Articles tagged with Alzheimer Disease
A study published in Nature Neuroscience has uncovered a link between gene activity and Alzheimer's disease, identifying genes involved in the pathology of the condition. The research found changes in histone acetylation across the genome, providing a framework for studying histone modification studies in other brain diseases.
A new study published in Frontiers in Aging Neuroscience suggests a causal link between herpes viruses and Alzheimer's disease, with antiviral drugs drastically reducing the risk of senile dementia in patients with severe herpes infections.
Researchers at Boston University School of Medicine discovered a strong link between chronic inflammation and increased risk for Alzheimer's disease in ApoE4 carriers. Sequential measurements of C-reactive protein revealed that ApoE4 linked with chronic low-grade inflammation significantly increases AD risk.
A team of scientists discovered that spontaneous genetic errors in brain cells could lead to neurodegenerative diseases like Alzheimer's and Parkinson's. These 'somatic mutations' are thought to arise during embryonic development, contributing to the roots of dementia in people without a family history.
A study of male and female mice found that chronic short sleep and chronic fragmentation of sleep accelerate Alzheimer's disease-related tau pathology. Healthy sleep habits during adolescence and early adulthood may help prevent progression of neurodegenerative diseases.
Researchers have discovered that brain oscillations can be used to measure the activity of grid cells, which form the brain's navigation system. This breakthrough may lead to earlier diagnosis and treatment of Alzheimer's disease by testing impaired functionality.
Researchers have found that Alzheimer's disease is closely linked to neuropsychiatric symptoms such as depression, anxiety, and sleep disturbances. The study used brains from over 1,000 healthy adults aged 50+, finding that AD pathology was present in many individuals who didn't show classic cognitive symptoms.
Researchers have identified glutathione, a key brain antioxidant, as significantly depleted in Alzheimer's patients compared to healthy individuals. Non-invasive imaging techniques revealed that lower levels of this antioxidant are associated with mild cognitive impairment and may hold potential for therapeutic development.
A Japanese team of researchers found that early changes to synapse gene regulation, including the phosphorylation of SRRM2 protein, can lead to Alzheimer's disease. This discovery offers new insights into the pathology of AD and may suggest possibilities for gene therapies using virus vectors.
A recent study from CNRS has cast doubt on the connection between magnetite particles and Alzheimer's disease, as previous research suggested that magnetite could cause oxidative stress and lead to neuron degeneration. The new findings suggest that magnetite is unlikely to be involved in this process.
A new study from the University of Eastern Finland has found that antiepileptic drugs are linked to a higher risk of stroke among persons with Alzheimer's disease. The study also revealed that this increased risk persisted even after accounting for other chronic conditions and socioeconomic factors.
Researchers aim to understand the molecular signatures of Alzheimer's, CTE, and other neurodegenerative diseases by mapping the three-dimensional structures of protein tangles. This knowledge will enable the design of drug molecules that prevent tangle buildup and aid in early detection through biomarkers.
Researchers at the Institute of Molecular Pathology Biomarkers at the University of Extremadura have discovered a new biomarker for Alzheimer's disease of sporadic origin, protein STIM1. A deficiency in this protein has been linked to calcium ion transport abnormalities, which can lead to neurodegeneration and cell death.
A comprehensive genome-wide map of RNA splicing variation in the aging brain has been created, offering new insights into genetic mechanisms underlying Alzheimer's disease progression. The study identified specific RNA splicing events linked to the disease and suggests a potential therapeutic strategy using antisense oligonucleotides.
Researchers at USC have created a new map of the mouse hippocampus, revealing its internal circuitry and nerve connections in vivid detail. The study aims to provide a resource for scientists to better understand the brain's memory bank and develop strategies to target neurons for treatment.
A novel study suggests that people who participate in dementia prevention trials are primarily motivated by a desire to help others. The findings also highlight the importance of human interaction, with trial participants preferring staff-administered assessments over automated technologies.
A new study combines imaging and neuropsychological testing to more accurately assess cognitive status, distinguishing individuals with mild cognitive impairment from those with normal cognition. The combined data model achieved an overall accuracy of over 90%, surpassing individual models alone.
A new AI algorithm can accurately predict cognitive decline and Alzheimer's disease, enabling early intervention and prevention strategies. The algorithm learns from MRI, genetics, and clinical data to identify individuals at risk, potentially delaying or preventing the onset of Alzheimer's.
A study by UIC researchers found that long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons similar to Alzheimer's disease. Chronic infection leads to neural effects, including senile plaque formation and brain inflammation.
A study published in European Neuropsychopharmacology found that up to half of people with Alzheimer's disease use a psychotropic drug, with those receiving first-line anti-dementia drugs showing a decreased risk of polypharmacy. The most common combination included antidepressants with antipsychotics or benzodiazepines.
