Articles tagged with Bacterial Pathogens
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The NIH has awarded grants to support research on bacteriophage therapy, an emerging field that could yield new ways to fight antimicrobial-resistant bacteria. Researchers will study the interaction between phages and bacteria to create lasting, re-usable therapeutics.
Bacterial mutants struggling to survive due to nutrient scarcity often form clusters to cooperate and share nutrients, rather than competing with wild-type bacteria. This cooperative behavior masks the true frequency of mutations, making it seem like a lower rate of mutant emergence is occurring.
Researchers found that treating apple flowers with specific bacteria strains reduced fire blight symptoms, altering floral microbiomes and disease rates. The study suggests that flowers may be a key site for biocontrol interventions, offering a new approach to managing this damaging disease.
Researchers detect molecular changes in infected human cells and bacterial pathogen, revealing new insights into infectious disease mechanisms. The findings may lead to novel methods for combatting invasive pathogens during spaceflight and on Earth.
Scientists have pinpointed a critical mechanism allowing deadly bacteria to resist antibiotics, and discovered a potential new target for effective treatment. The study identified quinolone antibiotic resistance mechanisms, including the production of pentapeptide repeat proteins, and revealed how they inhibit bacterial enzymes.
A new model links bacterial metabolism and growth to mechanisms of antibiotic resistance, enabling predictions of mutation types and levels. The study suggests a previously unobserved connection between nutrient uptake and resistance development, which can inform strategies for slowing resistance emergence.
A study by Virginia Tech researchers reveals that a specific bacterium in mom's milk can educate an infant's antibody response, potentially strengthening their immune system. The findings suggest that probiotics could be used to protect infants from enteric infections and autoimmune diseases.
A team of researchers has developed a new method to combat periodontitis by targeting only the bacteria that cause the disease. The approach uses a test substance that attacks glutaminyl cyclase, an enzyme in the bacteria that plays a special role in metabolism.
A rapid microbiological point-of-care test for respiratory infections has proved popular with GPs and may reduce unnecessary antibiotic prescribing. The study found that clinicians changed the diagnosis in one in five patients following testing and were more certain of the diagnosis after detecting a virus or bacterium.
A long-term study found that bottlenose dolphins in Louisiana's Barataria Bay, exposed to the Deepwater Horizon oil spill, show abnormal immune responses and are more susceptible to pathogens. The researchers observed dysfunctional T-reg cells, which may be irreversible, raising concerns for the long-term recovery of these dolphins.
Scientists at Charité - Universitätsmedizin Berlin have identified a promising target for new antibacterial agents in the formation of ribosomal components. The study, published in Molecular Cell, reveals that a helper protein called ObgE plays a key role in guiding the process, which could be inhibited to stop bacterial growth.
Climate change has a stronger influence on soil microbial communities than land-use change, leading to increased bacterial richness but reduced community complexity. This shift may reduce specialization and adaptation capacity of ecosystems.
A study published in PLOS Pathogens reveals that bacterial toxin colibactin is produced in patients with urinary tract infections (UTIs), a potential link to bladder cancer. The researchers detected colibactin in 55 of 223 patient samples and found it to induce DNA damage in bladder cells.
Researchers at Purdue University developed a method to detect pathogens in cells using Doppler technology, allowing for quick diagnoses and effective treatments. This innovation enables scientists to identify harmless microbes and determine the correct antibiotic to use against antibiotic-resistant bacteria.
A new study found that kittens with aEPEC bacteria can help understand the disease, and the researchers identified behavioral differences between healthy and sick kittens. The findings point to kittens as a potentially invaluable model for further exploration of aEPEC.
A team of scientists is exploring the use of beneficial bacteria to help corals cope with climate change and bleaching events. By improving the health of coral symbionts, researchers hope to provide a 'medicine' to help corals adapt to changing environmental pressures.
A new study has identified a universal strain of bacteria derived from healthy human skin that can treat the most common type of eczema. In a Phase I clinical trial, two-thirds of participants showed significant improvements in symptoms, including reduced itchiness and inflammation.
A study by MIT researchers has identified a class of metabolic mutations in bacteria that helps them develop resistance to antibiotics. The findings suggest that forcing bacteria to burn more energy could make them more susceptible to antibiotics, and may lead to the development of new drugs to enhance existing antibiotic effectiveness.
Researchers aim to combat antibiotic-resistant infections by developing new therapeutics, utilizing antibodies and artificial intelligence. The team targets bacteria such as Burkholderia and Pseudomonas aeruginosa, causing severe respiratory and other infections.
Research reveals that hospital wastewater selectively kills antibiotic-sensitive bacteria, while multi-resistant bacteria thrive in its presence. This finding highlights the potential for hospital wastewaters to drive the evolution of new forms of antibiotic resistance.
