Articles tagged with Salmonella
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Microbiologist Cheryl Nickerson is using the ISS platform to study the effects of microgravity on disease-causing organisms, aiming to unveil novel cellular and molecular mechanisms related to infectious disease progression.
A mass poultry vaccination programme has been credited with a significant decline in Salmonella cases, from 1.6 cases per 1,000 person years in 1993-96 to 0.2 cases per 1,000 person years in 2008-09. The number of laboratory-confirmed cases dropped from over 18,000 in 1993 to just 459 in 2010.
Researchers have found that Salmonella bacteria change key cells in the intestine to cross the gut wall and infect vital organs. This allows Salmonella to thrive and cause severe symptoms like diarrhoea, fever, and even death in young children.
Research by University of Cambridge scientists has identified a new mechanism used by Salmonella to spread in the body, which could lead to improved treatments and vaccinations. The study found that bacteria must escape from infected cells to disseminate, but this process is hindered when an active Phox system is present.
Researchers at Imperial College London have identified a way in which Salmonella bacteria counteract human cell defenses. The study found that Salmonella injects a protein that prevents cells from recycling transport carriers, effectively cutting off the supply line of toxic enzymes.
A new study reveals the emergence and spread of invasive non-Typhoidal Salmonella disease in sub-Saharan Africa, which has a significant mortality rate of up to 45% in infected people. The disease is caused by a rapidly evolving form of Salmonella Typhimurium that acquired resistance to multiple front-line drugs.
Cold atmospheric gas plasma technology has shown promise in inactivating Salmonella on fresh produce, but exposure length varies greatly depending on the type of produce. Researchers discovered that food surfaces' microscopic structures can block plasma from reaching bacteria, affecting treatment efficacy.
Researchers explore the role of Lactobacillus reuteri in protecting against foodborne infection, finding that its antimicrobial substance reuterin can protect intestinal epithelial cells from Salmonella infection. The study's results suggest the efficacy of using probiotic bacteria or their derivatives in future therapies.
A new test, RapidChek SELECTTM Salmonella, detects Salmonella Typhi shedding in stool with a 10-fold to 1000-fold improvement over traditional methods. This technology assesses the degree and duration of shedding after immunization, ensuring vaccine efficacy and community safety.
A new rapid-cooling process can extend egg shelf life by up to 12 weeks, maintaining protein quality and preventing bacterial invasion. The technology uses liquid carbon dioxide to cool eggs quickly, reducing the risk of salmonella illnesses.
Researchers used video microscopy and mathematical modelling to challenge common assumptions about Salmonella infection. They found that macrophage infection rates are lower than previously thought, but infected cells can still be reinfected by other bacteria.
Salmonella causes food poisoning, killing around 400,000 people worldwide every year. Researchers have discovered multiple gene switches that control the bacteria's weapon systems, offering new ways to curb human infection. The discovery could lead to the development of antibiotics to reduce disease caused by Salmonella.
Researchers at UCSB have discovered highly virulent Salmonella bacteria that can override vaccines and pose a significant risk to food safety. The discovery may help prevent outbreaks of food poisoning and mitigate the growing cost of foodborne illness in the US, estimated at up to $14.6 billion annually.
A recent discovery by UCSB researchers has identified 'hypervirulent' Salmonella bacteria, which pose a significant risk to human and animal health. The strains were found in livestock isolates and render current vaccines obsolete due to their ability to switch between virulence levels during infection.
Scientists have developed a rapid test to detect Salmonella in lettuce and water using popcorn-shaped gold particles. The test can identify the bacteria in just five minutes, making it a potential game-changer for food safety, particularly in remote areas or during outbreaks.
Scientists found that Salmonella bacteria attach differently to ripe and unripe tomatoes, with filaments forming on ripe ones. This could affect how pathogens are maintained on surfaces, according to researchers at Imperial College London.
A UCI-led study reveals how Salmonella thrives in the digestive tract despite the immune system's best efforts to destroy it. The findings highlight a novel molecular mechanism allowing the bacteria to acquire zinc and promote its growth.
Bacteria can multiply rapidly, but a lag phase precedes exponential growth. Researchers have developed a system to study this period, revealing genes and nutrient uptake mechanisms that help bacteria thrive in new environments.
Researchers at London School of Hygiene & Tropical Medicine discover that malaria patients' immune system is selectively weakened, making them more susceptible to fatal salmonella infections. The team identifies Tin Protoporphyrin as a potential candidate for prevention, but further testing is needed.
