Articles tagged with Bacterial Pathogens
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Helper bacteria, such as Mycetocola tolaasinivorans, protect white button mushrooms from the bacterial pathogen Pseudomonas tolaasii by enzymatically disabling its toxin and motility. This mechanism involves a lactonase enzyme that linearizes the tolaasin toxin into a non-toxic structure.
Plant researchers have identified the calcium channel responsible for stomatal closing, a crucial defense mechanism against pathogens. This discovery has the potential to engineer pathogen-resistant crops by allowing plants to 'close their gates' when threatened.
A study suggests that oral bacteria like Fusobacterium nucleatum can promote the growth of harmful pathogens in the vagina, leading to bacterial vaginosis (BV). The research found that Fusobacterium may engage in mutually beneficial relationships with other vaginal bacteria, encouraging dysbiosis and BV features.
A comprehensive database of 33,242 unique viral populations in the human digestive system has been assembled by Ohio State University scientists. This discovery reveals a complex relationship between viruses and bacteria in the gut, with higher diversity associated with healthier individuals.
Researchers from the University of Göttingen have developed a promising new approach involving antivitamins to combat bacterial infections. The study found that antivitamins can inhibit bacterial proteins, preventing their function and leading to potential antibiotic effects.
Research found that frequent use of antimicrobial drugs in early life shifts bacterial profiles in saliva, with azithromycin having the strongest effect on girls. The study also showed that AM use is associated with a decrease in Paludibacter and pathways related to amino acid degradations.
Research finds that bacteria in unicellular organisms become more infectious when they must switch host cells, thanks to changes in gene expression. This adaptation allows them to survive outside the host cell and maintain infectivity.
Researchers at UT Southwestern Medical Center discovered that Vibrio parahaemolyticus uses a novel pathway to escape human intestinal cells. The bacteria modify cholesterol molecules in the cell membrane, weakening it enough for the bacteria to break through and infect new cells.
Researchers at Monash University have discovered a previously unknown way bacteria evade immune responses, targeting mitochondria for disarming. The study suggests potential new ways to combat resistant bacterial infections and could lead to new therapeutic possibilities.
Researchers found treponematoses in ancient human remains from Finland, Estonia, and the Netherlands, dating back to the 15th-18th century. This suggests that syphilis may have originated or developed in Europe before Columbus' voyages to America.
A new study by the University of Exeter and Cefas highlights the potential risks of microplastics carrying pathogens, which could threaten food production and safety. The research found high levels of bacteria on microplastic particles, including those that can cause disease in humans and animals.
A team at SMART has found that exposing bacteria to hydrogen sulfide can increase antimicrobial sensitivity in bacteria that do not produce H2S, potentially providing a breakthrough in treating drug-resistant infections. The study suggests that the results may be applicable to all bacteria that do not naturally produce H2S.
Scientists created metabolic models of the bacterium associated with Huanglongbing, identifying 94 essential enzymes and metabolites required for its survival. These findings can lead to new antibacterial treatments and insights into long-lasting disease management strategies.
Researchers at Goethe University have isolated an ancient enzyme that enables early bacteria to produce energy without oxygen. The Rnf enzyme functions like a pumped-storage power plant, generating electricity and producing ATP.
A titanate nanowire mask can trap and destroy pathogens using photocatalytic properties of titanium dioxide, potentially reducing waste and environmental impact of disposable masks
Scientists at NTU Singapore developed a synthetic peptide, CSM5-K5, that makes multidrug-resistant bacteria sensitive to antibiotics when used with traditional antibiotics. The peptide also kills resistant bacteria on its own, offering hope for combination treatment strategies.
A new analysis found that microorganisms causing human diseases can be present in vultures, including multi-resistant bacteria. However, there is no clear evidence that vultures spread pathogens to humans and other species, but they may help prevent disease transmission by consuming carcasses.
A machine learning algorithm using high-temporal-resolution growth curves distinguishes bacterial pathogen strains with 92-98% accuracy, predicting antibiotic resistance as well as genetic-based methods. The method has the potential to be faster, simpler, and less expensive than current techniques.
Researchers at Université de Genève discovered that the RNA helicase protein contributes to the synthesis of fatty acids, a crucial component of bacterial membranes. The findings provide insight into golden staph's ability to adapt to changing environments and may lead to new treatment options.
Chlamydia bacteria reprogram human host cell metabolism to increase glutamine import, essential for proliferation. The discovery could lead to new treatments for chronic infections and severe diseases like cervical and ovarian cancer.