Researchers at North Carolina State University found that Campylobacter strains C. coli and C. jejuni exchange genetic material, leading to increased virulence and antibiotic resistance. The study discovered 21 new Campylobacter strains in 2019, indicating a significant increase in the bacteria's drug resistance profile.
Scientists identified how harmless E. coli gut bacteria in chickens can acquire genes to become life-threatening infections, highlighting the potential for horizontal gene transfer and increasing antibiotic resistance. The study warns of the risk of such infections crossing over to infect humans.
A new approach to extend probiotic survival in vivo is developed using Smectite, a drug commonly used for gastrointestinal diseases. The study found that Smectite promotes lactic acid bacteria (LAB) biofilm formation, leading to increased anti-tumour immune responses and improved immunotherapy efficacy.
Researchers found gulls carrying resistant strains of Campylobacter and Salmonella, causing gastroenteritis in humans. The study highlights the importance of wildlife fauna as a reservoir for antibiotic-resistant bacteria, emphasizing the need for a one health approach.
Researchers at Osaka City University demonstrated the mechanism behind FMT, showing how FMT can restore human intestinal flora by replacing damaged microflora with a healthy one. The study reveals the crucial role of bacteriophages and their host bacteria in the pathogenesis of rCDI and its recovery.
Research ties oral health issues to systemic diseases like type 2 diabetes, rheumatoid arthritis, and heart disease, highlighting the importance of a healthy mouth. Regular brushing, flossing, and dental cleanings can prevent oral diseases and promote overall well-being.
A new study by UC Riverside researchers found that a high-fat and sugar diet in childhood can alter the gut microbiome of mice for life. The study suggests that early-life diet has more long-lasting effects on the microbiome than exercise, highlighting the importance of nutrition during critical developmental periods.
Researchers developed a new manufacturing platform using freeze-dried components that can quickly make vaccines on demand. The platform eliminates the need for complex supply chains and refrigeration, making it ideal for low-resource settings. This innovation has the potential to expand access to life-saving medications.
Researchers in Costa Rica have found that some bacteria on amphibian skin can prevent growth of the fungus responsible for mass amphibian die-offs. The study identified a number of bacteria with inhibitory capacity against the pathogenic fungus Batrachochytrium dendrobatidis, which has led to the extinction of 90 species.
Researchers found that Lactobacillus bacteria use enzymes to manipulate bile acids, creating a favorable gut environment. The type of bile acid and the presence of specific enzymes affect the toxicity of the acids and bacterial survival.
Researchers at the University of California - Riverside discovered fermented food waste can boost beneficial bacteria in plants, increasing crop growth and resistance to pathogens. The treatment reduces carbon emissions from farming and has potential for sustainable agriculture practices.
Extracellular vesicles, secreted by the cells lining the airways, carry iron bound to transferrin and supply bacterial cells with essential nutrients, promoting bacterial growth. This mechanism allows bacteria to exploit the host's defense system against pathogens.
Computational research reveals that genetic transfer between bacteria may be more widespread than expected, with plasmids containing resistance genes found in various environments and species. This could lead to rapid development of resistance in human pathogens.
A new study reveals how a bacterial pathogen manipulates host senescence to cause citrus greening disease. Researchers identified an effector that promotes bacterial colonization and disease development in citrus.
Approximately nine out of ten US infants suffer from a gut microbiome deficiency, including a lack of Bifidobacterium longum subsp. infantis, which plays a critical role in infant health and development. This deficiency is linked to an increased presence of antibiotic-resistant bacteria, such as Escherichia coli, and a higher risk of a...
Researchers have identified a potent antifungal agent, attinimicin, produced by nearly two-thirds of Pseudonocardia strains in Brazilian ants. This compound has broad geographic distribution and shows promise as a potential drug candidate for fighting fungal infections.
Researchers at the University of Exeter have identified a population of dormant Vibrio parahaemolyticus bacteria that are better equipped to revive when conditions improve. The study also discovered an enzyme involved in this process, which breaks down lactic acid into pyruvate, allowing the bacteria to survive for extended periods.
Researchers at the University of Queensland have discovered that synthetic cannabidiol can kill certain types of bacteria responsible for serious infections. The study's findings suggest that cannabidiol could lead to the development of new antibiotics, which would be a major breakthrough in combating antibiotic resistance.
Researchers found C. diff produces toxins causing inflammation and damage to the gut lining, allowing it to thrive in an environment with less competition for nutrients. This process enables the pathogen to utilize amino acids from collagen for growth, further promoting its survival and persistence.
