Articles tagged with Human Gut Microbiota
A diverse gut microbiome is linked to better health, and a new study reveals how to determine which species are important and interact to create a healthy balance. The findings have significant implications for conditions like Inflammatory Bowel Disease, infections, autoimmune diseases, and cancers.
Researchers identified a gut-lung axis driven by intestinal antimicrobial peptide expression and mediated by the intestinal microbiota that influences hyperoxia-induced lung injury. Supplemental lysozyme reduced lung injury in neonatal mice, suggesting a potential therapeutic target.
Researchers found associations between PTSD and dietary patterns, specifically a Mediterranean diet rich in plant-based foods and fish. The study identified Eubacterium eligens as a protective species that may help alleviate PTSD symptoms.
A large-scale prospective study identified significant variations in the gut microbiome of individuals who developed pre-cancerous colonic lesions. These findings suggest that the microbiome could act as a valuable tool to improve existing tests, advancing early detection methods for colorectal cancer.
A recent study by the University of Alabama at Birmingham has identified 19 specific Bacteroides vulgatus genes that are linked to early colonization after fecal microbe transplants. These genes are part of a commensal colonization factor complex that promotes stable and resilient colonization in mice, suggesting their potential role i...
Research suggests that the gut microbiome plays a crucial role in forming a healthy placenta during pregnancy. Mice with depleted gut microbiomes had smaller placentas and less-developed blood vessels, which can deprive fetuses of nutrients. However, supplementing these mice with short-chain fatty acids restored placental growth.
Researchers have identified viral components of the skin's microbiome that drive the development of innovative therapies for atopic dermatitis. Bacteriophages, or 'bacteria eaters', were found to help certain bacteria grow faster in AD patients, contributing to the overpopulation of the skin microbiome.
A NUS study found that Blastocystis ST7 produces indole-3-acetyldehyde, which binds to immune cells, reducing gut tolerance and causing inflammation. Probiotic bacteria like lactobacillus may help negate its effects.
A new framework aims to ensure Indigenous communities reap benefits from their microbiome samples, promoting equitable and beneficial research. Researchers highlight the need for community ownership of microbiomes, collaboration, and respect for Indigenous sovereignty.
Researchers found that training the gut's immune system to target flagellin, a protein enabling bacterial motility, protects against emulsifier-induced chronic intestinal inflammation and metabolic dysregulation. This study suggests a potential new approach for preventing inflammatory conditions such as obesity and type 2 diabetes.
A study found that specific proteins in breast milk correlate with the abundance of certain gut microbes in infants, potentially playing a role in early immune and metabolic development. The research suggests a regulatory function of these proteins on the immune function of the gut microbiome in humans.
Babies with more mature gut microbiota at one year old are less likely to develop allergy-related wheeze or asthma. The study, which followed 1074 babies from birth to four years old, found that increased maturity of the gut microbiota was associated with a lower risk of these conditions.
Researchers have developed a human milk-based synbiotic that safely modulates damaged adult gut microbiomes. The study found that this symbiotic reshapes gut microbial composition and metabolites, offering new possibilities for treating dysbiotic conditions.
Research finds that infants born during the pandemic have fewer types of bacteria in their gut compared to those born earlier. The study suggests that social changes caused by the pandemic may have influenced this change, with potential implications for infant health.
Researchers at Prolacta and MD Anderson Cancer Center found a human milk-based synbiotic to safely control the gut microbiome in adults, opening the door to precision microbiome engineering. The study demonstrates significant precision in modulating adult gut microbiomes.
A new study found that antibiotics promote the growth of antibiotic-resistant bacteria in the gut by providing extra nutrients, allowing these 'bad' bacteria to multiply. The research suggests that targeting beneficial bacteria can help restrict the growth of resistant bacteria, paving the way for microbiome therapeutics treatments.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers found a common bacterial signature associated with the development of eczema, asthma, food allergy, and hay fever in children. The study suggests that early life influences on gut microbiota may play a key role in the development of these allergies.
Researchers found that the incidence of gut-colonizing ciprofloxacin-resistant E. coli increased in Seattle-area women over age 50, affecting about 1 in 5 women. The study suggests prioritizing strategies to control drug-resistant E. coli's ability to colonize the gut.
A new study from the University of Nottingham models how antibiotic resistance genes build up in gut bacteria through lifetime exposure to food intake and antibiotic treatment. The research suggests that reducing exposure to resistance genes is particularly effective during periods of antibiotic treatment, and that dietary advice shoul...
A study published in Blood journal found that children with diverse gut microbiota before stem cell transplant had significantly better overall patient survival and fewer complications. Higher microbiota diversity was also associated with lower risk of acute graft-versus-host disease.
Research reveals that a healthy gut microbiome can play a role in the acquisition and severity of HIV and EBV infections. The study found that animals colonized with resident microbiota had higher rates of HIV infection and increased viral loads, suggesting that altering the gut microbiota could be a potential therapeutic approach to c...
A small pilot study found associations between specific microbe species and infants' performance in tests of social attention and rhythmic processing. The researchers observed higher levels of Actinobacteria and Bifidobacterium microbes in infants with better cognitive abilities.
Researchers discovered that PYY prevents the fungus Candida albicans from turning into its more dangerous form while allowing commensal yeast forms to flourish. This peptide functions as an antimicrobial agent, playing a vital role in maintaining fungal commensalism in the gut.
