Articles tagged with Synthetic Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UT Institute of Agriculture will modify potato plants to detect and report potential threats such as nerve agents, radiation, and plant pathogens. The goal is to innovate a new sensor platform that can help protect deployed troops and civilians in post-conflict settings.
Ajoene, a stable organosulfur compound in garlic oil extracts, has similar health-promoting effects to allicin and exhibits anticancer activity. Researchers have developed a total synthesis approach to produce ajoene with improved yields, paving the way for its further evaluation in medicinal research.
Researchers at Rice University and the University of Houston created models to predict the output of custom-built genetic circuits, enabling unprecedented precision in programming microorganisms. The models can be used to design microbes for complex environments, such as the gut microbiome or soil, and improve the controllable manufact...
The BioBits kits allow students to learn about key biological concepts through experiments with DNA and produce glowing proteins or scents. The kits contain freeze-dried cellular components, making them inexpensive and accessible.
BioBits kits use freeze-dried cell-free reactions to enable simple, hands-on biological experiments without specialized lab equipment. The kits introduce molecular and synthetic biology concepts, inspiring students to consider STEM careers.
Researchers propose genetically engineering houseplants to serve as early sensors of environmental hazards like mold, radon gas, and volatile organic compounds. This technology could lead to more responsive interior environments that prioritize occupant health and well-being.
Researchers aim to create storage systems integrating synthetic biology with semiconductor technology, potentially storing 1,000 times more data than current capabilities. The goal is to develop devices with greater storage capacity and lower power usage.
Scientists at Colorado State University aim to engineer world's strongest biomaterial sporopollenin in lab, with $1.7 million DARPA grant. The goal is to produce tunable, scalable polymer for protective coatings on ships, bridges and other infrastructure.
Rice University scientists introduce a new technique to fine-tune two-component biological sensors, enabling tailor-made biosensors for diagnostic gut bacteria and environmental pollutant detection. The approach uses phosphatase activity to alter the sensitivity of these pathways, promising a major breakthrough in synthetic biology.
Researchers aim to develop an optimized cell-free platform to speed up synthetic biology design-build-test-analyze cycles, enabling faster characterization of novel and improved pathways. The proposed technology leverages advances in DNA synthesis, cell-free biosynthesis capabilities, and genome engineering tools.
Researchers develop a gene promoter library to precisely tune genetic inputs and outputs, allowing for the design of probiotics that can diagnose or fight disease. The toolkit enables the creation of non-leaky promoters that turn on as much as needed, opening new doors for fighting disease.
The European Research Council has awarded a €2 million ERC Consolidator Grant to TU Darmstadt's Heinz Koeppl for his project 'CONSYN', which aims to improve the design of synthetic genetic circuits. The grant will support computational modelling and computer-aided circuit synthesis to overcome experimental challenges in synthetic biology.
Researchers at the University of Bristol created a new platform for producing desperately needed antibiotics by combining synthetic biology with biology and chemistry. The team successfully generated a semi-synthetic pleuromutilin derivative with enhanced antibiotic activity, addressing the growing resistance to existing antibiotics.
The Pelvic Floor Society issues a consensus statement on the use of mesh surgeries for treating constipation and rectal prolapse. The statement emphasizes proper training, accreditation, and tracking of complications to ensure patient safety.
A team at Harvard's Wyss Institute has created genetically encodable RNA nano-devices that can perform an unprecedented 12-input logic operation, enabling cells to analyze complex environments efficiently. These programmable devices may enable the construction of more sophisticated synthetic biological circuits.
A team of scientists is working on synthesizing a human genome from scratch, tackling the technical and ethical challenges that come with it. They have already made significant progress in building smaller genomes, such as those of microbes, but still face significant hurdles in constructing the complex human genome.
Researchers developed a biocatalytic system to produce terephthalic acid from p-xylene using metabolically engineered E. coli, offering a greener alternative to traditional chemical methods. The resulting yield of 97 mol% demonstrates the feasibility of this bio-based technology for large-scale production.
Researchers at Rice University engineered bacteria capable of sensing colitis in mice, detecting elevated thiosulfate levels and finding a potential biomarker for human colitis. The breakthrough could lead to orally ingestible bacteria for monitoring gut health and disease.
Researchers developed a model to assess emerging synthetic biology products and identify priority information needs for policymakers. The Societal Risk Evaluation Scheme (SRES) evaluates eight categories of information, including human health risks and environmental concerns, to help determine policy actions.