A new poll by Michigan Medicine found that over half of older adults (50-64) are interested in DNA testing to guide medical care, understand health risks or know their ancestry. However, two-thirds expressed concern that genetic testing could lead to worrying about future health.
A new study suggests that EU countries are unprepared to rapidly move future Alzheimer's treatment into clinical use due to shortages of medical specialists and infusion capacity. The study estimates that up to 1 million people may be left without access to transformative care if a breakthrough occurs.
A new grant from the National Institute on Aging aims to boost Latino researchers studying Alzheimer's disease and related dementias. The San Diego Resource Center for Advancing Alzheimer's Research in Minority Seniors will provide mentorship, data, and intellectual resources to support emerging scholars.
Researchers found a new mechanism involving KCNB1 potassium channels that builds up toxins in brains affected by Alzheimer's disease. The build-up is caused by oxidation and can also contribute to other conditions such as traumatic brain injury.
A novel drug has reversed memory deficits and stopped Alzheimer disease pathology in an animal model, with proven non-toxicity for humans. The drug targets the Caspase-1/Caspase-6 neurodegenerative pathway, a significant breakthrough in treating age-related memory loss.
The study evaluated [18F]SRF101, a PET radiotracer for astrocytosis detection. The results showed no systemic signs of toxicity in mice and estimated the human radiation dosimetry to be comparable to other 18F radiopharmaceuticals.
A large-scale international study published in PLOS Medicine found that a new medication called Nilvadipine showed promise in slowing the progression of mild and moderate Alzheimer's disease. However, the overall group of patients did not benefit from the treatment. Further research is needed to explore its potential.
Researchers at the University of Cambridge have devised a strategy to 'go after' the cause of Alzheimer's disease, targeting toxic protein oligomers. This breakthrough could lead to new drug development and treatment options for dementia.
Researchers propose using blood-brain barrier breakdown as an early warning sign for Alzheimer's disease, which could lead to earlier diagnosis and treatment. Healthy blood vessels are crucial for normal brain functioning, and damage can be detected with imaging tests such as MRI.
A new $3 million NIA-funded study is examining the impact of early dementia screening on caregivers of older adults. Researchers aim to determine whether screening prepares family members for a caregiving role or depresses them, and if providing state-of-the-science diagnostic care and management can reduce caregiver burden.
A vicious feedback loop drives brain degeneration in Alzheimer's disease, but a clinically approved drug may provide a solution. The study identified Dkk1 as a central player in the cycle, and targeting it with fasudil shows promise in animal models.
A new brain imaging method can accurately diagnose Alzheimer's disease by detecting specific tau protein depositions. The method has shown great sensitivity and specificity in detecting 90-95% of all cases of Alzheimer's, outperforming existing diagnostic methods.
A study found associations between air pollution and dementia diagnoses in London patients, with higher NO2 and PM2.5 levels linked to a 40% increased risk of dementia. The study's findings suggest that traffic-related air pollution may contribute to neurodegeneration, particularly for Alzheimer's disease.
Computer simulation models how toxic proteins spread through the brain to reproduce patterns of atrophy associated with Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. The model reveals that biochemistry and connectivity play key roles in mediating disease progression.
A study found that daytime sleepiness is associated with an increased risk of brain deposits of beta amyloid, a hallmark of Alzheimer's disease. Participants who reported excessive daytime sleepiness were nearly three times more likely to develop beta-amyloid deposition in their brains years later.
A Massachusetts General Hospital study shows that exercise induces neurogenesis and improves cognition in a mouse model of Alzheimer's disease. Exercise mimics the beneficial effects of physical activity on cognitive function by creating a more hospitable brain environment for new neurons to survive.
Researchers have found that tau protein interferes with the nucleus's ability to communicate with the cell, disrupting the function of the nuclear pore complex. This alteration accelerates tau aggregation and neurofibrillary tangle formation, leading to neural dysfunction and death in Alzheimer's disease.
A study by Massachusetts General Hospital researchers found that the abnormal form of tau associated with Alzheimer's disease disrupts communication between a neuron's nucleus and cytoplasm. This disruption leads to brain cell dysfunction and death, contributing to neuronal loss in Alzheimer's disease.
Adults with and without Alzheimer's disease show better cognition skills in late summer and early fall than in winter and spring, equivalent to a 4.8-year difference in age-related decline. The odds of mild cognitive impairment or dementia were also higher in winter and spring.
Researchers have devised a novel strategy to identify people with mild cognitive impairment at risk of developing Alzheimer's disease. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) tool measures specific memory deficits that align with imaging findings for abnormal brain amyloid accumulation.