Research reveals high transmission rate of E. coli cells between cohabiting hosts, leading to similar evolutionary events and microbiome species composition. Social interactions play a crucial role in shaping adaptive evolution of new gut bacteria strains.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
Researchers found that taking probiotic Lactobacillus rhamnosus GG improved cognitive scores in participants with mild cognitive impairment, suggesting a potential strategy to support cognitive health. Gut microbiome composition could serve as an early indicator for mild cognitive impairment.
Research shows that a diet rich in soluble fiber like inulin can renew intestinal epithelial cells and improve intestinal health. The study found that gut microbiota plays a key role in this process.
Researchers have found that caecilians, an elusive type of amphibian, transfer microbes from their skin and gut to their young during skin-feeding. This unique method of parental care provides nutrients and helps establish a healthy microbiome in juvenile caecilians.
A new $7 million grant will support research into the mechanisms that exacerbate inflammatory disease. The study aims to understand how environmental chemicals affect the gut microbiome, a key factor in chronic diseases like obesity and type 2 diabetes.
Research found that mothers' childhood experiences and pregnancy anxiety are reflected in their 2-year-old children's gut microbiomes, with smaller populations of microorganisms and reduced genetic diversity. These changes may influence children's socioemotional development and brain-gut microbiome connection.
Researchers found that a diet high in soybean oil decreases beneficial bacteria and increases harmful bacteria, leading to increased inflammation and susceptibility to colitis. Olive oil, with lower amounts of linoleic acid, is considered a healthier alternative.
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
A recent study published in Nature Neuroscience clarifies the connection between autism and the microbiome, identifying autism-specific metabolic pathways associated with particular human gut microbes. The analysis, which harmonized dozens of previously published datasets, reveals a common microbial signature distinguishing autistic fr...
A new study found that consuming grapes can alter the gut microbiome, leading to potential health benefits. The research analyzed changes in bacteria detection, enzyme levels, and biological pathways, revealing unique patterns of microbe distribution in a subgroup of subjects.
Researchers discovered that certain bacterial species, including lactic acid bacteria, correlate with high levels of Candida yeasts in the gut microbiome. This suggests a complex interaction between these microorganisms, where lactic acid bacteria may favor Candida proliferation while making the fungus less virulent.
A UNLV study found a significant correlation between 10 specific types of gut bacteria and the likelihood of developing Alzheimer's disease, with certain bacteria identified as protective or risk factors. The findings suggest that an imbalance of gut microbiota may play a role in the disorder's development.
Two review articles explore the effectiveness of fecal microbiota transplants (FMTs) in treating recurrent infections with C. difficile and chronic noncommunicable diseases like ulcerative colitis and metabolic syndrome. While FMTs have shown promise, researchers agree that more research is needed to understand factors such as patient ...
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
A new study from the University of Illinois found that following the Dietary Guidelines for Americans promotes a diverse gut microbiota composition. The researchers analyzed data from the American Gut Project and discovered that individuals with higher diet quality had a greater abundance of beneficial bacteria involved in fiber metabo...
Consuming insects like crickets can contribute to healthy gut microbiota and provide essential nutrients. Research by CSU professor Tiffany Weir and colleagues highlights the potential benefits of edible insects on human health, including increased prebiotic effects and reduced intestinal inflammation.
Researchers have found that fermented sugar-based products and fermented vegetable-based products show promise in improving gut and brain health. Preliminary results suggest these foods contain beneficial metabolites that can positively impact mental health.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
A study published in the journal Cancer found that long-term pancreatic cancer survivors have a robust immune response and enriched gut microbiome species, including Faecalibacterium prausnitzii. The research suggests that these bacterial species may promote immune response to pancreas cancer.
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
Researchers found that a healthy gut microbiome can predict the efficacy of CAR-T cell therapy in patients with B-cell lymphomas. The study identified specific microbiome features associated with improved treatment outcomes, but highlights the need for further investigation into the causal nature of this relationship.
The study reveals that more than 70% of patients developed urinary tract infections caused by endogenous E. coli strains from their own gut microbiota. The researchers also found that non-lactose-fermenting E. coli strains, less common in other countries, were present in the gut microbiota of some patients.
A new study found that antibiotic treatment and certain types of microorganisms in the gut can impact CAR T-cell therapy outcomes. Patients with higher levels of Bifidobacterium longum had improved overall survival rates, while those with other bacteria were associated with poorer responses.
Researchers found that long-term antibiotic use during adolescence disrupts the healthy gut microbiome, leading to changes in liver metabolism that promotes central fat accumulation. The study suggests that antibiotic treatment may have lasting detrimental effects on liver metabolism and promote adiposity.
Researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by altering existing bile acids and creating a new class of bile acids within the gut's microbial environment. Selecting the right suite of BSH-producing bacteria is critical, as inter...
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers identified two Blastocystis strains, ST4 and ST7, with contrasting effects on the gut microbiome, promoting or disrupting a healthy balance. The study's findings suggest that geographical prevalence may influence the strain's impact on intestinal disease.
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
A study found that youth binge drinkers show alterations in the gut microbiome, associated with poor ability to recognize emotions and increased craving. The research suggests that the gut microbiome regulates social and emotional cognition, supporting the development of novel dietary or pre/probiotic interventions.
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
Researchers at Baylor College of Medicine discovered that an altered gut microbiome drives endometriosis disease progression in an animal model. The study found that mice lacking a gut microbiome had smaller endometriotic lesions, and treatment with certain metabolites significantly enhanced cellular proliferation and lesion growth.
A study led by Robert Dickson found that the gut microbiome plays a crucial role in regulating body temperature, both in health and during sepsis. The researchers discovered that certain bacteria from the Firmicutes phylum were strongly associated with increased fever response.