Articles tagged with Human Gut Microbiota
Researchers created a comprehensive metabolic model of C. elegans, linking over 2,000 processes to identify genes contributing to lifespan extension. The 'ElegCyc' model enables analysis of large datasets and will aid in understanding human diseases and microbiome interactions.
A new study examines the role of diet in promoting cooperation or conflict between gut microbes and human cells. The research proposes a framework for understanding the subtle interplay of diet and health, with potential implications for the management of inflammatory and metabolic disease.
A new study found that triclosan exposure causes rapid changes in the gut microbiome of zebrafish, compromising its function. This disruption may contribute to disease development or severity.
At DDW 2016, AGA presents notable clinical practice data and basic science research on the gut microbiome. The conference features seven highlighted abstracts focusing on obesity management, hollow organ failure, and upper GI cancers.
A targeted antibiotic, Debio 1452, was found to minimize disruptions to the gut microbiome in mice compared to broad-spectrum antibiotics. The study suggests that pathogen-selective approaches to antibiotic development can help preserve beneficial bacteria and prevent secondary infections.
A CU Anschutz study finds that breast milk hormones impact the development of healthy bacteria in infants' guts, potentially protecting them from intestinal inflammation, obesity, and diseases. Researchers found a positive association between insulin, leptin, and microbial diversity in the infant's stool.
Researchers at Wellcome Trust Sanger Institute have catalogued over 130 human intestine bacteria, enabling them to study the microbiome's role in health and disease. The discoveries hold promise for creating tailored treatments with specific beneficial bacteria.
A global study found that gut microbiomes of infants in Finland and Estonia are dominated by Bacteroides species, while Russian Karelian infants have an overrepresentation of Bifidobacterium. This difference may contribute to the spike in immune disorders seen in western societies.
A large-scale study has identified 69 factors linked to gut flora composition, including diet, health, and lifestyle. The research provides valuable insights for future disease studies and clinical trials.
Research identifies 14 core gut microbes found in over 95% of people, with certain species linked to diseases like ulcerative colitis and colorectal cancer. Analysis also reveals correlations between microbiome composition and diet, as well as the impact of medications and antibiotics on the gut microbiota.
Researchers studying intestinal bacteria and their effect on the human brain and mood found that an imbalance in gut microbiota can lead to heightened anxiety and stress. Feeding stressed mice probiotics improved behavior and reduced stress biomarkers, suggesting a potential treatment for PTSD.
A recent study suggests that decreased dietary diversity leads to reduced gut microbiota richness, which is associated with various metabolic disorders. The researchers emphasize the importance of dietary diversity for maintaining a healthy gastrointestinal microbiome.
Researchers found that lead exposure during gestation and lactation altered the gut microbiota of adult mice, leading to increased body weight. The study suggests a potential link between early life lead exposure and obesity in adulthood.
A recent study has discovered an intermediate gut microbiome from the Central African Republic's Bantu community, which incorporates some westernized lifestyle practices. The discovery sheds light on what factors may drive our microbiome differences, linked to metabolic disorders in Western populations.
A study showed that transferring healthy gut microbial species from children to mice can counter the negative effects of malnutrition, suggesting a possible therapeutic approach. Certain microbe species offset malnutrition's detrimental effects, enabling normal growth in undernourished children.
A study published in Gut journal found that oral and intravenous iron replacement therapies alter the gut microbiota significantly, particularly in Crohn's disease patients. These changes may lead to unstable bacterial ecosystems and increased risk of disease flares.
Researchers at the University of Oklahoma are using ancient DNA analysis to study the human microbiome and its impact on health. They have found that human behavior over the past 2000 years has impacted the gut microbiome, leading to disturbed microbial communities.
Age-related inflammation drives metaplasia in flies, causing changes in gut tissue and gut bacteria. Inhibiting this pathway prevents abnormal changes, maintains a healthy commensal population, and extends lifespan by up to 18%.
Researchers found that the number of bacterial species in a chimp's GI tract increases when they are more gregarious. The study suggests that social interactions with other chimps help maintain gut microbial diversity over a lifetime, just as initial exposure from mom does.
Researchers found that chimpanzees with more frequent social interactions had more diverse gut microbiomes. The study suggests that social networks play a crucial role in maintaining healthy gut microbial diversity, a finding with potential implications for human health.
A study of 102 infants found associations between the infant's gut microbiome composition and delivery method, as well as feeding practices. The research suggests that differences in the microbiome composition may be linked to short- and long-term health outcomes.
