Articles tagged with Bacterial Dna
Researchers have engineered bacteria that can detect tumor DNA in a live organism, using CRISPR technology. The bacteria, Acinetobacter baylyi, were designed to respond to specific DNA sequences associated with cancer, allowing for early detection and potentially preventing disease progression.
Researchers have discovered a gene, B5, in Egyptian cotton that confers powerful resistance to bacterial blight. The gene enables strong resistance to the disease under Oklahoma field conditions and accumulates high amounts of defense chemicals.
The study of ToxR's protein structure bound to DNA has revealed how it triggers cholera toxin production. The research provides insights into the molecular mechanism behind Vibrio cholerae's virulence, shedding light on potential treatments for this disease.
The researchers have demonstrated significant improvements for chip-based sensing devices that can detect or analyze substances across widely varying concentrations. They developed signal-processing techniques that enable seamless fluorescence detection of a mixture of nanobeads in concentrations across eight orders of magnitude.
Researchers at Georgia Institute of Technology have discovered a gene that drives the switch between chronic and acute P. aeruginosa infections. The gene encodes a small RNA called SicX, which plays a vital role in bacterial respiration under low oxygen conditions.
A new SCIVVS approach accelerates probiotics quality assessment by rapidly counting live bacteria, identifying species, and testing viability in just five hours. The method also tracks the source of individual cells in a sample, promising to transform current practice in quality control and intellectual-property protection.
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
Researchers discovered three 4,000-year-old cases of Yersinia pestis in human remains from mass burials in Somerset and Cumbria. The findings indicate the plague may have been easily transmitted across Britain, contradicting previous assumptions that it was brought by fleas.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
Researchers at Cedars-Sinai Medical Center identified a genetic variant associated with increased risk of developing perianal Crohn's disease, a debilitating manifestation of Crohn's disease. The study highlights the importance of targeting the alternative complement pathway and Complement Factor B (CFB) in treating this condition.
A Pitt lab discovery sheds light on how a specific mutation in the lsr2 gene helps bacteria resist phage infection. The team developed new tools to visualize phages attacking bacteria, revealing critical insights into the mechanisms of phage resistance.
The study reveals unexpected mechanisms that enable Aromatoleum aromaticum EbN1 T to adapt to changing environments. By analyzing its metabolic network, researchers developed a model to predict growth under diverse conditions.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
The NSF is funding projects that utilize the International Space Station (ISS) National Laboratory to advance tissue engineering and mechanobiology research. This solicitation aims to further drug discovery and therapeutic development through space-based research, with potential impacts on regenerative medicine and disease diagnosis.
Researchers develop CRISPR-Cas systems associated with transposons to rewrite large chunks of DNA in organisms like E. coli. This expands the CRISPR toolbox for flexible genome editing and has significant implications for therapeutics, biotechnology, and agriculture.
Researchers at Imperial College London discovered a 'silent' mutation in bacteria that helps them evade antibiotics. The mutation alters the structure of an mRNA intermediate, preventing ribosomes from producing protein, and has arisen independently several times globally.
A novel method developed by Brazilian researchers can analyze bacterial samples without isolating live bacteria, making it easier to detect antibiotic resistance in Streptococcus pneumoniae. The technique was tested on 873 samples and found that 51% were sensitive to antibiotics, while 17% were resistant.
Researchers at Cornell University have discovered a new CRISPR system called Craspase, which has the potential to develop promising antiviral and tissue engineering tools in animals and plants. The study uses cryo-electron microscopy snapshots to explain how Craspase identifies RNA targets and activates proteases.
A collaborative effort by UT Southwestern computational biologist Qian Cong and molecular biologists at the University of London elucidated the 3D structure of the Type IV secretion system (T4SS) complex. The study's findings provide a blueprint for designing drugs that can slow the development of antibiotic resistance.
A newly identified species of Liberibacter, a family of bacteria known for causing citrus greening disease, is rapidly evolving its ability to infect insect hosts. The research team found 21 genes associated with infectious qualities and identified mutations affecting pilus proteins that allow the bacteria to move into host insects.
A new study by Johns Hopkins Medicine researchers reveals a promising genetic method for identifying hundreds of disease agents using next-generation sequencing. The Respiratory Pathogen Infectious Diseases/Antimicrobial Resistance Panel (RPIP) system shows near-comparability to traditional diagnostics in identifying pathogens.
