Articles tagged with Human Gut Microbiota
A biomedical sciences researcher is studying the impact of environment on gut microbiota, immunity, and inflammation in a novel mouse model system. The goal is to define changes in the gut microbiota and mucosal immune system in relation to intestinal inflammation and colon cancer.
A UC Riverside-led study identifies how loss-of-function mutations in the gene PTPN2 affect intestinal epithelial cells' ability to maintain a barrier. The researchers found that increased fluid loss and diarrhea are linked to the mutation, which can be reversed by treating cells with synthetic matriptase.
A new NIH grant will fund research on how beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study aims to understand the interactions between mother's diet, breast milk, and infant needs, as well as the role of probiotics and maternal lifestyle.
A recent study suggests that the gut microbiome plays a significant role in mental health, with disruptions in beneficial microorganisms linked to depressive disorders. The researchers propose a multifaceted approach to manage depression through rebalancing and maintaining the gut microbiome using diet, probiotics, and lifestyle changes.
A new study published in Hypertension Journal Report found that flavonoid-rich foods, including berries and wine, can lower blood pressure by modulating the gut microbiome. The study of 904 adults suggested that increasing flavonoid intake may be a valuable strategy for preventing hypertension.
A study by Duke University researchers found antibiotic-resistant bacteria in the guts of lemurs living close to humans. The closer the contact, the more resistant bugs were found. Proximity to humans determined the type and abundance of resistance genes acquired.
Research from APC Microbiome Ireland discovers microbes can rejuvenate aspects of brain and immune function, potentially slowing down age-related cognitive decline. The study introduces a novel approach to reverse brain aging via microbial-based interventions.
A new study published in Genome Biology found that the ability of gut bacteria to produce spores is associated with their adaptation to humans. Bacteria that can produce spores have larger genomes and are less abundant in the gut, while those that cannot have smaller genomes and are more adapted to human hosts.
Research reveals significant differences in gut microbiomes worldwide, impacting immune responses and susceptibility to infections. The study found that microbial composition alone can impact immune resilience, with Guatemala's microbiome proving most resistant.
A study published in Gut journal found that children with autism have a distinctive and underdeveloped range of gut bacteria, significantly fewer linked to neurotransmitter activity. This characteristic microbial profile may play a role in social behaviors and warrants further investigation.
A diet rich in isoflavone may provide protection against multiple sclerosis-like symptoms when combined with specific gut bacteria that can break down the compound. The study found that mice fed an isoflavone diet had a microbiome similar to healthy individuals, while those without it lacked beneficial bacteria.
A recent study found that genetics plays a nearly universal role in shaping the gut microbiome of wild baboons, with heritability estimates strongly correlated between humans and baboons. The researchers discovered that microbiome traits are dynamic and context-dependent, varying by diet diversity, season, and host age.
Researchers discover new insights into gut-brain axis, finding microbiome manipulation may treat devastating neurological disorders. Probiotic treatment improves ALS symptoms by restoring gene expression patterns and function.
A University of Notre Dame study found that most gut microbiome traits are heritable, with 97% variation influenced by genetics. The research team discovered that environmental factors also play a significant role in shaping the microbiome, particularly across seasons and age.
The study reveals that harnessing the microbiome and its associated metabolic pathways could provide a useful approach to treating Alzheimer's disease and Amyotrophic Lateral Sclerosis. Probiotic treatment improved ALS symptoms in mice and humans, suggesting potential therapeutic benefits.
A double-blind, randomized trial found that patients with severe obesity and metabolic syndrome had improved insulin sensitivity after receiving a fecal microbial transplant followed by daily fibre supplements. The study, led by Professor Karen Madsen, suggests that the microbiome can be targeted to improve human health.
Researchers at Brigham and Women's Hospital developed a probiotic yeast that can target inflammation, tissue scarring, and balance issues in the gut. The 'Y-bots' probiotic successfully suppressed intestinal inflammation and restored a balanced gut microbiome in mice.
Researchers found that a low-tryptophan diet increased systemic inflammation and altered the gut microbiome in aged mice. The study suggests that a balanced metabolite mix may be essential for maintaining optimal gut function.
Researchers developed a new dietary fiber formulation that modulates the gut microbiome, improving potency of immunotherapies against cancer. The inulin gel doubled the rate of tumor eradication in rodents with colon carcinoma and melanoma, expanding beneficial microbes in the gastrointestinal tract.
