Articles tagged with Human Gut Microbiota
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Researchers at Universitat Pompeu Fabra and S-Biomedic demonstrated the use of living bacteria to temporarily modulate skin microbiome composition. The study, published in Microbiome, found that probiotic solutions from donor microbiomes can be applied to recipients, leading to a shift towards a healthier microbiome state.
A mathematical framework describes the ecology of a microbiome-host interaction landscape, allowing for global comparisons and understanding of diverse microbiomes' associations with similar health outcomes. The framework applies equally well to traditional genetic interactions.
A study led by Georgia State University researchers found that fecal miRNA can serve as a tool to assess gut microbiota healthiness and provide early clues to intestinal inflammation in mice. The findings offer new hope for diagnosing chronic gut conditions, such as inflammatory bowel disease.
Researchers found Veillonella bacteria in elite athletes' microbiomes, which converts lactic acid into propionate to improve exercise capacity. Supplementing with Veillonella may boost sedentary individuals' exercise abilities and protect against chronic diseases.
Researchers have discovered that plants can transmit antibiotic-resistant superbugs to humans, highlighting the importance of tackling foodborne resistance from all aspects of the food chain. The study found that certain antibiotics can increase the ability of bacteria to colonize the gut after ingestion, while others can prevent it.
Researchers identified Roseburia intestinalis as a gut bacterium triggering antiphospholipid antibodies in patients with antiphospholipid syndrome. The study suggests that eliminating this bacterium may help decrease antibody levels and open doors for future treatment options.
A recent study published in Nature Medicine Letters reveals that specific microbiome organisms are linked to the early stages of colorectal cancer development. The researchers found increases in these microorganisms in fecal samples from patients, which could potentially provide vital diagnostic clues.
A new study reveals that bacteriophages can have a profound impact on the dynamics of the gut microbiome, causing a cascade of effects on other species and modulating metabolite levels. This finding has significant implications for therapeutic use and understanding the potential effects of other treatments.
A new study by immunologists at the Babraham Institute has shown that fecal transplants from young mice can replenish and boost the gut microbiome of older mice, rejuvenating their immune system. The research suggests that targeting the gut microbiome could be a way to treat age-related symptoms and facilitate healthy aging.
Researchers have made an important advance in understanding the role of gut bacteria in human health, including diagnostic methods and therapies. The study found that patients with certain diseases had a smaller number of protein families in their microbiome compared to healthy individuals.
A study using mouse models reveals that gut bacteria directly contribute to autism-like behaviors, affecting gene expression and metabolite production. Researchers hope this discovery may lead to new treatments targeting the gut, rather than the brain.
A new study from Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard found that changes in the gut microbiome during IBD trigger an unhealthy inflammatory reaction. The research, part of the Human Microbiome Project, identified specific chemicals and microbial shifts that contribute to disease activity.
A recent study found that women's gut microbiomes are more diverse and mature earlier than men's, with a positive association between age and bacterial diversity. The research suggests that sex hormones may play a role in the development of the female gut microbiome.
Researchers have developed an 'anaerobic Intestine Chip' that stably maintains a complex human microbiome and provides a protective physiological barrier. This breakthrough technology allows for direct investigations of health and disease-related human-microbiome interactions under low oxygen conditions.
A new University of Connecticut study found that human activity influences the gut microbiota and body mass of Darwin's finches in the Galapagos. Researchers studied over 100 female finches and discovered that those living near humans had different gut bacteria communities, leading to changes in their physical characteristics.
Researchers analyzed B. fragilis' evolution in humans, finding 16 genes evolve within individuals, targeting pathways for fiber uptake and immune system interactions. The study also revealed differences in mutations between Western and Eastern cultures, with potential implications for probiotic choices and microbial therapies.
A new study found no major differences in gut microbiomes of people infected with roundworms or hookworms and uninfected peers. However, curing hookworm infections resulted in specific changes to the microbiome, while deworming had minimal effects.
Research from the NASA Twins Study found that extended spaceflight alters the ratio of two major categories of bacteria in the gut microbiome, but not its diversity. The study's findings could help protect astronauts' and space tourists' microbiomes during long bouts of space travel.
A study by CU Anschutz researchers found that men who have sex with men have unique gut microbiomes that drive immune activation and may increase their risk of HIV infection. The study suggests a direct link between microbiome composition and immune activation in HIV-negative and HIV-positive MSM.
A study found that gut microbes from high HIV-risk men who have sex with men drive immune activation in mice and HIV infection in cells. The researchers suggest that the gut microbiome might be a risk factor for HIV transmission in these individuals.
