Articles tagged with Human Gut Microbiota
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A recent study found that alterations in the human microbiome, including those in the gut, urinary, and salivary tracts, are linked to kidney stone formation. The research team discovered changes in these microbiomes were common among patients with kidney stones.
A study of 25 obese Chinese individuals reveals that intermittent energy restriction (IER) alters the gut microbiome and brain activity, leading to significant weight loss and reductions in obesity-related comorbidities. The changes are coupled over time, suggesting a complex relationship between the gut microbiome and brain.
A phase-one human clinical trial shows that Omadacycline causes a distinctly different effect on the gut microbiome than Vancomycin, making it a safe drug option for patients at high risk for C diff infection. The antibiotic achieves high concentrations in the gut quickly, reducing the risk of long-term colonization.
A new UCLA study found that the ketogenic diet alters key gut microbiome functions related to fatty acid oxidation and amino acid metabolism in pediatric epilepsy patients. These changes confer seizure resistance in mice when transplanted fecal matter is used, holding promise for new microbiome-based therapies.
Researchers at University of Chicago Medical Center discovered a correlation between gut microbiome composition and postoperative infections in liver transplant patients. The study found that metabolites in fecal samples could predict infection risk with high accuracy, providing a potential diagnostic tool.
Research at University of Oxford found that diverse gut bacteria communities can block the growth of harmful pathogens, with certain species playing a crucial role. The communities work by consuming nutrients needed by the pathogen, and increasing diversity boosts protection.
Researchers identified naturally occurring biochemical components and key bacterial strains that process these components in a new therapeutic food. The study suggests that identifying these components can guide treatment with the current food formulation and enable creation of new, more effective formulations.
Researchers found correlations between flaxseed diets and changes in the gut microbiome and mammary gland miRNA profiles. Flaxseed lignans were shown to modify the relationship between the microbiota and miRNAs to be non-cancer causing.
A review article links pesticide exposure to an increased risk of developing Parkinson's disease through alterations in the gut microbiota. The authors recommend reducing or replacing agrochemicals and implementing coordinated efforts to develop standardized biomarkers for gut integrity and microbiome changes.
Researchers developed a new framework to predict how microbes interact with each other in unique compositions. Most microbes had minimal impact on the final outcome, with only select few playing crucial roles. The model has potential applications in personalized medicine and understanding microbiome assembly.
Researchers have combined 14 studies on piglet gut bacteria to uncover common patterns in microbiome development over time. The analysis revealed predictable trajectories and important details at a fine time scale, with an accuracy of 70% in predicting animal age based on microbiomes.
Researchers found that 1,8-cineole inhibits inflammatory pathways in the gut, while ginsenoside Rk2 alleviates liver inflammation and restores intestinal barrier function. Another compound, specnuezhenide, modifies gut microbiota and has potential to inhibit colorectal tumor growth.
Scientists have identified a key genetic factor, abfA cluster, responsible for improving gut motility and alleviating constipation. The study found that Bifidobacteria longum strains with the abfA cluster can enhance arabinan utilization, leading to improved gastrointestinal transit time.
A new data-driven framework uses machine learning to identify keystone microbial species in human gut microbiomes, varying across communities. The study found that keystone species have context-dependent essentiality and can aid digestion, breaking down complex starches.
A new study has identified three novel viruses that target specific bacterial hosts in the human gut, paving the way for more effective phage therapy to combat antimicrobial resistance. The discovery could lead to new methods of improving gut health and metabolism.
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
Researchers identified two fungus strains, Cyberlindnera jadinii and Kluyveromyces lactis, with potential probiotic effects on gut inflammation. These strains may offer a new way to develop probiotics and treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis.
A recent meta-study found that consuming fruit and vegetables contributes positively to bacterial diversity in the human gut. The study discovered that early childhood is a critical window for colonization with plant-associated bacteria, which have probiotic properties.
Researchers identified a gut-lung axis driven by intestinal antimicrobial peptide expression and mediated by the intestinal microbiota that influences hyperoxia-induced lung injury. Supplemental lysozyme reduced lung injury in neonatal mice, suggesting a potential therapeutic target.
