Articles tagged with Long Noncoding Rna
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Researchers at Mount Sinai have identified a novel class of genes, specifically LINC00473, that regulate mood and drive sex-specific susceptibility versus resilience to depression. These findings provide evidence for an important new family of molecular targets that could help scientists develop more effective pharmacotherapies.
A team of researchers has identified a long noncoding RNA molecule that may control aging in blood vessel walls. The discovery could lead to new treatments for cardiovascular disease states and may provide insights into why heart disease risk increases with age.
A recent study published in Nature Communications discovered that a specific Long noncoding RNA called LincIRS2 is essential for maintaining healthy metabolism. Mice lacking this gene developed metabolic complications, while those with activated LincIRS2 maintained normal blood sugar levels even in obesity.
Researchers at UC San Diego School of Medicine identified a principal cellular player controlling HIV reproduction in immune cells, which when turned off or deleted eliminates dormant HIV reservoirs. The discovery highlights a potential therapeutic target to eradicate HIV and AIDS.
A team of scientists has discovered that the three-dimensional shape of an RNA molecule, called MEG3, is essential for its role in tumor suppression. The researchers found two critical elements within the molecule that form 'kissing loops', which interact with each other to maintain its function.
Chinese cabbage has an independent mechanism for flowering, differing from the model plant A. thaliana. IncRNA expression is induced by cold treatment, but not in the FLC locus.
A team of scientists has pinpointed a long noncoding RNA molecule that influences a key receptor involved in HIV infection. This discovery may lead to new targets for therapy and increase understanding of how genetic variations affect disease progression.
Researchers identified a new developmental timing mechanism involving a long non-coding RNA in the microscopic roundworm C. elegans that controls the timing of sex-specific changes and behavior. The discovery provides insight into how genetic cues regulate the transition to adulthood in humans.
Researchers have identified a long non-coding RNA, LDAIR, that regulates seasonal changes in stress response in medaka fish. This lncRNA affects corticotropin-releasing hormone receptor 2 and modulates self-protective behaviors during breeding seasons.
A new study from Cornell University has identified a genetic regulator called SAF that helps HIV-infected macrophages avoid cell death. By blocking SAF, researchers found that infected cells self-destructed while healthy cells remained untouched, presenting a novel angle for potential therapies to selectively eradicate reservoir cells.
Researchers at Rockefeller University have identified a genetic mechanism that may contribute to 10% of all obesity cases. Alterations in the cellular machinery regulating leptin production can lead to obesity treatable with leptin therapy, and human genetics studies suggest a similar mechanism may contribute to obesity in some patients.
A study published in Nature Genetics found that long non-coding RNA MALAT1 suppresses breast cancer metastasis, contradicting its previously described role as a metastasis promoter. The researchers used mouse models to show that MALAT1 binds and inactivates TEAD, a transcription factor involved in promoting metastasis.
A new study found that GM12371, a specific long non-coding RNA, controls expression of multiple genes involved in nervous system development and functioning. It affects the developing neurons' shape and ability to signal, highlighting the importance of long noncoding RNAs in brain cell growth and signaling.
Researchers at UNC School of Medicine have developed a powerful algorithm to quickly categorize long non-coding RNAs (lncRNAs) based on their molecular makeup and predicted functions. The method, called SEEKR, uses protein-binding sequences to identify lncRNA communities with similar functions in humans and other species.
A study has identified 600 novel long noncoding RNA molecules that regulate the effects of androgens and androgen receptors on gene expression in prostate tumors. These lncRNAs are powerful regulators of gene expression and interact with and magnify the effect of regulatory proteins, suggesting a new target for treatment.
Research into lncRNAs is demonstrating their importance in development and disease. LncRNAs are implicated in various biological processes, including transcription, dosage compensation, and messenger RNA degradation.
Scientists have discovered a new mechanism of sex determination in the crustacean Daphnia magna, where long chain noncoding RNAs activate male-determining genes. This finding contributes to our understanding of lncRNA function and diversity in sex-determination mechanisms.
A Danish-German research team has identified a novel long non-coding RNA, A-ROD, that enhances the production of specific proteins with involvement in cancer. The RNA functions as a lasso that brings transcription factors to specific sites in DNA to enhance gene expression.
Researchers at the University of Gothenburg have developed an RNA-based therapy that has been shown to cure lung tumors in mice by 40-50 percent. The therapy targets specific long non-coding RNA molecules involved in uncontrolled cell division, which are a key driver of cancer growth.
A new study found that a newly discovered gene called STEEL senses inadequate blood flow to tissues and triggers the growth of new blood vessels. This discovery could lead to advances in understanding and treating cardiovascular diseases such as heart disease and strokes.