A low-calorie diet significantly alters the composition of the human gut microbiome, leading to changes in nutrient absorption and influencing weight control. The study found that specific bacteria, such as Clostridioides difficile, play a role in this process.
A Rutgers-led study found that C-section babies can be restored to healthy bacteria through exposure to maternal vaginal fluids. The study's results suggest a normalization of microbiome development in the first year of life and may offer disease protection against obesity, asthma, and metabolic diseases.
Researchers will explore the beginning of human life, the role of gut bacteria, and collective intelligence in honeybees. Experts from various fields will share their findings on protein biochemistry, glycobiology, and epigenetic regulation, among other topics.
A new study at Northwestern University suggests that environmental inequities may lead to health disparities through the gut microbiome. Minoritized populations are more likely to have lower microbial diversity and associated health risks due to limited access to green space.
Researchers investigated bacterial persistence in the human gut microbiome, identifying three dispersal strategies and finding that most strains are highly persistent. The study's results will inform targeted probiotic and treatment approaches to maintain a healthy gut microbiome.
Research highlights the connection between discrimination and altered gut microbiomes, which can impact metabolic and immune functions. The study's authors emphasize the need for further investigation into the relationship between the human gut microbiome and health inequities.
A new study from Michigan State University found that infants' gut microbiomes are associated with their fear responses, which can be indicators of future mental health. The researchers discovered that specific features of the gut microbiome, such as uneven balances of bacteria, were linked to stronger fear reactions.
A Northwestern University study found that specific types of gut bacteria can protect other good bacteria from cancer treatments. By metabolizing chemotherapy drugs, these protective bacteria can temper short- and long-term side effects of treatment, potentially leading to new dietary supplements or probiotics.
A study published in Nature found that ancient people's gut microbiomes were more diverse and had fewer antibiotic-resistant genes compared to modern populations. The research suggests that a more diverse diet and lifestyle may have contributed to this difference.
Scientists have discovered dramatic differences in gut microbiomes between ancient North American peoples and modern industrialized populations. The analysis of human paleofeces from dry caves reveals novel species of microbes and higher numbers of transposases, which may help microbes adapt to changing environments.
A large population-level study analyzed stool samples from over 7,000 Finnish adults and found that certain bacterial strains in the gut microbiota were associated with increased mortality risk. The study's machine learning algorithm identified specific microbial species linked to a shorter lifespan.
Research suggests that an imbalance in gut microbiota, or dysbiosis, may play a significant role in the progression of Hidradenitis Suppurativa. The study found reduced abundance of certain bacteria in HS patients, leading to an inflammatory response.
Experts warn that rewilding the modern gut microbiota without careful consideration of microbial evolution could lead to health problems. Restoring the preindustrialized microbiome may not necessarily improve health, but rather reflect adaptive responses to industrial society.
A study by researchers at the University of Konstanz and Vienna discovered that specialized gut bacteria cooperate to process sulfoquinovose, a sulfonic acid derivative found in green vegetables. The analysis revealed that this process produces hydrogen sulfide, which has disparate effects on human health.
Researchers have discovered a sulfosugar from green vegetables that stimulates the growth of key gut bacteria, producing energy-rich compounds. This finding has implications for understanding the interactions between nutrition and the microbiome, potentially leading to new therapeutic strategies.
A study found that cesarean-born infants have less diverse gut microbiota at birth but catch up with their peers by age 3-5. The intestinal microbiota forms an ecosystem that takes years to mature, and its development can vary significantly among children.
A new study from MIT-led researchers found that people living in industrialized societies have gut bacteria that swap genes at much higher rates. This phenomenon occurs more frequently due to specific diets and lifestyles, potentially leading to intestinal health issues.
Children's gut microbiota largely reaches adult composition by five years, but important differences remain. Key bacterial taxa are acquired late in childhood and may affect health later in life.
A two-week dietary intervention increased fiber intake, altering gut microbial composition and short-chain fatty acids production. Researchers found a significant increase in Bifidobacterium abundance despite no detectable shift in fatty acid levels.
A new study reveals a connection between wisdom, loneliness and gut microbial diversity. Participants with lower levels of loneliness and higher levels of wisdom had greater phylogenetic richness and diversity in their gut microbiome. A more diverse gut microbiota may promote better resilience and stability.
