Articles tagged with Salmonella
Research from Malawi and the UK reveals a two-pronged immune response that could combat even the most resilient strains of nontyphoidal Salmonella. Protective antibodies have been identified that recognize bacteria in the blood and kill them without immune cell help, offering hope for an effective vaccine.
A dynamic mapping tool helps investigators uncover associations between diseases and environmental exposures, such as Salmonella infections and broiler chicken sales. The study reveals seasonal fluctuations and geographic clustering of the disease.
Scientists discovered that membrane ruffles are not essential for Salmonella to penetrate host cell membranes. A new factor called WASH promotes bacterial invasion by contributing to cytoskeletal filament formation.
Scientists have discovered how salmonella kills tumors by migrating into cancerous tissues and triggering a strong inflammatory response. The inflammatory response causes blood vessels in the tumor to become permeable, allowing salmonella to spread and ultimately kill the tumor.
UT Southwestern Medical Center researchers have found that autophagy prevents harmful bacteria like Salmonella from becoming successful pathogens. Decreases in autophagy may lead to abnormalities in the intestinal tract's response to bacterial infections.
Researchers identify glucose as the primary sugar fueling Salmonella's survival during infection. This breakthrough could lead to vaccine strains and protective immune responses against other disease-causing bacteria, including superbugs.
A single protein called SopB allows Salmonella to invade cells and hijack cellular functions, enabling it to avoid destruction. The study reveals how SopB coaxes cells to mark the protein with ubiquitin, making it recognizable to cellular machinery.
Scientists have discovered that Salmonella uses a secretion system to protect itself inside amoeba, allowing it to survive and multiply. This finding has significant implications for controlling the spread of Salmonella in water supplied to animals.
A Purdue University researcher has developed a device that uses high-voltage coils to create ozone inside sealed food packages, killing harmful bacteria such as E. coli and salmonella. The process eliminates the need for external devices or added ingredients, making it a potential game-changer in ensuring food safety.
A University of Georgia study found Salmonella in 79% of river and stream samples, with highest concentrations in summer months and after rainfall. The bacteria can persist and grow in water under certain conditions, potentially contributing to increased salmonella illnesses as a result of global warming.
Iowa State University researchers have developed a technique called tape-FISH that can test produce for Salmonella contamination in about two hours. This approach uses adhesive tape to collect a sample from the skin of the produce, which is then analyzed using Fluorescent In-Situ Hybridization.
A new study reveals that non-food factors such as swimming and private well water exposure pose significant risks for sporadic bacterial enteric infections, comparable to food-borne risk factors. The findings highlight the importance of controlling these environmental exposures to prevent outbreaks.
Researchers at Arizona State University have developed two new vaccine strains using Salmonella typhimurium as an antigen delivery system. These recombinant attenuated Salmonella vaccines (RASVs) trigger a powerful systemic immune response, offering a promising solution to infant bacterial pneumonia. The safety and efficacy of these no...
Researchers at Arizona State University discovered a key survival circuit that allows Salmonella bacteria to overcome the body's defense mechanisms. The bacteria use a complex system of regulatory proteins and genes to adapt to changing environments, including nutrient starvation and antimicrobial peptides.
A Salmonella infection has been used to study the immune system of Drosophila melanogaster flies, revealing a key role for growth factor Decapentaplegic (Dpp) in regulating immune responses. Dpp mutant flies have impaired immune cell production and are unable to fight off pathogens.
A recent study has uncovered the mechanism by which Salmonella enterica serovar Senftenberg attaches to salad leaves, causing contamination and health risk. The bacteria use their long stringy appendages called flagella to bind to the leaves, and understanding this process is crucial for developing new methods of prevention.
Salmonella bacteria use random molecular processes during cell division to form two groups that engage in job-sharing, with one group sacrificing itself to generate a greater common good. This phenomenon allows the bacteria to improve their chances of survival and spread in the gut.
A study found that sesame seed extract and konjac gum can bind to E. coli and Salmonella bacteria, potentially preventing them from entering host cells. This natural approach may offer protection against gastro-intestinal infections or reduce symptom severity.
The researchers have developed a biologically engineered organism that can effectively deliver an antigen in the body using live salmonella bacterium. The new method is a major step forward in developing a means of biological containment for vaccine delivery, making vaccines more affordable for developing countries.
Scientists have discovered a molecular trick used by Salmonella to evade the immune system, giving it crucial time to establish itself in the host before symptoms appear. The AvrA protein helps reduce inflammation, allowing the bacteria to avoid detection and spread more easily.