Scientists have discovered metabolons, complex enzyme clusters, for the first time using molecular movie technology. This breakthrough reveals plants' secret medicinal toolbox and unlocks new possibilities for harnessing plant-based medicines.
Researchers develop Poisson filter, a single-gene noise filter that can cancel out molecular environment effects, enabling context-independent behavior in biological circuits. The filter has potential to improve specificity and efficacy of synthetic biology applications such as new therapeutics or biosensing.
The US National Science Foundation has awarded five early-concept grants to investigate new approaches in STEM learning and innovation through making. The projects aim to create more accessible and engaging maker programs for diverse youth populations.
Researchers have developed a high-throughput method for creating stable vesicles of controlled size using microfluidics. The approach works for both liposomes and polymersomes, enabling applications in synthetic biology such as encapsulation of biological agents and creation of artificial cell membranes.
Wyss Institute researchers create protein actuators that can mechanically puncture cell membranes and release beneficial molecules. The system, inspired by bacterial R bodies, uses pH levels to extend and retract the nanoneedles, enabling precise control over cell delivery.
Researchers at Boston University aim to advance synthetic biology by creating a toolbox of carefully measured and catalogued biological parts. The project will use computing engineering principles to develop an open-source repository of biological pieces that can be used to engineer organisms with predictable results.
Scientists from Duke University developed a freely available computer program based on the traveling salesman mathematics problem to find the least-repetitive genetic code. This allows synthesizers to easily explore synthetic biomaterials previously unavailable to most researchers.
A study published in Molecular Cell reveals that cells have adaptive mechanisms to maintain perfect timing despite varying starting conditions. This finding has significant implications for understanding how cells avoid errors that promote cancer development and can inform the creation of robust mechanisms for synthetic life.
The BGU project Boomerang is a modular system that recognizes cancer cells at a high level of specificity and can cause disruption of genes essential for cancer survival or activate suicide genes. It has many applications in personalized medicine, paving the way to change the approach to cancer treatments.
The National Institute for Mathematical and Biological Synthesis (NIMBioS) has been awarded a two-year NSF grant to create the Quantitative Biology Concept Inventory (QBCI), an instrument to assess learning comprehension and skill development in college-level math courses with real-world examples versus abstract methods. The project ai...
Research from NIMBioS found that the timing of spawning is crucial for the survival of larval fish, with success rates higher on days when spawning is observed to occur. This study has important implications for fisheries management and conservation, highlighting the need to protect spawning aggregations.
Researchers at UC Berkeley have developed an easy way to contain bacteria using genetic mutations that require a specific molecule for viability. The method has promise as a practical method of biocontainment and could be applied to organisms engineered to treat diseases.
Researchers at Imperial College London have developed a new technique called BASIC for creating artificial DNA, which combines the best features of existing methods while overcoming their limitations. The system enables fast and flexible assembly of genes with high accuracy, making it suitable for industrial-scale use.
A research team aims to create semi-artificial chloroplasts to produce biofuels and other chemicals, using synthetic biology tools. The 'Sun2Chem' project, funded by the EU with 1.2 million euros, will modify natural chloroplasts to generate biotechnologically relevant products.
A new protein production method developed by Northwestern University researchers makes cell-free protein synthesis faster and cheaper, addressing a technological gap in the field. The approach uses standard lab equipment and produces crude extract catalysts in less time, enabling more researchers to enter the field.
The UK government has announced a £40 million investment in synthetic biology, aiming to create biological 'factories' that produce essential products like medicines and chemicals. Three new research centres will be established in Edinburgh, Manchester, and Warwick to boost national research capacity.
Researchers have used synthetic biology to produce affordable alternatives to anti-malaria drugs, clean fuels, and pharmaceuticals. The technology has the potential to reduce costs by up to 85% for future long-duration space missions, including those to Mars and the Moon.
Researchers at the Wyss Institute have developed synthetic gene controls that can be used to create programmable diagnostics and biosensors, which can detect specific diseases or infections using saliva or a drop of blood. The new tools are delivered on pocket-sized slips of paper, making them portable and accessible for widespread use.
Researchers design manmade proteins with new structures, including central cavities, to enhance biological functions and create novel molecules. The discovery is part of the growing field of synthetic biology at the University of Bristol.
A new study recreates the French-flag model of stripe formation by engineering synthetic gene networks in E. coli. Researchers successfully developed a theoretical framework and a mathematical model to understand how genetic information is translated into specific spatial patterns of cellular differentiation.