A study published in eLife found that domestication has a consistent effect on the gut microbiota of animals, similar to the effects of industrialisation in human populations. The research highlights the flexibility of the gut microbiota and its ability to respond to ecological changes.
A four-year federal grant of over $2 million is being awarded to Dr. Andrew Gewirtz at Georgia State University to investigate the role of inflammation and altered gut microbiota in the development of metabolic syndrome.
Researchers developed a mouse Intestine-on-Chip platform to study host-microbiome interactions, confirming that Enterococcus faecium promotes tolerance to S. typhimurium infection in mice. The technology mimics human Intestine Chips, enabling real-time analysis of normal and pathological processes.
New research suggests that microbes in the gut contribute to symptoms associated with complex neurological disorders, and modulating the gut microbiome improves social behavior but not hyperactivity. The study opens the possibility of treating other conditions like cancer, diabetes, and viral infections with microbiome-targeted therapies.
A study found that the gut microbiome can predict changes in glucose regulation, particularly related to insulin levels and secretion. The study suggests that certain microbes may be useful for predicting disease progression and informs future research.
Researchers at OHSU discovered a correlation between gut microbiome composition and cognitive performance in mice with genes associated with Alzheimer's. The study suggests a relationship between microbes and epigenetic changes in the brain, potentially leading to new treatments for Alzheimer's.
A new study by University of Alberta researchers reveals that urban coyotes consuming human food have more human-like gut bacteria, leading to poor health outcomes such as lower body fat and stressed immune systems. The study suggests limiting access to protein-poor human food could be an effective solution.
Researchers analyzed gut microbiomes from over 9,000 people, finding distinct signatures linked to healthy aging and survival. The unique microbial compositions were correlated with specific metabolites in blood plasma, suggesting a direct link between the microbiome and health as we age.
A new study found that altering the gut microbiome can take a patient with advanced melanoma who has never responded to immunotherapy and convert them into responders.
Researchers analyzed 50,000-year-old Neanderthal feces to identify beneficial bacteria essential for human health. The study suggests that targeted diet- and lifestyle-tailored solutions can help safeguard the microorganisms crucial to our physiology.
A new study found that gut microbes can affect bone mass and structure in mice, with treatments altering the gut microbiome potentially aiding healthy skeletal growth. The findings suggest that microbes can be inherited or transmitted between individuals and impact skeletal development.
A large-scale international study found a panel of 15 gut microbes associated with lower risks of common conditions. Diets rich in healthy foods encourage the presence of these beneficial microbes, which are linked to improved health outcomes.
A landmark study identified microbes linked to lower risks of diabetes, heart disease and obesity. Researchers discovered novel microbes associated with specific foods and diets.
A revised study verifies that nanoplastics affect the composition and diversity of our intestinal microbiome, causing damage to human health. Alterations in the gut microbiome lead to changes in immune, endocrine, and nervous systems.
Researchers found bacteria that feed on toxic halogenated compounds, providing a potential mechanism for measuring exposure to semi-volatile organic compounds. The study suggests that certain SVOCs are correlated with the abundance of bacterial and fungal species in children's guts.
Researchers at University of California - San Diego found a connection between gut bacteria diversity and active vitamin D levels in older men. The study suggests that microbiome diversity is closely associated with active vitamin D, while the precursor form has no significant link.
Researchers from University of Turku developed a new bioinformatics tool to predict microbial sensitivity to glyphosate. The tool classifies 80-90% of microbial species as sensitive or resistant, with 54% of human core gut bacterial species potentially affected.
Researchers found a correlation between household chemicals and reduced bacterial diversity in children's guts. The study suggests that exposure to semi-volatile organic compounds may impact human health, with potential implications for probiotic interventions.
Researchers found a relationship between zebra finch gut microbiome characteristics and cognitive performance, identifying potentially critical bacteria affecting learning and memory. The study provides evidence for the 'microbiota-gut-brain axis' in songbirds, raising questions about the generality of this system across species.
A recent study by Helmholtz Munich researchers found that a diverse environmental microbiome, particularly in farm children, can protect against childhood asthma. The gut microbiome plays a crucial role in this protective effect, with certain bacteria producing short-chain fatty acids that may contribute to asthma protection.
A continuous colonic mucus system forms a protective barrier between gut microbiota and host tissue in mice. The barrier consists of two types of O-glycan rich mucus that form in different regions of the colon, with proximal mucus encapsulating fecal pellets and distal mucus strengthening the barrier during elimination.