A new national study found that most Americans believe US-produced food is safe, but have concerns about imported food and the government inspection system. Many also worry about getting ill from food they eat, with certain groups, such as Hispanics and African-Americans, more likely to be concerned.
Researchers found that only two strains of Salmonella are common in garden birds, which are sensitive to antibiotics. This contrasts with the more resistant strains found in livestock and humans, highlighting the need for alternative approaches to infection control.
Researchers used a transgenic fruit fly model to study how Salmonella evades immune defenses, finding that the protein AvrA shuts down key signaling pathways. This allows the bacteria to cause severe intestinal infections. The study's results suggest that other pathogens may target similar biochemical networks to avoid elimination.
Prebiotic sugars have been shown to reduce Salmonella infection severity in animals, improving health and reducing economic losses. The study's findings suggest a potential solution to the growing problem of antibiotic resistance and foodborne illnesses.
Researchers at Kansas State University have validated a new method to destroy pathogens in beef jerky production, making it safer for consumers. The process involves additional drying time at 68 degrees Celsius to ensure both E. coli O157:H7 and Salmonella are eliminated.
UC Davis scientists discovered how salmonella becomes lethal for AIDS patients by finding the defect in immune response that allows it to cross the gut barrier and infect other organs. The study suggests Th17 cells play a crucial role in the inflammatory response, recruiting immune system cells to the site of infection.
A study on Salmonella Enteritidis infection reveals its complex life cycle in the internal organs of mice, with high concentrations found in liver and spleen. The bacteria can persist for up to 12 days in the gallbladder, a previously unknown site of carriage.
Researchers at Arizona State University are developing a vaccine that targets both Avian Pathogenic E. coli (APEC) and Salmonella, two leading causes of poultry disease and food-borne illness. The project has the potential to provide benefits not only to the poultry industry but also to human health by preventing outbreaks of diseases ...
A study found that Salmonella enteritidis primarily penetrates the jejunum and ileum of the gastrointestinal tract after oral challenge. The bacteria can persist in these regions for up to 18 weeks, raising questions about its potential as an opportunistic pathogen in humans.
A new mathematical model explains how persistent microbes co-exist with humans, suggesting an increase in virulent organisms as populations grow. The model proposes that larger populations select for more virulent microbes, leading to potentially severe epidemics.
A team of researchers at Kansas State University is working to understand the ecology of E. coli 0157 and develop practical interventions to combat it in cattle. They are also studying salmonella, which causes bloody diarrhea in feedlot cattle and dairy cattle abortions, with a focus on reducing its prevalence.
Researchers found that Bifantis delayed the onset of artificially induced arthritis and resulted in less severe arthritic symptoms. In a second study, Bifantis increased the numbers of immune cells controlling the response to harmful pathogens like Salmonella, limiting inflammation.
Researchers found new genetic information in Salmonella serovar Typhimurium DT104 that enables its survival and infection mechanism. The extra genetic characteristics make the pathogen stronger and more infectious.
Researchers have developed a novel strategy for cancer vaccine development using Salmonella typhimurium as a delivery vehicle. The study successfully elicited immune responses against NY-ESO-1, a known tumor cell antigen, and showed regression of established tumors in mice.
Research reveals that non-pathogenic bacteria from cow manure share antibiotic-resistance genes with multi-drug resistant Salmonella strains on the same farm. Ecology appears to play a major role in the spread of drug resistance, rather than therapeutic antibiotic use.
Outbreaks linked to unpasteurized orange juice have been on the rise since the mid-1990s. Recent research suggests that this type of orange juice can still carry Salmonella bacteria, highlighting the need for consumers to look for pasteurized options.
Researchers discovered a novel RNA-based sensor in Salmonella that responds to magnesium ions, allowing cells to assess and react to their environment. The discovery expands the types of molecules that can be detected by riboswitches.
Researchers identify key proteins in Salmonella metabolic paths, finding that blocking certain enzymes may not be effective against the bacteria. Only a few essential enzymes are necessary to keep Salmonella alive, and these are also present in other pathogens or human organisms.
A recent study published in Environmental Microbiology found that snakes become infected with Salmonella through exposure to contaminated environments, not just by eating contaminated food. The knowledge gained from this study can help prevent reptile-associated infections and inform safe handling practices for snakes and other pets.
Researchers aim to identify the point of salmonella transmission in the poultry industry, allowing intervention measures to be introduced effectively.
