Articles tagged with Salmonella
Scientists have developed a non-toxic strain of Salmonella to target and kill cancer cells, reducing tumor size by 20% in mice with prostate cancer. The bacteria's ability to penetrate cell barriers makes it an ideal candidate for bacteriotherapy, a promising new approach to treating cancer.
A six-month study in Pennsylvania found that eggs from small flocks have a higher prevalence of Salmonella enteritidis than those from large commercial flocks. The bacteria was present in internal and external egg contents, highlighting the need for education and quality-assurance practices in backyard and small layer flocks.
Two novel African types of Salmonella Enteritidis, genetically distinct from the Western type, have been identified through a global-scale genetic study. These bacteria have developed resistance to multiple antibiotics and are a major cause of blood poisoning and death in Africa.
Researchers at the University of Nevada, Reno have successfully reduced salmonella bacteria in ground poultry, pork, and beef by up to 90% using bacteriophages. The study's findings offer promising results for improving food safety in the meat industry.
Research at UC Davis Health System identified a mechanism by which antibiotics alter gut microbiota, increasing nutrients that benefit pathogen growth. The study found that oral antibiotic treatment increases the synthesis of an enzyme generating nitric oxide radicals, which oxidize sugars and promote Salmonella growth.
Researchers have found that antibiotic-resistant salmonella strains are becoming increasingly common in sub-Saharan Africa, posing a significant threat to public health. The emergence of multidrug-resistant strains, particularly among non-typhoid salmonella infections, is a major concern due to the lack of effective treatments.
Researchers found that fluid shear forces regulate disease progression in multidrug-resistant Salmonella ST313 strains, accelerating disease onset and enhancing survival. The study's findings have significant implications for the development of therapeutics against these deadly bacteria.
Research in a mouse model found that antibiotics deplete beneficial bacteria, increasing oxygen levels that favor the growth of pathogen Salmonella. This discovery has profound implications for preventing side effects of antibiotic treatment and informs new strategies to tackle bacterial infections.
Researchers found that polyandry in house mice does not enhance immune resistance against Salmonella infection. However, male mice showed surprising resistance to the disease, with lower bacterial loads compared to females.
A new study suggests that a combined vaccine therapy using live Salmonella is safe and effective in preventing diabetes in mice. The vaccine works by rebalancing the immune system and preventing the attack on insulin-producing cells. Researchers believe this targeted immunotherapy has great potential for treating type 1 diabetes.
Researchers at Uppsala University quantify selective forces shaping bacterial genomes, discovering that small changes in fitness can be selected against. They find that changing even a single codon reduces the fitness of bacteria by 0.01 procent per generation.
Whole-genome sequencing reveals the emergence and spread of the virulent Salmonella strain DT104 over 40 years in 21 countries. The strain's resistance to five antibiotics and ability to infect multiple livestock species contributed to its success.
Salmonella bacteria have a unique molecular switch called SsrB that allows them to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm. This switch enables the bacteria to survive inside macrophage vacuoles and then form biofilms, which can be resistant to host defenses and antibiotics.
Researchers at UGA found that harmful bacteria like salmonella can survive in dry foods for six months or longer, including cookie and cracker sandwiches. The study highlights the need to test all ingredients used in these foods to prevent contamination and outbreaks.
A World Health Organization task force found that up to 33 million healthy life years are lost each year due to foodborne diseases. Diarrheal disease agents were the most frequent causes of foodborne illness, particularly norovirus and Campylobacter spp.
A Penn-led team discovered that variations in Salmonella proteins determine their host specificity in cows, poultry, and humans. By analyzing genome-wide association studies, the researchers found a link between specific protein variants and host species, validating their findings with laboratory experiments.
Invasive Salmonella infections are a major cause of child illness and deaths in sub-Saharan Africa, with 3.4 million illnesses and 681,000 deaths worldwide in 2010, according to new research.
A UGA study found that salmonella levels in freshwater sources across Georgia pose a significant risk to human health. The research team discovered that strains of salmonella exhibit geographic trends, with higher rates found in south Georgia and wildlife carriers like raccoons and opossums contributing to the problem.
A University of Maryland study has found that extreme heat and precipitation events are associated with increased risk of Salmonella infections, particularly in coastal areas. The research team identified a disproportionate impact on coastal communities, highlighting the need for public health preparedness and response to climate change.
A new screen has identified key environmental signals that modulate bacterial behavior in Salmonella typhimurium, a food-poisoning bacterium. These signals trigger survival tactics and alter biofilm formation.
