A recent study found that wood smoke exposure results in higher inflammatory markers for male subjects and lower inflammatory markers for female subjects. The researchers suggest that sex-specific effects may be missed when lumping data together, emphasizing the need to consider sex-specific responses when studying environmental pollut...
A study by Takeo Nakanishi at Kanazawa University found that fever is regulated by prostaglandin E2 and OATP2A1 transporters, suggesting these as potential therapeutic targets for treating fever-related conditions.
Researchers at RCSI and Trinity College Dublin have discovered how the body clock regulates inflammatory response in macrophages, a key immune cell. This study may lead to targeted treatments at specific times of the day to alleviate excess inflammation in conditions like asthma, arthritis, and cardiovascular disease.
SourceRCSI·JournalProceedings of the National Academy of Sciences·DateAug 20, 2018
Researchers discovered seal blood serum has anti-inflammatory properties, protecting against damage to pulmonary tissues and inflammation. This unique adaptation allows elephant seals and Weddell seals to safely dive deep without lung damage or inflammation.
Research reveals that good bacteria interact with epithelial cells and immune system cells to balance immune responses and protect the gut from inflammation. Manipulating the microbiota may offer therapeutic benefits for conditions like inflammatory bowel disease.
A new study finds that diseases common in the developing world may cause lymphoid tissue fibrosis and impaired vaccine responses. Researchers found significant differences in lymphoid anatomy between Ugandans and US participants, with Ugandans showing evidence of inflammation and immune activation.
The University of Louisville will receive a five-year, $11.2 million federal grant to establish an interdisciplinary research program focused on the microbiome, inflammation, and disease development. Researchers will study various diseases, including inflammatory bowel disease, periodontitis, and neurological disorders.
A new drug has shown encouraging safety and efficacy in treating Still's disease, a serious orphan condition. The treatment, which blocks the action of an inflammation factor, has been tested on 23 patients with refractory forms of the disease, resulting in positive responses and significant symptom reduction.
Research found that resolvin D-1 limits heart attack-induced kidney inflammation and promotes reparative macrophage change. This suggests potential application to clinical settings for treating cardiorenal syndrome.
Researchers at Osaka University discovered that Arid5a translocates from the nucleus to the cytoplasm in response to inflammation, regulating IL-6 production. This finding offers potential therapeutic strategies for septic shock and autoimmune diseases.
A UCL-led research team found that an excessive inflammation reaction in older people can obstruct the immune system, leading to weaker immune responses. Blocking this inflammation with a short-term anti-inflammatory pill increased the immune system's effectiveness.
A recent study by the University of Bonn found that fast food can make the immune system more aggressive in the long term. Even after switching to a healthy diet, inflammation remains higher, potentially leading to diseases like arteriosclerosis and diabetes.
A new study finds that gut bacteria from old mice induce age-related chronic inflammation in young mice, suggesting a potential strategy for healthy ageing. The research highlights the importance of maintaining a balanced gut microbiota to prevent inflammaging and related diseases.
Researchers found that catheterization potentiates MRSA infection by inducing an inflammatory response and releasing the fibrinogen protein. This results in the facilitation of targeted treatments for MRSA CAUTI.
A team of researchers at FAU has identified a key mechanism involved in the resolution of inflammations in rheumatoid arthritis patients. Innate lymphoid cells can induce a 'hibernation' state, which persists in those with rheumatism but is reversed when these cells are 'woken up', stopping inflammation and joint damage.
Aging individuals with implants face unique challenges due to immunosenescence and delayed immune responses. The study investigates the impact of aging on macrophage activity and white blood cell function, seeking ways to optimize implant success and minimize negative effects.
Researchers found chemokines can activate chemokine receptors in different ways, leading to varying responses and chronic inflammation. This discovery may lead to the development of anti-inflammatory drugs targeting specific molecules.
A new study in mice reveals how the protein Brd4 boosts the inflammatory response, with both beneficial and harmful effects. The findings suggest that Brd4 can protect the body from infection but also contribute to chronic inflammatory diseases.
Researchers have identified a key mechanism driving the emotional response to painful inflammation, highlighting potential therapeutic targets for managing chronic pain. Prostaglandins in brainstem serotonin-producing neurons play a crucial role in this process.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified K-homology splicing regulatory protein (KHSRP) as a regulator of the innate immune response. Depleting KHSRP improves immune signaling and reduces viral replication, suggesting that drugs inhibiting the protein may have therapeutic value.
