that humans have highly individualized inflammatory responses to eating a high-fat meal. The researchers used a sensitive test to analyze gene expression in response to the meal, finding that responses by more than 13,000 genes differed between subjects.
Initial urinary tract infections can cause long-lasting changes to the bladder's immune response, making it more prone to future infections. The study found that targeting TNF-alpha or other inflammatory responses may help prevent or alleviate recurrent UTIs.
A study published in the Journal of Experimental Medicine found that phosphorylation of Regnase-1 allows IL-17 to trigger inflammation. Blocking this phosphorylation process could lead to therapeutic agents for treating autoimmune diseases related to IL-17, such as rheumatoid arthritis and multiple sclerosis.
Researchers identified a potential new therapeutic target for sepsis by uncovering a pathway involving Lipopolysaccharide (LPS) that could suppress the inflammatory response. This discovery offers a promising approach to treating sepsis, which can lead to organ failure and death if not recognized early.
A team of researchers from Trinity College Dublin has discovered that SARM plays an important role in the immune response and regulates inflammation. The study suggests that targeting SARM could provide a new option for treating diseases such as diabetes, cancer, and Alzheimer
A study published in Scientific Reports identifies changes to neutrophils that increase vulnerability of obese and diabetic individuals to infection. Alterations to neutrophils, a type of white blood cell, lead to impaired activation of toll-like receptors (TLRs), weakening the immune system's ability to combat pathogens.
A research team identified molecular and genetic mechanisms allowing bats to host multiple viral pathogens without suffering diseases. Bats have a unique ability to limit inflammation, which may be key to their long lifespans and virus reservoir status.
Scientists at the University of British Columbia have discovered a new protein 'switch' that can stop the progression of sepsis, a life-threatening disease. This discovery could lead to new treatments for chronic and acute inflammatory diseases.
A new study found that an HIV drug reduces age-related inflammation and signs of aging in mice, holding promise for treating Alzheimer's and other diseases. The drug works by halting retrotransposon activity in old cells, which are linked to age-associated disorders.
Researchers found that NSAID carprofen triggered low-grade inflammation in the heart and kidneys, amplifying cardiorenal syndrome. Biomarkers of kidney injury increased, indicating compromised glomerular structure integrity.
Researchers have identified a novel form of inflammatory regulation that increases response to painful stimuli. A protein fragment, ARD, plays a key role in this process, increasing PI3K activity and sensitizing pain receptors.
A new microneedle patch vaccine containing the inactivated RSV virus has been shown to be effective in enhancing protection against the disease and reducing inflammation. The vaccine, combined with an immune-stimulating compound, was found to induce a stronger immune response than traditional intramuscular vaccination.
Researchers studying fetal exposure to inflammation aim to understand its impact on infant immune responses and potential prevention methods. High levels of Th17 cells in pregnancy-inflammation mothers and preterm babies have been linked to tissue damage, but their role in infection protection is unclear.
Researchers from the Luxembourg Institute of Health uncover distinct microglial signatures in response to acute inflammation, highlighting potential benefits for resolving inflammation. Their single-cell transcriptomic study provides new resources for understanding brain disorders and developing novel therapeutic strategies.
A new study finds that long noncoding RNA lincRNA-Cox2 regulates the activity of genes involved in inflammation and immune system responses. It boosts production of the Cox2 enzyme and influences expression of other genes, shedding light on previously dismissed 'junk DNA' functions.
A recent study found that wood smoke exposure results in higher inflammatory markers for male subjects and lower inflammatory markers for female subjects. The researchers suggest that sex-specific effects may be missed when lumping data together, emphasizing the need to consider sex-specific responses when studying environmental pollut...
A study by Takeo Nakanishi at Kanazawa University found that fever is regulated by prostaglandin E2 and OATP2A1 transporters, suggesting these as potential therapeutic targets for treating fever-related conditions.
Researchers at RCSI and Trinity College Dublin have discovered how the body clock regulates inflammatory response in macrophages, a key immune cell. This study may lead to targeted treatments at specific times of the day to alleviate excess inflammation in conditions like asthma, arthritis, and cardiovascular disease.
Researchers discovered seal blood serum has anti-inflammatory properties, protecting against damage to pulmonary tissues and inflammation. This unique adaptation allows elephant seals and Weddell seals to safely dive deep without lung damage or inflammation.
Research reveals that good bacteria interact with epithelial cells and immune system cells to balance immune responses and protect the gut from inflammation. Manipulating the microbiota may offer therapeutic benefits for conditions like inflammatory bowel disease.
A new study finds that diseases common in the developing world may cause lymphoid tissue fibrosis and impaired vaccine responses. Researchers found significant differences in lymphoid anatomy between Ugandans and US participants, with Ugandans showing evidence of inflammation and immune activation.