A new study challenges a popular scenario explaining the origin of eukaryotes, suggesting that cells can grow to considerable volume without acquiring mitochondria. Researchers explore energy requirements and genome arrangement in prokaryotes and eukaryotes, revealing overlap between cell types rather than a hard boundary line.
Researchers at TUM have developed a cell-free production method for bacteriophages, which can be used to target and combat specific types of antibiotic-resistant bacteria. The new technology has the potential to produce personalized therapeutic phages for clinical trials, addressing multi-resistant germ infections.
Researchers at Gladstone Institutes developed a tool called Retro-Cascorder, which logs a cell's genetic activity for days at a time. This allows scientists to create living biosensors that can record changes to their environment.
Researchers used a new tool to capture hundreds of undiscovered mechanisms of gene regulation in MRSA, revealing a previously unknown layer of gene regulation. The study identified a regulatory RNA that promotes an enzyme involved in cell wall thickening, potentially identifying new targets for antibiotic treatment.
Researchers at Johns Hopkins Medicine found that Clostridioides difficile (C. difficile) bacteria may cause colorectal cancer in younger adults. The bacterium causes serious diarrheal infections and is linked to approximately 500,000 infections annually in the US.
A study by Norwegian University of Science and Technology found that parasites infesting farmed salmon have a distinct microbiome that interacts with the fish's microbiome. This interaction can impact the host's health, highlighting the importance of understanding the complex relationships between parasites and their hosts.
Rice University bioscientists have developed a novel approach to control the expression of 'silent' genes in bacteria using CRISPR technology. This strategy could lead to the discovery of new antibiotics and has potential applications in antifungal and anticancer agents, as well as agriculture.
Researchers identify key enzyme CbrR and cyclic-di-GMP as crucial for Campylobacter jejuni's motility and biofilm formation. By targeting these elements, scientists aim to develop a safe molecule to prevent infection.
The Emu project effectively identifies bacterial species by leveraging long DNA sequences spanning the entire length of the gene under study. This approach facilitates the analysis of key genes in microbiome researchers' efforts to sort out harmful and helpful bacteria.
Researchers have reconstructed what life was like for some of Earth's earliest organisms using light-capturing proteins in living microbes. The findings could help recognize signs of life on other planets with atmospheres similar to ancient Earth.
Researchers analyzed data from over 134,000 participants and found a strong association between Western diets and colorectal tumors containing the pks+ E. coli bacteria. The study suggests that specific components of Western-style diets may increase the risk of colorectal cancer by promoting the growth of these pathogenic bacteria.
SeqScreen, an open-source software toolkit, accurately characterizes short DNA sequences to detect pathogenic sequences. The program uses a curated database of thousands of gene sequences representing 32 types of virulence functions.
A recent study found that certain bacteria species in the gut are associated with a higher risk of colorectal cancer in younger populations. The research suggests that dietary patterns high in processed meats, low-calorie drinks, and liquor may contribute to this increased risk.
A new study from Tel Aviv University developed a unique treatment for AIDS that may be developed into a vaccine or a one time treatment. The treatment involves engineering type B white blood cells to secrete anti-HIV antibodies in response to the virus.
A group of researchers discovered a new species of green algae, Gormaniella terricola, in Central New York State. The alga's unique chloroplast genome was found to contain DNA from fungi and bacteria, highlighting the importance of horizontal transfer.
A new research group led by biologist Dr. Michael Gerth will investigate the interactions between bacteria and insects, with a focus on how bacterial DNA changes when transferred from one species to another. The team aims to identify successful host transfer strategies and understand environmental factors influencing these processes.
Bacteria's CRISPR system uses spacers to store viral information, but must balance risk of autoimmunity with immune memory. Longer spacers reduce autoimmune response risk, allowing more spacers to be stored without triggering an immune reaction.
Cornell researchers develop smaller gene-editing tool, IscB-ωRNA, to solve size problem of delivering CRISPR-Cas9 into every cell. The tool works similarly to CRISPR-Cas9 but with a smaller RNA component, offering new starting point for more powerful and accessible gene editing tools.
A new study by the University of Exeter found that antibiotic-resistant plasmid molecules can spread quickly through bacterial communities, making them more resistant to antibiotics. This raises concerns about the potential for antimicrobial resistance to spread in environmental settings and impact human health.