Researchers mapped gut microbes of colorectal cancer patients to identify disease-specific changes globally robust despite environmental differences. The study establishes a panel of gut microbes associated with colorectal cancer and shows potential for non-invasive cancer screening.
Scientists have developed edible antibodies that can survive digestion and reach the gut, offering an alternative to traditional treatments. The technology has potential applications in fighting gut infections, treating inflammatory disorders, and preventing diarrhea in pigs and humans.
A Columbia University study found that adversity-induced disruptions in gut microbes are associated with changes in brain function in young children. The research linked gastrointestinal symptoms in childhood to potential emotional health issues later in life.
Researchers develop nanovaccine using pyridine functionalized poly(2-hydroxyethyl methacrylate) material, overcoming restricted immune response in mice with gut-initiated metabolic syndrome. The study explores the interrelationship between nanomaterials, immune responses and the microbiome.
Researchers have identified over 7,000 structural variants in human gut microbiomes associated with disease risk and weight. These variants were found to be linked to a specific ability of bacteria to produce butyrate, a substance with anti-inflammatory effects.
The symposia series will focus on the gut microbiome's impact on health and disease, featuring speakers on topics such as gut-brain axes and antibiotic effects. Research highlights include studies on acetate, bioinformatics, and metabolomics.
Researchers have identified new pathways controlling inflammation in the gut and explored diet-based interventions to prevent C. difficile infections. Prebiotics may also help mitigate gastrointestinal toxicity from radiation treatment.
A study in mice suggests that altering the gut microbiome via prebiotics or probiotics may be a potential treatment for PCOS. The research found improvements in testosterone levels, ovulation, weight, and insulin resistance in mice with PCOS, linked to changes in gut bacteria composition.
A multi-disciplinary team of researchers at Harvard's Wyss Institute for Biologically Inspired Engineering discovered four human microbiome metabolites that enhance colon injury by enterohemorrhagic E. coli (EHEC) in a human-mouse comparative study using Organ-on-a-Chip technology.
A study of 150 volunteers found that consuming yogurt with probiotics increased the proportion of beneficial bifidobacteria, which can help metabolize lactose and produce vitamins. This shift in gut microbiota had a positive impact on the body's ability to resist inflammatory diseases and hormonal disorders.
Researchers from Virginia Tech and Eastern Washington University are collaborating on a $958,415 NSF grant to study the critical role of the honey bee gut microbiome in health and defense against parasites. The team aims to develop a network of genes from the parasite, microbiome, and host to determine their interactions with each other.
Researchers reconstruct nearly 61,000 microbial genomes from human gut metagenomes, uncovering 2,058 previously unknown species and shedding light on the metabolic capabilities of uncultivated microbes. The study improves genomic resources for global populations, especially in regions with limited data.
A new study reveals that Blastocystis subtype 7 selectively kills beneficial Bifidobacterium and Lactobacillus in the gut, leading to oxidative stress and lesions. This pathogenic microbe can contribute to inflammatory bowel disease, irritable bowel syndrome, and gastrointestinal cancers.
Research reveals that gut microbiota is essential for thermoregulation, particularly in animals exposed to cold. The study found that gut microbiota helps stimulate the activation of Brown Adipose Tissue and promotes white adipose tissue browning, leading to improved thermogenic capacity.
Researchers at University of Cologne decipher mechanism by which intestinal microbiota amplifies inflammatory reactions in lungs. Candida albicans stimulates Th17 cells, leading to cross-reactivity and immune system imbalance.
A review published in Advances in Nutrition suggests that noncaloric sweeteners have a negligible impact on daily energy intake and do not significantly alter the composition of human gut microbiota. The study concludes that there is not enough evidence to support adverse effects on health, including cancer or diabetes risk.
A large-scale analysis found that indirect breastfeeding via pumping is associated with a higher abundance of potential pathogens and lower oral bacteria compared to direct breastfeeding. This could increase the risk of respiratory infections in infants, particularly those fed pumped milk.
Acarbose, a type II diabetes drug, changes the gut microbiome in a reversible and diet-dependent way, according to new research. The findings suggest that more attention should be paid to how medications affect the gut microbiome, particularly for diabetes treatments.
A study has discovered and isolated more than 100 completely new species of bacteria from healthy people's intestines, creating the most comprehensive collection of human intestinal bacteria to date. This will help researchers worldwide to investigate how our microbiome keeps us healthy and its role in disease.
A recent study published in PLOS Pathogens reveals that whipworms disrupt the balance between gut immune cells and microbiota, leading to uncontrolled inflammation and tissue damage. The researchers discovered that a specific receptor, IL-10R?, plays a critical role in regulating these interactions.