A new review article suggests that protein aggregation inside aging neurons sets off inflammatory responses, which can lead to neurodegenerative diseases like Alzheimer's. Therapies targeting protein removal and prevention of inflammation hold potential to prevent or treat these conditions.
Scientists have linked a new class of bacterial enzymes to the chronic lung inflammation hallmark of cystic fibrosis. The discovery provides two potential strategies for interrupting or correcting this interference by opportunistic bacteria, such as Pseudomonas aeruginosa.
A study by University of Montreal researchers found that social status affects the immune system, leading to different responses to infection. Low-social status macaques showed a stronger pro-inflammatory response, while high-social status individuals had a stronger antiviral response.
The Toxoplasma parasite manipulates its host's immune response by producing a protein that activates and controls the p38α pathway. Researchers have now developed a method to produce an active form of p38α, allowing for the evaluation of anti-inflammatory drugs.
A recent study suggests that high-density lipoprotein (HDL) cholesterol may not always protect against heart disease as previously thought. HDL can actually enhance the inflammatory response of immune cells called macrophages, which counteracts its established anti-inflammatory effect in other cell types.
Researchers have identified a factor in umbilical cord blood that can counteract harmful inflammation and sepsis, with tripled survival rates in mice. The newly discovered factor, nNIF, is present for just two weeks after birth and may offer insights into controlling the inflammatory response.
A NYIT researcher has won an NIH grant to investigate methamphetamine's impact on the body's inflammatory response and wound healing. The study aims to understand how meth causes overproduction of IL-6, delaying inflammation and healing.
Researchers explore Fasudil as a therapeutic option for Alzheimer's disease, finding it reduces Aβ deposition, Tau phosphorylation, and inflammation. The treatment also improves learning and memory deficits in APP/PS1 transgenic mice.
A team of scientists at UMass Medical School identified a long non-coding RNA called lincRNA-EPS, which regulates innate immunity and prevents inflammation. In mice lacking this RNA, inflammatory responses were increased, leading to toxic shock.
A two-year study found that restricting calories by 25% in healthy non-obese individuals reduced markers of chronic inflammation without negatively affecting immune responses. Chronic inflammation is linked to age-related diseases such as cancer, heart disease, and dementia.
Researchers found that mosquito bites can facilitate viral replication and spread by triggering an inflammatory response in the skin. The study suggests new approaches for combating viruses, including using topical creams to suppress bite inflammation.
Immune cells build a molecular memory of their first meal after eating a dying neighboring cell, shaping their inflammatory behavior. This discovery may lead to novel therapies for inflammatory disorders such as atherosclerosis, cancer, and arthritis.
A research team at the University of Tsukuba identified a crucial role for spleen marginal zone B lymphocytes in exacerbating endotoxin shock through cytokine production. MZ B cells produce large quantities of IL-6 and other inflammatory chemokines in response to LPS, highlighting their strong pro-inflammatory role.
Researchers found that topoisomerase 1 inhibitors suppress inflammation in mice, potentially treating sepsis and other immune disorders. These drugs have shown promise in rescuing mice from a lethal inflammatory response caused by bacterial infections, suggesting a new approach to controlling acute infections.
Research found that TNF-alpha induces immune surveillance cells called M cells, which promote the body's ability to regulate and suppress inflammatory responses. This discovery could lead to more targeted drug therapies for treating IBD and other autoimmune diseases.
A recent study from Texas A&M University reveals that consuming saturated fats at certain times can disrupt the body's internal clock and trigger metabolic disorders. The research suggests that timing of fat consumption plays a crucial role in inflammation and disease prevention.
A high viral load is associated with a dampened inflammatory response in innate immune cells from HIV-infected individuals. Epigenetic modifications at the TNFα gene locus are observed in monocytes of patients with high virus levels.
UAB researchers have identified a protein called IL-37 that suppresses the inflammatory response after spinal cord injuries, minimizing tissue degeneration and functional disabilities. This discovery opens the door to a new treatment for acute spinal cord injuries, which currently has no effective treatment available.
A new study published in Nature Communications has identified predictors and response mechanisms to the hepatitis B vaccine. Researchers found that elevated levels of inflammatory response transcripts correlate with weaker responses, while augmented B-cell responses are linked to stronger reactions.
Researchers have identified alveolar macrophages as key contributors to cystic fibrosis airway inflammation, with the overabundance of XBP-1 protein mediating their inflammatory effect. This discovery bolsters the case for targeting this pathway in therapy.
