Articles tagged with Transcription Termination
For the first time, researchers have demonstrated how mechanical forces affect gene expression by showing that RNAP polymerase remains on the DNA template and can be pulled to start a subsequent cycle of transcription. This force-directed recycling mechanism can change the relative abundance of adjacent genes.
Researchers developed novel small molecule inhibitors of CPSF3, a key regulator of transcription termination in ovarian cancer cells. These inhibitors exhibited potent antiproliferative effects and suppressed tumor growth in vivo.
A team of scientists has identified a key player in the coupling between early transcription termination and RNA degradation. The ARS2 protein recruits ZC3H4, which interacts with the NEXT complex to target nascent transcripts for degradation.
Researchers have discovered a new mechanism underlying the control of gene expression in all living organisms. Transcriptional pausing by RNA polymerase provides a 'roadblock' to help regulate gene expression levels, which could aid our understanding of antibacterial drugs and future synthetic gene design.
Researchers have resolved the first protein structure in a family of proteins called transcription terminators, revealing their role as traffic signals for coordinating transcription and gene replication. The study provides insight into the mechanisms underlying cellular aging and tumor growth.
The new model integrates data from various studies to describe transcription termination as a complex process involving multiple regulatory factors. Key findings include the identification of essential genes and regulatory elements involved in controlling transcription termination.
Researchers at Cold Spring Harbor Laboratory have identified a new mechanism for gene regulation known as 'gene loops', which play a crucial role in controlling the expression of genes. This discovery has significant implications for our understanding of gene function and regulation.