Articles tagged with Salmonella
Researchers identified 421 previously unknown interactions between Salmonella proteins and host cell proteins, including those involved in cholesterol trafficking. This approach sheds light on how Salmonella survives inside host cells by manipulating protein machineries and pathways.
New research from the University of Georgia reveals that 60% of cattle fecal samples contain multiple antibiotic-resistant salmonella strains, which can cause severe illness in people. CRISPR-SeroSeq technology identifies molecular signatures in bacteria's DNA, allowing for more sensitive detection of resistant strains.
According to NIH scientists, Salmonella bacteria establish a foothold in the GI tract by hijacking intestinal epithelial cell response, driving colonization and fecal shedding. This process fuels the bacteria's ability to invade neighboring cells and seed the intestine for transmission.
University of Florida researchers have demonstrated a novel approach to triggering immunity against salmonella, using extracellular vesicles (EVs) that contain antigens from the bacteria. In mice, these EVs induced both innate and adaptive immune responses, offering a promising direction for developing a vaccine.
Researchers detect molecular changes in infected human cells and bacterial pathogen, revealing new insights into infectious disease mechanisms. The findings may lead to novel methods for combatting invasive pathogens during spaceflight and on Earth.
Researchers used genomics and epidemiology to study how African Salmonella evolved to cause bloodstream infections, killing ~50,000 annually. A new antibiotic-susceptible lineage emerged in Malawi in 2016, linked to changes in antibiotic usage between 2002-2015.
A new study shows promise in reducing foodborne pathogens on tomatoes by applying sanitizers in the field. The method uses FDA-approved additives, significantly reducing bacterial populations and saving labor costs for producers. This approach could become a practical solution for controlling foodborne pathogens.
The study concludes that a more holistic approach to poultry food safety is needed to better protect the public from foodborne pathogens like Salmonella. It highlights the limitations of current guidelines, which only consider pathogen prevalence and do not account for other risk factors such as serotype virulence and temperature abuse.
Researchers discovered multiple cell death systems preventing the spread of Salmonella, a major cause of typhoid fever. Cells use various mechanisms to die and protect against infection, including apoptosis, pyroptosis, and necroptosis.
A study by VIDO-InterVac researchers discovered that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals. Similar amyloid proteins have been associated with neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.
Wild strains of salmonella have been found to reopen stomates on plants, allowing them to bypass the immune defense system and cause foodborne illnesses. This finding highlights the increasing threat of opportunistic pathogens jumping from plants to humans through contaminated foods.
A recent study by the American Society of Agronomy found that reusing chicken litter can deter growth of pathogens like Salmonella. Researchers discovered 'good' bacteria in used poultry litter can hinder Salmonella growth, providing new information on the relationship between litter environment and microbiome.
Scientists investigated how immune cells respond to Salmonella infection and found that cathepsins move to the nucleus of infected cells, leading to inflammatory programmed cell death. This discovery shows the benefit of monitoring protein dynamics during infection and unraveling new pathways to defend against pathogens.
A natural product called dephostatin has been found to be an effective partner for the antibiotic colistin in treating infections caused by the bacteria Salmonella. The combination significantly prolonged animal survival and used a lower concentration of colistin, reducing its toxic effect.
Researchers have developed a sensitive and specific assay to detect different serotypes of Salmonella, enabling rapid tracing of infection origins. The new DNA test can distinguish between subtypes of Salmonella in just eight minutes and has the potential to simplify and accelerate food-borne illness investigations.
Researchers from Cornell and Mars Global Food Safety Center developed a method for whole-genome sequencing to determine salmonella serotypes in two hours. This improves the efficiency of food safety response to salmonella contamination incidents, which can occur in various foods.
Researchers discovered ancient Salmonella genomes in human skeletons dating back 6,500 years, shedding light on the evolution of a human pathogen. The study suggests that the Neolithic revolution facilitated the emergence of human-adapted pathogens, including Paratyphi C.
Researchers reconstructed eight ancient Salmonella enterica genomes from human remains, revealing a link between the spread of farming culture and the emergence of human-adapted pathogens. The study highlights how constant exposure to pathogens enabled their evolution over 6,500 years.
Researchers at Flinders University have developed a decontamination method that removes salmonella contamination from eggshells without impacting the egg's usability. The method involves treating eggs for 9 minutes using kitchen equipment commonly found in commercial kitchens, and has been shown to be effective in reducing the incidenc...