A University of Guelph-led study found that red squirrels with lower stress hormones have healthier microbiomes. The researchers tested squirrel microbiomes and analyzed their stress levels, discovering a link between stress and bacterial diversity.
Scientists have developed a human-gut-on-a-chip model that allows them to analyze the interactions between normal gut microbes and pathogenic bacteria, providing new insights into inflammatory bowel diseases. The technology has revealed four small proteins that stimulate inflammation, opening up a potential therapeutic pathway for trea...
A University of Iowa study found that changes in the gut microbiome can cause obesity by reducing the resting metabolic rate, leading to weight gain. The researchers discovered a significant decrease in non-aerobic resting metabolic rate sufficient to account for the animals' weight gain.
Researchers analyzed stool samples from 38 adults in the Cheyenne and Arapaho tribe, finding reduced abundance of certain bacteria and similar fecal metabolite profiles to those with metabolic disorders. The study suggests that lifestyle and social practices may play a role in health disparities among American Indians.
The Unified Microbiome Initiative aims to study the planet's least understood ecosystems, with potential breakthroughs in medicine, agriculture and environmental science. New genomic tools have linked microbes to various health issues, including obesity and brain development.
Scientists from Université de Genève found that depleting the gut microbiota triggers a metabolic mechanism that transforms white fat cells into beige fat, reducing obesity and insulin resistance. This discovery could lead to new anti-obesity treatments.
A study published in Molecular Systems Biology reveals that gut microbiota regulates glutathione and amino acid metabolism in mice, which may contribute to the development of obesity, type 2 diabetes, and other diseases. The research also highlights the potential for probiotics to deliver beneficial bacteria to the gut and prevent meta...
A consortium of scientists proposes a major research project to understand and harness microbiomes, aiming to improve human health, agriculture, bioenergy, and the environment. The Unified Microbiome Initiative calls for investments in new tools and cross-disciplinary collaborations to predict and manage microbial behavior.
Research found that long-chain fatty acids promote CNS reactive immune cells, while short-chain fatty acids regulate autoimmune responses. The study suggests a potential role for dietary interventions in managing multiple sclerosis.
Researchers found that a humanized mouse model of gluten sensitivity showed increased immune responses and gut damage when exposed to gluten, but protection was seen in mice with a balanced microbiome. The study suggests that microbial imbalance may contribute to the development of celiac disease.
A mathematical calculation platform predicts how patients respond to modified diets depending on their gut microbiome composition. The study reveals that individuals with low-diversity gut microbiomes experience improved blood chemistry when following a weight loss diet.
Analyzing intestinal bacteria could predict health outcomes as we age. The study discovered changes in gut microbes precede and predict the death of fruit flies.
A new study found that bariatric surgeries alter the gut microbiome in ways that last for at least a decade, leading to sustained weight loss and improved metabolic health. The changes are specific to the surgery and not just a reflection of weight loss alone.
A metagenome-wide association study uncovered markers in the oral and gut microbiomes that are associated with rheumatoid arthritis (RA). The study found that Haemophilus sp. is depleted in RA patients and Lactobacillus salivarius is over-represented, suggesting potential new targets for diagnosis and treatment.
Research suggests that a lack of dietary diversity contributes to health issues like obesity and Type 2 diabetes. Diversifying the diet can optimize the gut microbiome, which plays a key role in metabolic and GI regulatory systems.
Researchers at MIT successfully engineered Bacteroides thetaiotaomicron to express genes on demand, allowing for precise control over its functions in the mouse gut microbiome. This breakthrough has significant implications for tackling health-related problems and may lead to the development of new therapeutic applications.
A new study by NYU Langone Medical Center researchers found that multiple courses of commonly used antibiotics in children can have significant effects on their development. The study showed that antibiotic-exposed mice gained more weight and developed larger bones than untreated mice, while also disrupting the gut microbiome.
A study engineered a gut microbiome with low urease expression to alleviate hyperammonemia symptoms in mice. This approach reduced circulating ammonia levels and improved mortality rates in animals with liver disease.
A Wyss Institute team is developing genetically engineered bacteria that can sense, report, and combat harmful microbial invaders in the human gut. The team aims to create a probiotic pill form of the microbes that could reduce the length of gastrointestinal illness, returning individuals to their activities sooner.
