Articles tagged with Synthetic Biology
Researchers at Rice University engineered bacteria capable of sensing colitis in mice, detecting elevated thiosulfate levels and finding a potential biomarker for human colitis. The breakthrough could lead to orally ingestible bacteria for monitoring gut health and disease.
Researchers developed a model to assess emerging synthetic biology products and identify priority information needs for policymakers. The Societal Risk Evaluation Scheme (SRES) evaluates eight categories of information, including human health risks and environmental concerns, to help determine policy actions.
Scientists have discovered metabolons, complex enzyme clusters, for the first time using molecular movie technology. This breakthrough reveals plants' secret medicinal toolbox and unlocks new possibilities for harnessing plant-based medicines.
Researchers develop Poisson filter, a single-gene noise filter that can cancel out molecular environment effects, enabling context-independent behavior in biological circuits. The filter has potential to improve specificity and efficacy of synthetic biology applications such as new therapeutics or biosensing.
The US National Science Foundation has awarded five early-concept grants to investigate new approaches in STEM learning and innovation through making. The projects aim to create more accessible and engaging maker programs for diverse youth populations.
Researchers have developed a high-throughput method for creating stable vesicles of controlled size using microfluidics. The approach works for both liposomes and polymersomes, enabling applications in synthetic biology such as encapsulation of biological agents and creation of artificial cell membranes.
Wyss Institute researchers create protein actuators that can mechanically puncture cell membranes and release beneficial molecules. The system, inspired by bacterial R bodies, uses pH levels to extend and retract the nanoneedles, enabling precise control over cell delivery.
Researchers at Boston University aim to advance synthetic biology by creating a toolbox of carefully measured and catalogued biological parts. The project will use computing engineering principles to develop an open-source repository of biological pieces that can be used to engineer organisms with predictable results.
Scientists from Duke University developed a freely available computer program based on the traveling salesman mathematics problem to find the least-repetitive genetic code. This allows synthesizers to easily explore synthetic biomaterials previously unavailable to most researchers.
A study published in Molecular Cell reveals that cells have adaptive mechanisms to maintain perfect timing despite varying starting conditions. This finding has significant implications for understanding how cells avoid errors that promote cancer development and can inform the creation of robust mechanisms for synthetic life.
The BGU project Boomerang is a modular system that recognizes cancer cells at a high level of specificity and can cause disruption of genes essential for cancer survival or activate suicide genes. It has many applications in personalized medicine, paving the way to change the approach to cancer treatments.
The National Institute for Mathematical and Biological Synthesis (NIMBioS) has been awarded a two-year NSF grant to create the Quantitative Biology Concept Inventory (QBCI), an instrument to assess learning comprehension and skill development in college-level math courses with real-world examples versus abstract methods. The project ai...
Research from NIMBioS found that the timing of spawning is crucial for the survival of larval fish, with success rates higher on days when spawning is observed to occur. This study has important implications for fisheries management and conservation, highlighting the need to protect spawning aggregations.
Researchers at UC Berkeley have developed an easy way to contain bacteria using genetic mutations that require a specific molecule for viability. The method has promise as a practical method of biocontainment and could be applied to organisms engineered to treat diseases.
Researchers at Imperial College London have developed a new technique called BASIC for creating artificial DNA, which combines the best features of existing methods while overcoming their limitations. The system enables fast and flexible assembly of genes with high accuracy, making it suitable for industrial-scale use.
A research team aims to create semi-artificial chloroplasts to produce biofuels and other chemicals, using synthetic biology tools. The 'Sun2Chem' project, funded by the EU with 1.2 million euros, will modify natural chloroplasts to generate biotechnologically relevant products.
A new protein production method developed by Northwestern University researchers makes cell-free protein synthesis faster and cheaper, addressing a technological gap in the field. The approach uses standard lab equipment and produces crude extract catalysts in less time, enabling more researchers to enter the field.
The UK government has announced a £40 million investment in synthetic biology, aiming to create biological 'factories' that produce essential products like medicines and chemicals. Three new research centres will be established in Edinburgh, Manchester, and Warwick to boost national research capacity.
Researchers have used synthetic biology to produce affordable alternatives to anti-malaria drugs, clean fuels, and pharmaceuticals. The technology has the potential to reduce costs by up to 85% for future long-duration space missions, including those to Mars and the Moon.