A newly discovered gene called MeXis has been found to act within clogged arteries to remove excess cholesterol from blood vessels. This study suggests that long non-coding RNAs play a crucial role in the development of heart disease and may lead to new insights into treating cardiovascular disease.
A team of researchers at the University of Michigan Comprehensive Cancer Center identified a novel gene called THOR that plays a role in cancer development. Knocking out THOR was found to halt tumor growth, while overexpressing it led to increased cell proliferation.
A recent study by Case Western Reserve University School of Medicine identified specific lncRNAs that modulate connective tissue proteins like collagen in skin cells. The researchers found that these long non-coding RNAs work with the Wnt/β-catenin pathway to control gene expression, suggesting a new form of genetic control.
Researchers identified several lncRNAs linked to ovarian cancer, including DNM30S, which correlates with worse survival rates. Targeting these lncRNAs may represent a viable treatment strategy for ovarian cancer.
A Tel Aviv University study identifies the first group of long non-coding RNAs in the auditory system, which may help devise strategies for curing deafness. The researchers found that these RNA molecules play a crucial role in regulating genes involved in deafness.
Scientists have identified a new player in viral infection, revealing how certain long noncoding RNAs can aid viruses in hijacking host cells. The discovery highlights the importance of understanding host-virus interactions to develop effective antiviral strategies.
Researchers at Texas A&M AgriLife Research have discovered a long non-coding RNA that increases thale cress plants' resistance to drought and salt stress. Increasing the lncRNA's levels shows corresponding increases in drought and salt tolerance.
Scientists have identified a class of mammalian lncRNAs that evolved from ancestral genes, gaining regulatory powers and serving as master switches in various biological processes. These 'recycled' genes may hold the key to understanding human diseases and developing new treatments.
A study by Case Western Reserve University researchers has identified long non-coding RNAs that play a critical role in orchestrating sperm development. The lncRNAs help regulate various stages of sperm development and are found exclusively in the testes, suggesting they could be used to develop novel infertility drugs.
A non-coding RNA, PNUTS lncRNA, encourages cancer growth and metastasis by soaking up microRNA-205 that prevents epithelial-to-mesenchymal transition. In breast and lung cancer cell lines, PNUTS lncRNA promotes tumor development.
A new study from Sanford Burnham Prebys Medical Discovery Institute uncovers the role of non-coding RNA SPRIGHTLY in tumor growth and metastasis, suggesting it as a potential therapeutic target or diagnostic marker for skin cancer. The molecule binds to over 115 RNA partners, including genes implicated in various cancers.
Researchers at Oregon State University discovered that sulforaphane, a dietary compound from broccoli, may work by influencing long, non-coding RNAs. This finding suggests that these lncRNAs play a critical role in triggering cells to become malignant and spread.
A comprehensive atlas of human long non-coding RNAs shows that nearly 2,000 have potential involvement in diseases and genetic traits. The research suggests that many long non-coding RNAs are generated from enhancer elements, deepening the understanding of their origins.
A new computational tool, Global Score, predicts protein interactions with long non-coding RNAs, integrating global and local features to prioritize binding partners for experimental validation. This methodological advance will help better study the functions of these molecules in normal cell function and disease.
A recent study by Beth Israel Deaconess Medical Center researchers found that a specific long non-coding RNA, LINC00961, plays a key role in regulating the activity of the mTORC1 protein complex. This complex is involved in various cellular processes including translation, metabolism, cell growth and proliferation.
Researchers at MIT deciphered the structure of a long noncoding RNA and found that it interacts with a protein to control heart muscle cell development. The study reveals the importance of RNA structure in understanding its function, which could lead to new therapeutic approaches for cardiovascular disease.
A Penn study identifies Morrbid, a special RNA molecule, as key controller for immune health when fighting infection or preventing inflammatory disorders. The discovery offers a potential drug target for several inflammatory disorders characterized by an abnormal lifespan in white blood cells.
Researchers have identified a long non-coding RNA in the placenta that plays a crucial role in protecting the unborn baby from invading pathogens. The lncRNA, called lncRHOXF1, regulates the immune response and appears to be sensing and modulating its expression based on the presence of viruses.
A new study has identified a long non-coding RNA that plays a crucial role in the repair of DNA breaks in triple-negative breast cancer cells. The research found that blocking this RNA significantly increases sensitivity to radiation therapy, providing new insight into the biology of this tough-to-treat breast cancer subtype.
A team co-led by Penn Medicine researcher discovers that a mysterious lncRNA has no obvious function in regulating its neighbor's gene expression, but the DNA from which it originates does. The study reveals a new mechanism for enhancer functions in the genome, pointing to a broader role of non-coding DNA and RNA.
