Researchers at the University of Manchester have pioneered new methods to modify antibiotics' molecular structure, enabling the development of new types of antibiotics capable of combating increasingly resistant bacteria. This innovation provides access to thousands of lipopeptide variants that cannot be produced easily in any other way.
A study by Children's Hospital of The King's Daughters found that dads break or fracture the bones of their children far more often than moms. The abuse can be horrific, with one case involving 31 broken or fractured bones.
The Integrated Microbial Genomes (IMG) data management system has been updated to version 2.4, featuring 3,637 genomes from the Version 25 release of NCBI RefSeq. The new update includes a reorganized user interface and enhanced functional annotation capabilities.
A new study found that up to 37% of males and 44% of females will be obese when they turn 35 years old, leading to increased heart attacks, chronic chest pain, and deaths. The study projects over 100,000 extra cases of heart disease by 2035.
A UTSouthwestern urologist has used botulinum toxin A (Botox) injections to treat involuntary bladder contractions in quadriplegic patients. The treatment has shown promising results, enabling patients to regain control of their bladders and improve their quality of life.
Studies show that watching violent programs can cause parts of the brain to become less active, leading to reduced ability to control aggressive behavior. This effect is seen after repeated viewings of violence and is not observed with non-violent movies.
A Yale University study found that children follow adults' actions faithfully, even when they are unnecessary, leading to confusion and difficulties in learning. The research suggests that children's ability to imitate can actually hinder their learning process if they observe an adult performing inefficient behavior.
Researchers at Cornell University and their colleagues discovered that implanting embryonic cardiac cells into mice with heart attacks prevented arrhythmias. The technique improved electrical connections between cells and activated transplanted cells, restoring heart function and reducing arrhythmia risk.
A UBC study suggests that an ancient magma ocean may have existed beneath the Earth's surface, accounting for the discrepancy between the planet's mantle and core composition. This layer of molten rock would have stored some of the elements found in chondrite, primitive rocks from the earliest time of the solar system.
A double-blind study published in Nutrition Research reveals Pycnogenol improves physical function by 52 percent in patients suffering from OA. The antioxidant plant extract also controls inflammation and complements existing strategies for treating osteoarthritis.
Researchers developed an unmanned seaplane, dubbed 'Flying Fish,' that can initiate and perform its own takeoffs and landings on water. The autonomous craft features a 7-foot wingspan and is designed for the Department of Defense's persistent ocean surveillance program.
Physicists at the University of Alberta have made a major advance in understanding supersolidity by manipulating solid helium under extreme pressure and temperature conditions. They found that the material exhibits unusual behavior, becoming stiffer at lower temperatures.
A US study found that despite historic advances in public health, the gap in health rates between socioeconomic classes has persisted. The relative advantage in child mortality rates and health associated with social and economic status remained stable over the past century.
A new study shows transcranial magnetic stimulation (TMS) to be an effective, non-drug treatment for major depression, with response and remission rates approximately twice those of sham TMS. The treatment was well-tolerated by patients with mild side effects.
A UC Davis study found that physician styles, practice volumes, and HMO affiliations significantly influence the length of patient visits. Patient satisfaction is a crucial aspect of care, and doctors working in busy practices or within HMOs often risk shortening visit lengths.
A systematic review of over 5,500 patients found that both single-drug antifungal prophylaxis (SAP) and selective digestive tract decontamination (SDD) reduce yeast-related morbidity and mortality. SDD was more effective in reducing yeast colonization and infection, while SAP responded best to candidemia.
Cross River gorillas are restricted to Nigeria and Cameroon, with only around 300 individuals remaining due to habitat loss. The Wildlife Conservation Society announces new field surveys to catalogue potential gorilla habitat and protect this endangered subspecies.
A new study published in the International Journal of Climatology found that urban snow conditions significantly impact skier activity in New England. Researchers discovered that attendees are more likely to visit ski areas based on Boston weather patterns rather than local conditions.
In a study of 79 women with breast cancer, breast MRI revealed important diagnostic information altering treatment plans in 20 percent of cases. The imaging modality detected additional cancers, discovered cancer in the opposite breast, or determined tumors were larger than expected.
Researchers have identified a gene variant associated with increased alcohol consumption in mice, which may provide new targets for developing treatments for alcohol dependence. The study suggests that glutamate pathways play a critical role in addiction and may be targeted by future drugs.
Normal aging is linked to brain system disruption, causing cognitive decline even in absence of Alzheimer's disease pathology. The researchers found a correlation between reduced functional connections and decreased white matter integrity.
