Articles tagged with Bacterial Pathogens
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Researchers at Vanderbilt University Medical Center have identified a new antibacterial mechanism where immune cells cooperate to capture and 'eat' bacteria. This cooperation enhances the killing power of macrophages, increasing phagocytosis of bacterial pathogens, including antibiotic-resistant staph
A mechanical engineering faculty-researcher at RIT is developing a microfluidic device to improve the detection of drug-resistant bacteria in blood, which can cause severe infection and death. The goal is to detect these strains early, allowing for prompt treatment and recovery.
Scientists are still unraveling how pathogens adapt to changing conditions, including climate change and global trade. Genome sequencing and big data technologies have revealed that dramatic events like hybridization between pathogen species can lead to rapid evolution of virulence on new host plants.
A study published in International Journal of Environment and Public Health Research reveals that oral bacteria, specifically P. gingivalis and Lactobacillaceae families, are associated with periodontitis. Genetic differences among hosts contribute to susceptibility to pathogens, but the oral microbiome plays a more significant role in...
A study found that palm phytoplasmas in Florida were transmitted by the American palm cixiid bug, originating from Jamaica. The research revealed a network of movement across the Caribbean basin, with distinct groups of insects found in different countries.
Studies on mice and septic patients show that a specific B lymphocyte subpopulation produces large amounts of CD39, leading to increased adenosine levels and reduced macrophage activity. This results in heightened susceptibility to opportunistic infections, with survivors experiencing a sevenfold higher risk of severe infections.
Scientists found that rain-borne microbes can successfully colonize plants' aboveground microbial communities, protecting them from stressors. The study suggests that rain is a potentially important reservoir for phyllosphere bacteria, which could be used to improve plant health.
Using sequential antibiotic treatment with similar but swapped antibiotics slows down bacterial adaptation to drugs, reducing cross-resistance. The study used Pseudomonas aeruginosa and found that fast switching between antibiotics constrained bacterial evolution.
A study reveals the biological process used by Xanthomonas to weaken plants' defense systems and discovers a novel class of enzymes called CE20 that can assist infection. This discovery contributes to developing strategies to combat citrus canker and obtaining advanced sugars from agroindustrial waste.
Researchers have determined the structure of a molecule that helps S. pneumoniae take up manganese, a mineral essential for its survival. This finding could aid in designing new drugs to block this pathway and deny the bacteria its manganese supply.
A study found that commercial composts contain more airborne pathogens than backyard composts, while immature compost samples have high levels of antibiotic resistance genes. The researchers hope to improve their detection method to assess the threat to humans.
A study by Kazan Federal University found that probiotics administered to antibiotic-treated mice improved behavior, reduced oxidative stress, and restored gut microbiota diversity. The researchers demonstrated a strong link between the gut microbiota and brain functioning, with potential therapeutic benefits for treating dysbiosis-rel...
Researchers identified a key mechanism by which Xanthomonas bacteria infect crops, allowing them to hijack plant immune systems. Understanding this process is crucial for developing methods to prevent bacterial infections and produce crop-resistant varieties.
A recent study published in Clinical Infectious Diseases documents the person-to-person transmission of antimicrobial-resistant pneumonic plague in an outbreak in rural Madagascar. The AMR strain was resistant to streptomycin but susceptible to co-trimoxazole, and all patients treated with antibiotics survived.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
Researchers found that fasting decreases signs of bacterial infection and inflammation in mice. Fasting also alters gut microbiomes, which appear to sequester nutrients and prevent pathogens from infecting the host.
Dr. Jitender Mehla has received a National Institutes of Health Grant to study small molecule-based inhibition of multidrug efflux pump in Pseudomonas aeruginosa, a serious threat to hospital-acquired infections. The proposed research aims to develop antibacterials effective against multidrug-resistant Gram-negative pathogens.
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
Researchers identified two proteins, HMW1 and HMW2, that stimulate protective immunity against diverse NTHi strains. Immunization with these proteins provides protection against bacterial colonization by other strains, highlighting the vaccine potential for a nontypeable Haemophilus influenzae vaccine.
Researchers at UIC have received a $725,000 grant to develop an AI system that can help protect US Navy divers from waterborne bacteria, parasites, and other harmful pathogens. The system aims to provide real-time information on water conditions, allowing divers to make informed decisions about their mission.
Researchers created a 3D view of diseased lung tissue using microCT to reveal that TB granulomas are complex and branched, with unique connections to airways. This has significant implications for treatment, including the potential for aerosolized drug delivery to reduce treatment times.
