Articles tagged with Mrna Abundance
Researchers found that abundant mRNA molecules tend to cluster together in brain neurons, driven by chance overlap rather than coordinated movement. This discovery provides insights into how neurons manage genetic instructions and supports learning and memory, with potential implications for conditions like Fragile X syndrome.
Researchers at UCSF describe how to curb MYC levels by disrupting the protein assembly line controlled by RBM42. Disrupting RBM42 in pancreatic cancer cells stopped them from growing, suggesting drugs could be developed to do the same for other fast-growing cancers.
For the first time, researchers have demonstrated how mechanical forces affect gene expression by showing that RNAP polymerase remains on the DNA template and can be pulled to start a subsequent cycle of transcription. This force-directed recycling mechanism can change the relative abundance of adjacent genes.
Researchers investigated molecular changes in aging mouse sweat glands, finding 171 mRNAs enriched in secretory cells. Altered mRNA and protein abundance were associated with age-related declines in sweat gland function.
Researchers used a novel deep proteomics approach to investigate the effects of aging and resistance training on skeletal muscle. The study found that aging predominantly affects non-contractile proteins, while resistance training has minimal effects on protein abundance.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
Researchers at Weill Cornell Medicine have discovered that a tiny chemical modification on mRNAs, known as m6A, is key to the formation of stress granules during cell stress. Longer mRNAs dominate stress granules because they have high levels of m6A, which triggers their sequestration.
A new method developed by Flatiron Institute researchers can diagnose COVID-19 with near-perfect accuracy, even in asymptomatic patients. The technique monitors the body's molecular response to a viral attack and measures mRNA molecules to identify an immune response.
A new study has identified distinct patterns of circular RNA expression in human ALS muscle tissue, which display disease-specific gradients and could inform about neuromuscular molecular programs in ALS. The research reveals that specific circRNAs are elevated in ALS muscle biopsies but reduced in spinal cord samples from ALS patients.
Researchers found that neurogranin and FMRP proteins quickly form a complex to enable memory encoding within minutes of encountering a novel context. This process is crucial for understanding how abnormalities in these proteins contribute to human neuropsychiatric disorders.
A recent study published in PeerJ challenges previous findings that suggested translation and protein turnover play a larger role in determining protein expression levels than transcription. The new analysis reveals that mRNA levels explain ~81% of the variance in protein levels, while transcription explains ~71%.
Researchers found new regions of the genome under circadian control using a technique called gene trapping, contradicting accepted dogma. The study suggests that clock-controlled mRNA synthesis may be more common than previously estimated, potentially leading to improved crop productivity and resistance to stressful conditions.
A chemist at Washington University has created a molecule that mimics the behavior of ribozymes, acting as a catalyst to dismantle dangerous genetic codes involved in viral and fungal diseases, certain cancers, and HIV. The discovery shows great promise for improved drug treatments.