Researchers at the Institute of Food Research discovered how Salmonella bacteria synchronize gene expression for invasion. They found that RpoS, DksA and ppGpp work together to coordinate the deployment of SPI1 and SPI2.
Researchers have genetically modified Salmonella to kill cancer cells and shrink tumors, offering a potential new therapy. The modified bacteria can target and destroy cancer cells while remaining safe for patients.
Researchers discovered that Salmonella lowers its cytoplasmic pH in response to acidic environments, triggering the secretion of virulence proteins. This low-pH signal activates an intracellular cascade that induces the formation of a nanomachine used for injecting virulence proteins into host cells.
A Chapman University study found that 24.1% of tested herbs from Los Angeles and Seattle markets contained E. coli, while one sample showed Salmonella. The research highlights the need for better food safety measures at farmers' markets.
Researchers at the University of Cambridge used a new technique to study the immune response to live Salmonella vaccines, finding they enhance the ability to prevent bacterial replication and spread. This is crucial for preventing conditions like bacteraemia, a major killer in Africa.
Long antibiotic treatments are ineffective against slowly growing bacteria that persist in tissues, leading to ongoing disease. Slowly growing pathogens dominate treatment, posing a risk for relapse despite effective initial therapy.
A highly virulent, multidrug-resistant form of Pseudomonas aeruginosa has been discovered in patient samples in Ohio. The strain contains a gene for a drug-resistant enzyme called metallo beta-lactamase, making it resistant to multiple antibiotics.
Research reveals Salmonella Typhi uses Vi capsular polysaccharide to evade neutrophil recognition, allowing it to disseminate throughout the body. The 'cloaking device' makes S. Typhi practically invisible to neutrophils.
Researchers found that blocking the activation of five genes responsible for transporting fructose-asparagine could be a new strategy to fight Salmonella infections. The nutrient is composed of a sugar and amino acid, and its identification alone is unusual since it has never been discovered as a nutrient for any organism.
A new study refines a test for tracing food-borne illnesses to their source, providing clearer guidance on interpreting DNA sequence changes. The findings suggest that isolates with certain variations in bacterial DNA can be linked together, helping investigators pinpoint outbreaks more accurately.
A Penn Vet study reveals that Salmonella bacteria evade the immune system by exploiting metabolic pathways, including the citric acid cycle. The research identifies key genes involved in this evasion strategy and suggests that the immune system may recognize bacterial metabolites like citrate to trigger an inflammatory response.
A study published in Cell Reports reveals that a specific protein, EIIAGlc, is essential for Salmonella's ability to inject toxins into host cells and manipulate host processes. The discovery opens up new avenues for developing targeted treatments against life-threatening Salmonella infections.
A study by the FDA found that Paenibacillus alvei significantly reduced Salmonella on contaminated tomato plants, reducing the risk of food-borne illnesses. The beneficial bacterium has no known history of human pathology and is being considered as a biological control agent to prevent outbreaks.
Research discovered that glucose is the major nutrient used by Salmonella bacteria, but it's also able to use other nutrients. This finding informs potential therapeutic interventions to combat Salmonella infections. The study reveals a wealth of strategies employed by Salmonella to overcome host defenses and evade immune systems.
The new vaccine technology uses reengineered salmonella to deliver protective immunity against various infections. The study demonstrates a 10-fold improvement in salmonella survivability in a mouse model, modified to mimic human stomach acid conditions, offering hope for safe and effective oral vaccines.
A new study reveals a previously undefined immune pathway in humans that provides vital information for designing vaccines and medicines to combat bacterial infections. The research found that T-cells can respond defensively to bacterial attacks without specific antigens, leading to a maximal response and improved survival.
A study by researchers at the University of California, Irvine found that interleukin-22 enhances the growth of dangerous bacteria like Salmonella while curbing the growth of healthy gut bacteria. This unexpected finding suggests that a protective immune response can actually aid the growth of harmful pathogens.
Scientists have developed a faster and more specific method to detect bacteria-tainted food, using nanomechanical cantilevers that can identify eight different types of Salmonella. The technique has the potential to prevent food poisoning and save thousands of lives annually.
A study published in Infection and Immunity reveals that Salmonella infection can reduce asthma inflammation by regulating immune cells. Researchers hope to develop treatments based on probiotics or therapeutic applications of myeloid cells.
Researchers at the University of Basel have discovered how Salmonella bacteria outsmart the host's immune cells, allowing them to survive and spread infection. This knowledge may lead to new treatments for typhoid fever, a life-threatening disease affecting millions worldwide.