The University of Louisville will receive a five-year, $11.2 million federal grant to establish an interdisciplinary research program focused on the microbiome, inflammation, and disease development. Researchers will study various diseases, including inflammatory bowel disease, periodontitis, and neurological disorders.
A new drug has shown encouraging safety and efficacy in treating Still's disease, a serious orphan condition. The treatment, which blocks the action of an inflammation factor, has been tested on 23 patients with refractory forms of the disease, resulting in positive responses and significant symptom reduction.
Research found that resolvin D-1 limits heart attack-induced kidney inflammation and promotes reparative macrophage change. This suggests potential application to clinical settings for treating cardiorenal syndrome.
Researchers at Osaka University discovered that Arid5a translocates from the nucleus to the cytoplasm in response to inflammation, regulating IL-6 production. This finding offers potential therapeutic strategies for septic shock and autoimmune diseases.
A UCL-led research team found that an excessive inflammation reaction in older people can obstruct the immune system, leading to weaker immune responses. Blocking this inflammation with a short-term anti-inflammatory pill increased the immune system's effectiveness.
A recent study by the University of Bonn found that fast food can make the immune system more aggressive in the long term. Even after switching to a healthy diet, inflammation remains higher, potentially leading to diseases like arteriosclerosis and diabetes.
A new study finds that gut bacteria from old mice induce age-related chronic inflammation in young mice, suggesting a potential strategy for healthy ageing. The research highlights the importance of maintaining a balanced gut microbiota to prevent inflammaging and related diseases.
Researchers found that catheterization potentiates MRSA infection by inducing an inflammatory response and releasing the fibrinogen protein. This results in the facilitation of targeted treatments for MRSA CAUTI.
A team of researchers at FAU has identified a key mechanism involved in the resolution of inflammations in rheumatoid arthritis patients. Innate lymphoid cells can induce a 'hibernation' state, which persists in those with rheumatism but is reversed when these cells are 'woken up', stopping inflammation and joint damage.
Aging individuals with implants face unique challenges due to immunosenescence and delayed immune responses. The study investigates the impact of aging on macrophage activity and white blood cell function, seeking ways to optimize implant success and minimize negative effects.
Researchers found chemokines can activate chemokine receptors in different ways, leading to varying responses and chronic inflammation. This discovery may lead to the development of anti-inflammatory drugs targeting specific molecules.
A new study in mice reveals how the protein Brd4 boosts the inflammatory response, with both beneficial and harmful effects. The findings suggest that Brd4 can protect the body from infection but also contribute to chronic inflammatory diseases.
Researchers have identified a key mechanism driving the emotional response to painful inflammation, highlighting potential therapeutic targets for managing chronic pain. Prostaglandins in brainstem serotonin-producing neurons play a crucial role in this process.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified K-homology splicing regulatory protein (KHSRP) as a regulator of the innate immune response. Depleting KHSRP improves immune signaling and reduces viral replication, suggesting that drugs inhibiting the protein may have therapeutic value.
A new review article suggests that protein aggregation inside aging neurons sets off inflammatory responses, which can lead to neurodegenerative diseases like Alzheimer's. Therapies targeting protein removal and prevention of inflammation hold potential to prevent or treat these conditions.
Scientists have linked a new class of bacterial enzymes to the chronic lung inflammation hallmark of cystic fibrosis. The discovery provides two potential strategies for interrupting or correcting this interference by opportunistic bacteria, such as Pseudomonas aeruginosa.
A study by University of Montreal researchers found that social status affects the immune system, leading to different responses to infection. Low-social status macaques showed a stronger pro-inflammatory response, while high-social status individuals had a stronger antiviral response.
The Toxoplasma parasite manipulates its host's immune response by producing a protein that activates and controls the p38α pathway. Researchers have now developed a method to produce an active form of p38α, allowing for the evaluation of anti-inflammatory drugs.
A recent study suggests that high-density lipoprotein (HDL) cholesterol may not always protect against heart disease as previously thought. HDL can actually enhance the inflammatory response of immune cells called macrophages, which counteracts its established anti-inflammatory effect in other cell types.
Researchers have identified a factor in umbilical cord blood that can counteract harmful inflammation and sepsis, with tripled survival rates in mice. The newly discovered factor, nNIF, is present for just two weeks after birth and may offer insights into controlling the inflammatory response.
A NYIT researcher has won an NIH grant to investigate methamphetamine's impact on the body's inflammatory response and wound healing. The study aims to understand how meth causes overproduction of IL-6, delaying inflammation and healing.
Researchers explore Fasudil as a therapeutic option for Alzheimer's disease, finding it reduces Aβ deposition, Tau phosphorylation, and inflammation. The treatment also improves learning and memory deficits in APP/PS1 transgenic mice.