Articles tagged with Gene Regulation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research reveals that chronic alcohol consumption alters neural systems in the brain, leading to cognitive deficits and disorders of memory and learning. Dynorphins, a key player in this process, are found to be upregulated in the prefrontal cortex and hippocampus, impairing learning and memory.
Scientists have identified a gene called Lrh1 that plays a crucial role in regulating ovulation. Deleting this gene in mice prevents ovulation, opening up potential avenues for developing more effective contraceptives and fertility treatments. This discovery could benefit up to 15% of infertile couples seeking help.
Researchers at UCSC have identified a novel type of gene regulation in mammals involving hammerhead ribozymes, which control the activity of important immune response and bone metabolism genes. The discovery challenges previous views on gene expression and suggests a more versatile role for RNA molecules.
Researchers at UT Southwestern Medical Center have identified a new target for RNAs that regulate genes, finding that these tiny strands bind to non-coding RNA transcripts and recruit proteins to activate or inhibit gene expression.
Researchers have identified a novel mechanism in plants that regulates circadian rhythms, which are integral to responses to light, temperature, and other environmental cues. The PRR gene family plays a crucial role in these mechanisms, with its members transcribed and translated at different times of day.
Researchers have identified approximately 2000 genes that contribute to the increased drought tolerance of two Andean potato clones. The study found up-regulated genes involved in osmotic adjustment, detoxification, and cell communication and signaling, as well as increased solute concentrations to induce water uptake from drying soils.
Researchers at the University of Cincinnati have identified the role of transcription factors in controlling cell death in the heart, paving the way for gene regulatory therapy. They have successfully developed non-viral delivery mechanisms to transfer DNA and repress activation of specific transcription factors.
The Genetic Information Nondiscrimination Act (GINA) has been signed into law, providing protections for patients and research participants from genetic discrimination in health insurance and employment. However, gaps in oversight of genetic tests and the need for regulatory guidance remain to be addressed.
Researchers at USC identified a gene variant associated with fasting glucose levels, providing new insights into blood sugar regulation. The study found that genetic variation in the G6PC2 gene may be responsible for reducing insulin secretion and increasing glucose concentrations.
Researchers at Baylor College of Medicine used high throughput microscopy to study the regulation of estrogen receptor-alpha, finding that its response depends on the manner of regulation. The technique enabled them to analyze thousands of images of cells and differentiate between ligand- and steroid-dependent regulation.
Researchers identified regulatory sequences that act like zip codes, determining where odour receptors are expressed in olfactory neurons. These elements positively and negatively regulate receptor expression, suggesting a broader role in nervous system development.
Researchers at Gladstone Institutes have identified genes responsible for fat storage in cells, which may lead to new understanding and potential treatments for obesity, diabetes, and heart disease. The study found that ~1.5% of all genes function in lipid-droplet formation and regulation.
Researchers have mapped nucleosome organization along genes in Drosophila melanogaster, revealing a critical stop sign for transcription. This discovery highlights the importance of nucleosomes in regulating gene expression and has implications for developing effective anti-viral drugs against HIV.
Scientists chart the epigenome of plant Arabidopsis thaliana, mapping precise DNA modifications and their effects on gene activity. The study provides insights into plant productivity, stress resistance, human genome dynamics, and cancer research.
New data reveals miRNAs control female mouse fertility by regulating the corpus luteum's blood vessel formation and TIMP1 expression. Injection of specific miRNAs into ovaries improved corpus luteum function in Dicerd/d mice.
Researchers discovered a gene in flies whose activity is controlled by protein and sugar intake, suggesting a second mechanism for glucose release under specific dietary conditions. The findings also reveal potential links between diet, insulin signaling, and life span, particularly with high-protein diets.
Researchers examined two emotion regulation strategies: reappraisal and suppression. Reappraisal reduced negative emotions and activated prefrontal cortex, while suppression increased amygdala activity. These findings suggest reappraisal as a more successful coping strategy.
Researchers at the University of Washington have identified 25 genes regulating lifespan in yeast and roundworms, with at least 15 having similar versions in humans. The study provides quantitative evidence that these genes have been conserved during evolution, suggesting potential targets for treating age-related diseases.
Researchers have identified 25 genes that regulate aging in both yeast and nematodes, with significant overlap between nutrient-response pathways. These findings suggest that similar mechanisms may contribute to human aging, providing a foundation for understanding age-associated diseases.