New research shows that nerve cells in the gut regulate gut immunity, maintain homeostasis, and provide active protection against infection. Gut neurons activate pain-sensing neurons to release neurochemicals slowing M cell differentiation and boosting SFB microbes, which guard against Salmonella invasion.
A Michigan State University study finds that antibiotic-resistant salmonella strains are increasing, leading to longer hospital stays and worse symptoms. The study also reveals regional differences in the types of salmonella infections, with rural areas affected by enteritis infections.
Scientists discovered that blood stem cells acquire energy from bone marrow support cells in response to salmonella infection, enabling them to produce millions of bacteria-fighting white blood cells. This discovery could lead to new approaches to treating people with salmonella and other bacterial illnesses.
The BfR has developed a digital tool to track product contamination sources, while strategies for reducing Salmonella and Campylobacter infections are discussed. Viral foodborne diseases like hepatitis E and A are also on the agenda.
Agri-Neo's Neo-Temper technology eliminates harmful pathogens in flour through an organic, non-thermal process, preserving nutritional qualities while integrating seamlessly into existing tempering processes. The solution has been validated in four commercial mills in the US and Canada, with a waiting list for additional millers.
Scientists have detected extensively drug-resistant Salmonella strains in central Africa that are resistant to nearly all commonly available drugs, a significant threat to public health. The study reveals that these new strains exhibit genetic and behavioral changes that suggest ongoing evolution towards bloodstream infections.
A new whole-genome sequencing technique is being adopted to detect salmonella in the food industry. This method provides a more reliable and precise identification of salmonella strains, enabling the origin and path of outbreaks to be determined.
Researchers developed an algorithm that analyzes immune cell responses to predict disease onset and progression. The algorithm uses 'first impressions' from early interactions between immune cells and bacteria to identify patterns that can be applied to real-time blood tests.
A new ultrasensitive chemiluminescence-based method has been developed to rapidly detect Salmonella and Listeria monocytogenes. This test can be carried out in the field and requires no containment laboratory, significantly faster than conventional methods.
Researchers at North Carolina State University discovered a gene that makes Salmonella resistant to colistin, the drug of last resort for treating multidrug-resistant infections. The mcr-3.1 gene was found in a human patient who had traveled to China two weeks prior to becoming ill with a Salmonella infection.
Researchers have identified a gut microbe, Mucispirillum schaedleri, that helps protect against Salmonella infections. The bacterium competes with Salmonella for nutrients, such as nitrate, and prevents the growth of pathogens by reducing their ability to express virulence factors.
Researchers at the University of Sydney developed a method to predict salmonella outbreaks and found that future epidemics are likely to be more severe. The study suggests that genetic networks of salmonella pathogens are linked through just a few degrees of separation, indicating an increasing severity of future epidemics.
The study found that the live oral typhoid vaccine Ty21a can strengthen the immune response against subsequent, unrelated infections, including those caused by other pathogens. This promising research could lead to broader protection and lower mortality rates globally.
A team of scientists developed a machine-learning approach to predict the animal source of certain Salmonella outbreaks with 83% accuracy. The system identified poultry and swine sources as the top predictors, followed by bovine and wild bird sources.
Researchers discovered 677 genes and small RNAs expressed differently between African and global Salmonella strains, leading to alterations at the protein level. The study provides a powerful tool for understanding the bacteria's genetic basis and potential antibiotic resistance.
Researchers at Virginia Tech have developed a novel drug delivery system that uses attenuated bacteria cells to transport anti-cancer drugs directly to cancer sites, showing up to 100-fold improvements in distribution and retention. This innovative approach has the potential to revolutionize cancer treatment options.
Researchers at McMaster University discovered a new way bacteria evade the human immune system by shutting down flagella expression, making it difficult for the immune system to detect and respond. This finding has significant implications for understanding antibiotic resistance and developing new treatments.
Salmonella bacteria produce proteins that mimic DNA and target specific immune response genes, leaving others untouched. This precise mechanism allows the bacteria to fine-tune the host's immune system.
Researchers discovered that non-circulating memory T cells offer optimal protection against Salmonella infection, leading to the development of more effective and safe vaccines. The study's findings have significant implications for addressing enteric fever and invasive non-typhoidal Salmonellosis in resource-poor communities.
A 10-year US study found the highest Salmonella enterica serotype Newport infection incidence in the South and among children under 5. Antimicrobial resistance rates were also highest, with 88% of isolates susceptible to all tested antimicrobials.
