Articles tagged with Dna Strands
Researchers discovered a crucial RNA strand called CYTOR that helps build muscle mass, and found it decreases with age. Gene therapy stimulated CYTOR production, leading to increased fast-twitch muscle fibers and improved muscle function in humans and mice.
Researchers at Hokkaido University have developed a tuneable, elastic and temperature-sensitive gel by using complementary DNA strands to connect star-shaped polymer molecules together. The gel exhibits predictable behavior, self-healing properties and durability suitable for medical and engineering applications.
A new method identifies proteins binding to R-loops, revealing the role of DDX41 in regulating R-loop levels and preventing DNA damage. Elevated R-loop levels increase cancer risk.
Scientists have observed that ionizing radiation can cause intermolecular Coulombic decay in organic molecules, leading to damage in DNA and proteins. This new understanding could lead to the development of more effective substances for radiation therapy and improve knowledge of how radiation damages healthy tissue.
A special form of four-stranded DNA has been found to interact with the gene that causes Cockayne Syndrome when faulty. G-quadruplexes, which form knot-like structures in DNA, specifically bind to a protein called CSB, affecting its function and potentially leading to premature ageing.
Researchers from Tokyo Tech have developed a long DNA molecule-based junction that shows remarkable conductivity and self-restoring ability under electrical failure. The 'zipper' configuration allows for high electron transport and reveals delocalized ς-electrons moving freely within the molecule.
Researchers develop DNA Nanoswitch Calipers to measure distances within single molecules using force, enabling the identification of single proteins in samples. This technique creates a unique 'fingerprint' that can be used to identify known molecules or infer structural information about unknown ones.
Researchers found that DNA tangles create mutational hotspots in bacterial genomes, influencing evolution. By altering the sequence to prevent hairpin tangles, they can predict how microbes might mutate under selective pressure.
Researchers at DTU Health Tech have invented a one-pot assay, NISDA, for rapid detection of SARS-CoV-2 RNA without the need for enzyme-based methods. The assay detects low concentrations of RNA in 30 minutes and has shown high accuracy and sensitivity.
A team of scientists from Incheon National University developed a programmable DNA-based microfluidic chip that can perform complex mathematical calculations, such as Boolean logic operations. The chip uses a motor-operated valve system to execute a series of reactions in rapid and convenient manner.
A new study by Newcastle University researchers has developed dynamic DNA data structures that can store and retrieve information in an ordered way. The study presents an in vitro implementation of a stack data structure using DNA polymers, which stores and retrieves information in a last-in-first-out order.
Researchers created designed and biologically active 2-D and 3-D protein arrays using DNA-based assembly, maintaining structural stability and biological activity. The method has potential applications in structural biology, biomaterials, nanomedicine, and biocatalysis.
Researchers at Northwestern University used cryo-electron microscopy to visualize DNA breakage sensing and repair, gaining new insight into the process. The study's findings could potentially form the basis for understanding how cells respond to chemotherapy and radiation, leading to improved cancer treatments.
Researchers developed a reversible gene editing technology called CRISPRoff that allows controlling gene expression while leaving the underlying DNA sequence unchanged. The new method can silence the vast majority of genes with great homogeneity and in a reversible manner.
DNA origami is a technique that folds long DNA strands to create mini 3D structures for biosensors and drug delivery. A new guide from NIST provides a comprehensive resource for researchers to design efficient nanostructures using state-of-the-art tools.
Chemists at Scripps Research Institute demonstrate a simple compound called diamidophosphate can assemble DNA building blocks into primordial DNA strands. This finding supports the theory that DNA and RNA arose together as products of similar chemical reactions.
Klimov is developing a computational platform to design antibody-antigen interfaces based on DNA origami. The goal is to predict high-affinity peptide sequences that bind to tetanus toxin, targeting structured or unstructured antigen regions.
Researchers at Arizona State University are exploring DNA-based storage technologies that can store and retrieve information securely. The project aims to create microscopic forms with encryption capabilities rivaling silicon-based semiconductor memories.
Researchers at Arizona State University have developed a new type of meta-DNA structure that can be used to engineer sophisticated nanoscale structures and devices. The meta-DNA self-assembly concept has opened up new possibilities for optoelectronics, including information storage and encryption, as well as synthetic biology.
Scientists at NIST have found a way to significantly enhance the accuracy of key information on how heat affects the stability of folded DNA structures. The novel mathematical algorithm automatically accounts for unknown effects, allowing scientists to design durable and complex structures made from DNA.
