Articles tagged with Gut Microbiota
A large clinical study found that patients who consumed more sweets while taking antibiotics experienced a greater loss of microbiome diversity, with a 24% drop in bacterial diversity for every 100-gram increase in sweets. Preserving microbiome diversity has been linked to improved clinical outcomes for cancer patients.
A recent study published in eGastroenterology reveals that intestinal neutral ceramidase plays a crucial role in metabolic steatohepatitis (MASH) progression by altering gut microbial composition and metabolite profiles. The study suggests that targeting this enzyme and its downstream effects may lead to novel therapeutic strategies fo...
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
Researchers found that gut bacteria-derived polyamines, including putrescine and spermidine, contribute to extended lifespan in fruit flies. The study used genetically engineered E. coli to investigate the specific contribution of polyamines to host lifespan, revealing a sex-dependent effect with males living longer than females.
Mizzou researchers have developed an AI tool called MeLSI that can identify specific microbes driving key biological changes in the gut microbiome, which may indicate early warning signs of disease. The tool has shown promising results in detecting meaningful patterns in microbiome data that conventional methods miss.
Academic researchers from Michigan State University have found a molecule called indole that inhibits the growth of Campylobacter jejuni, a leading cause of food poisoning. The discovery could lead to new non-antibiotic treatments and explore how dietary approaches influence gut environments to control infection.
Scientists have engineered a nonpathogenic E. coli bacterium to carry a phage that specifically targets salmonella, resulting in a protective lining against infections. This breakthrough could lead to the development of new treatments for other diseases, particularly those with high global disease burdens.
A study found that a bacterial enzyme BvDPP4, produced by gut microbes, weakens a protective intestinal signal GLP-2, aggravating colitis in a preclinical model. Inhibiting BvDPP4 with theaflavin improved colitis symptoms.
A new UCLA study has found a connection between brain aging and gut biology, suggesting that people's brains may be aging decades before symptoms appear. The study, published in eBioMedicine, analyzed brain scans and stool samples to identify a link between brain communication patterns, gut bacteria, and brain aging.
A study found that probiotic supplement use increased 287% among adults and 786% among young people, while fiber intake remained unchanged, between 2009 and 2023. Probiotic users consumed more high-microbial foods and fiber content than non-users, but these beneficial diet habits may be decreasing due to supplement use.
Researchers found altered gene expression in wharf roach guts after consuming expanded polystyrene, but no significant impact on lifespan. The gut microbiome showed little change, but rare microbes were detected in EPS-fed specimens. This highlights the need to manage EPS waste carefully and prioritize coastal cleanup efforts.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
Researchers found associations between gut microbiome and brain chemistry in specific brain regions, including GABA and glutamate levels. The study suggests a regionally specific picture of the gut-brain axis, with different microbial pathways linked to different brain regions and psychological wellbeing.
The new center aims to better understand diseases and treatment response by combining human genetics and microbiome research with AI. Researchers will investigate how genetic variation and the gut microbiome jointly shape disease progression and treatment response.
Researchers found that corisin, a bacterial protein fragment, drives tissue fibrosis by disrupting the cell's quality-control system. Antibody treatment can help by blocking corisin, demonstrating its biologically active and causally supported role in disease.
Researchers at Umeå University have mapped interactions between 36 representative gut bacterial species, revealing that inhibitory effects dominate, while cooperative mechanisms also exist. The study provides a comprehensive dataset for understanding gut microbiome composition and dynamics.
Researchers analyzed the make-up of oral microbes to detect signals associated with gastric and colorectal cancer, finding distinct signatures in patients with cancer. The study's findings could lead to the development of new, less-invasive screening tests for gastrointestinal cancers.
Researchers at Karolinska Institutet discovered that gut bacteria convert dietary nitrate and iron into protective molecules, such as dinitrosyl iron complexes, which may improve cardiovascular and metabolic health markers. These findings suggest a previously unknown mechanism by which a specific diet and gut bacteria can promote health.
A new study from the University of Copenhagen reveals that astronauts experience changes in their gut bacteria shortly after leaving Earth and gravity behind. The researchers found increased protein fermentation, which may contribute to constipation, and suggest potential interventions for future long-duration space missions.