Scientists have developed a way to visualize brain cells communicating through neurotransmitters, providing insight into conditions such as Alzheimer's disease and depression. The new lab technique enables the study of poorly understood neurotransmitters like acetylcholine, which affects memory, mood, and emotional regulation.
Researchers from Far Eastern Federal University have discovered a new group of Kunitz-type peptides in Heteractis magnifica sea anemones, which exhibit neuroprotective properties. The peptides inhibit the development of inflammations and reduce levels of active oxygen forms that cause cell damage.
Researchers will examine connections between cardiovascular disease and brain health in a 3,000-participant study. The study aims to determine whether heart health explains increased incidence of Alzheimer's disease among different racial and ethnic groups.
A team of researchers at the University of Florida has identified a novel approach to treating Alzheimer's disease by harnessing the power of an immune cell protein. Soluble versions of TLR5 can reduce amyloid plaque buildup and prevent neuronal damage in mouse models.
A study from the University of Arizona found that individuals with the APOE e4 gene variant who carry it described memories with less vivid detail than those without it. The researchers hope to develop a clinical test sensitive enough to detect preclinical brain changes of Alzheimer's disease.
A study explores the use of optical coherence tomographic angiography (OCTA) to analyze retinal changes in people with preclinical Alzheimer's disease. Researchers found certain retina alterations were more common among those with preclinical AD, suggesting potential for non-invasive early detection.
Scientists will investigate necroptosis, a form of programmed cell death, as a key contributor to neuronal loss in Alzheimer's. The goal is to develop therapeutics capable of blocking the necroptosis pathway and slowing or arresting cell death characteristic of the disease.
Scientists have detected signs of Alzheimer's disease in the eyes of patients who showed no symptoms, using a non-invasive technique called optical coherence tomography angiography. The study found that patients with elevated levels of Alzheimer's proteins had significant thinning in the center of their retinas.
A type of cellular stress known as senescence has been linked to Alzheimer's disease and other human brain diseases. Researchers identified senescent cells in postmortem tissue from Alzheimer's patients and found them in another brain disease, progressive supranuclear palsy.
Jesse Mez will examine clinical, radiologic, and neuropathologic markers of Alzheimer's disease in Framingham Heart Study participants to test the hypothesis that TBI and military service independently and jointly contribute to its development. The study aims to identify risk factors beyond genetics and lifestyle choices.
A University of Adelaide-led team suggests a potential link between iron handling and rare gene mutations causing Alzheimer's disease. The theory proposes that abnormalities in how neurons handle iron could result in the devastating early onset form of the disease.
Researchers have discovered new genes that may contribute to the development of Alzheimer's disease, a complex condition characterized by neurodegeneration and memory decline. The study identified rare variations in genes associated with an inflammatory response and changes in protein production.
A recent study found that benzodiazepine use is associated with a modestly increased risk of Alzheimer's disease. The research, conducted in the nationwide MEDALZ cohort, suggests that the threshold for prescribing these medications should be high due to their adverse effects and potential risks.
A new study reveals that older adults who initiate hemodialysis for kidney failure are at a higher risk of being diagnosed with dementia and Alzheimer's disease. The study found that age, Black race, female sex, and institutionalization were the strongest risk factors for dementia and Alzheimer's disease.
Researchers have discovered a signal pathway within cells that could stop degeneration and improve learning and memory in affected patients. The study also invented a potential drug to target tauopathies, a class of diseases caused by misfolding of the tau protein.
The Harrington Discovery Institute has announced three new scholars in collaboration with FFB and ADDF, selected through a competitive review process for their research on therapies for retinal degenerative diseases and Alzheimer's disease. The institute provides financial support and drug development assistance to accelerate these pro...
A study by Penn State researchers identified 13 types of problems with screening questions for Alzheimer's disease, including vagueness and emotional triggers. The findings suggest that clinicians can improve their understanding of patients' unique experiences by asking better questions.
A significant link was discovered between age-related macular degeneration, diabetic retinopathy, glaucoma and Alzheimer's disease. Patients with these eye conditions were at a 40-50% greater risk of developing Alzheimer's disease compared to similar individuals without these conditions.
Scientists at TUM have discovered a new class of designed macrocyclic peptides that are highly potent inhibitors of amyloid formation, which could be an alternative to current antibody-based approaches. The researchers are now planning further investigations to verify their effectiveness in in vivo models.
Researchers from Brigham and Women's Hospital discovered a neuroprotective microRNA, miR-132, which shows promise in treating tauopathies like Alzheimer's. The study found that miR-132 supplementation reduced toxic forms of tau and glutamate excitotoxicity, providing new avenues for potential treatments.