Rice University bioengineers are developing optogenetic tools to study B. subtilis' stress response, combining experimental results with theoretical findings to understand genetic design principles. This research aims to reveal clues about bacterial survival and potentially lead to new antimicrobial drugs.
Researchers at Stockholm University have identified a novel mechanism for regulating the supply of DNA building blocks, providing a potential new target for designing better antibiotics. By targeting the pathogen's ability to reproduce, scientists may be able to control the growth of bacteria such as Mycobacterium tuberculosis.
Eukaryotes emerged in an anoxic environment in the ocean, and their mitochondria-bearing cells likely resulted from a merger between archaea and bacteria. This finding contradicts the long-held view that oxygenation of Earth's surface environment led to eukaryogenesis.
A ground-breaking software combines DNA sequencing and machine learning to identify antibiotic-resistant bacteria transmission between humans, animals, and the environment. The study found antimicrobial genes shared across animals, farm workers, and environments, including unknown genes associated with resistance.
Researchers developed a new way to help protect the natural flora of the human digestive tract by engineering bacteria to break down beta-lactam antibiotics. This approach protects the microbiota in the gut while allowing antibiotics to remain effective, reducing the risk of infection and antibiotic resistance.
The study found two DNA defense systems in Vibrio cholerae bacteria that work together to eliminate plasmids and prevent the spread of antibiotic resistance. These defense systems, called DdmDE and DdmABC, are encoded within distinct pathogenicity islands and help the bacteria survive pandemics.
A new technique called Operational Genomic Units (OGU) allows for improved resolution and simplicity in analyzing microbiome samples. By using individual genomes as basic units, researchers can pinpoint biologically relevant characteristics such as age and sex with greater accuracy.
Chronic skin wounds and biofilm infections pose significant challenges in healthcare. A new NIH-funded project aims to develop a novel class of molecules targeting bacterial iron homeostasis to combat these infections. The researchers have identified proof-of-concept small molecules that can inhibit the BfrB-Bfd protein-protein interac...
Researchers have discovered that sea sponges themselves produce biologically active compounds, including terpenes with potential malaria-fighting properties. This finding represents a 'fundamental shift' in the field and opens up new avenues for drug discovery using animals as vessels.
Columbia University researchers have engineered a microbial encapsulation system that temporarily hides therapeutic bacteria from immune systems, allowing them to deliver drugs to tumors and kill cancer cells in mice. The system, called iCAP, controls the bacteria's surface by manipulating gene circuits.
Researchers discovered a link between the immune system and microbiome in primary sclerosing cholangitis (PSC), a liver disease associated with inflammatory bowel disease. MAIT cells activated by bile-derived pathogens could play an important role in PSC pathophysiology, offering potential new treatment implications.
A recent study confirms that tuberculosis strains associated with marine mammals were also present in inland populations in pre-colonial South America. The researchers found three new ancient TB genomes from human remains in the highlands of Colombia, which resemble a TB variant found in seals and sea lions.
Researchers developed a technique to track changes in bacterial mutation frequencies, which can inform initial and switched antibiotics. The study found that rare antibiotic-resistant bacteria can rapidly expand within days in response to treatment.
A team of researchers has developed a new method using environmental DNA analysis to track the source of fecal contamination in surface water. By analyzing specific DNA sequences, they can identify the main contributors to pollution and potentially pinpoint areas with faulty wastewater treatment infrastructure or poor manure management.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Biomedical engineers at Duke University have developed a gene therapy that helps heart muscle cells electrically activate in live mice. The approach features engineered bacterial genes that code for sodium ion channels, which could lead to therapies to treat electrical heart diseases and disorders.
Researchers at San Diego State University have discovered a novel way bacteria infect cells by producing long threads, which grows up to 100 times the size of a bacterium in 30 hours. This mechanism allows the bacteria to rapidly infect multiple cells and access more nutrients for growth.
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
Beneficial gut microbes transfer genes to acquire vitamin B12, increasing their ability to survive. This process, called bacterial sex, allows them to form a tube that DNA can pass through to another cell, demonstrating the horizontal gene exchange among microbes.
Researchers found that the way a newborn is fed affects its oral bacteria makeup, with exclusively breastfed infants sharing fewer maternal bacteria than those fed formula or a combination of both. This suggests that breast milk may play a role in regulating the mother-derived oral bacterial colonization.