Researchers discovered that newborn German cockroaches use pheromones in feces to recognize their own colony and form a kind of social bond. This behavior was found to be mediated by both innate attraction to conspecific fecal odor and learned preferences for specific odorants encountered during coprophagy soon after they hatch.
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
Researchers at UC Davis identified a naturally occurring metabolite, 10-hydroxystearic acid (10-HSA), that repairs gut damage caused by HIV infection. Combining 10-HSA with standard antiretroviral therapy improved viral suppression and helped rebuild gut immune defenses in animal models of AIDS.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
A study led by Robert Koeth found a connection between elevated blood levels of TMAO, a gut bacteria byproduct, and an increased risk of atrial fibrillation. The research team discovered that TMAO changes the heart's electrical environment, making it more susceptible to abnormal rhythms.
Researchers found that certain gut bacteria are associated with faster or slower biological aging, explaining about 15% of the differences. The study provides evidence for the importance of the gut microbiome in understanding biological aging and its potential influence on longevity.
Research suggests that time zone changes disrupt the synchronization between human biological clocks and gut microbiota, leading to digestive complaints, poorer sleep quality, and reduced energy levels. Gradually adjusting one's biological clock through light exposure and meal timing before departure can help reduce jet lag effects.
A randomized clinical trial found that ingesting fecal microbes from healthy donors improved sleep efficiency and reduced wake after sleep onset in participants with chronic insomnia. Sleep quality scores also showed significant improvement over two months.
A study published in RMD Open found that specific oral microbiome imbalances may contribute to the development of hand osteoarthritis by influencing systemic inflammation and gut microbiome dysbiosis. The research suggests a potential role for the oral-gut microbiome axis in symptomatic hand arthritis pathogenesis.
Researchers discovered that fructooligosaccharide induces the selective enrichment of Anaerotruncus colihominis, a UA-degrading bacterium, via modulation of the gut microbiota. This interaction alleviates oxidative damage to the kidney and offers a new therapeutic rationale for prebiotic-based management of hyperuricemia
A new study argues that the microbiome-gut-brain axis has been predominantly studied in wealthy, industrialised nations, limiting scientific discovery. The authors call for greater international collaboration and investment in research infrastructure to uncover universal biological principles that can improve mental health worldwide.
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Researchers from the University of Nebraska-Lincoln have identified a specific gut bacterium, Bacteroides uniformis, and its metabolites that can positively impact the body's immune response to cancer. The study found that these metabolites can suppress tumor growth and boost anti-tumor immunity in mice.
Scientists are conducting a European clinical trial aiming to reduce antibiotic use and lower recurrent urinary tract infection rates by targeting pathogenic E. coli strains with CRISPR-enhanced phage cocktails and microbiome restoration therapies.
A systematic review found that babies born by caesarean section or exposed to antibiotics around the time of birth tend to have differences in their gut bacteria composition, with less diversity and beneficial bacterial groups less abundant. Exclusively breastfed infants appear to show a partial restoration of microbial balance.
A new preclinical study has identified a gut bacterium, Akkermansia muciniphila, that helps prime intestinal stem cells for faster recovery after radiation treatment. Fasting increases the population of this bacterium, which produces a small molecule that changes histone tags to allow gene expression in intestinal cells.
A recent study published in Nature Communications has identified a clear link between the composition of gut bacteria and frailty in older women. The research found that lower gut bacterial diversity and impaired function are associated with increased vulnerability to disease, falls, functional impairment, and death.
A new study found that specific gut bacteria from children with stunted growth can be passed to their offspring, causing inflammation and damage to the intestinal lining. The researchers identified Campylobacter concisus as a key contributor to this process, which may hold promise for future treatment and prevention strategies.
Researchers analyzed DNA samples from foraging honeybees, hive workers, and their honey to understand plant-microbe interactions in honeybee ecology. The study found that these complementary sources provide distinct insights into the complex relationships between plants, microbes, and honeybees.
A large Swedish study found that certain bacteria in the gut microbiota can be seen in people who develop type 2 diabetes years later. Fluctuations in metabolism and low fibre intake may also contribute to the risk. The discovery paves the way for early identification of at-risk individuals.