Salmonella forms two genetically identical types, each with an advantage in infection and evasion. The bacteria's ability to produce flagellin triggers a self-destructive response in immune cells, but restricting production helps it colonize hosts.
Researchers have developed a biosensor using carbon nanotubes that can detect salmonella bacteria, offering a potential solution to preventing food poisoning. The device's sensitivity and specificity make it a promising tool for controlling food safety outbreaks.
Paul Kenis and James Slauch have been recognized as University Scholars for their exceptional contributions to the field of chemical engineering and microbiology. Their research focuses on developing novel microfluidic tools and studying Salmonella bacteria to understand its virulence and develop new treatments.
A study by Purdue University researchers found that E. coli and Salmonella can survive inside plant tissues, rendering exterior sanitization ineffective. The pathogens were detected in every major tissue of the plants, including those transporting nutrients. Cooking foods to known temperatures eliminates these bacteria from inner tissues.
Researchers found that Salmonella cells use a beta form of amino acid lysine to cause illness, making it an attractive drug target. Deleting genes involved in this process or inserting alpha lysine instead renders the bacteria non-virulent and sensitive to antibiotics.
A new study identified a multidrug-resistant strain of Salmonella with high resistance to ciprofloxacin, infecting 489 patients in France, England and Wales, and Denmark between 2000 and 2008. Poultry is believed to be a major vehicle for spreading these infections.
Researchers have found a new target for nitric oxide's antimicrobial actions, which disrupts Salmonella's metabolism and prevents its growth. The discovery sheds light on the body's natural defenses against infection and may lead to the development of new broad-spectrum antimicrobials.
Researchers at Arizona State University have developed a technique to make salmonella-based vaccines safer and more effective, with potential applications in fighting diseases like hepatitis B, tuberculosis, and pneumonia. The new approach retains strong immunogenic properties while reducing unwanted side effects.
A new study reveals that Bdellovibrio can reduce Salmonella bacteria by 90% without harming birds. The research confirms the safety and effectiveness of this natural predator as a potential alternative to antibiotics.
Purdue University scientist Kevin Keener's research suggests that rapidly cooling eggs can increase the activity of lysozyme, an enzyme that defends egg whites from bacteria. By re-saturating egg whites with carbon dioxide and altering pH levels, the technology aims to create a safer food product.
Researchers at Goethe University Frankfurt have elucidated the molecular mechanism of autophagy in intestinal cells, revealing how salmonella is marked and digested. Impaired autophagy may be linked to cancer and neurodegenerative diseases.
Researchers at Helmholtz Centre for Infection Research found a new Salmonella infection mechanism targeting the actin cytoskeleton and exploiting myosin II motor protein. This approach allows bacteria to pull themselves into host cells without forming ruffles, expanding the known invasion strategies.
Researchers are using genetically modified salmonella packaged with Interlueken 2 to create a two-prong attack on cancer. The therapy, administered orally, shows promise in controlling tumors in the gut and may offer a cheaper and less toxic alternative to chemotherapy and radiation.
A team of USDA scientists has developed a new approach to detecting pathogenic Escherichia coli and Salmonella bacteria in waterways, achieving lower detection levels than previous methods. The process uses a combination of techniques, including filtration, biochemical testing, and polymerase chain reaction technology, to identify even...
Researchers at UC Berkeley successfully repurposed Salmonella to safely transport virus-stopping enzymes into cells, effectively treating mice infected with cytomegalovirus. The new technique uses a live but weakened bacteria as a vector for the ribozyme that can stop the gene activity of cytomegalovirus.
Researchers at Yale University describe how Salmonella hijacks cellular mechanisms to infect millions worldwide. A novel bacterial sorting platform attracts and lines up proteins in the right sequence, allowing the bacteria to commandeer host cell functions.
Research reveals erythropoietin (EPO) has contrasting influences on infectious and inflammatory diseases. EPO reduces the ability of the immune system to fight off systemic infections but decreases inflammation in non-infectious conditions.
A new test for salmonella in poultry and eggs can produce faster and more accurate results than most currently available tests. This could have prevented contaminated eggs from being shipped to stores and kept consumers safe.
The University of Arizona is receiving $2.9 million to improve the safety and post-harvest quality of field-grown organic leafy greens. Researchers will test edible films, compost teas, and irrigation water for bacterial contamination, aiming to provide safer products for consumers while increasing profitability for growers.
A new study from the University of Michigan suggests that Helicobacter pylori infection in the stomach may reduce the severity of colitis caused by Salmonella. The research found that H. pylori infection alters the immunological environment of the lower gastrointestinal tract, leading to reduced inflammation.