Researchers have identified a new group of massive viruses, known as megaphages, that target specific bacteria found in the guts of individuals eating non-Western, high-fiber diets. These phages, which are 10 times larger than average phages, can carry genes that exacerbate human illnesses and may move between humans and animals.
A new study published in The FASEB Journal found that maternal gut microbiota changes significantly during pregnancy and lactation. Coriobacteriaceae and Escherichia bacteria increase gradually over gestational time, while short-chain fatty acids production increases during lactation.
Researchers at Medical University of South Carolina found that antibiotic disruption of the gut microbiome leads to increased osteoclast activity, dysregulating post-pubertal skeletal development. The study also revealed changes in immune cell populations, including an increase in myeloid-derived suppressor cells.
After obesity surgery, new microbial strains emerged in the human fecal microbiota, changing the gut environment. The study used a novel informatics technique to identify these new strains, which were more competitive in the altered GI tract environment.
Research at Montana State University reveals that the gut microbiome plays a crucial role in protecting against acute arsenic toxicity. The study found that certain microorganisms in the human gut can neutralize arsenic, reducing its toxic effects.
A new study reveals that the gut microbiome helps regulate the host's immune system by moderating vitamin A levels. The bacteria fine-tune the conversion of vitamin A to its active form, reducing an overactive immune response and promoting co-existence with the microbiome.
A new study found that a probiotic supplement reduced hospitalization time and in-patient treatment for patients with mania. The results suggest that modulating the intestinal microbiota could be a new treatment avenue for patients suffering from psychiatric mood disorders.
Researchers at Wake Forest School of Medicine discovered that gut bacteria can enhance or inhibit the effectiveness of anti-diabetes drugs. The review of over 100 studies suggests that modulation of the gut microbiome may be a target to improve or reverse medication efficacy for type-2 diabetes.
Researchers discovered 12 bacteria types consistently varying in abundance by ethnicity, highlighting a baseline for understanding healthy microbiome differences among individuals. The findings hold promise for developing personalized approaches to prevent and treat chronic diseases disproportionately affecting ethnic minorities.
Researchers at Montana State University are studying Familial dysautonomia, a rare genetic neurological disease, to understand its connection with the human gut microbiome and metabolism. The study aims to develop new treatments for neurodegenerative diseases like Alzheimer's and Parkinson's.
Scientists have discovered that specific molecules produced by intestinal bacteria are altered during three instances associated with human obesity. The study also found that the gut microbiome undergoes fluctuations in a 24-hour rhythm and influences circadian biology, predisposing individuals to obesity and glucose intolerance.
Researchers found that live probiotics in SymproveTM successfully colonized the gut and modified immune response, leading to changes in gut flora and a positive anti-inflammatory effect. The addition of Symprove resulted in increased beneficial bacteria and reduced inflammatory markers.
A study by Stanford University researchers found that four Himalayan populations with different dietary histories have distinct gut microbiome compositions. The findings suggest that changes in human lifestyle can occur within a lifetime and may be driven by dietary factors.
A recent study found that hydrogen peroxide generated by lactation suppresses microbial diversity during infant gut microbiota development. Mouse pups fed with breast milk had lower levels of Lactobacillus compared to those without LAO1 gene deletion.
A recent study found that consuming whole cranberry powder reduced the negative effects of low-fiber, animal-based diets on the gut microbiota. The study showed that cranberry compounds helped maintain beneficial short-chain fatty acids and reduced potentially carcinogenic secondary bile acids.
Stephanie Ganal-Vonarburg's research shows that maternal microbiota influences child's immune system from birth through placenta and breast milk. The award supports her future work to investigate long-term effects of maternal microbiota on children's immunity.
Researchers found that immigrants quickly lose native microbes and acquire alien microbes more common in European-American people, resulting in a loss of gut microbiota diversity. This Westernization is associated with greater obesity and is compounded across generations.
Research suggests that human hosts are starving their microbial communities of nutrients, potentially undermining the benefits of the microbiome. This could lead to a shift in the balance of power between humans and microbes, with implications for our health and well-being.
A new study reveals that the unique compositions of bacteria in mice' guts are inherited from parents and remain stable over generations. The dominant mode of transmission is vertical inheritance, but some bacterial pathogens can be transmitted horizontally, possibly due to increased oxygen tolerance.
Researchers found a correlation between AMY1 gene copy numbers and faster starch digestion rates. Individuals with more copies of the gene displayed higher blood glucose responses to starchy foods.