Researchers found that psychological stress speeds up aging-like changes in hematopoietic stem cells by altering the intestinal microbiota and reducing spermidine levels. Chronic stress impacts the balance of gut microbes, leading to immune dysfunction and bone marrow defects.
A Thai study found that shelter dogs in more crowded conditions tend to have disrupted gut microbiomes compared to those with more space. The research analyzed stress, metabolism, and fecal microbiota in dogs, providing insights into the impact of shelter conditions on animal health.
A study published in Frontiers in Cellular and Infection Microbiology found that healthy infant gut microbiomes are linked to reduced risk of malaria. Babies with beneficial microbes like Bifidobacterium were less likely to develop the disease. However, further research is needed to confirm this association.
Researchers have identified a consistent microbial signature of colorectal cancer by reanalyzing nearly 6,800 gut microbiome profiles. The study found that microbes detected in stool samples reflect microbes found directly within colorectal tumours.
Two studies found that certain fungal species in the gut play a key role in immune dysregulation and pediatric allergic diseases, positioning the infant mycobiome as a promising target for therapies. Infants' early-life antibiotic use may have a direct impact on these fungi, leading to immune dysregulation and allergic asthma.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers from Institute of Science Tokyo found that postbiotic foods can improve gum health in adults with mild gingivitis, reducing gum bleeding and inflammation. The study suggests a simple way to support oral health without altering oral care habits.
A study found that prebiotic xylo-oligosaccharides reduced harmful metabolites and improved liver health in overweight adults. The composition of the gut microbiota prior to supplementation influenced the benefits observed.
Researchers found that cohabiting individuals shared significantly more oral and gut strains than those living in different households. On average, cohabitors shared 19% of their gut microbiome and 26% of their oral microbiome strains with each other.
Professor Saeedi's appointment reflects ISM's commitment to advancing microbiota research toward clinical translation and precision medicine. He will contribute to identifying emerging scientific priorities and promoting the integration of microbiome science with aging biology, metabolism, cardiovascular medicine, and precision health.
Researchers found that eliminating sugar from a low-fat diet can lead to impaired glucose control, insulin resistance, and gut microbial imbalance. Balanced dietary carbohydrates are essential for supporting gut and immune homeostasis.
NUTRITION 2026 brings together thousands of researchers and health professionals to share new evidence on protein needs, infant formula regulation, microbiome mysteries, and more. The meeting features over 1,650 scientific studies and provides a platform for experts to discuss the future of nutrition science.
New research links food insecurity to altered gut microbiomes in children, with potential implications for child health and development. The study found higher levels of certain bacteria, such as Sutterella, in children from food-insecure households.
Researchers investigated the interplay between host and gut microbiota in selenium metabolism, finding that gut microbiota transform selenium into metabolites influencing utilization, detoxification, and excretion. The study also revealed that Se intake affects bacterial diversity and that gut microbes produce unique selenometabolites.
A new mathematical model developed by Arizona State University researchers estimates how much of the calories people absorb from food, considering the role of gut microbes. The model, DAMM, suggests that short-chain fatty acids produced by gut microbes contribute to an average of about 140 calories per day.
A study by Harvard T.H. Chan School of Public Health found that gut microbiome alterations persist even after adenoma removal, increasing the risk of colorectal cancer. The researchers discovered that diet and physical activity were closely tied to CRC-associated gut microbes, suggesting lifestyle habits may contribute to sustained risk.
A new screening tool tests for microbial metabolites in urine to identify children at risk for autism, with 90% sensitivity and 100% specificity. The test may guide more targeted interventions, including approaches to restore a healthy gut microbiome.
Researchers found that the gut responds to protein deficiency by activating a fast neural circuit and a slower hormonal signal, which selectively changes dietary priorities. The study reveals a previously unknown gut-brain signaling system that rapidly alters feeding behavior in animals.
A study reveals that medical exposure can rapidly change the human microbiome, with gut microbes shifting toward patterns more commonly seen in urban populations. The research found a decline in microbial diversity and a shift towards bacterial groups more common in industrialized societies.