Articles tagged with Bacterial Dna
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Researchers found compounds in commonly consumed foods trigger phage production, killing harmful bacteria and promoting beneficial bacteria growth. This 'landscape' approach has far-reaching implications for controlling harmful microbes and maintaining a healthy gut microbiome.
A new method called ON-rep-seq enables the precise identification of bacteria using selective, strain-specific fragments of the bacterial genome. This approach reduces analysis time and costs to less than $2 per bacterium, increasing accuracy to over 99%.
A new CRISPR-based gene-drive system, Pro-AG, has been developed to target antibiotic-resistant bacteria with increased efficiency. The system uses a self-amplifying editing mechanism to insert tailored genetic payloads into target sites with high precision.
Researchers at UC Davis discovered that rectal microbes can impact HIV vaccine efficacy, with Lactobacillus supplements boosting antibody production and Prevotella bacteria hindering immune responses. The study suggests targeting specific gut bacteria may improve vaccine performance.
Scientists identify a new type of RNA modification in bacteria that is attached under stress and removed quickly. The sulfur-containing base modification helps regulate protein synthesis and could serve as an efficient detoxification mechanism to remove reactive chemical groups.
Phages construct an impenetrable compartment to protect their vulnerable DNA from CRISPR and restriction enzymes. This unique mechanism makes them virtually indestructible, with only two jumbo phages showing pan-CRISPR resistance.
The TU Dresden team presented their DipGene project, a DNA sequence-specific diagnostic method applicable in bacteria and human genomic DNA. The method is faster and cheaper than PCR, taking only five to ten minutes to detect predispositions to monogenic diseases.
A new online tool called Uniqprimer has been developed to detect blackleg disease in potatoes with high accuracy and ease of use. It quickly designs species-specific DNA tags for detecting pathogens using DNA testing, allowing for accurate pathogen detection and informing farmers' on-farm decision making.
A new study reveals the critical role of c-di-GMP in controlling the transition from vegetative growth to sporulation in Streptomyces bacteria. The signaling molecule binds to master repressor BldD, controlling gene activity and ultimately preventing reproductive hyphae from differentiating into spores.
A team of researchers at the University of Arizona has uncovered a previously unknown cellular structure that enables bacteria to rapidly defend against viruses. This newly formed filament increases DNA-cleaving ability by 200 times, making it an essential component of bacterial immune responses.
A new study published in Nature Microbiology has discovered that epigenetic chemical modifications play a crucial role in the survival and spread of C. difficile bacteria. The research found that inhibiting these modifications can reduce bacterial populations by up to 100 times, paving the way for potential treatments for this deadly i...
Acinetobacter baumannii is a highly resistant bacteria that causes persistent skin and soft tissue infections. Researchers are investigating the use of selenium as an antimicrobial agent, which has shown promise in inhibiting bacterial virulence.
The BacFITBase database identifies key genes for host cell invasion and infection, aiding in the development of new antibiotics. The database contains over 90,000 entries with information on specific pathogenic bacterial genes and their contribution to infectious conditions in five different host species.
A study found that probiotics can cause bloodstream infections in ICU patients, with 1.1% of cases linked to Lactobacillus bacteria. Genetic analysis revealed a mutation that made the bacteria resistant to antibiotics, highlighting the need for caution when using probiotics in critically ill patients.
Researchers discovered that itaconate, a compound produced by the immune system, tricks Mtb into using propionate as a growth source. This reaction produces a stable biradical that lingers for over an hour, enabling researchers to grow crystals of the enzyme and understand its mechanism.
Scientists have discovered that human gut bacteria require a unique genetic code to thrive, which is different from person to person. The study found that immunity genes from one bacterium are often shared by others, suggesting a complex and adaptive immune system in the gut.
Researchers at Indiana University have discovered a previously unknown role of protein pili in helping bacteria reel in DNA. The study's findings may help inform strategies to stop bacterial infection and combat antibiotic resistance, which is estimated to cause 10 million deaths by 2050.
Vibrio cholerae uses its type VI secretion system (T6SS) to compete with other bacteria and acquire new genetic material, leading to rapid evolution and pathogen emergence. The bacterium can steal up to 150,000 nucleic acid base pairs, or roughly 150 genes, in a single attack.
A new CRISPR delivery system developed by Western University researchers enables targeted attacks on specific bacteria, including Staph A and E. coli. This breakthrough has the potential to create personalized antimicrobial agents and revolutionize the treatment of bacterial infections.
Researchers have developed a new CRISPR-Cas9 variant that reduces unintended changes in DNA, increasing precision in gene therapy. The SaCas9-HF variant shows high on-target efficiency and nearly undetectable off-target activity, offering a promising alternative for precise genome editing.