Researchers at VIB, KU Leuven and UGent have discovered a non-coding RNA gene called SAMMSON that is specifically expressed in human malignant melanoma. The growth of aggressive skin cancer is highly dependent on this gene, paving the way for improved diagnostic tools and treatment options.
A team of scientists from the University of Michigan Medical School has discovered a new way for RNA to regulate genetic activity on the X chromosome in females. The finding, which could lead to better treatment for sex-linked disorders, shows that female cells produce a special type of RNA called XistAR to silence one of their two X c...
A comprehensive study of non-protein-coding RNAs in human cancers has identified alterations linked to 13 different cancer types. The research provides a rich resource for investigating lncRNA dysregulation and identifying potential diagnostic and therapeutic tools.
Scientists identify novel long non-coding RNA DACOR1 that suppresses tumor cells in colon cancer. Reactivating DACOR1 can slow or stop cancer cell growth, and may lead to therapy development for colon cancer prevention.
Researchers at Hiroshima University found that long noncoding RNA CCDC26 controls receptor tyrosine kinase KIT expression in leukemia cells. This discovery provides new insights into leukemia recurrence and may help develop new therapies.
Stefanie Dimmelers research suggests that long non-coding RNAs play a role in creating heart attacks, strokes, and cancer by regulating endothelial cells. She will use the ERC Advanced Grant to identify new treatments for preventing arteriosclerosis.
Researchers at Caltech have discovered the detailed mechanism of action for Xist, an lncRNA that silences the X chromosome in female embryos. By understanding how Xist works, scientists can gain insights into long non-coding RNAs and their role in regulating cellular processes.
Researchers at Duke-NUS Medical School have discovered a long non-coding RNA that regulates brown fat development in mice. This finding holds promise for developing new therapeutic strategies to prevent and treat obesity.
Researchers at MD Anderson Cancer Center found that CCAT2, a long non-coding RNA, regulates cancer metabolism in both human samples and animal models. This regulation appears to be linked to an increased risk of colon cancer, suggesting potential new targets for cancer treatment.
A research team at UCSF has discovered a noncoding RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells. The study suggests that Pnky may have broad applications in regenerative medicine, including treatments for Alzheimer's disease and Parkinson's disease.
Researchers at Hebrew University of Jerusalem discover malaria parasite uses long noncoding RNA to switch genes and evade human immune system. They develop novel method to suppress virulence genes, breaking code of its immune evasion.
Long noncoding RNAs play a crucial role in regulating inflammatory gene expression and controlling immune responses. Researchers propose lncRNAs as potential targets for novel anti-inflammatory therapeutics.
A new analysis has identified over 58,000 long non-coding RNA genes that may play a role in cancer. The study also found that one lncRNA, SChLAP1, is a potential biomarker for aggressive prostate cancer.
Researchers at Ohio State University found that patterns of molecules called long noncoding RNAs can predict response to chemotherapy and overall survival in older patients with acute myeloid leukemia. The study identified a group of 48 lncRNAs associated with survival, allowing for personalized treatment approaches.
A new study identifies Ewing sarcoma-associated transcript 1 (EWSAT1) as a critical target of the EWS-FLI1 fusion protein, contributing to cancer cell growth and repression of key genes. This finding supports the notion that long noncoding RNAs can drive cancer development and highlights an important mediator in Ewing Sarcoma.
Scientists at MD Anderson Cancer Center identified a long non-coding RNA called BCAR4 as playing a key role in the hedgehog signaling pathway's contribution to breast cancer metastasis. The study suggests that targeting this pathway with locked nucleic acids may provide a new approach for treating aggressive breast cancers.
A new study identifies a set of RNA molecules in urine and tissue samples that can detect prostate cancer with high sensitivity and specificity. These long noncoding RNAs have the potential to serve as biomarkers for early detection and diagnosis of prostate cancer, offering a promising approach to reduce overtreatment and morbidity.
New research suggests that long non-coding RNAs play a crucial role in regulating the human immune system's response to infection. The study reveals how these molecules can promote, fine-tune, and restrain the body's inflammatory response by controlling gene expression.
Scientists at UT Southwestern Medical Center discovered a new way internal body clocks are regulated by long non-coding RNA qrf. The discovery sheds light on how circadian clocks work and has implications for understanding human diseases such as sleep disorders and depression.
Case Western Reserve researchers discovered thousands of novel long non-coding RNA transcripts that can direct protein synthesis in cells. This breakthrough challenges conventional wisdom on lncRNA's role and holds promise for treating cancer and genetic disorders.