Researchers found that plant root-associated bacteria prefer to colonize their native host plants, rather than non-native ones, with increased competitiveness and persistence. This host preference is driven by the formation of species-specific niches and differential transcriptional reprogramming of plant roots.
Researchers found that Pseudomonas bacteria use a network of proteins to regulate twitching and respond to mechanical forces, allowing them to navigate based on what they feel in front of them. This 'sense of touch' helps the microbes move forward in the same direction when moving as a group.
Researchers developed a cutting-edge method to analyze how individual immune cells respond to Mtb, the bacteria that cause tuberculosis. The study found an almost perfect correlation between the fitness status of the bacterium and the transcriptional profile in the host cell.
Rice University and Baylor College of Medicine researchers have developed a new model for studying intestinal infections, using custom hydrogel-based platforms. The study found that softer hydrogels promote bacterial adhesion to epithelial cells, which is crucial for understanding the dynamics of infectious diseases.
Researchers at RIKEN discovered that acetate triggers an immune response against harmful bacteria by increasing IgA production and altering the balance of intestinal bacteria. The study suggests that acetate can be used to regulate the gut microbiome and prevent disease.
A study published in the Proceedings of the National Academy of Sciences identifies Neuraminidase 3 (Neu3) as a key enzyme responsible for colitis, a chronic digestive disease. Inhibiting Neu3 with Relenza breaks the chain of inflammation, and augmenting intestinal alkaline phosphatase appears to be equally beneficial.
Researchers have discovered a human cell protein that uses detergent-like action to dissolve bacterial membranes, killing invading pathogens. The protein, APOL3, is found in non-immune cells and offers wide protection against infections.
Targeting an RNA sequence in pathogenic bacteria could make them more sensitive to antibiotics, offering a new avenue for treating drug-resistant bacteria. The study found that eliminating this regulatory RNA sequence had an impact on urinary tract infections related to E. coli.
A new light-producing bacterial reporter is being used to quantify plant resistance levels through imaging, allowing for the simultaneous analysis of over 30 Arabidopsis mutants. This novel method shows a high correlation with conventional culture-based techniques, demonstrating its robustness and potential applications.
Researchers at Michigan Technological University have developed a food generator concept that turns plastic waste and inedible biomass into edible protein. The project, which won the 2021 Future Insight Prize, uses microbes to break down plastics and non-edible plant biomass into safe and nutritious food.
A new study found that silver-impregnated PVC foil significantly reduces levels of contamination on high-touch surfaces in hospitals. Clinically important bacteria, including Enterococci, were less likely to be present on foil-covered surfaces.
Newborns are more susceptible to GBS meningitis due to immature gut microbiota and epithelial barriers. This study highlights the critical role of microbiota in protecting against infection, demonstrating its importance in newborn health.
Researchers developed a biomaterial-based infection vaccine (ciVAX) approach to combat infectious diseases. ciVAX vaccines combine two technologies that capture immunogenic antigens from pathogens and reprogram the immune system, offering potential solutions for sepsis prophylaxis, pandemic threats, and biothreats.
A study by ITQB NOVA researchers found that asymptomatic adults in Portugal can carry pneumococci for several months, with a median duration of almost two months. This suggests that some adults may act as reservoirs of the bacterium, potentially impacting herd immunity.
Researchers found that the presence of beneficial bacteria in plant roots promotes growth under low light conditions, but reduces defense against leaf pathogens. The study suggests a complex interplay between plant growth and defense responses mediated by root microbiota.
Researchers at the University of Freiburg have identified a novel flavoprotein dioxygenase crucial for bacterial tropone biosynthesis. The enzyme activates oxygen in a previously unknown way and incorporates it into a chemical precursor compound, generating the basic structure of tropone.
Researchers identified a core set of 24 genes that activate in response to bacterial colonization, acting as volume control for plant responses and predicting the extent of colonization
Researchers developed smart wound dressings with fluorescent sensors that glow under UV light to alert patients of potential infections. The magnesium hydroxide nanosheets are non-toxic, scaleable, and up to 20 times cheaper than silver-based dressings.
Researchers have designed a miniaturized device using microplasma technology to treat middle ear infections. The treatment is effective in inactivating bacteria and may offer an alternative to antibiotics, which are often ineffective or lead to antibiotic resistance.
