Articles tagged with Human Gut Microbiota
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Researchers have found that fermented sugar-based products and fermented vegetable-based products show promise in improving gut and brain health. Preliminary results suggest these foods contain beneficial metabolites that can positively impact mental health.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
A study published in the journal Cancer found that long-term pancreatic cancer survivors have a robust immune response and enriched gut microbiome species, including Faecalibacterium prausnitzii. The research suggests that these bacterial species may promote immune response to pancreas cancer.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
Researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by altering existing bile acids and creating a new class of bile acids within the gut's microbial environment. Selecting the right suite of BSH-producing bacteria is critical, as inter...
Researchers found that a healthy gut microbiome can predict the efficacy of CAR-T cell therapy in patients with B-cell lymphomas. The study identified specific microbiome features associated with improved treatment outcomes, but highlights the need for further investigation into the causal nature of this relationship.
The study reveals that more than 70% of patients developed urinary tract infections caused by endogenous E. coli strains from their own gut microbiota. The researchers also found that non-lactose-fermenting E. coli strains, less common in other countries, were present in the gut microbiota of some patients.
A new study found that antibiotic treatment and certain types of microorganisms in the gut can impact CAR T-cell therapy outcomes. Patients with higher levels of Bifidobacterium longum had improved overall survival rates, while those with other bacteria were associated with poorer responses.
Researchers found that long-term antibiotic use during adolescence disrupts the healthy gut microbiome, leading to changes in liver metabolism that promotes central fat accumulation. The study suggests that antibiotic treatment may have lasting detrimental effects on liver metabolism and promote adiposity.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers identified two Blastocystis strains, ST4 and ST7, with contrasting effects on the gut microbiome, promoting or disrupting a healthy balance. The study's findings suggest that geographical prevalence may influence the strain's impact on intestinal disease.
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
A study found that youth binge drinkers show alterations in the gut microbiome, associated with poor ability to recognize emotions and increased craving. The research suggests that the gut microbiome regulates social and emotional cognition, supporting the development of novel dietary or pre/probiotic interventions.
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
Researchers at Baylor College of Medicine discovered that an altered gut microbiome drives endometriosis disease progression in an animal model. The study found that mice lacking a gut microbiome had smaller endometriotic lesions, and treatment with certain metabolites significantly enhanced cellular proliferation and lesion growth.
A study led by Robert Dickson found that the gut microbiome plays a crucial role in regulating body temperature, both in health and during sepsis. The researchers discovered that certain bacteria from the Firmicutes phylum were strongly associated with increased fever response.
Researchers identified a new type of flagellin in the human gut that binds to Toll-like receptor 5 without inducing an inflammatory response. This discovery provides a mechanism for the immune system to tolerate beneficial microbes while remaining responsive to pathogens.
Researchers have isolated two new bacterial species from patients with inflammatory bowel disease (IBD), which break down the protective mucus layer of the gut. The bacteria, Allobaculum mucilyticum and Allobaculum fili, are highly efficient at degrading intestinal mucus, leading to potent immune responses.
Researchers discovered a new mode of vertical mother-to-infant microbiome transmission, where microbes shared genes with each other. The study found links between gut metabolites, bacteria, and breastmilk substrates, influencing infant development before and after birth.
New research reveals that healthy newborn babies' gut bacteria do not contain multi-drug resistant strains of common hospital pathogens. The study found multiple synergistic relationships between different bacteria, which could potentially be harnessed to outcompete resistant or harmful bacterial strains.
A recent human study published in Antioxidants found that consuming grapes protected against ultraviolet (UV) damage to the skin. The study showed increased resistance to sunburn and unique microbiomic and metabolomic profiles in subjects who consumed whole grape powder, suggesting a correlation between the gut and skin.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
A systematic review of 29 studies found that combining probiotics with antibiotics can prevent or lessen some changes to the gut microbiome composition. Probiotics can also help protect species diversity and restore friendly bacteria populations, such as Faecalibacterium prausnitzii.