Researchers found Salmonella biofilms on various surfaces cannot be killed with common disinfectants, even after prolonged exposure. The study highlights the importance of proper food handling and cleaning practices to prevent outbreaks.
Researchers have discovered a mechanism by which bacteria can evade antibiotics, forming 'persisters' that are tolerant to many drugs. The study found Salmonella bacteria forms large numbers of persisters after being engulfed by immune cells, allowing it to survive antibiotic treatment and cause recurrent infections.
Researchers discovered that Salmonella protein tyrosine phosphatase (SptP) shuts down mast cell ability to release chemical signals without impacting other cellular functions. This leads to the failure of immune cells being recruited to the infection site, allowing Salmonella to multiply and spread unchecked.
Researchers have mapped every salmonella gene's response to human body environments, providing a detailed picture of the bacterium's choreographed infection process. This knowledge could lead to targeted therapies and vaccines specifically designed to combat salmonella's strategies for survival within the human body.
Researchers discovered that Salmonella Typhimurium obtains energy for its attack by stealing hydrogen from the microbiota. This 'theft-based hydrogen economy' allows the pathogen to find an energy source in any new animal host.
Researchers found that certain management practices, such as manure application and irrigation timing, can boost or decrease the risk of contamination from salmonella and Listeria monocytogenes. Adjusting these practices can significantly reduce the risk of produce-borne illness with minimal cost to growers.
Researchers at Purdue University have developed a system that concentrates foodborne salmonella and other pathogens faster than traditional methods, enabling potential routine analysis within a single work shift. The device uses hollow thread-like fibers to filter out cells and recovers up to 70% of living pathogen cells.
A genomic study found that Salmonella populations in humans and animals living side by side have distinct genetic variations, challenging the notion that local animals are a primary source of antibiotic-resistant infections. The research also revealed greater diversity in antibiotic resistance genes in human-infecting bacteria.
A new method developed by Michael DiMarzio identifies and tracks antibiotic-resistant Salmonella Typhimurium strains, which account for 15% of human salmonellosis infections. The study uses CRISPR sequences to separate isolates with common resistance patterns in both animals and humans.
Salmonella bacteria can manipulate macrophages to switch from an inflammatory to anti-inflammatory state, promoting chronic asymptomatic carriage of typhoid fever. This mechanism could lead to new treatments for typhoid fever, a disease that causes hundreds of thousands of deaths each year.
Researchers at Arizona State University have developed a new design for salmonella-based vaccines that can survive the acidic environment of the stomach. This improvement allows for stronger immune responses and potentially longer-term protection against diseases.
A probiotic strain of E. coli reduces Salmonella colonization by competing for iron, leading to decreased Salmonella counts in the gut. The approach has potential for treating other gut bacterial pathogens that require iron to grow.
A study found that whole chickens purchased from farmers markets had significantly higher levels of bacteria like Campylobacter and Salmonella compared to those from grocery stores. This suggests interventions like antimicrobial rinses may be necessary to lower pathogen loads on poultry carcasses.
The study reveals that Salmonella typhi's powerful typhoid toxin is responsible for the devastating symptoms of typhoid fever. The discovery could lead to the development of effective vaccines and therapeutics targeting this toxin, offering hope for saving millions of lives.
A study examining food poisoning infection in mice reveals Salmonella takes over beneficial bacteria in the gut, using a previously unknown sugar called fucose. The research provides new insights into infection dynamics and could lead to better prevention or treatments.
Researchers have developed a faster method to identify Salmonella strains, reducing the time it takes to detect outbreaks from one to three days. The new approach, called CRISPR-MVLST, is comparable in accuracy to existing methods and has the potential to be much cheaper.
A study by researchers at the University of Georgia found a strong correlation between poultry farm contamination and later processing plant contamination. The findings suggest that reducing pathogens on farms can reduce contamination levels at processing plants, potentially lowering the risk of foodborne illness.
Researchers found a protective molecular switch in Salmonella Typhimurium that helps the bacteria adapt to hostile environments during infection. This switch, using S-thiolation, may provide insight into fighting systemic illness and could be exploited to develop new treatments.
A retrospective study of nearly 40,000 proficiency test results found that food laboratories report false negatives for Campylobacter (9.1%) and Salmonella (4.9%), while also experiencing high false positive rates for these pathogens. Improved accuracy is crucial for a safer food supply.
Researchers at Norwich BioScience Institutes discovered a novel way in which certain gut bacteria can inactivate Salmonella, a foodborne pathogen. The study found that cell contact between good and bad bacteria is necessary for this process to occur.