Research from NC State University reveals how MutL and MutS proteins create an immobile structure to prevent replication errors, reducing errors by a thousand-fold. The complex also prevents mismatched regions from being packed back into the cell during division.
Researchers discovered a new DNA storage technique that encodes and retrieves information with unprecedented accuracy and efficiency. The method harnesses the capacity of intertwined DNA strands to store durable and compact data, outperforming current methods in information accuracy and efficiency.
Researchers have developed a novel method to quantify deoxyribonucleotide triphosphates (dNTP) concentrations in small tissue samples, which is useful for studying mitochondrial diseases and cancer. The technique uses DNA polymerase and fluorescent dye, allowing for accurate measurement even in samples with low dNTP concentration.
Scientists at the University of Konstanz have visualized the biochemical processes involved in detecting DNA strand breaks using PARP1, a key enzyme in DNA repair. This study provides important insights into the molecular mechanisms underlying cancer development and aging processes.
Scientists have identified a molecular mechanism that could reverse the genetic defect responsible for Friedreich's ataxia by enhancing a natural process that contracts repetitive DNA sequences in living tissue. This contraction occurs during DNA replication and is triggered by the formation of an unusual triple-helical DNA structure.
Researchers created a mutated form of DNA repair protein RAD51 to study its critical functions at stalled replication forks. The study found that RAD51's strand exchange activity is not required for fork regression, but is crucial for restarting replication once the obstacle has been removed.
A study published in PNAS reveals that DNA helicases unwind the double strand more easily in one direction than the other, with the speed of unwinding depending on the sequence composition of the bases. This discovery has implications for understanding gene expression and the regulation of cellular activities.
A new CRISPR approach called prime editing has been developed by combining two key proteins and a new RNA to make targeted insertions, deletions, and single-letter changes in human cells. The system expands the scope of gene editing with up to 89% precision and potential correction of disease-causing genetic variations.
Researchers found that intrinsic mechanical properties of chromatin determine how fibers entwine during DNA replication, preventing tangles and ensuring proper segregation. The study highlights the importance of physical principles in biological processes and provides new insights into chromatin behavior.
Researchers are using DNA to build nanoscale devices that can generate, transmit, and sense mechanical forces. These devices have potential uses in drug delivery, nano computers, and nano robots, and could lead to breakthroughs in biomedical research and materials science.
Scientists have successfully created a nanocluster of exactly 16 silver atoms stabilized by a wrapping of DNA strands. The crystal structure revealed that each nanocluster is tightly wrapped and almost completely shielded by two DNA strands, with novel silver-silver interactions observed within the cluster.
Researchers captured high-resolution images of a gene-editing tool called CRISPR-Cas9 using cryo-EM technology, revealing new information about its mechanism. The findings hold promise for developing more efficient and precise versions of the enzyme to correct disease-causing DNA mutations.
Researchers developed DNA Enrichment and Nested Separation (DENSe) techniques to label and retrieve DNA data files, increasing estimated file names from 30,000 to 900 million. The system uses nested primer-binding sequences and molecular tags for efficient data retrieval.
A study published in ACS Central Science found that many DNA cage nanostructures are not taken up by cells, but rather degraded by enzymes outside the cell. The researchers' findings have significant implications for the use of DNA strands as a tool for delivering therapeutic agents into diseased cells.
Researchers have identified two sets of proteins that work together to keep DNA strands unknotted and tangle-free. These proteins, known as SMC and TopoII, use a mechanism similar to a belay device on climbers' rope to resolve knots and links in DNA.
Researchers have developed a technique using time signals 'temporal barcodes' that can label molecules with distinct flashing patterns. This allows for the detection and identification of any number of molecules, including proteins, at the molecular scale, increasing efficiency and reducing costs compared to traditional methods.
A new approach called BIO-PC uses semi-permeable capsules containing diverse DNA logic gates for molecular sensing and computation. This method increases speed, modularity, and designability of computational circuits, reducing cross-talk between DNA strands.
Researchers used cryo-force spectroscopy to study DNA elasticity and binding forces at low temperatures. The study reveals that DNA behaves as a chain of small coil springs, with the spring constant determined for individual components.
Caltech scientists develop dynamic DNA nanostructures, enabling the creation of a microscopic tic-tac-toe game board with reconfigurable parts. The technology combines self-assembling tiles and strand displacement to allow for molecular self-reconfiguration, paving the way for more sophisticated nanomachines.
A team of Polish-American-Italian researchers has successfully created a record-long polymer DNA negative, featuring a sequence with all four nucleobases. The synthetic molecule functions chemically like a normal strand of deoxyribonucleic acid and demonstrates improved properties over natural DNA.
