Articles tagged with Human Gut Microbiota
Research reveals that a healthy gut microbiome can play a role in the acquisition and severity of HIV and EBV infections. The study found that animals colonized with resident microbiota had higher rates of HIV infection and increased viral loads, suggesting that altering the gut microbiota could be a potential therapeutic approach to c...
A small pilot study found associations between specific microbe species and infants' performance in tests of social attention and rhythmic processing. The researchers observed higher levels of Actinobacteria and Bifidobacterium microbes in infants with better cognitive abilities.
Researchers discovered that PYY prevents the fungus Candida albicans from turning into its more dangerous form while allowing commensal yeast forms to flourish. This peptide functions as an antimicrobial agent, playing a vital role in maintaining fungal commensalism in the gut.
Research reveals high transmission rate of E. coli cells between cohabiting hosts, leading to similar evolutionary events and microbiome species composition. Social interactions play a crucial role in shaping adaptive evolution of new gut bacteria strains.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
Researchers found that taking probiotic Lactobacillus rhamnosus GG improved cognitive scores in participants with mild cognitive impairment, suggesting a potential strategy to support cognitive health. Gut microbiome composition could serve as an early indicator for mild cognitive impairment.
Research shows that a diet rich in soluble fiber like inulin can renew intestinal epithelial cells and improve intestinal health. The study found that gut microbiota plays a key role in this process.
Researchers have found that caecilians, an elusive type of amphibian, transfer microbes from their skin and gut to their young during skin-feeding. This unique method of parental care provides nutrients and helps establish a healthy microbiome in juvenile caecilians.
A new $7 million grant will support research into the mechanisms that exacerbate inflammatory disease. The study aims to understand how environmental chemicals affect the gut microbiome, a key factor in chronic diseases like obesity and type 2 diabetes.
Research found that mothers' childhood experiences and pregnancy anxiety are reflected in their 2-year-old children's gut microbiomes, with smaller populations of microorganisms and reduced genetic diversity. These changes may influence children's socioemotional development and brain-gut microbiome connection.
Researchers found that a diet high in soybean oil decreases beneficial bacteria and increases harmful bacteria, leading to increased inflammation and susceptibility to colitis. Olive oil, with lower amounts of linoleic acid, is considered a healthier alternative.
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
A recent study published in Nature Neuroscience clarifies the connection between autism and the microbiome, identifying autism-specific metabolic pathways associated with particular human gut microbes. The analysis, which harmonized dozens of previously published datasets, reveals a common microbial signature distinguishing autistic fr...
A new study found that consuming grapes can alter the gut microbiome, leading to potential health benefits. The research analyzed changes in bacteria detection, enzyme levels, and biological pathways, revealing unique patterns of microbe distribution in a subgroup of subjects.
Researchers discovered that certain bacterial species, including lactic acid bacteria, correlate with high levels of Candida yeasts in the gut microbiome. This suggests a complex interaction between these microorganisms, where lactic acid bacteria may favor Candida proliferation while making the fungus less virulent.
A UNLV study found a significant correlation between 10 specific types of gut bacteria and the likelihood of developing Alzheimer's disease, with certain bacteria identified as protective or risk factors. The findings suggest that an imbalance of gut microbiota may play a role in the disorder's development.
Two review articles explore the effectiveness of fecal microbiota transplants (FMTs) in treating recurrent infections with C. difficile and chronic noncommunicable diseases like ulcerative colitis and metabolic syndrome. While FMTs have shown promise, researchers agree that more research is needed to understand factors such as patient ...
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
A new study from the University of Illinois found that following the Dietary Guidelines for Americans promotes a diverse gut microbiota composition. The researchers analyzed data from the American Gut Project and discovered that individuals with higher diet quality had a greater abundance of beneficial bacteria involved in fiber metabo...
Consuming insects like crickets can contribute to healthy gut microbiota and provide essential nutrients. Research by CSU professor Tiffany Weir and colleagues highlights the potential benefits of edible insects on human health, including increased prebiotic effects and reduced intestinal inflammation.
Researchers have found that fermented sugar-based products and fermented vegetable-based products show promise in improving gut and brain health. Preliminary results suggest these foods contain beneficial metabolites that can positively impact mental health.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
A study published in the journal Cancer found that long-term pancreatic cancer survivors have a robust immune response and enriched gut microbiome species, including Faecalibacterium prausnitzii. The research suggests that these bacterial species may promote immune response to pancreas cancer.
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
A new study found that antibiotic treatment and certain types of microorganisms in the gut can impact CAR T-cell therapy outcomes. Patients with higher levels of Bifidobacterium longum had improved overall survival rates, while those with other bacteria were associated with poorer responses.
Researchers found that long-term antibiotic use during adolescence disrupts the healthy gut microbiome, leading to changes in liver metabolism that promotes central fat accumulation. The study suggests that antibiotic treatment may have lasting detrimental effects on liver metabolism and promote adiposity.
Researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by altering existing bile acids and creating a new class of bile acids within the gut's microbial environment. Selecting the right suite of BSH-producing bacteria is critical, as inter...
Researchers found that a healthy gut microbiome can predict the efficacy of CAR-T cell therapy in patients with B-cell lymphomas. The study identified specific microbiome features associated with improved treatment outcomes, but highlights the need for further investigation into the causal nature of this relationship.