Researchers at EMBL discovered that estrogen causes rapid epigenetic changes in breast cancer cells, challenging the long-held assumption of methylation as a mechanism of long-term gene regulation. This cyclical nature of methylation may shed light on the molecular bases of cancer and development.
Scientists at the University of Helsinki and the University of California have discovered a gene regulating carbon dioxide uptake and water evaporation in plants. This gene helps develop drought-tolerant crops, addressing climate change's impact on global food production.
A team at CSHL led by Professor Leemor Joshua-Tor discovered a new wrinkle in the regulation of gene expression that governs metabolic state in yeast cells. The discovery revealed a key role for the NADP molecule in adapting to changes in nutritional environments.
The study found that mice lacking HOXA11 had no uterosacral ligaments, highlighting the gene's importance in their development. In women with pelvic organ prolapse (POP), decreased HOXA11 expression was linked to weakened connective tissue and increased levels of a degradation mediator.
Researchers at The Wistar Institute have solved the structure of p300/CBP, a gene regulator implicated in deadliest cancers. The breakthrough reveals how p300/CBP regulates a wide variety of genes and enables the development of targeted cancer therapies.
PARP-1 and histone H1 compete for binding to gene promoters, with PARP-1 turning genes on. The study reveals a surprising number of genes are kept on by the presence of PARP-1.
VEGF-B has been shown to inhibit apoptosis in retinal cells and brain cells in mouse models of injury and stroke, suggesting its potential as a new treatment for neurodegenerative diseases. Autophagy is also identified as a virulence-associated trait and survival mechanism for the fungal pathogen Cryptococcus neoformans.
Uppsala University scientists have developed a method to analyze genetic regulation and identified genes that govern fat levels and energy conversion. This breakthrough provides new understanding of the causes of disturbed metabolism, including familial combined hyperlipidemia.
Researchers at Ohio State University have discovered two genes, E2F7 and E2F8, that play a vital role in preventing massive cell death in developing embryos. The study shows that these genes suppress the activity of another gene, E2f1, which is involved in triggering programmed cell death.
Swedish researchers have identified several genes that regulate the autoimmune disease SLE, including BANK1, which affects B cells and auto-antibody production. The findings may lead to new treatments targeting B cell functions.
Researchers successfully switched a gene regulatory element from a bat to a mouse, resulting in abnormally long forelimbs. This study demonstrates that evolution can be driven by changes in gene expression patterns, rather than solely genetic changes.
Researchers at Tufts University found that brain-derived neurotrophic factor (BDNF) is critical for mediating satiety in adult mice. Mice with deleted BDNF genes ate more and became heavier, highlighting the protein's role in energy balance.
The Baumann lab has identified the long-sought telomerase RNA gene in a single-cell research model, providing a critical tool for studying telomerase in human cells. This breakthrough sheds light on the correlations between telomere shortening and various diseases, including cancer and coronary heart disease.
Researchers discovered a new regulatory element in the CFTR gene that controls its expression in the gastrointestinal tract. The study identified three key regulatory factors that modify chromatin structure, leading to altered CFTR expression.
Researchers have shed new light on the role of RNA polymerase II in gene expression, revealing a complex mechanism that allows for efficient use of existing genes. The study found that phosphorylation of serine 7 at the carboxyterminal domain is essential for processing and maturation of specific gene products.
Researchers found that a common genetic mechanism, involving the Kitlg gene, is responsible for the evolution of skin pigmentation in both fish and humans. This discovery reveals a surprising parallel between the evolutionary history of stickleback fish and human populations.
A University of California, Irvine study identifies a single amino acid that triggers circadian rhythms, opening up potential for new pharmaceuticals to treat sleep disorders and related ailments. The finding uncovers the most specific information about the body's internal clock to date.
Two studies published in BMC Genomics have identified over 1,400 genes involved in grape ripening and revealed the first biochemical evidence of reactive oxygen species accumulation during color transition. The findings provide a powerful new resource for understanding fruit ripening control in non-climacteric plants.
Researchers compared 12 closely related fruit fly species to better understand genetic adaptation, immune systems and gene regulation. The study, led by Cornell University, found evidence of evolutionary pressures on genes and regulatory elements that control diseases, development and behavior.
Researchers identify novel TRF2 target promoters, distinguishing between three classes of genes dependent on TBP or TRF2. Depletion of TRF2 leads to reduced ribosomal gene transcription and chromosomal defects.