Researchers at the Wyss Institute have developed synthetic gene controls that can be used to create programmable diagnostics and biosensors, which can detect specific diseases or infections using saliva or a drop of blood. The new tools are delivered on pocket-sized slips of paper, making them portable and accessible for widespread use.
Researchers design manmade proteins with new structures, including central cavities, to enhance biological functions and create novel molecules. The discovery is part of the growing field of synthetic biology at the University of Bristol.
A new study recreates the French-flag model of stripe formation by engineering synthetic gene networks in E. coli. Researchers successfully developed a theoretical framework and a mathematical model to understand how genetic information is translated into specific spatial patterns of cellular differentiation.
Researchers at Rice University and the University of Kansas Medical Center have developed modular genetic circuits that can handle multiple chemical inputs simultaneously. These new tools allow scientists to design synthetic cells for specific tasks, such as biofuel production, environmental remediation, and disease treatment.
A new report outlines key research areas to study synthetic biology's potential ecological impacts, including species comparative research and genome stability. The report highlights the need for long-term support and interdisciplinary collaboration to address complex questions about synthetic biology's effects on the environment.
Jiang and DeAngelis' theoretical paper explores how species modify their environment to gain benefits, affecting community diversity. Their work is likely to foster further research and generate hypotheses for experimental studies.
Researchers at Northwestern University developed a new technology to modify human cells for programmable therapeutics that can target cancer and disease sites. The Modular Extracellular Sensor Architecture (MESA) enables cells to sense specific factors and respond with customized gene expression programs.
Adam Arkin, director of Berkeley Lab's Physical Biosciences Division, has made significant contributions to systems and synthetic biology. He received the 2013 Ernest Orlando Lawrence Award for his work on cellular networks and populations.
Researchers from UH and Rice University collaborated to engineer a synthetic gene circuit that compensates for temperature changes. The team used mathematical modeling to design the plasmid and created a genetic clock with a stable period across various temperatures.
The University of Liverpool has been awarded £2M for a state-of-the-art DNA synthesis facility, GeneMill, to support genome engineering in academia and industry. The lab will provide rapid, cost-effective, and accessible fabrication facilities for DNA parts, enabling researchers to focus on designing and testing re-engineered organisms.
Researchers at Virginia Tech and MIT have developed a computer-aided design tool called GenoCAD to create genetic languages for designing biological systems. The tool helps capture biological rules to engineer organisms that produce useful products or healthcare solutions from inexpensive materials. GenoCAD enables the standardization ...
The UK has established three new synthetic biology research centres, with £40M+ investment, to drive advancement in modern synthetic biology research and develop new technologies. The centres will focus on diverse expertise to stimulate innovation in this area.
The Synthetic Biology Project at Woodrow Wilson International Center has been awarded a €4 million EU grant to foster responsible governance of synthetic biology. The project aims to initiate mutual learning among stakeholders from science, industry, and civil society.
A mathematical model accurately matches the historical record on the emergence of complex states in ancient societies. Simulated warfare drives the formation of large-scale complex societies.
Researchers at Arizona State University have made significant progress in understanding cell fate determination, a process that governs how cells develop and transition. By using mathematical modeling and synthetic biology techniques, they created artificial gene networks and observed the behavior of cells as they approached their tipp...
Scientists have successfully synthesized ribosomes from scratch using a novel technology that mimics the natural process. This breakthrough enables the creation of functional ribosomes with exotic functions and could lead to the discovery of new antibiotics and modified protein-generators.
A new study reveals that females tend to prefer traits linked to fitness, influencing mate choice and population divergence. This finding settles a long debate about magic traits and predicts their commonality in nature.
The Institute for Genomic Biology will develop foundational synthetic biology technologies and computational platforms for genetic modification of plants and animals. The grant aims to address grand challenges in human health and environmental sustainability, with potential applications in crop yields and disease treatment.
A streamlined approach to genetic engineering has been developed, reducing the time and effort needed to insert new genes into bacteria. This new method, called clonetegration, enables the rapid construction of synthetic biological systems and could facilitate genetic engineering with difficult-to-clone sequences.
Sanofi launches large-scale production of partially synthetic artemisinin, a breakthrough in synthetic biology. The drug, developed by Professor Jay Keasling's team, aims to provide stable supply and low cost for developing countries.
The Office of Naval Research has launched a collaborative initiative to use synthetic cells to help Sailors and Marines execute their missions. Researchers are developing genetically programmed cells that can detect chemicals and respond to signals, enabling the creation of 'smart' hybrid biological-robotic systems.