Scientists discovered that taurine helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae. Taurine, found naturally in bile acids, triggers Deltaproteobacteria activity to fight off infections. The study suggests taurine may offer an alternative treatment for bacterial infections.
Researchers found that certain oral pathogens are more prevalent in esophageal cancer patients, particularly in dental plaque and saliva. The study suggests that these pathogens may be associated with a high risk of esophageal cancer and could form the basis of future screening methods.
Scientists at TU Graz have identified a bacterium inside the seed of rice plants that can lead to complete resistance to a particular pathogen. The bacterium, Sphingomonas melonis, produces an organic acid that inhibits the pathogen and renders it harmless.
Researchers developed nanocrystals with a unique surface texture that increases mobility and generates reactive oxygen species lethal to bacteria. The system is effective in killing embedded bacteria resistant to antibiotics and can be easily controlled.
Researchers discovered that random DNA sequences can generate new genes producing antibiotic resistance, which can spread quickly among bacteria. The study used laboratory experiments with E. coli and found six peptides causing Colistin resistance by modifying the cell membrane.
Researchers at Rice University have created a lab tool that simplifies simulations of the human intestine, allowing for more practical studies on diseases like infectious diarrhea. The device enables the real-time growth of bacterial infections and provides a mechanical model for studying how invading bacteria cause disease.
A new sequencing-based approach has been developed to determine infection clearance and microbiota recovery. The technique has shown promise in understanding the activity of microbial drug resistance mechanisms and identifying causative microbes.
A new study suggests that sea star wasting disease is caused by a lack of oxygen, as elevated microbial activity depletes the water's oxygen levels. This creates a hypoxic environment that surrounds the starfish, leading to respiratory distress and ultimately, their death.
Researchers develop peptide that disrupts protective outer coating of TB pathogen, making it susceptible to antibiotics and die. The peptide specifically targets the fatty acid on the pathogen's surface, allowing it to effectively kill the bacteria without harming good bacteria.
A new study reveals that periodontitis-causing bacteria Porphyromonas gingivalis borrows growth molecules from harmless Veillonella parvula, enabling its replication and causing gum disease. The relationship is one-directional, with V. parvula receiving no obvious benefit from sharing its growth molecules.
Researchers from Immanuel Kant Baltic Federal University develop novel compounds with potential as effective antibacterial drugs against drug-resistant tuberculosis pathogens. The new substances outperform existing antibiotics in sensitivity and minimal concentration needed for inhibition.
Researchers identified multiple bacterial strains that increase adherence of PGPB to plant roots, enabling them to work together for mutual benefit. This finding may lead to the development of groups of bacteria that can better protect crop plants and improve their growth.
Wistar scientists have discovered a new class of compounds that combine direct antibiotic killing with a rapid immune response to combat antimicrobial resistance. These dual-acting immuno-antibiotics target an essential bacterial pathway and stimulate the adaptive immune system, showing promise in treating pan drug-resistant infections.
Scientists discovered that metabolites from a wild potato relative inhibit the production of enzymes and communication in the pathogenic bacteria, leading to increased disease resistance. The findings offer insights into how to improve crop yields by studying wild relatives of food plants.
Researchers found a gene cluster in Vibrio cholerae that helps the bacteria acquire unique traits needed to become pandemic strains. The discovery sheds light on how environmental strains of V. cholerae evolve into deadly pathogens.
A preclinical study by researchers from the Institute of Biomedicine of Seville found that a combination of imipenem and meropenem may be effective in treating infections caused by carbapenemase-producing A. baumannii. The study showed promise for treating severe infections, including pneumonia and bacteremias.
This atlas of S. pneumoniae and host gene expression provides a comprehensive understanding of the pathogen's adaptation to different body locations and the host's response. Certain bacterial genes are highly expressed across all anatomical sites, making them ideal targets for new treatments.
Researchers have created a comprehensive gene expression database to study pneumococcal infections. The database reveals that the bacteria behaves differently depending on the site of infection and the organs respond accordingly. This could lead to new treatments, such as anti-inflammatory therapies.
A recent study by UC San Francisco researchers reveals that ticks possess an antibiotic gene called dae2, which protects them from contracting pathogens, including Staphylococcus bacteria. This discovery provides new insights into the complex interactions between ticks and human skin microbiota.
Researchers discovered a unique evolutionary event in which an antibacterial enzyme in ticks protects them from bacteria on human skin while allowing the Borrelia burgdorferi bacterium to thrive. The ticks acquired this gene 40 million years ago through horizontal gene transfer.
A study published in eLife journal reveals that a specific strain of lung bacteria, Lactobacillus murinus, can inhibit the growth of pneumococcal pathogens and prevent colonization. The findings suggest that probiotics could be a potential treatment alternative to antibiotics for respiratory illnesses.