Researchers at Rice University and the University of Kansas Medical Center have developed modular genetic circuits that can handle multiple chemical inputs simultaneously. These new tools allow scientists to design synthetic cells for specific tasks, such as biofuel production, environmental remediation, and disease treatment.
A new report outlines key research areas to study synthetic biology's potential ecological impacts, including species comparative research and genome stability. The report highlights the need for long-term support and interdisciplinary collaboration to address complex questions about synthetic biology's effects on the environment.
Jiang and DeAngelis' theoretical paper explores how species modify their environment to gain benefits, affecting community diversity. Their work is likely to foster further research and generate hypotheses for experimental studies.
Researchers at Northwestern University developed a new technology to modify human cells for programmable therapeutics that can target cancer and disease sites. The Modular Extracellular Sensor Architecture (MESA) enables cells to sense specific factors and respond with customized gene expression programs.
Adam Arkin, director of Berkeley Lab's Physical Biosciences Division, has made significant contributions to systems and synthetic biology. He received the 2013 Ernest Orlando Lawrence Award for his work on cellular networks and populations.
Researchers from UH and Rice University collaborated to engineer a synthetic gene circuit that compensates for temperature changes. The team used mathematical modeling to design the plasmid and created a genetic clock with a stable period across various temperatures.
The University of Liverpool has been awarded £2M for a state-of-the-art DNA synthesis facility, GeneMill, to support genome engineering in academia and industry. The lab will provide rapid, cost-effective, and accessible fabrication facilities for DNA parts, enabling researchers to focus on designing and testing re-engineered organisms.
Researchers at Virginia Tech and MIT have developed a computer-aided design tool called GenoCAD to create genetic languages for designing biological systems. The tool helps capture biological rules to engineer organisms that produce useful products or healthcare solutions from inexpensive materials. GenoCAD enables the standardization ...
The UK has established three new synthetic biology research centres, with £40M+ investment, to drive advancement in modern synthetic biology research and develop new technologies. The centres will focus on diverse expertise to stimulate innovation in this area.
The Synthetic Biology Project at Woodrow Wilson International Center has been awarded a €4 million EU grant to foster responsible governance of synthetic biology. The project aims to initiate mutual learning among stakeholders from science, industry, and civil society.
A mathematical model accurately matches the historical record on the emergence of complex states in ancient societies. Simulated warfare drives the formation of large-scale complex societies.
Researchers at Arizona State University have made significant progress in understanding cell fate determination, a process that governs how cells develop and transition. By using mathematical modeling and synthetic biology techniques, they created artificial gene networks and observed the behavior of cells as they approached their tipp...
Scientists have successfully synthesized ribosomes from scratch using a novel technology that mimics the natural process. This breakthrough enables the creation of functional ribosomes with exotic functions and could lead to the discovery of new antibiotics and modified protein-generators.
A new study reveals that females tend to prefer traits linked to fitness, influencing mate choice and population divergence. This finding settles a long debate about magic traits and predicts their commonality in nature.
The Institute for Genomic Biology will develop foundational synthetic biology technologies and computational platforms for genetic modification of plants and animals. The grant aims to address grand challenges in human health and environmental sustainability, with potential applications in crop yields and disease treatment.
A streamlined approach to genetic engineering has been developed, reducing the time and effort needed to insert new genes into bacteria. This new method, called clonetegration, enables the rapid construction of synthetic biological systems and could facilitate genetic engineering with difficult-to-clone sequences.
Sanofi launches large-scale production of partially synthetic artemisinin, a breakthrough in synthetic biology. The drug, developed by Professor Jay Keasling's team, aims to provide stable supply and low cost for developing countries.
The Office of Naval Research has launched a collaborative initiative to use synthetic cells to help Sailors and Marines execute their missions. Researchers are developing genetically programmed cells that can detect chemicals and respond to signals, enabling the creation of 'smart' hybrid biological-robotic systems.
The rapid development of synthetic biology presents new dialogue opportunities between conservation and synthetic biology communities to address ecological and ethical concerns. The authors highlight five emerging issues requiring discussion, including potential impacts on biodiversity and conservation strategies.
Researchers unveil public domain DNA sequences and statistical models to engineer microbes with precision, increasing reliability and accuracy. This technological foundation enables more precise genetic engineering in the future.
A new study from NIMBioS found that using insecticide-treated bed nets can positively affect malaria's reproduction number, leading to potential elimination. The use of ITNs could reduce the transmission of malaria by reducing mosquito density and lifespan.