Researchers discovered multiple cell death systems preventing the spread of Salmonella, a major cause of typhoid fever. Cells use various mechanisms to die and protect against infection, including apoptosis, pyroptosis, and necroptosis.
A recent study found alarming levels of human bacterial pathogens and microdebris materials, including plastics and milk supplement powders, in oysters from the eastern Andaman Sea. The research suggests that coastal urbanization increases contamination in seafood, posing significant health risks to humans and threatening global food s...
A team of researchers at Aarhus University discovered a novel class of carbohydrate receptors in bacteria, which play a crucial role in biofilm formation, cell-to-cell interactions, and pathogenesis.
The review paper reveals the intricacies of bacterial organelles, which support functions essential for survival and growth. Organelles enable bacteria to perform extraordinary tasks, such as photosynthesis and orientation relative to magnetic fields.
Researchers used AI to predict bacterial infections in patients with pneumonia, enabling early antibiotic prescriptions. The analysis of over 50,000 ICU admissions data showed promising results in identifying MRSA and pseudomonas bacteria.
A new technology dubbed MorphEUS enables rapid screening of drug candidates against Mycobcterium tuberculosis (M. tb), the bacterium that causes TB. It uses high throughput imaging and machine learning to uncover patterns in how antibacterials kill, improving the efficiency and effectiveness of treatment development.
A research team discovered that certain sections of bacterial genetic material are doubled or multiplied, giving bacteria new capabilities to influence the immune system and adapt to changing environments. This process is crucial for pathogens to develop and evolve in their battle against the human immune system.
Emerging disease has spread to ten US states and South America, infecting over 80% of corn plants in some fields. Research reveals global spread, host range, and potential DNA transfers among strains.
A portable testing lab that fits into a suitcase has been developed by Newcastle University experts to detect waterborne hazards. The lab enables quick and affordable screening of millions of bacteria in a single water sample, providing critical data for public health officials to identify and deal with local hazards.
A new AI-powered holographic imaging system detects bacteria growth in water samples with high sensitivity and speed, saving over 12 hours compared to traditional methods. The platform can classify three types of bacteria, including E. coli, within 9 hours.
A new, evidence-based guideline has been created to treat patients with NTM lung disease. The guidelines, developed by experts from leading international societies, provide thirty-one recommendations for the treatment of patients suffering from NTM pathogens.
Researchers have discovered a single protein derived from a harmless bacteria that can halt the CRISPR-Cas13 editing process. This 'kill switch' enables scientists to edit RNA with more precision and exact control, potentially benefiting coronavirus researchers and applications.
Researchers analyzed fecal samples from healthy Japanese individuals and detected phage-derived antibacterial enzymes that control pathobionts. These enzymes were shown to regulate C. difficile infection in mice, providing a potential treatment for this disease.
Researchers found that curli amyloid produced by Salmonella bacteria triggers autoimmune reactions in mice, leading to reactive arthritis. The study suggests that curli proteins may play a role in other autoimmune diseases and neurodegenerative processes.
Researchers discovered that Nissle, a harmless E. coli strain, can protect intestinal tissue against pathogenic strains like enterohemorrhagic E. coli (EHEC). The probiotic was found to decline rapidly in the tissue while allowing it to withstand damage better.
The study reveals that Burkholderia pseudomallei infection sets off a series of events that provoke the host's immune system, causing infected cells to self-destruct. The researchers found that abnormal cell fusion stimulates the type 1 interferon signaling pathway, leading to autophagy and cell death.
Researchers at the University of Cincinnati found that a strain of E. coli Nissle protects human cells against pathogenic E. coli bacteria. The study suggests that Nissle may be used to develop a treatment for E. coli infections, which affect millions annually.
A University of Pittsburgh research team received $330K to study the effect of silver on water disinfection. The goal is to determine if silver-coated shower fixtures effectively prevent opportunistic pathogen exposure and minimize antibiotic resistance.
Researchers created miniature gut organoids that demonstrate segment-specific gene activity patterns and immune binding sites, shedding light on the causes of inflammatory diseases. These findings have implications for understanding cancer development and human disease.
Scientists have discovered that the Anaplasmosis bacterium interferes with tick gene expression to survive and spread to new hosts. The study found that the bacterium reduces a regulatory molecule's production, leading to increased levels of Organic Anion Transporting Polypeptide (OATP), which enables its spread to vertebrate hosts.
Researchers observed that C. jejuni swims faster in viscous liquids due to its flagella, which wrap around the helical body to propel itself forward. This finding could lead to new strategies for preventing C. jejuni infections by targeting its movement mechanisms.