Researchers at Georgia State University have discovered a critical role for CYLD in controlling the body's inflammatory response to pathogens. This finding could lead to the development of novel anti-inflammatory agents, as traditional treatments like steroids can cause serious side effects.
Researchers identified quebecol, a molecule in maple syrup with anti-inflammatory properties, and its derivatives show promise as potential treatments for arthritis and other inflammatory diseases. The discovery could lead to a new class of anti-inflammatory agents with reduced side effects.
Researchers found that patients with IBS have reduced sensitivity in their gut nerves, contradicting previous theories of over-sensitivity. This desensitization could be a protective measure to prevent overstimulation.
Researchers identified molecular signatures that predict immune protection in response to flu vaccination, with elderly individuals showing high levels of monocytes and low antibody-producing B cells. This study provides insight into potential mechanisms underlying reduced vaccine efficacy in older adults.
A new study found that a Mediterranean-type diet high in monounsaturated fats and low in saturated fats decreased the inflammatory response, compared to diets high or low in palmitic acid. The research suggests that dietary fats may play a key role in obesity-related diseases.
A recent study by TSRI researchers has uncovered a novel pathway between the cell's powerhouses (mitochondria) and the immune system. RIPK3, an enzyme involved in cell death, relays signals between mitochondria and NKT cells, regulating both cancer and inflammatory responses.
The Paul G. Allen Family Foundation has partnered with the Alzheimer's Association to award three grants totaling $500,000 to study the role of inflammation on characteristic plaques and tangles of devastating brain disease. Researchers aim to better understand the interactions between the immune system and Alzheimer's pathologies.
Dr. Jian-Dong Li is developing novel anti-inflammatory therapeutics against middle-ear infections, a major childhood bacterial infection causing conductive hearing loss. The goal is to suppress overactive inflammation and improve middle-ear hearing function.
Researchers have identified a 'decoy' molecule that can modulate the body's immune response to the flu virus, reducing the risk of deadly inflammation. The molecule, 2R9, has shown promising results in mice, with only 22% dying from flu compared to 90% in untreated groups.
A study measuring adults' reactions to stress found that maintaining positive moods can reduce inflammation, a risk factor for obesity, heart disease, and cancer. Women are particularly at heightened risk of chronic inflammation.
A study published in Science Translational Medicine uses a computer simulation to replicate known individual outcomes and predict population results for traumatic injury. The model accurately predicted hospital length of stay and multi-organ dysfunction, but found limitations in extrapolating from single mechanisms to outcomes.
Researchers found that a protein called senataxin plays a crucial role in moderating the inflammatory response to certain viral infections. This discovery may lead to new avenues for treating neurological diseases like ALS and ataxia, which are associated with persistent inflammation.
Researchers have found that the receptor TLR4 and protein galectin-3 are crucial in amplifying brain inflammation. Galectin-3 is secreted by microglial cells and binds to TLR4, intensifying the inflammatory response.
A study by the Institute of Cancer Research found that breast cancer cells with a 'mesenchymal-like' shape are more sensitive to inflammatory signals, which could be harnessed to treat cancer. The researchers used robotic microscopy and automated algorithms to measure the shape of hundreds of thousands of different breast cancer cells.
Researchers have deciphered the mechanism of interleukin 37 (IL-37), a powerful inhibitor of inflammation, revealing its ability to regulate and control inflammation by binding to specific receptors on target cells. The findings hold promise for developing new drugs to treat inflammatory diseases such as stroke, heart attack, and autoi...
Researchers found that aged mice developed more severe intestinal permeability and bacterial infections after stroke, leading to higher mortality rates. In contrast, social isolation improved recovery in aged mice by reducing inflammation and enhancing brain function.
Research published in Annals of the Rheumatic Diseases found that smoking impairs the response to biological drugs used to treat inflammatory back arthritis. Current smokers responded significantly less well to treatment and achieved smaller reductions in disease activity scores compared to non-smokers.
Researchers identified key immune biomarkers that can help distinguish between HIV patients who experience life-threatening complications and those who fare well on treatment. The findings suggest that personalized approaches may be necessary for these patients, as a one-size-fits-all approach could worsen outcomes.
A study published in the Journal of the American Society of Nephrology reveals a key signaling pathway that helps protect healthy tissue from excessive immune activation. This finding may lead to improved treatment options for patients with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Researchers found that vaccines eliciting only CD4 T cell responses led to an overwhelming inflammatory reaction in mice, while those with both CD4 and CD8 responses were protected. This study cautions against developing vaccines that solely target one arm of the immune system.