A diverse gut microbiome is linked to better health, and a new study reveals how to determine which species are important and interact to create a healthy balance. The findings have significant implications for conditions like Inflammatory Bowel Disease, infections, autoimmune diseases, and cancers.
Researchers found associations between PTSD and dietary patterns, specifically a Mediterranean diet rich in plant-based foods and fish. The study identified Eubacterium eligens as a protective species that may help alleviate PTSD symptoms.
A large-scale prospective study identified significant variations in the gut microbiome of individuals who developed pre-cancerous colonic lesions. These findings suggest that the microbiome could act as a valuable tool to improve existing tests, advancing early detection methods for colorectal cancer.
A recent study by the University of Alabama at Birmingham has identified 19 specific Bacteroides vulgatus genes that are linked to early colonization after fecal microbe transplants. These genes are part of a commensal colonization factor complex that promotes stable and resilient colonization in mice, suggesting their potential role i...
Research suggests that the gut microbiome plays a crucial role in forming a healthy placenta during pregnancy. Mice with depleted gut microbiomes had smaller placentas and less-developed blood vessels, which can deprive fetuses of nutrients. However, supplementing these mice with short-chain fatty acids restored placental growth.
A NUS study found that Blastocystis ST7 produces indole-3-acetyldehyde, which binds to immune cells, reducing gut tolerance and causing inflammation. Probiotic bacteria like lactobacillus may help negate its effects.
Researchers have identified viral components of the skin's microbiome that drive the development of innovative therapies for atopic dermatitis. Bacteriophages, or 'bacteria eaters', were found to help certain bacteria grow faster in AD patients, contributing to the overpopulation of the skin microbiome.
A new framework aims to ensure Indigenous communities reap benefits from their microbiome samples, promoting equitable and beneficial research. Researchers highlight the need for community ownership of microbiomes, collaboration, and respect for Indigenous sovereignty.
Researchers found that training the gut's immune system to target flagellin, a protein enabling bacterial motility, protects against emulsifier-induced chronic intestinal inflammation and metabolic dysregulation. This study suggests a potential new approach for preventing inflammatory conditions such as obesity and type 2 diabetes.
A study found that specific proteins in breast milk correlate with the abundance of certain gut microbes in infants, potentially playing a role in early immune and metabolic development. The research suggests a regulatory function of these proteins on the immune function of the gut microbiome in humans.
Babies with more mature gut microbiota at one year old are less likely to develop allergy-related wheeze or asthma. The study, which followed 1074 babies from birth to four years old, found that increased maturity of the gut microbiota was associated with a lower risk of these conditions.
Researchers at Prolacta and MD Anderson Cancer Center found a human milk-based synbiotic to safely control the gut microbiome in adults, opening the door to precision microbiome engineering. The study demonstrates significant precision in modulating adult gut microbiomes.
Researchers have developed a human milk-based synbiotic that safely modulates damaged adult gut microbiomes. The study found that this symbiotic reshapes gut microbial composition and metabolites, offering new possibilities for treating dysbiotic conditions.
Research finds that infants born during the pandemic have fewer types of bacteria in their gut compared to those born earlier. The study suggests that social changes caused by the pandemic may have influenced this change, with potential implications for infant health.
A new study found that antibiotics promote the growth of antibiotic-resistant bacteria in the gut by providing extra nutrients, allowing these 'bad' bacteria to multiply. The research suggests that targeting beneficial bacteria can help restrict the growth of resistant bacteria, paving the way for microbiome therapeutics treatments.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers found a common bacterial signature associated with the development of eczema, asthma, food allergy, and hay fever in children. The study suggests that early life influences on gut microbiota may play a key role in the development of these allergies.
Researchers found that the incidence of gut-colonizing ciprofloxacin-resistant E. coli increased in Seattle-area women over age 50, affecting about 1 in 5 women. The study suggests prioritizing strategies to control drug-resistant E. coli's ability to colonize the gut.
A new study from the University of Nottingham models how antibiotic resistance genes build up in gut bacteria through lifetime exposure to food intake and antibiotic treatment. The research suggests that reducing exposure to resistance genes is particularly effective during periods of antibiotic treatment, and that dietary advice shoul...