Researchers develop technique SCAR-seq to study epigenetic cellular memory transmission and find key protein MCM2. They discovered a controlled process in DNA replication ensuring symmetry between two new DNA strands.
Researchers at University of Illinois Chicago discovered that persistent binding of the Cas9 protein to DNA causes CRISPR failure. To improve efficiency, they found that consistent strand selection forces RNA polymerases to collide with Cas9, knocking it off DNA.
A team at the University of California San Diego has developed a wireless chip that can detect genetic mutations, including single nucleotide polymorphisms (SNPs), in real-time. The chip is at least 1,000 times more sensitive than current technology and could lead to cheaper, faster, and portable biosensors for early disease detection.
Researchers at USC Dornsife have discovered how the cell's emergency response team, known as paramedics, uses walking molecules to transport damaged DNA to the nucleus for repair. This process is crucial for preventing cancer formation and has implications for human health and genome editing.
Researchers at Arizona State University have created a DNA walker that can rapidly traverse a track, significantly increasing speed and paving the way for new innovations in DNA nanotechnology. By optimizing DNA strand length and sequences, the device can cover ground up to 100 times faster than previous devices.
MIT researchers have discovered the factors that determine whether a DNA knot moves along the strand or jams in place. By manipulating the electric field strength, they can induce knots to move towards one end of the molecule, potentially enabling more accurate genome sequencing and knot removal methods.
Researchers at Ohio State University have discovered a new CRISPR mechanism that can help prevent gene-editing errors. The discovery reveals how the Cas9 enzyme determines where and when to cut DNA strands, allowing for more precise control over gene editing.
Scientists have created asymmetrical polymer structures that bind together in a spatially defined manner, similar to atoms coming together to make molecules. This breakthrough technique could lead to new materials for applications ranging from drug delivery to 'soft robotics',
Scientists develop single-stranded DNA origami, a breakthrough in nanotechnology that can create complex structures without knots. The technology has potential applications in medicine, including delivering drugs inside cells.
Researchers at Caltech developed a method to assemble large DNA structures with customizable patterns, creating a 'canvas' that can display any image. They used fractal assembly to recreate the world's smallest Mona Lisa using DNA origami.
The team built larger objects, including gears for nanomotors and microtubes with sizes comparable to bacteria. They also constructed closed cage structures with discrete-size cages attaining molecular weights and sizes comparable to viruses and small cell organelles.
Researchers have discovered a novel mechanism to reactivate gene expression in mouse embryonic stem cells without causing DNA damage. The new pathway involves enzymatic oxidation of the methyl group attached to cytidine, converting it into 5-formylcytidine, which is then rapidly converted back into unmethylated cytidine.
Researchers develop a method for assembling colloidal clusters using origami DNA, allowing precise control over particle orientation and properties. The technique enables the creation of clusters with specified chirality, which could lead to improved understanding and utilization of particles with unique optical or magnetic properties.
Researchers develop a single-strand DNA robot that can autonomously pick up and sort molecules into distinct regions on a surface. The robot successfully sorted six scattered molecules in 24 hours, and its design can be generalized to work with dozens of types of cargos.
Researchers have created miniature DNA robots that can pick up particles and deliver them to different areas using origami tracks. The robots, which move randomly along the track, have an 80% chance of successful delivery and can perform tasks such as assembling chemical compounds or rearranging nanoparticles on circuits.
A breakthrough in gene synthesis has been achieved using a chemical method that overcomes limitations of existing methods by incorporating epigenetic information into genes. This new approach, click DNA ligation, enables rapid and efficient assembly of modified DNA fragments into functional genes.
Researchers have built simple machines out of DNA consisting of arrays whose units switch reversibly between two different shapes. The arrays' properties shed light on how to build structures with more complex, dynamic behaviors. By harnessing these DNA mini-machines, scientists may be able to create nanotech sensors and amplifiers.
A team of scientists has developed a method to create structures with DNA building blocks, a millionth of a meter in size. They manipulated the sequencing of DNA to offer an intricate approach to synthesize materials at the most fundamental level.
Researchers watched individual DNA strands replicate and found that polymerases on the leading and lagging strands are completely autonomous, with no coordination. The study reveals a new stochastic view of DNA replication, challenging conventional wisdom and providing insights into this essential biological process.
New simulations reveal DNA's constant motion enables rapid transcription factor diffusion, contradicting the long-held assumption of rigid DNA. The findings have significant implications for understanding cell processes and potentially boost speed and accuracy in biological and medical research.