Jay Rosenblatt, a renowned researcher at Rutgers University, has been awarded the Senior Investigator Award from the International Society for Developmental Psychobiology. His work on maternal behavior and learning early in life has had a lasting impact on the field of developmental psychobiology.
Researchers found that over half of vaccination-related videos on YouTube portray childhood, HPV, flu vaccinations negatively or ambiguously. A staggering 45% of these videos contradict the Canadian Immunization Guide.
A new investigational drug, tesamorelin, significantly improved symptoms of HIV lipodystrophy by reducing deep abdominal fat deposits and improving lipid abnormalities. Participants reported significant improvements in body image and reduced distress.
Ancient and modern pot sherds found in New Mexico indicate possible fermentation of corn, potentially predating Spanish arrival. Gas chromatography analysis suggests similarities between ancient and Tarahumara Indian brews, but definitive proof elusive.
Researchers at Rockefeller University found that elevated CO2 levels within the first five days of birth can alter a fly's carbon dioxide detection circuit. The circuit's genetic plan adjusts to real-world conditions, suggesting a general feature of the olfactory system.
Iowa State engineer Terry Meyer is developing high-speed laser-based sensors to capture images of combustion chambers at thousands of frames per second. These sensors record data on pollutants, fuel sprays, and energy release, aiming to reduce pollutant emissions and enable alternative fuels.
Researchers found that mice lacking the renin enzyme are lean and resistant to diet-induced obesity, even without exercise. The study suggests that renin-blocking drugs could improve obesity and insulin sensitivity, providing new insights into the metabolic syndrome.
Reducing salt intake by 15% and implementing WHO's tobacco control framework could avert 8.5 million deaths between 2006-2015. Tobacco control measures alone would reduce smoking prevalence by 20.8%, thereby averting 5.5 million deaths.
Research by Atsuko Kasahara and colleagues found that mitochondrial respiration deficiencies are associated with changed social behavior and elevated spatial memory in laboratory mice. The study suggests a potential link between mitochondrial breakdowns and mental illness in humans.
A recent survey found that nearly half of respondents would choose an endodontist for their root canal procedure. The American Association of Endodontists reports that endodontists perform an average of 25 root canals per week, significantly more than general dentists who perform about two a week.
New research suggests transplanting kidneys from donors who died after cardiac arrest could increase the donor pool. A study found comparable short-term results between kidneys donated after cardiac death and brain death, with similar survival rates for patients and transplanted organs.
Researchers Katherine White and Darren W. Dahl found that consumers actively avoid products associated with groups they want to distance themselves from, but not those of outgroups they don't belong to or aren't motivated to avoid. The study highlights the role of social pressure in shaping consumer choices.
Researchers at Kyoto University School of Medicine successfully regenerated damaged nerves using bone marrow cells containing adult stem cells. The transplanted cells differentiated into Schwann cells, promoting axon regeneration and healthier vascularity.
Researchers from the University of California, San Diego, have identified a protein called LRP1 that may help ease neuropathic pain by blocking the response of glial cells. The study found that administering LRP1 into injured peripheral nerves decreased the level and activity of proinflammatory cytokines, leading to reduced pain.
A study of over 13,000 patients found that bivalirudin alone and other regimens have comparable mortality and ischemic outcomes at 1 year. Bivalirudin monotherapy reduces bleeding complications and hospital costs, making it a favored treatment option
Scientists have confirmed that microbes can travel across continents on dust particles, surviving for centuries and defying intercontinental transport. Geo-chemical analyses of Charles Darwin's samples revealed diverse microbes, including ascomycetes and eubacteria, with wind-fractionated dust from West Africa reaching the Caribbean.
A study found no significant differences in rates of ischemia, death, and other events among patients treated with three anticoagulant regimens. The results suggest that bivalirudin monotherapy or a selective GP IIb/IIIa inhibitor strategy may be safe alternatives to traditional heparin-based regimens.
A new study identifies four major motivators for high school senior drinking: experimentation, thrill-seeking, relaxation, and coping with life issues. Students who drink for these reasons show the heaviest and most problematic drinking behaviors, according to the study published in Prevention Science.
A multidrug regimen targeting high-risk individuals for cardiovascular disease could avert 17.9 million deaths globally, representing one-fifth of chronic disease-related deaths. The strategy would require an average yearly cost of $1.08 across 23 countries, with lower costs in low-income settings.