Researchers at Caltech have developed a new reporter gene that allows for the visualization of genetic activity using ultrasound, enabling the study of gene expression in tumors, immune cells, and other cell types. The breakthrough could lead to new diagnostic tools for diseases such as cancer and neurological disorders.
Researchers at MIPT have identified a promising class of antibiotics, 2-pyrazol-1-yl-thiazole derivatives, which exhibit antibacterial properties and inhibit protein synthesis. The discovery was made possible by a semi-automatic analysis method that enabled the screening of over 125,000 molecules.
Researchers at Newcastle University have confirmed that bacteria can lose their cell wall to avoid detection by antibiotics, leading to recurring urinary tract infections. The study found that L-form switching allows bacteria to survive and re-form their cell wall, making it harder for the immune system to target them.
A new experimental test made from bacterial innards has high potential as a basis for an inexpensive, easy malnutrition test for use in the field. The test can detect zinc levels and quantify clinically relevant levels, allowing aid agencies to get immediate information and influence policy decisions on nutritional interventions.
A large-scale study found that vaginally born babies have different gut bacteria than those delivered by Caesarean. Researchers discovered that the mode of delivery impacted the gut microbiome, with vaginal delivery promoting mother's gut bacteria and Caesarean deliveries resulting in hospital-borne bacteria.
A new study published in PLOS ONE suggests that many volatile compounds from a male cat's anal sacs are produced by a community of bacteria, rather than the cat itself. This discovery challenges traditional views on scent marking and communication in cats.
Researchers at Brown University discovered that diet can mitigate or exacerbate changes in the gut microbiome caused by antibiotics. In a mouse study, diet high in fiber and low in simple sugars protected certain beneficial bacteria from antibiotic harm.
A recent study has characterized the diverse array of bacterial species residing in human guts, revealing 157 different types of organisms. The research, led by Hiroki Morizono, aims to improve public health by establishing a baseline for healthy gut microbiomes and exploring health implications for patients.
Research found that common mouth bacteria responsible for acute periodontitis fared better when paired with bacteria and other microbes from outside the mouth, including those found in the colon or dirt. This suggests that not all relationships within a microbiome are cooperative, and some may have 'high fences' and share sparsely.
Researchers found a new mechanism for resistance gene transmission in intestinal bacteria that's independent of antibiotics. Persistent bacteria can survive and share genes with other bacteria, spreading resistance, according to ETH Zurich scientists.
Research suggests that distinct types of gut bacteria are associated with different forms of high blood pressure, including 'Depressive Hypertension'. The study found unique patterns of bacteria in people with high blood pressure plus depression, and may lead to the development of new treatments for treatment-resistant hypertension.
Researchers found that temperature influences functional traits between plants and microbes, leading to changes in nutrient cycling and carbon processing. As temperatures varied from tropical to boreal forests, the team observed shifts in bacterial genes tied to these processes.
Bacteria can swap DNA through mechanisms similar to sexual selection in animals, and this genetic mixing may have benefits for cell survival and evolution. Researchers suggest that bacterial transformation, a process where cells release and take up DNA, could be governed by sexual selection.
Scientists have discovered a key protein structure that could lead to the development of treatments for Epstein-Barr virus infections. The portal protein plays a crucial role in the virus's DNA entry and exit mechanisms, and understanding its structure may enable the design of virus-specific inhibitors.
Researchers have sequenced the microbiome within crown gall tumors of grapevines, providing a database to assess disease stage and paving the way for new advances to combat the debilitating disease. The study sheds light on the complex interaction between the grapevine and its microbial community.
A new assay uses cell-free DNA to identify viruses and bacteria in the human body while also quantifying injuries to organs. This test is simple, fast, low-cost, and generalizable enough to identify thousands of pathogens, making it a major step towards personalizing therapy and making organ transplantation safer.
Researchers are studying how cells remove non-coding junk DNA to make sense of the remaining RNA instructions. By examining how simple organisms perform this task, scientists can gain insights into more complex lifeforms, including humans, and develop RNA-based therapeutics for diseases.
Researchers at Technical University of Denmark have developed a method to quickly couple enzymes with specific methylation patterns, revealing which enzymes are responsible for certain patterns. This discovery holds great promise for improving DNA transformation and introducing foreign DNA into host organisms.
Researchers investigate the microbiome of Stentor coeruleus and find a distinct bacterial community associated with the ciliate. The study reveals that different ciliates can host unique bacterial populations, highlighting the importance of further research into protistan microbiomes.
The study analyzed DNA sequencing data from over 3,500 human microbiome samples, revealing nearly 46 million bacterial genes. More than half of these genes were unique to each individual, performing specialized functions and suggesting a key role in microbial evolution.