Research found babies born naturally have higher antibody levels after vaccination compared to those born via C-section. Breastfeeding also boosts antibody levels, with formula-fed children having 3.5 times lower levels.
Research finds that increased body weight is associated with higher levels of inflammation, signs of gut permeability, and poorer asthma control. The study suggests that targeting the gut could be an effective treatment target for improving asthma control in patients with obesity. Weight loss may also improve symptoms for these patients.
A new study on rhesus macaques reveals a strong link between social connections and the abundance of beneficial gut bacteria. Monkeys with more sociable behavior have a higher presence of microbes like Faecalibacterium, which has anti-inflammatory properties.
ISB researchers found that the gut microbiome is responsible for variation in circulating blood metabolites across people. The study examined 930 blood metabolites and found that over 60% were associated with either host genetics or the gut microbiome.
The study highlights the importance of the gut microbiome in metabolic conditions like obesity and neurological diseases such as Parkinson's. Pesticide exposure is also found to disrupt the gut microbiota, leading to brain-gut alterations that can exacerbate these conditions.
Research suggests that antibiotics used in ovarian cancer treatment can accelerate cancer progression and lower survival rates. Reintroducing healthy gut bacteria may slow down cancer growth and restore sensitivity to chemotherapy.
The 13th International Conference on Skin Ageing & Challenges will be held in Lisbon, Portugal, with over 61 communications and innovations presented. Key findings include the impact of olfactory receptors on microbiota & wound healing, as well as recent artificial intelligence developments for skin cancer detection.
The researchers designed a chemical system inspired by soil that can respond to external stimuli and modulate gut microbiota abundance and dysregulated microbes. This system shows promise for treating gastrointestinal disorders and may have implications for human health and agro-ecosystems.
Researchers at King's College London found that eating almonds increases butyrate production, promoting gut health and potentially alleviating constipation. The study also showed improved nutrient intake and a positive impact on the gut microbiome.
A new study suggests that lifestyle choices can help prevent severe COVID-19 by reducing chronic inflammation and regulating the immune system. By adopting healthy habits such as regular exercise, balanced diet, and stress management, individuals can lower their risk of developing severe disease and mitigate post-infection symptoms.
Tagbo Niepa's research aims to capture and store a person's healthy gut microbiome, then restore balance when ill. The technology has the potential to revolutionize illness treatment, especially for diseases like C. diff infection.
A recent study published in Nature Communications has found a strong connection between the gut microbiome and certain blood metabolites. The research, led by Uppsala University, analyzed fecal and blood samples from over 8,500 participants in the SCAPIS study, identifying novel associations between gut bacteria and plasma metabolite s...
New research reveals that human gut bacteria use plant N-glycans as nutrients, enabling better management of good gut health. The discovery has biotechnological applications, such as reducing allergenic responses to food and medicine.
Researchers found that over 60% of investigated microbial species matched their human host's evolutionary history, indicating a co-evolutionary relationship spanning ~100,000 years. This discovery fundamentally changes how the human gut microbiome is viewed and opens up new possibilities for population-specific therapies.
A team of EMBL researchers used data from over 300 human faecal microbiota transplants to investigate the ecological understanding of what happens when two gut microbiomes clash together. The study found that species richness and how different a recipient's gut microbiome is from a donor's are key factors in determining which microorga...
A large-scale international study has identified dozens of gut bacteria associated with multiple sclerosis, revealing potential new mechanisms for disease development and treatment response. The study also found geographical location and participant's disease status as significant factors influencing gut microbiome variations.
Researchers are exploring ways to target and manipulate the human microbiome, with potential applications in treating diseases such as depression, obesity, and retinal disorders. The conference will feature presentations on innovative strategies and recent findings in modulating microbiota and microbial components.
A study on wild geladas reveals maternal effects on the gut microbiome both before and after weaning, influencing infant development and health. The research found that infants of first-time moms had slower gut microbiota development, potentially leading to a developmental disadvantage.
