Articles tagged with Synthetic Biology
Washington University in St. Louis' Zhang lab has been awarded a $458,490 NSF grant to refine their synthetic biology platform for producing muscle fibers with improved material properties. The team plans to examine genetic changes associated with titin protein and create fibers with defined sequences to study material properties.
Scientists at Okayama University designed and tested a modified cholera toxin to study glycosylation in eukaryotic cells. They tracked the toxin's movement through organelles using bioluminescence, gaining insights into protein modification. This method may lead to new treatments for diseases caused by enzyme deficiencies.
A team of researchers at Max-Planck-Gesellschaft developed METIS, a modular software system for optimizing biological systems using machine learning. The tool allows users to optimize their already discovered or synthesized biological systems and can be used with different lab equipment.
Researchers at Lawrence Berkeley National Laboratory have created a new type of fuel that has higher energy density than traditional heavy-duty fuels. The biofuel, called POP-FAMEs, is produced by bacteria fed with plant matter and can significantly reduce greenhouse gas emissions when burned.
Rice University bioengineers are developing optogenetic tools to study B. subtilis' stress response, combining experimental results with theoretical findings to understand genetic design principles. This research aims to reveal clues about bacterial survival and potentially lead to new antimicrobial drugs.
Researchers have developed a new method for precisely altering gene expression by supplying and removing electrons, enabling controlled biomedical implants and bioreactors. The improved system allows for accurate control of gene expression in the presence of oxygen, opening up new possibilities for synthetic biology.
Researchers developed novel cofactor engineering strategies to enhance NADPH, FAD(H2), and SAM supply, re-localization, and recycling in yeast. This led to the efficient synthesis of phenolic acids, providing a sustainable platform for complex natural product production.
Researchers at Gladstone Institutes and UC San Francisco have developed a comprehensive rule book for designing therapeutic cells with improved specificity and safety. The new receptor system, dubbed SNIPRs, is small enough for cost-effective engineering into human cells and can detect and respond to even small amounts of its target. T...
Researchers developed a new way to help protect the natural flora of the human digestive tract by engineering bacteria to break down beta-lactam antibiotics. This approach protects the microbiota in the gut while allowing antibiotics to remain effective, reducing the risk of infection and antibiotic resistance.
The five-year grant aims to develop electrobiology techniques that enable applications like living sensors to quickly detect environmental pollutants. The project will involve multiple disciplines, including synthetic biology, protein engineering, soft materials, microsystems integration, and machine learning.
Researchers developed long-lived biological computers using RNA, which can persist inside cells. Unlike DNA-based devices, these RNA circuits are dependable and versatile, enabling continuous production in living cells.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
A novel diagnostic platform has been developed for rapid, low-cost and decentralized patient testing for infectious diseases like Zika. The platform achieved a diagnostic accuracy of 98.5% with 268 patient samples collected in Recife, Brazil.
Scientists have developed a new computational tool that mimics the processes of natural selection, producing proteins for medicinal and household uses. This innovation reduces the time required for laboratory evolution from months or years to just days.
Researchers developed artificial Sars-CoV-2 virions to study the spike protein's interaction with host cells and its ability to evade the immune system. By understanding this mechanism, they hope to develop targeted therapies and vaccines.
Researchers engineered bacteria to produce proteins that can be broken down when nutrients are scarce, allowing cells to continue growing. This system mimics a biological battery, enabling cells to survive in challenging environments.
A new DNA-based device can detect contamination levels in water, providing a more accurate picture of water quality. The device uses genetic networks to mimic electronic circuits and can detect zinc, lead, and other contaminants at varying concentrations.
Stanford researchers have made a breakthrough in developing protein circuits that can enable cell-to-cell communication, mimicking the natural process of cells interacting with neighboring cells. The new platform, RELEASE, allows proteins to be secreted and displayed on the cell surface, enabling cells to respond to these signals.
Harris Wang, a synthetic and systems biologist at Columbia University, received the Vilcek Prize for Creative Promise in Biomedical Science for his development of tools to track and engineer microbes. His research aims to improve diagnostic and therapeutic applications using genomic technologies.
A cloud-based repository called CellRepo has been launched to track and organize digital data from engineered microorganisms. The database uses cell barcodes to monitor and track organisms, enabling faster tracing of lab origins and design details.