Research published in BMC Neuroscience found that genetic genes controlling the body clock also regulate the need for sleep, linking sleep to energy metabolism. The study used mice with different genetic make-ups to explore this connection, revealing changes in gene expression associated with sleep deprivation and recovery.
The study reveals that f and m type plant thioredoxins are not only localized to chloroplasts but also found in nonphotosynthetic tissues such as stems, leaves, roots, and flowers. These findings suggest new roles for these proteins in cell division, germination, and plant reproduction.
A virtual bazaar called PAZAR has been established to share gene regulation data, allowing researchers to access information without charge. This open-access database aggregates data on transcription factor and regulatory sequences, enabling the development of novel cancer therapies and stem cell treatments.
A Yale University study found that structural changes to the human genome, including missing or rearranged segments, contribute to individual differences. These variations were identified using Paired-End Mapping and rapid sequencing methods.
A new study reveals that genetic variation in regions controlling gene activity is a significant contributor to common diseases. The researchers analyzed the activity of almost 14,000 genes and found over 1300 genes affected by DNA sequence changes in regulatory regions.
Researchers at the University of Alberta have found a new cause of blindness linked to a gene that regulates pH levels in the retina. The study suggests that targeting this process could lead to potential treatments for previously unknown causes of blindness, including hereditary vitreoretinal degenerations.
The study used knockout mice to test the hypothesis that ultraconserved elements are vital for life, but surprisingly found that mice lacking these elements were viable and fertile. The results suggest that the presence of ultraconserved elements is not required for organism viability.
The Conaway Lab has discovered a critical role for the chromatin remodeling complex INO80 in activating transcription mediated by the transcription factor YY1. This finding provides new insights into how YY1 regulates gene expression, which is crucial for cell cycle control and may have implications for cancer therapy.
Researchers compared gene expression in the frontal cortex of cirrhotic and non-cirrhotic alcoholics, finding widespread effects on cellular pathways related to cirrhosis. This suggests that heavy drinking can cause more brain damage in individuals with liver scarring.
A University of Toronto-led study found that alternative splicing is more highly regulated in nervous system tissues, allowing for specific functions in memory and learning. This new understanding of gene regulation has significant implications for human diseases such as cancers.
New research from Duke University reveals that the way genes are used in humans differs significantly from that of chimps and other primates. The study found dramatic differences in gene regulation related to brain development and diet, which may have contributed to human adaptability and susceptibility to certain diseases.
Yale researchers found that gene regulation plays a crucial role in shaping differences between species. By mapping DNA binding sites and analyzing regulatory regions, they discovered functional differences in yeast species, shedding light on the balance between gene content and regulation.
Researchers identified distinct genetic factors for blood pressure regulation in males and females, shedding light on gender-based disparities in cardiovascular health. The study's findings suggest that genetic diagnostic and therapeutic indices for hypertension must consider gender differences.
Researchers at Virginia Commonwealth University identified two key proteins, KLF2 and EKLF, that regulate overlapping groups of genes during red blood cell development. The study may lead to future gene therapies for sickle cell anemia and beta-thalassemia.
Researchers found that green tea slowed skin cell growth and regulated genes involved in skin cell life cycles, potentially treating psoriasis and dandruff. However, more human studies are needed to determine the full effects of this treatment.
A team of researchers at Rice University studied the gene LMO4 in zebrafish, discovering its role in regulating brain growth and development. They found that overexpression of the gene led to shrinkage of brain areas, while underexpression caused their enlargement.
Aging hematopoietic stem cells decline in function due to increased inflammatory response and decreased chromatin remodeling, leading to epigenetic dysregulation. Despite this decline, overall blood production remains stable.
A team of Canadian scientists has identified 1,155 genes under the control of Oct4, a master regulator of the stem cell state. These genes help maintain stem cells in a flexible state by controlling DNA packaging, cell division, and signaling pathways.
Researchers at University of Utah have developed a faster and less expensive technique for mutating vast, non-gene stretches of DNA. This new approach enables the evaluation of regulatory sequences that control gene expression, potentially leading to breakthroughs in human disease research.
A comprehensive analysis of the human genome has shown that a significant portion of the genome is actively transcribed and copied into RNA, relaying information to cellular machinery. The study identified new regions of gene regulation and altered our understanding of how genes are controlled.
Almac Diagnostics plans to develop and clear its In Vitro Diagnostic for colorectal cancer using the 510(k) approach, accelerating regulatory submission. The company's prognostic gene signature was developed from FFPE samples and aims to help clinicians determine cancer recurrence risk in stage II CRC patients.