Researchers followed a long-term UTI sufferer and found that recurring infections came from a single bacterial reservoir in the body. This discovery could lead to more effective treatments by targeting the intestinal reservoir rather than just treating the bladder.
Researchers have found a physical explanation for how bacteria swim against the current, with a new mathematical formula describing their motion behavior. The discovery could enable design of special tube surfaces to slow down bacterial migration.
A new genus of bacteria has been identified as a major contributor to coral decline, siphoning energy from corals and making them more susceptible to disease. The study found that the bacterial genus is globally associated with many different coral hosts and has genes that enable it to parasitize its hosts for amino acids and ATP.
Researchers at McMaster University developed a novel antibacterial gel made entirely from bacteria-killing viruses, which can be targeted to attack specific forms of bacteria. The gel holds promise for numerous beneficial applications in medicine and environmental protection.
A team of researchers from Tufts University has developed a 3D-printed pill that can sample bacteria in the gut without causing harm. The pill provides accurate identification of bacterial populations and their relative abundance, enabling better understanding of the role of different intestinal bacterial species in health and disease.
Researchers developed an algorithm that can identify a certain type of bacterial viruses called inoviruses, significantly expanding their known diversity. The tool was trained on a reference dataset and combed through over 70,000 microbial and metagenome datasets, ultimately identifying more than 10,000 inovirus-like sequences.
Researchers optimized bacteria to produce proteins with unconventional amino acids, a significant breakthrough in synthetic biology. The study demonstrates the potential of semi-synthetic organisms to create new life forms with expanded genetic codes.
Researchers discovered Cas9's ability to block gene activity without cutting DNA in pathogenic bacterium Francisella novicida, regulating disease-causing genes. This finding expands the versatility of CRISPR/Cas9 for genome engineering and potential antibiotic resistance solutions.
Researchers discover that gastric stem cells release a protein called intelectin 1 to bind to Helicobacter pylori bacteria, preventing damage. This mechanism is triggered by the presence of H. pylori and stimulates stem cell proliferation and tissue regeneration.
A recent study has found bacteriophages, viruses that infect bacteria, living in kitchen sponges. The phages were isolated from used kitchen sponges and shown to be effective against antibiotic-resistant bacteria. The discovery could potentially provide a new solution to the growing threat of antibiotic resistance.
Scientists at Cornell University have discovered an unexpected mechanism of activation and inactivation of RNR, a crucial enzyme for DNA replication. This finding provides a potential means to shut off harmful bacteria by understanding the
Researchers have identified a new family of bacteria, Deianiraeaceae, which belongs to the order Rickettsiales and exhibits a unique extracellular lifestyle as a predator. This discovery reveals a significant departure from previously known intracellular parasites.
Critically ill children with reduced numbers of 'good' bacteria and decreased levels of beneficial chemicals have a higher risk of organ failure. Chemical analysis revealed dramatic depletion of certain bacterial compounds, including hippurate, formate, and 4-cresol sulphate.
A study published in Science reveals that certain gut bacteria can degrade levodopa, the primary treatment for Parkinson's disease, by converting it into dopamine outside the brain. Researchers identified Lactobacillus brevis as a key player in this process and found a molecule capable of inhibiting the bacterial enzyme responsible. Th...
Researchers at the University of California San Diego discovered a complex process where viral components are transported along filaments within bacterial cells. This 'treadmill-like' structure allows for efficient movement of cargo, similar to human cell mechanisms, and has significant implications for understanding phage therapy.
Researchers have developed a new gene editing tool called INTEGRATE that harnesses bacterial jumping genes to insert any DNA sequence into the genome without cutting DNA. This technology offers a precise and reliable alternative to current gene-editing tools, which can lead to errors.
Researchers discovered a grappling hook-like appendage called type IV pili that enables Vibrio cholerae to take up DNA, bind to nutrient-rich surfaces and recognize 'family' members. The findings reveal a multifunctional toolkit for the bacterium's survival in ocean environments.
A recent study found that nearly all newborns had bacteria in their first poop, contradicting the long-held assumption of a sterile womb. The researchers collected amniotic fluid samples from 50 healthy women undergoing planned caesarean deliveries and discovered bacterial DNA in almost all viable samples.
Scientists explore the emergence of novel genes and functional proteins from random DNA sequences, revealing peptides that confer high resistance to aminoglycosides. The study demonstrates how de novo evolution can be studied experimentally in the laboratory.
Researchers discovered that bacteria employ Cas13 to counter viral attacks, employing a dormancy strategy to hinder virus replication. This approach offers superior protection against viral mutations and phage escape.