Roswell Biotechnologies has developed a molecular electronics sensor on a semiconductor chip, enabling real-time detection of single molecules for diverse applications including drug discovery, diagnostics, and DNA sequencing. The platform offers unlimited scalability in sensor pixel density and high resolution measurements.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
Researchers have developed Find Cut-and-Transfer (FiCAT) technology, a tool capable of accurately writing small and large genes. FiCAT allows precise insertion of large fragments into the genome, enabling development of therapeutic solutions for diseases like Duchenne muscular dystrophy and hereditary blindness.
Researchers from Rice University and the University of Wyoming discovered self-organization into circular aggregates in Myxococcus xanthus, a model system for social cooperation. The circular behavior is linked to TraAB protein overexpression, which creates a sticky bond between cells, preventing reversals.
Scientists at Tokyo University of Science have developed a novel polymer-based hydrogel that can prevent postoperative pancreatic fistulae, a frequent complication of pancreatic surgery. The Exceval hydrogel shows great promise for clinical applications due to its adjustable properties and high absorption abilities.
Engineered biofilms made of E. coli bacteria exhibit emergent drug resistance properties when printed using the new technique. This study provides valuable insights into harnessing the beneficial aspects of biofilms while combating their negative effects, potentially leading to breakthroughs in medicine and materials science.
Researchers in Japan have designed the first de novo-designed peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. The peptides can detect specific molecules, including DNA, and have the potential to mimic natural proteins' ability to detect specific proteins.
Researchers from the University of Copenhagen have discovered a natural substance, a flavonoid, that can inhibit cancer cells' ability to defend themselves against chemotherapy by targeting efflux pumps. This could lead to more effective treatment and potentially even combat antibiotic resistance.
Scientists at Washington University in St. Louis have created a biocompatible adhesive hydrogel that can stick to various surfaces underwater, with properties similar to natural mussel foot protein and spider silk. This breakthrough has potential applications in tissue repair, particularly for tendon-bone repair.
Scientists have developed a method to synthesize nanocrystals in live cells through space-time coupled synthesis, enabling the creation of super biosystems. This approach has been successfully applied to various cell types, including yeast, bacteria, and mammalian cells.
Researchers at UC Berkeley engineered bacteria to produce an unnatural molecule through a combination of synthetic chemistry and biology. This breakthrough enables the creation of previously impossible chemicals, paving the way for sustainable materials and innovative products.
Researchers at CRG and Pulmobiotics have created the first 'living medicine' to treat antibiotic-resistant bacteria growing on medical implants. The experimental treatment successfully treated infections across in vitro, ex vivo, and in vivo testing methods.
A new method for recording information to DNA has been proposed by Northwestern University researchers, taking minutes to complete instead of hours or days. This method, called TURTLES, uses a novel enzymatic system to synthesize DNA that records rapidly changing environmental signals directly into DNA sequences.
Scientists have created a novel method for synthesizing starch from carbon dioxide and hydrogen without using living cells. This breakthrough could revolutionize industrial biomanufacturing of starch, which is used in paper, bioplastics, and animal feed.
Researchers at Rice University have been awarded a four-year, $1.2 million National Institutes of Health grant to advance the art and science of creating custom-designed microbial colonies. The grant will enable the development of technologies like synthetic tissues that enhance soils or gut microbiomes.
The Vilcek Foundation has awarded four prizes worth $250,000 to foreign-born scientists in the United States. The prizes recognize outstanding career contributions to biomedical science and innovative research. This year's recipients include Vishva M. Dixit, Markita del Carpio Landry, Hani Goodarzi, and Harris Wang.
Researchers at Washington University in St. Louis have developed a method to produce synthetic muscle protein using microbes, which can be spun into fibers with exceptional toughness and strength. The resulting material has potential biomedical applications, such as sutures and tissue engineering.
Isaac Hilton is using non-integrating episomal DNA viruses to create a new platform technology for cell and gene therapies. He aims to hijack these viruses to safely program medicinal functions in human cells.
The center will provide a one-stop shop for custom DNA constructs, accelerating cancer research through access to state-of-the-art tools. The facility will enable transformative, large-scale experimental projects that were previously impossible for individual labs.
SYNB1618 demonstrates dose-responsive, non-saturated increases in gastrointestinal Phe consumption, suggesting therapeutic potential for Phenylketonuria (PKU). A mechanistic model predicts SYNB1618's function in PKU patients and informs clinical development.
