Articles tagged with Gene Regulation
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Researchers have solved a 72-year-old mystery surrounding cholesterol production, revealing that Insig proteins play a crucial role in regulating this process. The study found that mice lacking these proteins accumulate excessive cholesterol and fat in the liver, highlighting the importance of Insig in maintaining normal lipid metabolism.
Recent studies suggest that multiple rare mutations within a single gene may increase risk for autism. The SERT gene regulates brain levels of serotonin, which is involved in various biological processes and has been found to be elevated in about 25% of people with autism. SSRIs have improved some symptoms, leading scientists to propos...
Researchers have identified new genes that regulate aging, with effects on insulin signaling, metabolism, and dietary regulation. Inhibiting these genes increases lifespan in certain organisms, suggesting potential therapeutic applications for age-related diseases.
Researchers discovered that induction of the HIF-1 pathway can act as a 'super-antibiotic', increasing bacterial killing in low-oxygen environments. Additionally, studies on skeletal muscle and kidney regeneration found that these organs' natural repair mechanisms play a crucial role in maintaining function and tissue health.
A study published in the Journal of Neuroscience Research found that patients with multiple sclerosis (MS) have lower expression of the FOXP3 gene, leading to reduced immune suppression. A new drug called NeuroVax was shown to increase FOXP3 levels and restore immune regulation in some patients.
A new transcription factor system in bacteria has been identified, which represses expression of genes involved in DNA replication. The system was discovered using comparative genomics and phylogenetic footprinting, revealing a highly conserved signal sequence and the regulatory transcription factor that binds it.
Researchers have identified a regulatory element within the 52-kilobase deletion region responsible for Van Buchem disease. This discovery provides strong causal evidence linking the deletion to the disease and opens up new avenues for understanding bone formation and potentially developing therapeutic agents.
Researchers have identified the regulatory element responsible for Van Buchem disease, a hereditary disorder that causes facial distortions, osteosclerosis, and vision and hearing loss. The discovery provides insight into long-range gene regulation and could lead to new treatments for osteoporosis.
A study by UT Southwestern researchers found that the Clock gene regulates reward responses to cocaine and dopamine pathways. The study suggests a link between disrupted circadian rhythms and the tendency to abuse drugs.
Scientists developed a new bioinformatics technique to analyze key DNA regions controlling gene activity. The approach uses machine learning to predict binding site combinations and regulate genes, achieving success rates comparable to existing methods.
Scientists found a new role for protein ATF2 in DNA repair, which may pave the way to cancer treatments. The study reveals that ATF2's dual function in regulating cell cycle and programmed cell death can be uncoupled from its DNA repair function.
A team of researchers, including a UCR chemist, has discovered a novel site of histone acetylation that regulates gene expression in yeast. The study used mass spectrometry to show that this new site is associated with gene activation by attracting the SWI/SNF chromatin remodeling complex.
A massive study of 100,000 individuals found that Caucasians have the highest prevalence of hemochromatosis/iron overload due to a specific gene mutation. In contrast, Asian and Pacific Islanders have high blood iron levels despite lower genetic mutations, suggesting a different underlying cause.
Researchers at NYU's Center for Comparative Functional Genomics have discovered a complex system of microRNA gene regulation, with individual genes controlling an average of 200 different transcripts. The team developed PicTar, a new algorithm to predict microRNA target sites in the genome, and made several experimental validations.
Researchers at Boston University have discovered a new gene, STAT6(B), that regulates vascular endothelial growth factor (VEGF) and affects TNF-alpha levels. This finding offers new opportunities for treating cancer and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.
Researchers at Yale University have discovered that the microRNA let-7 regulates the Ras cancer gene by binding to its mRNA and inhibiting translation. This finding has significant implications for understanding cancer progression and developing new treatments, including gene therapy with let-7.
Dr. Goldstein and Dr. Brown will discuss their research on the regulated intramembrane proteolysis (RIP) of sterol regulatory element binding proteins (SREBPs), which regulates lipid biosynthesis and plasma cholesterol levels. Their work has been recognized with numerous awards, including Nobel Prize in Physiology or Medicine.
Researchers have identified networks of genes that respond to alcohol in the brain, which may play a role in determining genetic differences in behavioral responses to alcohol. The study found that certain genes were regulated differently in two mouse strains, leading to distinct behavioral responses to alcohol.
Charles Yanofsky, a renowned molecular biologist at Stanford University, has been awarded the National Medal of Science for his groundbreaking work on gene expression and protein production. His research has significantly advanced our understanding of how genes are regulated to produce specific proteins.