Researchers identified a molecule, propionate, produced by Bacteroides bacteria, that inhibits Salmonella growth in the intestinal tract of mice. This finding may lead to better treatment strategies and understanding why some people are more resistant to infection.
A 800-year-old Norwegian skeleton has revealed traces of Salmonella Paratyphi C, a rare cause of enteric fever. The discovery suggests that the bacteria have long caused illness across northern Europe.
A new machine learning tool can identify genetic changes in emerging strains of Salmonella that are more likely to cause dangerous bloodstream infections. The tool was developed using a dataset of old lineages and identified almost 200 genes involved in determining the pathogen's behavior.
Research found that chlorine can make foodborne pathogens undetectable by standard laboratory culture techniques. Chlorine-induced states enable some bacteria to survive and potentially cause disease. The study's findings have significant implications for food safety, biocidal products, and post-BREXIT trade agreements.
Researchers have pinpointed a single genetic code variation in African Salmonella that enables its virulence, contributing to devastating bloodstream infections. The discovery has implications for understanding and combating this dangerous strain of bacteria.
African Salmonella's deadly epidemic is caused by a specific genetic change, known as a SNP, which helps the bacteria survive in the human bloodstream. The discovery could lead to new insights into other pathogens and pave the way for a vaccine against this devastating infection.
A team of researchers discovered that mild heat stress damages the cell wall of Salmonella bacteria without rupturing them. This finding could lead to more efficient ways to deactivate bacteria using shorter heating times at lower temperatures, improving food safety and reducing energy consumption.
The National School Lunch Program's zero-tolerance policy for Salmonella and E. coli bacteria has led to highly effective food safety standards, with 99% of shipments being Salmonella-free. This effective program is critical for child nutrition policy and anti-poverty measures.
A new study found that most antibiotics decrease bacterial motility in multidrug-resistant Salmonella, but kanamycin increased swarming in one strain. Researchers hope to identify the accessory genes responsible for this effect to inform antibiotic choice.
Researchers have identified a different strain of Salmonella Typhimurium in the UK that is less severe and susceptible to antibiotics compared to the strain causing high levels of disease in sub-Saharan Africa. The genomic differences between the two strains may hold clues to why the African strain causes such high mortality rates.
A new test allows accurate, rapid testing for Salmonella, a leading cause of food-borne illness. The test detects the bacteria in environmental and clinical samples, reducing diagnosis time from five days to 24 hours.
Duke scientists discovered a gene variant linked to susceptibility to typhoid fever and found that cholesterol-lowering drug ezetimibe protected zebrafish against Salmonella Typhi. The study provides insight into human susceptibility to infectious disease and potential avenues for protection.
A recent study published in Frontiers found that improper iron supplementation can make people more susceptible to Salmonella infections. In contrast, genetically susceptible individuals may fare better due to a lack of iron in macrophages.
A Canadian research team found a new antibiotic resistance gene, fosA7, in Salmonella from broiler chickens, which confers high resistance to the antibiotic fosfomycin. The researchers tested the gene's strength and confirmed its ability to boost resistance levels by over 256-fold.
Researchers at ETH Zurich found that inflammation triggers the transfer of phage genes to Salmonella bacteria, increasing their pathogenicity. Vaccination can prevent this process, alleviating the risk of phage release.
Researchers have discovered a new variant of the mcr-1 gene in a healthy individual carrying Salmonella, highlighting the potential for spread of antimicrobial resistance. The finding raises concerns about food safety and the need for increased monitoring of this gene and its variants.
Researchers developed a model to predict the impact of vaccine campaigns on invasive non-typhoidal Salmonella disease in young children in Mali. The study found that a two-dose schedule with booster would prevent 73% of iNTS cases and 43% of deaths.
Researchers have discovered that genetic changes in African Salmonella strains allow them to hijack immune cells and spread throughout the body. This enables the bacteria to cause systemic diseases like bloodstream infections and meningitis, which are often fatal.
A study found that when a bacteria reduces its virulence by blocking loss of appetite, it increases mouse survival and helps the pathogen spread. Salmonella Typhimurium, a natural intestinal pathogen in mice, uses this strategy to replicate and transmit to other hosts.
Research from the Salk Institute shows that certain bacteria, such as Salmonella Typhimurium, can block the host's appetite loss response to make themselves healthier while also promoting transmission. This discovery could have implications in treating infectious diseases and may lead to new therapies for metabolic disease.
Researchers found no direct association between hot weather and increased Salmonella prevalence at free range egg production farms. The study emphasizes the critical role of hand hygiene in reducing food poisoning from eggs.