A recent study by University of Illinois researchers has identified a key gene that controls Salmonella's ability to live dormantly or cause disease in pigs. The finding, led by Richard E. Isaacson, could lead to the development of methods to prevent Salmonella from causing illness in farm animals.
Researchers have genetically modified Salmonella bacteria to reduce virulence and increase safety while retaining tumor-targeting properties. The modified bacteria exhibit reduced ability to induce TNF-alpha and cause septic shock, making them safer for human use.
A team of researchers has successfully created a genetically engineered Salmonella bacterium that can serve as an oral contraceptive for feral cats. The vaccine induces antibodies that block sperm fertilization, potentially helping to control the nation's stray cat population and mitigate their impact on songbird populations.
Engineered Salmonella bacteria, stripped of pathogenicity, target solid tumors in laboratory animals while having little or no adverse effects. The safe versions can significantly prolong the life of mice with melanoma.