Researchers found that chronic lymphocytic leukemia (CLL) cells are born at a fast rate but die, leading to a slow rise in cell count over time due to variable birth and death rates. This dynamic interplay between CLL cell division and cell death may enable physicians to predict disease progression.
Researchers discovered a key protein, BZR1, that regulates plant growth by binding to a specific DNA sequence and stopping the production of an enzyme needed for BR synthesis. This feedback loop helps maintain optimal steroid levels for plant growth.
Lynne E. Maquat and her team identified a novel pathway for regulating RNA degradation, called Staufen1-mediated degradation (SMD). This mechanism affects numerous transcripts and is a new form of gene regulation. SMD activity may be regulated by cell signaling pathways.
Campylobacter jejuni, a common bacterial cause of diarrhea in the US, exploits human cells for nutrients and causes disease through gene regulation changes. Researchers have identified CJ1461 as a critical protein involved in this process, offering hope for developing treatments and vaccines.
Researchers have created a method to identify gene regulator proteins' roles in cell differentiation, cancer, and more. By analyzing genome-binding sites, they've identified 6,302 binding sites for CREB, including those near known genes.
The American Physiological Society has announced its 2005 Distinguished Lecturers, recognizing outstanding contributors and representatives in various fields of physiology. The award winners include researchers who have made significant contributions to their respective fields through original research, education, and mentorship.
Research found that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid from fish oils, stimulates the secretion of leptin in primary cell cultures of fat from rats. This effect may be beneficial for maintaining body weight during obesity treatment and improving associated pathologies.
Researchers found that African Americans are more likely to carry genetic variants stimulating inflammation and less likely to have anti-inflammatory proteins. These findings suggest evolutionary changes in the human genome may impact inflammation.
A recent study by Charlotte Ling and colleagues found that aging decreases the expression of PGC-1alpha and PGC-1beta in muscle, increasing insulin resistance and T2DM susceptibility. The age-dependent decrease was partially heritable, suggesting a genetic link to the development of insulin resistance.
In Arabidopsis leaves, specific mutations affect leaf patterning by altering microRNA binding sites. MicroRNAs interact with nascent mRNA to alter chromatin states, leading to reduced methylation of PHB and PHV genes. This study demonstrates the role of microRNA-directed DNA modification in regulating plant development.
A mouse study revealed that the molecular clock genes Bmal1 and Clock play a crucial role in regulating blood sugar levels. Disrupting these genes led to impaired glucose regulation, even with insulin treatment. The study suggests that our internal circadian clock may influence blood sugar control beyond diet.
A new Wistar Institute study suggests that epigenetic information can be passed from generation to generation, complicating the standard model of genetics. The research findings support the theories of Jean-Baptiste Lamarck, who proposed that traits acquired by parents during their lives could be passed on to offspring.
A team of scientists at the University of Rochester Medical Center discovered that mice without the TR4 gene are born smaller, less fertile, and have poor parenting skills. The miniature mice exhibit reduced nest-building, nursing, and offspring care, resulting in high pup mortality rates.
A new method developed by Princeton scientists can detect small chromosome alterations in cancer cells with high accuracy. The technique allows researchers to identify previously unknown additions and deletions, which may lead to new treatments for breast cancer.
Research suggests that retrotransposons, previously considered 'junk DNA', can initiate synchronous gene expression in mouse eggs and early embryos. This discovery may contribute to the reprogramming of the mammalian embryonic genome.
Steve McKnight's research on gene regulation and the body's internal clock has led to discoveries that may help understand and treat insomnia and depression. The NIH Pioneer Award recognizes his innovative work in taking creative risks and achieving groundbreaking accomplishments.
Scientists have developed a new method to quickly identify the precise landing sites of gene regulators in yeast, which are essential for understanding how genes and their regulators 'talk' to each other. This breakthrough could lead to a better understanding of diseases such as diabetes and cancer.
Male fruit flies without specific circadian clock genes spend up to 30-50% more time in copulation than normal counterparts. The findings broaden the known behaviors controlled by these genes and suggest they may regulate biological processes within short and long time scales.
Researchers found that mutations in clock genes caused male flies to copulate significantly longer than usual, revealing a novel role for these genes in regulating behavioral timing on the order of minutes. The study also suggests that clock genes may have important regulatory functions in other areas beyond cyclic patterns.
Researchers create synthetic transcription factors, mimicking natural regulators to probe gene regulation and explore new treatment approaches. The artificial activation domains developed in Mapp's lab were as effective as a natural activation domain at turning on genes.
A study from the Ludwig Institute for Cancer Research has uncovered a fundamental mechanism of lymphatic vessel formation, revealing abnormally shaped vessels covered in smooth muscle cells. The findings may lead to better treatments for lymphedema, which affects people worldwide and can be inherited or caused by tumor removal.