Researchers discovered a reservoir of rapidly replicating Salmonella inside epithelial cells, which are then pushed out into the gut cavity, triggering an inflammatory response. This understanding may lead to a treatment that prevents the spread of infection and sheds light on the mechanisms behind acute intestinal inflammation.
Scientists have developed a laboratory model to study innovative approaches against typhoid fever in a living system. The 'humanized' mouse model enables researchers to test new treatments before testing them on people.
Researchers at UC Davis discovered that Salmonella bacteria create an environment in the human intestine to enhance its reproductive success. The bacteria use tetrathionate respiration, a sulfur compound produced by the immune system's response, to outgrow beneficial microbes and promote severe diarrhea.
Manuela Raffatellu, a UC Irvine researcher, received the 2010 ICAAC Young Investigator Award from ASM for her work on Salmonella typhimurium's interaction with the gut. Her research has identified novel roles for early T cell responses and IL-17 in preventing bacterial dissemination.
Researchers discovered a common pathway critical for Salmonella's ability to cause disease and resist antibiotics. Mutant strains exhibited abnormalities under stressful conditions, highlighting the importance of stress response mechanisms.
The study found that the vitamin D receptor helps regulate bacterial activity, responds to cues, and counters their presence. It also plays a key role in defending against Salmonella infection and squelching inflammation by binding to NF-Kappa B and preventing it from activating other inflammatory molecules.
A new method for detecting and genetically identifying salmonella from contaminated foods can provide DNA sequencing-like results in hours, rather than days. This could help recognize outbreaks sooner and stop tainted food from being delivered.
Researchers found that antibodies from HIV-infected Africans bind to LPS, blocking protective 'killing' antibodies. Removing these antibodies allows for effective killing of Salmonella bacteria. The study identifies potential alternative vaccine targets in outer membrane proteins.
A new thesis at the University of Gothenburg reveals that a probiotic, Lactobacillus plantarum, has no effect on Salmonella bacteria. Researchers found that the probiotic did not reduce diarrhoea or shorten the duration of infection in patients with Salmonella.
A new switch has been discovered that enables Salmonella bacteria to sabotage host cells, allowing it to replicate and establish an infection. This finding could lead to the development of drugs to combat Salmonella-related diseases.
New strains of Salmonella are emerging in HIV-infected individuals in Africa, causing severe disease by invading blood and bone marrow cells. These multi-drug resistant strains can lead to death in one in four cases due to the loss of immune cells in HIV patients.
Researchers at the University of Colorado Boulder have discovered a novel approach to studying Hemophagocytic Lymphohistiocytosis (HLH), a rare and deadly inflammatory disease. Mice infected with Salmonella bacteria developed symptoms consistent with human secondary HLH, including fever, anemia, and neurological signs.
A new study found that typhoid fever bacteria form persistent communities on gallstones, making carriers particularly hard to treat. The infection is transmitted through fecal-oral contact and can lead to hundreds of thousands of deaths worldwide each year.
Research from Malawi and the UK reveals a two-pronged immune response that could combat even the most resilient strains of nontyphoidal Salmonella. Protective antibodies have been identified that recognize bacteria in the blood and kill them without immune cell help, offering hope for an effective vaccine.
A dynamic mapping tool helps investigators uncover associations between diseases and environmental exposures, such as Salmonella infections and broiler chicken sales. The study reveals seasonal fluctuations and geographic clustering of the disease.
Scientists discovered that membrane ruffles are not essential for Salmonella to penetrate host cell membranes. A new factor called WASH promotes bacterial invasion by contributing to cytoskeletal filament formation.
Scientists have discovered how salmonella kills tumors by migrating into cancerous tissues and triggering a strong inflammatory response. The inflammatory response causes blood vessels in the tumor to become permeable, allowing salmonella to spread and ultimately kill the tumor.
UT Southwestern Medical Center researchers have found that autophagy prevents harmful bacteria like Salmonella from becoming successful pathogens. Decreases in autophagy may lead to abnormalities in the intestinal tract's response to bacterial infections.
Researchers identify glucose as the primary sugar fueling Salmonella's survival during infection. This breakthrough could lead to vaccine strains and protective immune responses against other disease-causing bacteria, including superbugs.
A single protein called SopB allows Salmonella to invade cells and hijack cellular functions, enabling it to avoid destruction. The study reveals how SopB coaxes cells to mark the protein with ubiquitin, making it recognizable to cellular machinery.
Scientists have discovered that Salmonella uses a secretion system to protect itself inside amoeba, allowing it to survive and multiply. This finding has significant implications for controlling the spread of Salmonella in water supplied to animals.