Articles tagged with Human Gut Microbiota
A panel of international experts has drawn up guidelines to standardize the analysis and use of gut microbiota tests. The consensus paper aims to reduce the use of inappropriate tests and pave the way for evidence-based development of human microbiota diagnostics in medicine.
The ESMO Immuno-Oncology Congress 2024 will present key findings on new therapeutic opportunities and management of treatment-related toxicities. Leading experts will share their research advancements in the rapidly evolving field of immuno-oncology.
A new study found that changes in the gut environment influence the composition and activity of gut bacteria. The study involved swallowing a capsule with pH sensors through breakfast, revealing unique gut environments and travel times among individuals. This may help explain individual differences in digestion, nutrient uptake, and bo...
Dr Bøsch's work explores betalains' potential to impact blood pressure, diabetes, cardiovascular health, and gut microbiota. The award highlights the significance of her research in advancing functional food and feed applications with implications for human and animal health.
A new study has found that tamoxifen works better for some people due to their unique gut microbiota. Researchers discovered a specific enzyme, beta-glucuronidase, in certain bacteria that helps recycle the drug into its effective form. This finding may lead to tailored treatment interventions for breast cancer patients.
The study found that substituting pure maple syrup for refined sugars reduced several cardiometabolic risk factors in humans, including improved blood sugar levels and lowered blood pressure. Visceral fat mass also decreased significantly in the maple syrup group. The study's findings suggest that incorporating maple syrup into daily d...
Scientists at UMC Utrecht developed a new technology to isolate and study gut bacteria recognized by IgA antibodies, which are associated with various diseases. The next-generation IgA-SEQ method allows for high-throughput identification and analysis of these immunostimulatory bacteria, shedding light on their role in health and disease.
A new study maps the gut microbiome of over 1,300 children under five years old in Ethiopia, revealing a clear link between gut bacteria composition and the duration of diarrhea. The researchers identify beneficial bacteria that produce short-chain fatty acids, which are lacking in children with chronic diarrhea.
A new study developed a machine-learning model to predict microbial load, the density of microbes in our guts. The model revealed that many factors can influence microbial load, including lifestyle, diseases, and medications.
Research highlights the role of gut dysbiosis in pancreatic ductal adenocarcinoma (PDAC), with specific microbial profiles associated with PDAC. Fecal microbiota transplantation (FMT) is proposed as a potential adjunct therapy to improve patient outcomes through microbiome modulation and immune system recalibration.
A new study from the University of Copenhagen aims to replace fecal capsules with a standardized treatment using fermented feces. The method employs fermentation to cultivate beneficial microorganisms, producing a complex mixture of bacteria and bacteriophages that can fight gastrointestinal disorders.
A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms. The findings open the door for developing new microbial-based therapies to help individuals better manage stress-related mental health conditions.
New research from the University of Chicago shows that gut bacteria can acquire a gene that shuts down their own deadly weapon and activates a new one, allowing them to outcompete other bacteria. This transfer of genes enables the bacteria to carve out niches in the tightly packed recesses of the gut.
A study by FSU researchers has found a potential link between an infection caused by gut bacteria and the progression of Alzheimer's disease. The research suggests that antibiotic exposure can lead to issues not just in the gut but also in the brain, triggering neuroinflammation and neurocognitive impairment.
Researchers at USC found a link between per- and polyfluoroalkyl substances (PFAS) and kidney damage, which may be tied to dysregulation of the gut microbiome. The study, published in Science of the Total Environment, suggests that changes in gut bacteria and related metabolites can explain up to 50% of decreased kidney function.
Researchers at University College Cork found that wild birds' gut microbiome impacts their growth, weight, and survival. The study manipulated the birds' microbiome by feeding them beneficial bacteria Lactobacillus kimchicus.
Researchers found a significant difference in gut microbiome between patients with and without lumbar degenerative spondylolisthesis. The study suggests that gut bacteria may play a role in back pain and disability, potentially leading to new treatment options.
Research highlights the dynamic interplay between the gut microbiome and aging, with microbiota-dependent mechanisms regulating aging. Microbiome modulation through prebiotics, probiotics, and dietary interventions shows promise in promoting healthy aging.
The 'MiCCrobioTAckle' project investigates the complex interactions between the gut microbiome and tumor cachexia to find ways of slowing down muscle breakdown. Twelve doctoral researchers from twelve countries will work together across Europe, gaining new insights into the relationship between the gut microbiome and cancer cachexia.
Researchers identified T. immunophila as a key player in breaking down the gut's protective immune barrier, leading to increased susceptibility to pathogens and delayed repair of the gut barrier. The discovery provides a promising new avenue for treatment of inflammatory bowel disease, Crohn's, and ulcerative colitis.