Researchers found that disrupting the circadian clock gene led to abnormal estrous cycles and high rates of mid-gestation pregnancy failure. The study's findings have implications for human infertility, particularly for women working swing-shifts, who are more susceptible to irregular menstrual cycles and miscarriage.
Researchers identified NRH1 as essential for regulating convergent extension in frogs, a process also influenced by Wnt/PCP signaling. Overexpression of NRH1 resulted in shortening of the body axis and failure of mesodermal marker gene expression, while loss-of-function led to inhibition of convergent extension.
A recent study by Takayuki Onai et al. reveals that XsalF, the Xenopus homolog of spalt, regulates forebrain and midbrain-specific gene expression. The research demonstrates direct linkage between XsalF expression and forebrain/midbrain identity.
Researchers found a natural mutation of the SUMO-4 gene, which regulates immune system activity, to be a major contributor to type 1 diabetes. The mutation increases the immune system's reactivity to environmental triggers, leading to an autoimmune response that attacks the patient's own tissue.
Researchers at SLU have identified the first gene regulating programmed cell death in plant embryos, revealing a previously unknown mechanism. This discovery has significant implications for plant breeding and forestry, as it may help increase production and bolster resistance in plants.
Researchers have identified a critical regulatory region for the development of the enteric nervous system, which plays a vital role in gastrointestinal functions. Genetic mutations in this region may lead to incomplete development of the enteric nervous system, often causing Hirschsprung disease.
A study published in Cancer Research identified a cancer-causing gene, HMG-I, that contributes to the development of leukemia and lymphoma in humans. The researchers found that overexpression of the gene led to the rapid development of tumors in genetically engineered mice.
Mice with disrupted STAT3 proteins exhibit severe obesity and enlarged livers due to excessive fat deposits. The study also reveals a link between STAT3 and energy balance through its effect on leptin, which could lead to new therapeutics for treating obesity and infertility.
Researchers at the University of California - Davis have cloned the VRN2 gene in wheat, which controls vernalization and plays a crucial role in the crop's adaptation to different environments. The study provides valuable insights into breeding strategies for improving wheat varieties through manipulation of flowering times.
Researchers identified four genetic variants strongly associated with type 2 diabetes in Finnish and Ashkenazi Jewish populations. The variants cluster in the regulatory region of the HNF4A gene, influencing insulin secretion in response to glucose.
Researchers found that gene regulation is bipolar, with a small set of genes relying on the TATA box for proper function, while most genes rely on the TFIID complex. This discovery provides clues about how to understand gene function and regulation in yeast and potentially applicable to human genetics.
Gene expression scales closely with initial expression levels, with highly expressed genes showing dynamic changes and lower-expressed genes less variability. A 'rich-travel-more' mechanism governs this proportionality, underlying complex biological networks.
Scientists have developed a new genomics tool that enables the efficient mapping of genome binding sites for transcription factors in human organs. This technology has been used to study the role of transcription factor HNF4 in type 2 diabetes, revealing its association with about half of all genes needed to make the pancreas and liver.
Researchers at Scripps Research Institute solved the structure of a regulatory protein that controls gene expression by recognizing specific RNA sequences. The discovery provides valuable insights into post-transcriptional gene regulation and its potential to target diseases such as inflammation.
Elevated iron stores, particularly plasma ferritin concentration, may predict type 2 diabetes risk in healthy individuals. Healthy women with moderately elevated iron levels were found to have higher baseline intake of heme iron and lower fiber and magnesium consumption.
Tumors use Stat3 signaling to secrete factors that inhibit the immune system, keeping dendritic cells from maturing. This activation blocks expression of inflammatory mediators required to trigger the immune response. New treatments aimed at flushing cancer cells into the open may help the body's armies against disease destroy them.
A new study by researchers at The Wistar Institute shows that gene activation is a highly dynamic process requiring specific molecular modifications, including the addition and removal of ubiquitin. This process involves a sequence of events and not just the accumulation of molecular groups.
A genome-wide analysis of 1,875 people found a significant link between a region on chromosome 1 and blood pressure regulation. The study identified 24 genes that may play a role in hypertension, with three genes showing specific genetic changes associated with the condition.
Researchers identified a mutation in the human serotonin transporter gene, hSERT, associated with OCD, which may result from a genetic double hit increasing serotonin transport and leading to treatment resistance. The study provides insights into transporter function and potential tests for identifying and treating mental illness.
Researchers found that a mutated fruit fly gene controlling hearing produces similar consequences in humans, including hearing loss and limb deformities. The study suggests that hearing may have evolved earlier than previously thought, linking human genetics to those of fruit flies.