Researchers used cryo-electron tomography to reveal the molecular architecture of Uromodulin filaments, which form a fishbone-like structure that traps bacteria. The findings provide insights into Umod's role in protecting against urinary tract infections and its other physiological functions.
Researchers discovered that uromodulin forms long filaments that envelop pathogens, neutralizing them and preventing infection. The findings offer pointers for developing new treatments and drugs to prevent urinary tract infections without antibiotics.
Researchers discovered widespread expression of immune genes in structural cells, which contribute to the response to pathogens. The study highlights that structural cells are not only essential building blocks but also play a key role in defending against infections.
Researchers at NYU Langone Health have developed a new vaccination strategy that targets the toxic molecules released by Staphylococcal bacteria, including MRSA, to prevent deadly infections. In a study published in the Journal of Experimental Medicine, mice vaccinated with this experimental vaccine demonstrated an immune response and ...
Wild strains of salmonella have been found to reopen stomates on plants, allowing them to bypass the immune defense system and cause foodborne illnesses. This finding highlights the increasing threat of opportunistic pathogens jumping from plants to humans through contaminated foods.
A new study from UC Davis found that raw milk can harbor antimicrobial-resistant genes, potentially spreading resistance if consumed. The researchers analyzed over 2,000 retail milk samples and found that raw milk had the highest prevalence of antibiotic-resistant microbes when left at room temperature.
Researchers have developed a function-based sequencing technique using optical tweezers to analyze individual bacteria cells, enabling direct genome sequencing and antibiotic resistance testing from a single cell. This breakthrough technology supports rapid antibiotic selection and more precise treatment of bacterial infections.
Researchers found that bacterial toxins bind unrelated human receptors, causing diarrhea and fatal toxic shock syndrome. The discovery reveals a mechanism by which pathogens evolve receptor preferences to infect different organs.
Scientists have identified a specific protein mutation in E. coli that increases bacterial virulence, leading to increased resistance to antibiotics and antibacterial substances. The mutation affects the lipopolysaccharide transporter, causing the bacteria to produce more outer membrane vesicles and become more deadly.
Researchers from Kanazawa University purified and characterized Monalysin, a pore-forming bacterial toxin, to study its interaction with the innate immune system. The study revealed that activated Monalysin forms pores in cell membranes, leading to cell death, and that it preferentially inserts into curved parts of membranes.
Researchers have found that CD47, a natural brake on the immune system, can be turned off to help fight infections. By blocking CD47-mediated signaling, scientists may develop a new immunotherapy to treat a wide range of infectious diseases.
Biosurfactant from yeast dissolves Pseudomonas aeruginosa biofilms, weakening interaction between biofilm and surface and breaking internal cohesiveness, leading to disruption. Combination with chemical surfactants demonstrates stronger antibiofilm effects at lower concentrations.
A new study reveals that antibiotics are being recommended far more frequently and on a greater variety of crops than previously thought. The research found that over 100 crops use antibiotics, including some critically important for human medicine, with significant regional variations.
A team of researchers sequenced a measles genome from 1912 and found it likely arose in human populations around the 6th century BCE. This finding suggests that large cities may have played a role in the emergence of the virus. Understanding the origins of COVID-19 could help protect against and fight the pandemic.
Researchers at UConn's CEVR have made a breakthrough in vaccine development for Mycoplasma pneumoniae, a common and difficult-to-treat pneumonia-causing pathogen. By identifying the cause of vaccine-enhanced disease (VED), they were able to develop a new vaccine formulation that eliminates safety concerns.
Researchers developed a high-throughput structure mapping method, Lead-Seq, to determine RNA structures in bacterial cells. The team successfully mapped the structures of thousands of RNAs simultaneously, including previously unknown 'RNA thermometers' that detect temperature changes.
Researchers analyzed bacterial RNA and protein expression patterns during plant-bacterial interactions, revealing the impact of plant immunity on bacterial mRNAs and proteins. The study identified previously unknown transcriptional regulators controlling bacterial gene expression and virulence.
The tuberculosis pathogen Mycobacterium tuberculosis can survive for a longer period of time when combined with other bacteria in the air. This is because larger aerosol particles from mycobacterial clusters are produced together with components of dead cells, making them more viable in the air.
Research highlights importance of microbiome in disease interactions, including how it strengthens resistance to pathogens and influences the spread of diseases like chytridiomycosis. Climate change can disrupt the balance of the microbiome, making organisms more susceptible to infection.