A study published in Blood journal found that children with diverse gut microbiota before stem cell transplant had significantly better overall patient survival and fewer complications. Higher microbiota diversity was also associated with lower risk of acute graft-versus-host disease.
Research reveals that a healthy gut microbiome can play a role in the acquisition and severity of HIV and EBV infections. The study found that animals colonized with resident microbiota had higher rates of HIV infection and increased viral loads, suggesting that altering the gut microbiota could be a potential therapeutic approach to c...
A small pilot study found associations between specific microbe species and infants' performance in tests of social attention and rhythmic processing. The researchers observed higher levels of Actinobacteria and Bifidobacterium microbes in infants with better cognitive abilities.
Researchers discovered that PYY prevents the fungus Candida albicans from turning into its more dangerous form while allowing commensal yeast forms to flourish. This peptide functions as an antimicrobial agent, playing a vital role in maintaining fungal commensalism in the gut.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
Research reveals high transmission rate of E. coli cells between cohabiting hosts, leading to similar evolutionary events and microbiome species composition. Social interactions play a crucial role in shaping adaptive evolution of new gut bacteria strains.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
Researchers have found that caecilians, an elusive type of amphibian, transfer microbes from their skin and gut to their young during skin-feeding. This unique method of parental care provides nutrients and helps establish a healthy microbiome in juvenile caecilians.
Researchers found that taking probiotic Lactobacillus rhamnosus GG improved cognitive scores in participants with mild cognitive impairment, suggesting a potential strategy to support cognitive health. Gut microbiome composition could serve as an early indicator for mild cognitive impairment.
Research shows that a diet rich in soluble fiber like inulin can renew intestinal epithelial cells and improve intestinal health. The study found that gut microbiota plays a key role in this process.
A new $7 million grant will support research into the mechanisms that exacerbate inflammatory disease. The study aims to understand how environmental chemicals affect the gut microbiome, a key factor in chronic diseases like obesity and type 2 diabetes.
Research found that mothers' childhood experiences and pregnancy anxiety are reflected in their 2-year-old children's gut microbiomes, with smaller populations of microorganisms and reduced genetic diversity. These changes may influence children's socioemotional development and brain-gut microbiome connection.
Researchers found that a diet high in soybean oil decreases beneficial bacteria and increases harmful bacteria, leading to increased inflammation and susceptibility to colitis. Olive oil, with lower amounts of linoleic acid, is considered a healthier alternative.
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
A recent study published in Nature Neuroscience clarifies the connection between autism and the microbiome, identifying autism-specific metabolic pathways associated with particular human gut microbes. The analysis, which harmonized dozens of previously published datasets, reveals a common microbial signature distinguishing autistic fr...
A new study found that consuming grapes can alter the gut microbiome, leading to potential health benefits. The research analyzed changes in bacteria detection, enzyme levels, and biological pathways, revealing unique patterns of microbe distribution in a subgroup of subjects.
Researchers discovered that certain bacterial species, including lactic acid bacteria, correlate with high levels of Candida yeasts in the gut microbiome. This suggests a complex interaction between these microorganisms, where lactic acid bacteria may favor Candida proliferation while making the fungus less virulent.
A UNLV study found a significant correlation between 10 specific types of gut bacteria and the likelihood of developing Alzheimer's disease, with certain bacteria identified as protective or risk factors. The findings suggest that an imbalance of gut microbiota may play a role in the disorder's development.
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
Two review articles explore the effectiveness of fecal microbiota transplants (FMTs) in treating recurrent infections with C. difficile and chronic noncommunicable diseases like ulcerative colitis and metabolic syndrome. While FMTs have shown promise, researchers agree that more research is needed to understand factors such as patient ...
A new study from the University of Illinois found that following the Dietary Guidelines for Americans promotes a diverse gut microbiota composition. The researchers analyzed data from the American Gut Project and discovered that individuals with higher diet quality had a greater abundance of beneficial bacteria involved in fiber metabo...
Consuming insects like crickets can contribute to healthy gut microbiota and provide essential nutrients. Research by CSU professor Tiffany Weir and colleagues highlights the potential benefits of edible insects on human health, including increased prebiotic effects and reduced intestinal inflammation.