Researchers discovered that certain bacteria display communal behaviors protecting sensitive species from drugs, allowing them to grow normally in a community. The study found that high drug concentrations cause microbiome communities to collapse and cross-protection strategies are replaced by cross-sensitisation.
Blanca Barquera's research aims to improve understanding of the energy metabolism of Bacteroides, a crucial step towards designing effective probiotic formulations. The study will investigate how Bacteroides utilize carbohydrates and Vitamin K from host diets.
Researchers found that microbial communities in mice influence immune cell populations, with adaptive cells more prominent in lower intestine and innate cells in upper segments. A tool has been created for studying interactions between gut microbes and inflammatory diseases.
Repeated antibiotic use can cause defects in the gut's protective mucus barrier, even months after treatment. This is due to changes in the microbiota or direct effects of antibiotics on the mucus layer. The findings suggest that antibiotics should be used responsibly to prevent long-lasting damage.
Jakob Zimmermann is receiving a total of 1.6 million euros from the European Research Council (ERC) to study T-cell immune memory in the intestine and its connection with intestinal flora, aiming to develop new treatments for chronic inflammatory bowel diseases and vaccines.
Researchers have discovered a new class of natural antimicrobials called microcins that can target specific strains of bacteria causing cholera, inflammatory bowel disease, and colon cancer. Microcins are highly selective and can potentially remove unwanted bacteria without disrupting the human gut microbiome.
A new study has found a natural probiotic in the microbiomes of UK newborns, which could be used to develop personalized infant therapeutic probiotics. The researchers analyzed stool samples from 1,288 healthy infants and found that one of the pioneer bacteria was genetically adapted to utilize breast milk nutrients and block pathogens.
A Mayo Clinic team developed a computational tool that analyzes the gut microbiome with at least 80% accuracy. The Gut Microbiome Wellness Index 2 identifies subtle changes in gut health, enabling proactive health indicators and potential prevention of chronic diseases.
Researchers have developed a comprehensive database of the 'food microbiome' by sequencing metagenomes from 2,533 foods, identifying 10,899 food-associated microbes. The study shows that these microbes can influence human health and provide insights into how to improve food quality, safety, and authenticity.
A McGill-led study found significant shifts in certain gut bacteria corresponding to changes in liver and intestinal genes, suggesting spaceflight may suppress the immune system and alter metabolism. The research could help ensure the success of future space missions and medical advancements on Earth.
A study in mice found that the bacteria Bifidobacterium breve supports healthy brain development in fetuses, improving nutrient transport and cell processes. This discovery suggests using probiotics during pregnancy may support fetal brain health and future treatments for growth restriction could focus on maternal gut health.
Scientists have developed a new technique called Boba-seq to study gene function in microbes, allowing for rapid identification of gene traits and properties. The approach enables the analysis of hundreds of thousands of genetic variants simultaneously, providing insights into microbial genomes.
A study in mice found that early life exposure to persistent organic pollutants, such as TCDF, disrupts the gut microbiome and leads to metabolic disorders. The altered microbiome is associated with changes in bacterial species, including Akkermansia muciniphila, which plays a crucial role in overall gut health.
The 19th International Symposium on Microbial Ecology will convene in Cape Town, bringing together over 1,500 scientists from 50 countries. The event aims to understand the relationship between microorganisms and their environment.
New studies from the University of Illinois found that adding honey to yogurt supports the survival of probiotic bacteria in the gut. The research suggests that pairing honey with yogurt is a delicious and healthy way to support digestive health and gut microbiome, with potential benefits for mood and cognition.
Researchers found that Megamonas degrades intestinal myo-inositol, enhances lipid absorption, and contributes to obesity. The study suggests potential strategies for future obesity management by illustrating the bacterium's mechanism.
Researchers analyzed fecal samples from fat cats undergoing different dietary changes and found striking similarities to human studies, particularly in the presence of short-chain fatty acids. The study suggests that feline gut microbiome shifts may correlate with metabolic outcomes and provide valuable insights for obesity treatment.
Researchers have identified a phage-derived enzyme that targets E. faecalis biofilms, reducing the severity of acute graft-versus-host disease in patients. The enzyme exhibits narrow-spectrum activity against E. faecalis and effectively lyses biofilms without affecting other bacteria.
The team created stable microbial therapeutics using synthetic extremophiles, maintaining potency and function over time despite extreme temperatures and harsh manufacturing processes. These formulations have potential applications in healthcare, agriculture, and space exploration.
A large-scale study of over 50,000 individuals found that carriers of the gut microbe Blastocystis have better cardiovascular health and decreased body fat. Higher levels of Blastocystis were linked to improved blood sugar and lipid profiles, suggesting a potential positive impact on cardiometabolic health.