The rapid development of synthetic biology presents new dialogue opportunities between conservation and synthetic biology communities to address ecological and ethical concerns. The authors highlight five emerging issues requiring discussion, including potential impacts on biodiversity and conservation strategies.
Researchers unveil public domain DNA sequences and statistical models to engineer microbes with precision, increasing reliability and accuracy. This technological foundation enables more precise genetic engineering in the future.
A new study from NIMBioS found that using insecticide-treated bed nets can positively affect malaria's reproduction number, leading to potential elimination. The use of ITNs could reduce the transmission of malaria by reducing mosquito density and lifespan.
Researchers at Imperial College London have developed a rapid method to create new parts for biological factories, which could lead to the mass production of sophisticated devices and unlock their potential in society. This breakthrough brings scientists one step closer to an 'industrial revolution' in synthetic biology.
The University of Nottingham has been awarded £2.9m to develop low-carbon fuel and address global challenges through synthetic biology. Researchers aim to convert carbon monoxide into useful chemicals and fuels without competing with food resources.
The MIT team has developed a synthetic biology circuit that integrates four sensors for different molecules, allowing cells to precisely monitor their environments and respond accordingly. The breakthrough was achieved by creating genetic components that don't interfere with each other, enabling the production of complex circuits.
Researchers have developed an adaptor that makes genetic engineering of microbial components more predictable, converting regulators of translation into regulators of transcription in Escherichia coli. This allows for the construction of increasingly complex functions in microorganisms, enabling safer and more efficient production of e...
Dr. Jay Keasling has made significant contributions to synthetic biology, engineering microbial factories to produce affordable antimalarial drugs and biofuels. His work has improved the lives of millions of people in impoverished areas, making him a true science hero.
A new study demonstrates that female choice and faithfulness played a crucial role in human evolution, leading to the emergence of the modern family. The transition from promiscuity to pair-bonding was characterized by a reduction in male-to-male competition in favor of providing for females and close parental involvement.
The UK's world-leading researchers in synthetic biology will establish platform technology with a new grant of almost £5 million. The platform technology will be based on an information system – SynBIS – which uses a web-based environment, hosting BioCAD and modelling tools for the field.
Northwestern University researchers have received two Grand Challenges Explorations grants to develop new compounds for malaria treatment and biosensors for low-cost diagnoses. The projects aim to improve the health of people in developing countries using synthetic biology techniques.
Researchers at Imperial College London have developed a way to 're-wire' DNA in yeast, creating a new type of biological wire that can be easily re-engineered. This breakthrough enables the creation of potentially complex biological machines with applications in pollution monitoring and cleaner fuels.
Synthetic biology faces significant environmental risks if not addressed proactively. The authors propose four areas of focus: physiology differences, escaped organisms' impact, evolution, and genetic material exchange. Interdisciplinary research is crucial to mitigate these risks.
Researchers aim to create bacteria that form geometrical patterns to understand stem cell behavior. By modifying E. coli with genetic circuits, they hope to unlock the genetic programming behind complex cellular structures.
Researchers aim to create biological circuits using RNA molecules for the engineering of programmable genetic networks. They have successfully eliminated protein requirements and developed a system that can sense RNA input and synthesize output signals, performing logic operations and regulating multiple genes. This breakthrough has si...
A rigorous bioinformatic analysis of the strengths and limitations of a screening protocol method recommended by the federal government was conducted, leading to the development of GenoTHREAT. The software tool helps detect the use of synthetic DNA as bioterrorism agents and is being released in an open-source format.
A nationwide survey found that two-thirds of Americans believe synthetic biology should continue, but with more research on human and environmental impacts. The public also harbors concerns about security, moral, and health risks, as well as potential damage to the environment.
A bioinformatics team from Virginia Tech and ENSIMAG is using federal guidance to detect the misuse of synthetic biology. The team's work will help gene synthesis companies identify potential threats, improving national security.
The DIYbio community, comprising over 2,000 amateur biologists, is partnering with the Woodrow Wilson Center on a biosafety initiative to ensure safe science. The project aims to develop a positive culture around citizen science and establish best practices for safety in the community.
Matthew Lux, a Virginia Tech Ph.D. student, has been awarded a US Department of Defense SMART scholarship to explore opportunities in synthetic biology for defense applications. His research involves developing intelligent sensors and countermeasures using calibrated genetic parts.