Researchers genetically mapped one of the oldest human parasites, the whipworm, using stool samples from Viking latrines. The study reveals a delicate relationship between humans and the parasite, which can make us healthier or ill, and provides new knowledge on its development and prehistoric dispersal.
Biomedical engineers at Duke University found that high levels of horizontal gene transfer help keep microbiomes stable and efficient, allowing for the creation of bespoke systems for environmental cleanup and biofuel production. The study suggests a dynamic division of labor among microorganisms enables robustness and flexibility.
Researchers found that genetic makeup of mice affects bacteria in their gut, with heritable species and co-evolution observed. The study's findings could provide new insights into treating human gut-related conditions like Inflammatory Bowel Disease (IBD).
Researchers at Cedars-Sinai Medical Center have developed a new method to identify which human gut microbes contribute to inflammatory diseases. By analyzing protein levels in blood serum, the team discovered specific bacteria that trigger immune activation and inflammation.
Research led by Drs. Yuhai Zhao and Walter J Lukiw reports a pathway from the gut to the brain that contributes to Alzheimer's disease development. Adequate dietary fiber intake can prevent this process. The study suggests a potential means to modify the abundance of microbes in the microbiome.
Researchers have developed a novel approach to engineering live bacterial therapeutics by using native microbes that can survive in the gut. This method overcomes previous limitations of introducing engineered bacteria into the gut, demonstrating potential for long-term therapy and reversal of disease pathologies in mouse models.
Researchers successfully engineered E. coli collected from human and mice gut microbiomes, showing potential to treat diseases such as diabetes. The engineered bacteria retain their activity for the entire lifetime of the host and positively influence diabetes progression in mice.
Researchers have designed a phage combination therapy that precisely targets and suppresses gut bacteria associated with inflammatory bowel diseases (IBD). The team identified effective phages against IBD-contributing Kp strains, which attenuated inflammation and tissue damage in mice models.
Researchers from NUS Medicine developed a probiotic that detects antibiotic-induced microbiome imbalance and regulates bile salt metabolism to prevent Clostridioides difficile infection. The probiotic significantly reduced CDI in laboratory models, demonstrating a 100% survival rate and improved clinical outcomes.
A new study found that higher red meat consumption is linked to a 22% increased risk of cardiovascular disease in older adults, with gut bacterial metabolites like TMAO playing a key role. The study also suggests that traditional ASCVD risk pathways like blood cholesterol and blood pressure may be less important than previously thought.
A new study from Duke University suggests that consuming more fiber can lead to improved gut health, regardless of the specific supplement used. Participants who had been eating the least amount of fiber before the study showed the greatest benefit from supplements.
A new study at the University of Missouri found that prenatal opioid exposure can trigger long-term neurological or behavioral effects in children. The research suggests that opioids impact the developing fetus' gut microbiome, leading to changes in metabolic pathways and potentially affecting overall health and wellness.
The team is creating a virtual gut system to test chemical reactions and networks, which will help identify the best treatments for obesity. The MATOMIC project aims to develop mathematical models that can simulate the intestinal microbiome at an atomic level.
The ISM Annual Meeting highlights new topics in oral, vaginal, skin, and gut microbiota, as well as their metabolites and potential implications in diseases like cancer, depression, and stroke. The meeting aims to explore the mechanism behind microbiota efficacy and its potential application in precision medicine.
Researchers discovered cancer cells produce a unique collagen that alters the tumor microbiome and promotes cancer progression. Loss of this collagen reduces cancer cell proliferation and boosts anti-tumor immune response, offering a potential therapeutic strategy.
A preclinical study found that antibiotics have sex-specific effects on the gut microbiome of lab rats, resulting in significant changes in diversity. The findings could have implications for using antibiotics to treat or prevent bacterial infections in humans.
A new study uses machine learning models to predict cancer patients' responses to immunotherapy based on their gut microbiome features. The research identifies common gut bacterial taxa associated with responders versus non-responders, providing a potential tool for distinguishing and predicting immunotherapy responders.