MIT researchers develop a methodology for designing protein interactions that occur at a fast timescale, allowing circuits to respond within seconds. This approach has potential applications in creating environmental sensors and diagnostics.
Researchers from the University of Warwick have developed a cheap way to switch bacteria into chemical production mode using a natural nutrient, drastically reducing costs. This breakthrough brings closer the realization of sustainable industrial-scale production of high-value chemicals from cheap feedstocks.
Researchers at the University of Bristol developed the concept of 'evotype' to capture the evolutionary potential of biosystems. The evotype framework provides a means for bioengineers to control evolution by adjusting variation, function, and selection.
Researchers developed a design-driven process using computational modeling to identify useful genetic designs for cellular engineering. The approach accelerates the development of new treatments for diseases by enabling the efficient identification and testing of genetic programs.
Researchers used synthetic biology to develop a genetic design that reproduces key processes in natural systems, such as symmetry breakage observed in embryos. The new platform can generate spatial patterns seen in more complex animals like Drosophila melanogaster and humans.
Researchers have developed a new type of model using synthetic biology to replicate symmetry breakage observed in embryos, enabling the creation of complex structures. The study identified essential parameters that modulate spatial pattern emergence in E. coli, paving the way for understanding embryonic development.
A new study found that patients with rheumatoid arthritis taking biologic DMARDs have a 17% lower risk of developing dementia compared to those on conventional synthetic DMARDs. The treatment reduces inflammation, which may explain the decreased risk.
A partnership between Sandia National Laboratories and BioBright LLC aims to improve synthetic biology equipment security. The team is developing countermeasures to risks, protecting America's bioeconomy and digital infrastructure from potential data theft or targeted attacks.
Researchers have developed machine learning algorithms to predict which RNA-based toehold switches function well, enabling the identification and optimization of these tools. The algorithms analyzed a massive dataset of over 100,000 toehold switch sequences and predicted their behavior with high accuracy.
Berkeley Lab scientists develop a tool using machine learning algorithms to guide synthetic biology development systematically. The Automated Recommendation Tool (ART) predicts how changes in a cell's DNA or biochemistry will affect its behavior and recommends the next engineering cycle.
A new platform technology can assess water safety and quality with just a single drop and minutes. The platform tests for 17 different contaminants, including toxic metals, pharmaceuticals, and cosmetics, providing fast and easy results.
A Bristol team has developed a new photosynthetic protein system that enables an enhanced and more sustainable approach to solar-powered technological devices. The system uses both chlorophyll and bacteriochlorophyll, demonstrating poly-chromatic solar energy harvesting for the first time.
A new conservation tool has identified top priorities and projections of what species would benefit from increased conservation dollars. The algorithm considers diverse data, including land acquisition costs, development patterns, budget allocations, and threatened species, to find optimal protection opportunities.
Researchers have created a highly stable artificial protein called SUWA, which can withstand temperatures of up to 122°C without denaturing. This breakthrough could lead to new applications in nanotechnology and synthetic biology.
Northwestern University researchers Julius Lucks and Sera Young present innovative solutions for monitoring water quality and addressing household water insecurity. The Household Water Insecurity Experiences Scale (HWISE.org) measures experiences of household-level water access and use globally.
A new synthetic biology toolkit called COMET allows researchers to design and tune gene expression programs in mammalian cells with unprecedented precision. This breakthrough could lead to the development of novel cell-based therapies for cancer and other challenging diseases.
A new test developed by Northwestern University can detect high levels of fluoride in drinking water, exceeding EPA standards. The test is inexpensive, easy to use, and requires no scientific expertise, making it a potential solution for communities with naturally high fluoride levels.
The TU Dresden team presented their DipGene project, a DNA sequence-specific diagnostic method applicable in bacteria and human genomic DNA. The method is faster and cheaper than PCR, taking only five to ten minutes to detect predispositions to monogenic diseases.
Researchers have made significant breakthroughs in cell-free gene expression, enabling high-yielding protein synthesis and expanding genetically encoded chemistry. This has opened doors to create new types of enzymes, materials, and therapeutics. Northwestern University's Center for Synthetic Biology is at the forefront of this field.
Researchers have created a biohybrid system that combines gene circuits with electrodes to detect specific nucleic acid sequences. This approach enables parallel detection of multiple pathogens and has the potential to transform medicine, biotech, academic research, food safety, and other applications.