Scientists have discovered a molecular mechanism by which bacteria can recognize and respond to tiny antimicrobial peptide molecules, making them more virulent. This finding may lead to new ways to overcome bacterial resistance and improve treatment options for diseases caused by Salmonella typhimurium.
Scientists found significant differences in Salmonella and E. coli's use of a gene linked to processes that govern antibiotic resistance, altering their ability to survive in different environments. The study suggests that understanding such changes will help develop new treatments for disease-causing microorganisms.
A new study by UGA researcher Rob Maier found that Salmonella uses molecular hydrogen as an energy source, expanding previous findings on major human pathogens. This discovery has profound implications for the treatment of some diseases and could lead to therapeutic interventions by targeting unique metal clusters in bacteria.
The 5-year project aims to determine which microbial proteins interact with human host cells, pointing the way to new drugs. Researchers will use advanced proteomics instruments to analyze these interactions, accelerating treatment development during outbreaks.
A study of 13,271 Salmonella infection cases in Sweden found that 87% were contracted abroad, with most coming from Spain, Greece, and Turkey. The number of diagnoses for a rare type of Salmonella Enteritidis increased dramatically among visitors to Greece in 2001.
A study found nearly 12% of salmonellosis cases in children under 5 were reptile-associated. Experts recommend keeping reptiles out of households with young children to prevent infection.
Researchers discovered that Salmonella bacteria can alter the lipid composition of a vacuole to avoid destruction by a lysozome, allowing it to survive and replicate rapidly. This remarkable mechanism may lead to new targets for therapeutic strategies to control food poisoning and typhoid fever.
Researchers from Duke University Medical Center used a common worm as a model to identify specific genes within Salmonella that enable the bacteria to infect host cells. The study found four genes required for maximum potency in infecting the worm, which are also present in human mammals.
A new study isolated a compound called dodecenal from fresh cilantro leaves, which is found in salsa, and showed it to be twice as potent as the antibiotic gentamicin at killing Salmonella. The researchers believe that eating more fresh salsa could help prevent foodborne illness.
Vazquez-Torres is a leading researcher studying how Candida and Salmonella cause disease, and how the body fights off these pathogens. He has discovered new pathways by which cells can sample the intestinal lumen, migrate to the spleen, and trigger systemic immune responses.
A new strain of Salmonella enterica serotype choleraesuis has been isolated that is resistant to all commonly used antimicrobials, including ceftriaxone and ciprofloxacin. Constant surveillance is needed to prevent further spread of this multidrug-resistant bacterium.
Researchers discovered how Salmonella injects proteins into host cells that staple actin molecules together, changing the cell's structure to facilitate bacterial invasion. This complex protein secretion system allows Salmonella to manipulate host cells in unique ways, enabling it to evade immune responses.
Researchers at UVa and Rockefeller University found that SipA, a Salmonella protein, tethers to actin, allowing bacteria to infect cells. The study's findings may lead to the development of new treatments against severe infections.
A joint U.S.-Georgian team aims to develop a novel treatment against bacterial pathogens causing salmonella infection. The grant supports phage therapy research to prevent massive outbreaks and address growing antibiotic resistance.
The UCSB researchers have developed a cross-protective Salmonella vaccine using the DNA adenine methylase technology, which is also being explored for use in other bacterial and viral pathogens. This breakthrough offers significant potential for combating biowarfare agents and could render current vaccines obsolete.
Researchers have identified 156 probable membrane proteins that could serve as new drug targets to combat antibiotic-resistant salmonella. The study also revealed two previously unknown gene clusters required for producing hair-like strands on the bacteria's surface.
Researchers found that feeding hot pepper oil to chickens increases resistance to Salmonella enteritidis without adverse effects on feed consumption or taste. The oil causes mild inflammation in the intestines, making it difficult for the bacteria to bind and invade the body.
Researchers at Yale University have found that combining Salmonella injections with radiation therapy can effectively suppress tumor growth, prolonging the life of mice by six times. The study suggests this combination therapy could be a future use for Salmonella in cancer treatment.
A recent study by University of Illinois researchers has identified a key gene that controls Salmonella's ability to live dormantly or cause disease in pigs. The finding, led by Richard E. Isaacson, could lead to the development of methods to prevent Salmonella from causing illness in farm animals.
Researchers have genetically modified Salmonella bacteria to reduce virulence and increase safety while retaining tumor-targeting properties. The modified bacteria exhibit reduced ability to induce TNF-alpha and cause septic shock, making them safer for human use.