Articles tagged with Long Noncoding Rna
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Researchers have discovered hundreds of non-coding RNAs in the developing and adult lungs that regulate gene expression by controlling DNA scaffolding. These 'genomic dark matter' RNAs, including NANCI and LL34, play critical roles in lung development and may underlie human diseases such as Brain-Lung-Thyroid Syndrome.
Researchers found that long noncoding RNAs distinguish between two major types of heart failure and change expression patterns after LVAD support. These RNA molecules may play a role in coordinating the regulation of multiple genes involved in heart function.
Researchers have identified hundreds of open reading frames in long non-coding RNAs that may give rise to functional proteins using ribosome profiling. The method allowed direct quantification of messenger RNA fragments protected by the ribosome, revealing translated small open reading frames.
Researchers discovered how lncRNAs use positional information to locate and bind to nearby genes, forming a compartment where multiple genes can be regulated together. This unique mechanism allows lncRNAs to organize key proteins involved in gene expression.
Prader-Willi syndrome is associated with the loss of non-coding RNAs, resulting in dysregulation of circadian and metabolic genes. The study found that mice engineered with the loss of a long non-coding RNA showed altered energy use and metabolic differences during sleep.
A study found altered noncoding long chain RNA sequences in Rett Syndrome, which regulates gene expression and neurotransmitter function. The research could lead to new therapeutic strategies targeting lncRNA molecules or GABA receptors.
Researchers at UCSF discovered that long noncoding RNA molecules, once considered 'junk', are involved in brain development and may contribute to neurodegenerative diseases. The study identified 88 lncRNAs associated with Huntington's disease and found weaker associations with Alzheimer's and other conditions.
Researchers at Whitehead Institute have identified long noncoding RNAs as essential regulators of white fat cell development, which can lead to obesity. The study found that knocking down specific lncRNAs reduced the formation of lipid droplets in fat cells.
A recent study published in PNAS reveals that DNA transcription produces mRNA and long noncoding RNA (lncRNA) pairs, which are transcribed coordinately as stem cells differentiate into other cell types. The finding could redefine our understanding of gene organization and regulation.
Researchers have discovered a new class of non-coding RNAs essential for embryonic heart development. Knocking down the long non-coding RNA Fendrr led to lethal malformations and impaired body wall formation in mouse embryos. The study sheds light on the role of epigenetic control in regulating cardiogenesis.
Two papers connect long non-coding RNAs to inherited conditions in humans, revealing a chromosomal translocation disrupting expression of PTHLH and SOX9 genes. A lncRNA on chromosome 12 is also linked to the development of the placenta.
LncRNAs have been found to regulate gene expression in various diseases, including brachydactyly and HELLP syndrome. Additionally, research on obesity has shown that early genetic intervention can rescue mice from obesity-induced metabolic disorders. Furthermore, editing mistakes in miR-376 cluster have been linked to invasive brain tu...
A team of researchers has identified a previously unknown non-coding RNA, called BANCR, that plays an important role in the biology of melanoma. By analyzing the RNA transcriptome of patient samples, they found that BANCR is required for full migratory capacity in melanoma and could be a potential target for therapy.
Researchers discovered a long non-coding RNA (lncRNA) that prevents programmed cell death in maturing red blood cells, a process linked to leukemias and cancers. This lncRNA may represent a new avenue of attack for therapeutics.
Research reveals that long non-coding RNA SPRY4-IT1 promotes cellular survival and invasion in melanoma cells, suggesting its potential as an early biomarker. The study also found reduced levels of another non-coding RNA, miR-211, in melanoma cells.
Researchers have identified a new way genes are regulated that is unique to primates, involving Alu elements and long noncoding RNAs. This mechanism could prove to be a valuable treatment target as researchers seek to manipulate gene expression to improve human health.
Scientists have discovered that long non-protein-coding RNA (lncRNA) are involved in the host response to viral infection. The study found that lncRNAs were triggered by virus infection and regulated in response, suggesting a new paradigm shift in understanding of innate immunity.
Researchers found that long noncoding RNA MALAT1 plays a key role in regulating pre-mRNA splicing, a critical step in protein production. This study suggests that MALAT1's regulation of splicing factors may contribute to cancer development.