Researchers have identified a novel type of T cell that can recognize and respond to multiple bacterial strains in the gut. This breakthrough finding has significant implications for treating diseases such as cancer and inflammatory bowel disease. The discovery was made by Kazuki Nagashima, winner of the NOSTER & Science Microbiome Prize.
A new study published in Nature Metabolism found that daily fluctuations in the gut microbiome alter its composition significantly throughout the day. The researchers propose standardized guidelines for consistency in sample collection times and methodology to address the replicability crisis in microbiome research.
A study published in Gut reveals that specific bacteria in the gut are involved in compulsive eating and obesity, with a beneficial bacterium called Blautia showing protective effects. The research also highlights the role of microRNAs in food addiction and suggests potential new treatments involving beneficial bacteria and dietary sup...
A large-scale study has found a consistent set of microbial species linked to type 2 diabetes across diverse populations. The researchers discovered that certain strains of bacteria have varied functions, including the ability to produce branched-chain amino acids, which may increase T2D risk.
Researchers developed a novel approach to simulate personalized, microbiome-mediated responses to diet using microbial community-scale metabolic modeling. The method predicts individual-specific short-chain fatty acid (SCFA) production rates in response to different dietary, prebiotic, and probiotic inputs.
A study of over 10,000 people found that those with fewer butyrate-producing bacteria in their gut were more likely to develop serious infections. The research suggests a strong link between the microbiome and the immune system, opening up new possibilities for preventing serious infections.
A team of scientists discovered a mutually beneficial relationship between A. caccae, a microbe, and lactulose, a prebiotic, which increased butyrate levels in the intestinal tracts of mice and stifled allergic responses to cow's milk. The production of butyrate has huge effects on gut health.
A new study reveals patterns in disease-associated gut microbiomes that could inform new cost-effective treatments based on diet, lifestyle, and environmental microbiome exposures. The research also found a new approach to describing and measuring the health of gut and soil microbiomes.
Researchers discovered that Klebsiella oxytoca bacteria compete with salmonella for nutrients, employing multiple strategies to combat the spread of the infection. The bacteria also produce a toxin that has anti-salmonella effects, which may be harnessed to develop new treatments.
Researchers found that aged mouse gut microbes increase inflammation in young mice, suggesting a link between microbiome changes and aging-induced inflammatory processes.
A global research team identified 863,498 promising antimicrobial peptides in marine and soil environments, as well as human and animal guts, to combat antimicrobial resistance. The findings come with a renewed focus on combatting the growing number of superbugs resistant to current drugs.
A molecule produced by gut bacteria, indole-3-propionic acid (IPA), has been found to reduce viral load and inflammation in mice infected with influenza virus. Researchers at the State University of Campinas and Pasteur Institute discovered that supplementing IPA supplementation reduced symptoms and improved outcomes.
A new study highlights the benefits of intermittent fasting and protein-pacing on gut health, weight loss, and metabolic responses. Participants showed improved diversity of the gut microbiota, decreased symptoms of gastrointestinal problems, and increased beneficial microbes linked to a lean body type.
Researchers from the University of South Australia have developed a new coating that targets the gut microbiome to improve antipsychotic medication absorption, mitigating unwanted weight gain. The reformulated Lurasidone reduces weight gain by 8-fold and boosts serotonin levels by over 250%.
A study found that individuals taking probiotic supplements showed increased sensitivity to fairness and a greater inclination to reject unequal offers. This was accompanied by changes in gut microbiota composition and levels of dopamine precursors. The findings suggest a potential causal mechanism linking gut bacteria to social behavior.
Taking pro- and prebiotics affects levels of altruistic punishment in ultimatum game players. Participants who took supplements were more likely to reject unfair offers, with those having a high Firmicutes-to-Bacteroidetes ratio seeing the greatest changes.
Researchers created a new model to study the effects of undernutrition on the microbiome, which can help identify specific microbes that impact development. The model mimics early childhood experiences and shows promise in understanding the underlying causes of stunted growth and other harmful effects of undernutrition.
Researchers at Brigham and Women's Hospital found an association between appendix removal and a decreased risk of colorectal cancer positive for the bacterium Fusobacterium nucleatum. The study involved large prospective cohort studies and analyzed data from over 139,000 participants.
Researchers at the University of Trento have identified a collection of molecular tools to rewrite DNA, including a compact Cas9 enzyme from the human microbiome. The discovery has potential for gene therapy applications and could speed up the development of therapies for genetic diseases.
Researchers found that altering a male mouse's gut microbiota increases the probability of low birth weight and premature death in their offspring. The study suggests a 'gut-germline axis' exists, connecting the gut microbiota to the germline and potentially influencing inherited traits.