Researchers have developed a method to control the size of nanoparticles, allowing for mass production and diverse applications. This breakthrough has significant implications for fields like medicine, renewable energy, and cosmetics, where nanoparticles can be tailored to perform specific tasks.
College freshmen show heightened cigarette use in early weeks of school, followed by decline, with most smoking on Fridays and Saturdays. Adolescents with ADHD are also found to be at high risk for smoking due to brain dysfunction and nicotine dependence.
A landmark public health study has found that people who had a low birth weight are more likely to experience depression and anxiety later in life. The study, which analyzed data from over 4,600 people born in Great Britain in 1946, suggests a dose-response relationship between birth weight and mental health outcomes.
Researchers found that activating a protein in muscle tissue increased average lifespan and prevented some age-related diseases in mice. The protein, uncoupling protein-1, converts energy from food into heat and mimics the effects of exercise.
The Hawley Lab has identified two molecular mechanisms that restart the meiotic cycle in oocytes, including the controlled expression of Polo kinase and the inactivation of inhibitory protein Matrimony. This discovery has significant implications for understanding egg maturation and releasing, as well as treating infertility and cancer.
The 'mica hypothesis' proposes that the narrow spaces between nonliving mica layers provided conditions for the rise of the first biomolecules. Mica's structure offers support, shelter, and an energy source for precellular life.
A study led by Ronald Epstein found that doctors voiced empathy in only 15% of office visits, despite repeated prompting from patients. Patients reported high satisfaction when doctors empathized with them, especially in challenging situations.
A recent study by Indiana University researchers found that fluoridated tap water reduces dental fillings and costs for all age groups, with older adults benefiting the most due to limited access to dental insurance. The study breaks new ground on adult dentistry, highlighting the importance of community water fluoridation for people o...
A study by Michelle L. Roehm and Michael K. Brady found that high-equity brands initially face a disadvantage after failure, but may fare better when the issue is severe. This phenomenon can be attributed to a reduction in cognitive resources, allowing customers to focus on resolving the problem rather than re-evaluating the brand.
The University of Illinois Chicago's 9.4 Tesla MRI successfully completed safety trials, allowing for the visualization of biological processes in the human brain. This technology has the potential to tailor radiation therapy based on a brain tumor's real-time response to treatment.
Researchers found that learning different names for things makes it easier to place them into the correct categories. In a series of experiments, participants learned labels for aliens on a computer screen and categorized them into two types, demonstrating that redundant labels facilitate learning of novel categories.
HIV-infected children in Central Africa show low levels of antibodies to vaccines after childhood immunization. Researchers suggest adapted vaccine schedules may be needed for HIV-exposed infants.
Researchers found that despite strong contradictory evidence, favorable citations for vitamin E persisted in medical literature until 2005. For beta-carotene and estrogen, similar findings were observed, with a majority of citing articles remaining favorable even after contradicting evidence was published.
The proposed global goal aims to reduce chronic disease mortality by 2% yearly, averting millions of deaths and saving billions of dollars. In 23 studied countries, this reduction could extend life expectancy by up to 18 years.
A team of researchers at Children's Hospital of Pittsburgh identified a molecular receptor known as Toll-like receptor-4 (TLR4) that, when blocked, may help reverse necrotizing enterocolitis (NEC) in premature infants. Blocking the TLR4 signal allowed enterocytes to heal damaged intestinal tissue.
A Virginia Commonwealth University research team has received a $1.3 million NCI grant to improve histone deacetylase inhibitors in treating leukemia. The goal is to develop novel combination regimens incorporating these agents with NF-kappa B antagonists.
Researchers at Scripps Research Institute have developed two new tests that can identify lethal prion strains quickly and accurately. The tests, the Standard Scrapie Cell Assay and the Cell Panel Assay, significantly accelerate prion research by producing results in under two weeks.
Researchers have discovered a protein called CIB1 that plays a major role in controlling new blood vessel growth, providing a potential target for drug therapies. The findings may help control unwanted blood vessel growth in diseases such as diabetic retinopathy and wound healing.
New research at Yucca Mountain, Nevada, limits potential ground movement to 3.6 meters per second, reducing earthquake risk. Small earthquakes may serve as predictors for large ones, contradicting conventional seismology theories.
A study by Rebecca W. Hamilton and Debora Viana Thompson found that consumers who try products before buying them prefer simpler products that are easier to use, rather than those with more features. After direct experience, consumers focus on product feasibility over desirability.