The study reveals that more than 70% of patients developed urinary tract infections caused by endogenous E. coli strains from their own gut microbiota. The researchers also found that non-lactose-fermenting E. coli strains, less common in other countries, were present in the gut microbiota of some patients.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers identified two Blastocystis strains, ST4 and ST7, with contrasting effects on the gut microbiome, promoting or disrupting a healthy balance. The study's findings suggest that geographical prevalence may influence the strain's impact on intestinal disease.
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
A study found that youth binge drinkers show alterations in the gut microbiome, associated with poor ability to recognize emotions and increased craving. The research suggests that the gut microbiome regulates social and emotional cognition, supporting the development of novel dietary or pre/probiotic interventions.
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
Researchers at Baylor College of Medicine discovered that an altered gut microbiome drives endometriosis disease progression in an animal model. The study found that mice lacking a gut microbiome had smaller endometriotic lesions, and treatment with certain metabolites significantly enhanced cellular proliferation and lesion growth.
A study led by Robert Dickson found that the gut microbiome plays a crucial role in regulating body temperature, both in health and during sepsis. The researchers discovered that certain bacteria from the Firmicutes phylum were strongly associated with increased fever response.
Researchers identified a new type of flagellin in the human gut that binds to Toll-like receptor 5 without inducing an inflammatory response. This discovery provides a mechanism for the immune system to tolerate beneficial microbes while remaining responsive to pathogens.
Researchers have isolated two new bacterial species from patients with inflammatory bowel disease (IBD), which break down the protective mucus layer of the gut. The bacteria, Allobaculum mucilyticum and Allobaculum fili, are highly efficient at degrading intestinal mucus, leading to potent immune responses.
Researchers discovered a new mode of vertical mother-to-infant microbiome transmission, where microbes shared genes with each other. The study found links between gut metabolites, bacteria, and breastmilk substrates, influencing infant development before and after birth.
New research reveals that healthy newborn babies' gut bacteria do not contain multi-drug resistant strains of common hospital pathogens. The study found multiple synergistic relationships between different bacteria, which could potentially be harnessed to outcompete resistant or harmful bacterial strains.
A recent human study published in Antioxidants found that consuming grapes protected against ultraviolet (UV) damage to the skin. The study showed increased resistance to sunburn and unique microbiomic and metabolomic profiles in subjects who consumed whole grape powder, suggesting a correlation between the gut and skin.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
A systematic review of 29 studies found that combining probiotics with antibiotics can prevent or lessen some changes to the gut microbiome composition. Probiotics can also help protect species diversity and restore friendly bacteria populations, such as Faecalibacterium prausnitzii.
Research finds that increased body weight is associated with higher levels of inflammation, signs of gut permeability, and poorer asthma control. The study suggests that targeting the gut could be an effective treatment target for improving asthma control in patients with obesity. Weight loss may also improve symptoms for these patients.
Research found babies born naturally have higher antibody levels after vaccination compared to those born via C-section. Breastfeeding also boosts antibody levels, with formula-fed children having 3.5 times lower levels.
A new study on rhesus macaques reveals a strong link between social connections and the abundance of beneficial gut bacteria. Monkeys with more sociable behavior have a higher presence of microbes like Faecalibacterium, which has anti-inflammatory properties.
ISB researchers found that the gut microbiome is responsible for variation in circulating blood metabolites across people. The study examined 930 blood metabolites and found that over 60% were associated with either host genetics or the gut microbiome.
The study highlights the importance of the gut microbiome in metabolic conditions like obesity and neurological diseases such as Parkinson's. Pesticide exposure is also found to disrupt the gut microbiota, leading to brain-gut alterations that can exacerbate these conditions.
Research suggests that antibiotics used in ovarian cancer treatment can accelerate cancer progression and lower survival rates. Reintroducing healthy gut bacteria may slow down cancer growth and restore sensitivity to chemotherapy.
The 13th International Conference on Skin Ageing & Challenges will be held in Lisbon, Portugal, with over 61 communications and innovations presented. Key findings include the impact of olfactory receptors on microbiota & wound healing, as well as recent artificial intelligence developments for skin cancer detection.
The researchers designed a chemical system inspired by soil that can respond to external stimuli and modulate gut microbiota abundance and dysregulated microbes. This system shows promise for treating gastrointestinal disorders and may have implications for human health and agro-ecosystems.
Researchers at King's College London found that eating almonds increases butyrate production, promoting gut health and potentially alleviating constipation. The study also showed improved nutrient intake and a positive impact on the gut microbiome.
A new study suggests that lifestyle choices can help prevent severe COVID-19 by reducing chronic inflammation and regulating the immune system. By adopting healthy habits such as regular exercise, balanced diet, and stress management, individuals can lower their risk of developing severe disease and mitigate post-infection symptoms.
Tagbo Niepa's research aims to capture and store a person's healthy gut microbiome, then restore balance when ill. The technology has the potential to revolutionize illness treatment, especially for diseases like C. diff infection.
A recent study published in Nature Communications has found a strong connection between the gut microbiome and certain blood metabolites. The research, led by Uppsala University, analyzed fecal and blood samples from over 8,500 participants in the SCAPIS study, identifying novel associations between gut bacteria and plasma metabolite s...
New research reveals that human gut bacteria use plant N-glycans as nutrients, enabling better management of good gut health. The discovery has biotechnological applications, such as reducing allergenic responses to food and medicine.
Researchers found that over 60% of investigated microbial species matched their human host's evolutionary history, indicating a co-evolutionary relationship spanning ~100,000 years. This discovery fundamentally changes how the human gut microbiome is viewed and opens up new possibilities for population-specific therapies.