Research at University of Chicago Medical Center reveals how immune system shapes gut microbiota to limit infections, providing a potential new approach to prevent bacterial infections without antibiotics. The study identifies a critical protein ID2 that plays a key role in this process.
Researchers analyzed saliva of cirrhosis patients to predict inflammasions and hospitalization, revealing a new target for research. The study found that oral microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy.
Researchers found that Papua New Guineans have microbiomes with greater bacterial diversity and lower inter-individual variation compared to US residents. The study proposes a model based on ecological theory that explains the decline of microbiota diversity in urban-industrialized societies.
Researchers at Michigan Medicine are creating mini-guts in a dish using human stem cells to study the complex interaction between microbes, cells, and disease-causing bacteria. The 'guts in a dish' model aims to aid research on a wide range of diseases, including gastrointestinal disorders and emerging infections.
A University of Calgary study found that rats fed a fibre supplement while on a high fat and high sugar diet showed a much lower weight gain than those who did not eat the fibre. The study suggests that oligofructose, a naturally occurring dietary fibre, may help reduce weight gain by affecting gut microbiota and gut hormones.
A new study finds that high-fat diets produce changes in gut microbiome, leading to altered behavior and cognitive function. Mice with high-fat diet-induced gut microbiota showed increased anxiety, impaired memory, and signs of brain inflammation.
A team of researchers has discovered a strong association between the lifestyles of indigenous communities and their gut microbial ecologies. The study found that hunter-gatherers in South America and Africa have similar gut microbiota profiles, while urban-industrialists have distinct profiles, suggesting a link between lifestyle and ...
A longitudinal study found that infants who developed type 1 diabetes had a significant drop in microbial diversity prior to disease onset, including a decrease in health-promoting bacteria and an increase in potentially harmful ones. The study also revealed stable biological functions served by the microbiome across individuals.
Researchers found that exclusively breastfed babies had microbial communities more ready for solid foods, while those with mixed diets experienced a dramatic shift. This study provides support for exclusive breastfeeding during the first six months of life.
A large-scale analysis of the gut microbiome has identified significant variations in gene copy numbers across different strains of the same microbe species. These strain-level variations can affect the microbes' capabilities, lifestyle, and impact on human health, including obesity and inflammatory bowel disease.
Researchers found patients with Crohn's disease and ulcerative colitis had greater viral diversity than healthy volunteers, suggesting viruses play a role in the diseases. The study suggests that studying the virome may reveal new insights into obesity and diabetes.
Research explores how gut bacteria influence brain activity, sleep, stress responses, and disease development. The human microbiome's role in brain function is a growing area of study, with potential therapeutic applications through dietary modification.
Researchers have developed a new computational model that can predict and identify gut metabolites produced by microorganisms, which could lead to improved diagnosis and treatment of GI diseases. The model focused on aromatic amino acids and predicted over 49 different metabolites exclusive to the microbiota.
Researchers found that humans have less diverse gut microbiomes than African apes, with a possible link to modern diets and lifestyle changes. The rate of change in microbial diversity accelerated in humans from some parts of the world, potentially leading to negative health effects.
Two major research projects will investigate the microbiome and its impact on autism symptoms, as well as chronic constipation treatment to improve behavioral symptoms. The studies aim to establish clear guidelines for personalized treatments and may lead to stool tests guiding treatments for autism and its associated medical conditions.
Researchers found that artificial sweeteners can induce glucose intolerance by changing the composition and function of the gut microbiota. The study used mice and human data to show that certain bacteria in the gut react to artificial sweeteners, leading to inflammation and metabolic changes.
Researchers found that gut bacteria can sway food choices by releasing signaling molecules into the gut, influencing physiological and behavioral responses. The microbiome's diversity of interests can be manipulated through diet and supplement changes, offering a tractable approach to obesity and unhealthy eating.
A study tracking bacterial populations over a year found daily fluctuations in response to diet and other factors. The researchers also discovered that certain strains of bacteria, such as Faecalibacterium prausnitzii, can be protected against inflammatory bowel disease by eating citrus.
Researchers have established a comprehensive catalog of the human gut microbial genes, with over 9.8 million genes available for global researchers to explore. The study highlights differences in nutrient metabolism and xenobiotic detoxification between Chinese and Danish adults, as well as enrichment in antibiotic resistance genes.
The AGA Institute published a special issue on the intestinal microbiome, exploring its role in maintaining human health and developing certain diseases. The research focuses on basic concepts, gut microbiome and disease interactions, and modification of the microbiome to maintain health or treat disease.