A recent study found that genes involved in bacterial signaling play a crucial role in the virulence of Psa3, a highly aggressive biovar of the pathogen Pseudomonas syringae pv. actinidiae. This discovery highlights the importance of understanding the diversity of virulence strategies among closely related bacterial strains.
Research from Anglia Ruskin University found that common artificial sweeteners like saccharin and sucralose can make previously healthy gut bacteria pathogenic. The study discovered that these pathogenic bacteria can invade intestinal cells and cause damage.
A low-calorie diet significantly alters the composition of the human gut microbiome, leading to changes in nutrient absorption and influencing weight control. The study found that specific bacteria, such as Clostridioides difficile, play a role in this process.
A team of Ben-Gurion University researchers has developed an artificial nose capable of detecting bacteria through volatile metabolites. The technology uses carbon nanoparticles to sense gas molecules and has the potential to identify 'good' vs. pathogenic bacteria in the microbiome, detect food spoilage, and identify poisonous gases.
A UNIGE team has identified an RNA helicase regulator in Pseudomonas aeruginosa that significantly reduces its infectious power and virulence. The absence of this protein makes the bacteria almost harmless while remaining alive.
Neutrophils use an internal start-stop system to balance search and destroy phases for efficient pathogen elimination. This system helps prevent excessive inflammation and tissue damage. The study provides new insights into neutrophil biology, essential for immune host defense against bacteria.
A study published in Cell revealed that activated Bifidobacterium infantis EVC001 programs immune cells to control inflammation and autoimmune disease risk. Breastfed infants fed this strain experienced reduced systemic inflammation and improved immune system development.
Research reveals minor microbes, like fungi and environmental bacteria, play crucial roles in maintaining bee gut health. These forgotten microbes produce antibiotics, break down toxins, and metabolize nutrients, helping bees resist pathogens and climate change.
Researchers have identified a promising strategy for combating antibiotic-resistant bacterial infections by targeting the production of hydrogen sulfide. The approach, which inhibits the enzyme cystathionine gamma-lyase, enhances the deadly effects of antimicrobials on drug-resistant pathogens.
Researchers discovered that blocking bacterial H2S biogenesis strengthens antibiotics by inhibiting persister formation and biofilm growth, offering a novel alternative to traditional antibiotic discovery. The study suggests using small molecule potentiators to enhance the effect of major classes of clinically important antibiotics.
Researchers at Flinders University have discovered that fish oil fatty acids can render bacteria more susceptible to antibiotics. This discovery is vital in combating the rise of superbugs with unprecedented levels of antibiotic resistance.
Two types of coating made from new coordination polymers with silver effectively kill bacteria, including those that form biofilms. The most promising coating destroys 99.99% of bacteria, offering a breakthrough in antibiofilm applications.
A novel liquid surface coating on human catheters could help reduce protein deposition that leads to urinary tract and bloodstream infections. The research explores the development of liquid-infused catheter surfaces for controlling protein deposition.
A study revealed that Staphylococcus saprophyticus can originate from food, particularly meat production, and is a major cause of urinary tract infections in young women. The bacteria's transmission occurs between persons within the community, emphasizing the importance of hygiene practices to prevent infectious diseases.
Researchers at Tel Aviv University discovered a mechanism through which 'good' viruses can target and destroy 'bad' bacteria, using a bacteriophage protein to exploit the bacterial DNA's need for repair. This finding may lead to new tools to combat antibiotic-resistant bacteria.
Researchers found numerous novel genes promoting microbial resistance in international travelers' gut microbiomes. The study highlights the global spread of antimicrobial resistance through travel and emphasizes the need for broader surveillance.
Researchers at ETH Zurich developed a vaccine that guides bacteria's evolution to make them a weaker pathogen, rather than trying to kill them. The combination vaccine was shown to be more effective in preventing Salmonella infections than existing vaccines.
Francisella tularensis can persist in a dormant state for over six months in cold water without nutrients, remaining fully virulent. This discovery changes the understanding of the bacterium's ecology, suggesting it spends most of its time outside a host and amplifies disease events in mammals.
A new species of bacteria, Candidatus Phytoplasma dypsidis, has been found to cause a fatal disease in palms in Queensland, Australia. The bacterium is thought to be spread by insects and poses a significant threat to Australia's ornamental palm industry.
Researchers found that horned passalus beetles, known as bessbugs, have frass teeming with antibiotic and antifungal compounds produced by actinomycetes beneficial bacteria. This discovery could help speed the search for new antibiotics and improve strategies to prevent antibiotic-resistant infections.