Articles tagged with Alzheimer Disease
Scientists at TUM have discovered a new class of designed macrocyclic peptides that are highly potent inhibitors of amyloid formation, which could be an alternative to current antibody-based approaches. The researchers are now planning further investigations to verify their effectiveness in in vivo models.
Researchers from Brigham and Women's Hospital discovered a neuroprotective microRNA, miR-132, which shows promise in treating tauopathies like Alzheimer's. The study found that miR-132 supplementation reduced toxic forms of tau and glutamate excitotoxicity, providing new avenues for potential treatments.
A study suggests a simple imbalance in acid-alkaline chemistry inside endosomes may lead to amyloid protein accumulation and nerve cell degeneration. Researchers found that histone deacetylase inhibitors can reverse pH problems and improve amyloid beta clearance in lab-grown mouse brain cells.
BACE inhibitors may fail Alzheimer's trials due to impaired differentiation of newborn cells, according to a study published in eNeuro. The research suggests that partial BACE inhibition could represent an alternative strategy for reducing AD pathology while maintaining adult neurogenesis.
Researchers found reduced complexity of adult-born neurons in mice with ApoE4 compared to ApoE3-expressing mice. The study suggests that the Apolipoprotein E risk gene contributes to memory impairment by impairing new neuron development.
Researchers have highlighted the importance of testing and targeting different forms of Aβ protein, which can take various shapes including monomers and twisted tangles. Two new studies found that certain forms of Aβ are more toxic than others, and developed a screening test to identify potential therapeutics.
A Massachusetts General Hospital research team has developed a system that incorporates neuroinflammation into their 'Alzheimer's in a dish' model, fully replicating the disease's pathology. The system includes neural cell death and glial cells that provide immune functions.
Researchers have found that improving lymphatic vessel function can enhance cognitive ability in aged mice and reduce the accumulation of harmful amyloid plaques. This breakthrough discovery offers new hope for treating or preventing Alzheimer's disease and other neurodegenerative diseases.
New research highlights the importance of targeted clinical trials to address the shortage, with 142 active trials worldwide and only 29 disease-modifying therapies in phase 2 or 3 development. The study suggests that considering biomarkers and risk factors can increase the power per patient screened to detect potential treatments.
Researchers at Virginia Tech have discovered that meningeal lymphatic vessels in the brain play a crucial role in maintaining healthy brain function, and dysfunction can contribute to cognitive decline. Treating these vessels with a molecule increased fluid flow and improved learning and memory tasks in aged mice.
The SPRINT MIND Study found significant reductions in the risk of mild cognitive impairment (MCI) and combined risk of MCI plus all-cause dementia through intensive blood pressure control. This study provides the strongest evidence to date on reducing MCI and dementia risk through cardiovascular disease treatment.
Researchers found reduced levels of plasmalogens in the liver are associated with an increased risk of Alzheimer's disease, mild cognitive impairment, and other biomarkers of neurodegeneration. The study suggests that a deficiency in these lipids could lead to the eventual destruction of peroxisomes, increasing Alzheimer's risk.
Studies investigate how changes in gut bacteria and lipid metabolism may influence brain health and cognitive decline. Research suggests that altered plasmalogens production by the liver may result in reduced availability of critical lipids to the brain, contributing to impaired cognitive function and neurodegeneration in Alzheimer's.
A new study highlights the need for effective treatments for non-cognitive symptoms of dementia, such as agitation and behavioral changes. Researchers found that synthetic cannabinoid treatment, like nabilone, may be an effective option for treating agitation in people with Alzheimer's disease.
The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) has made large-scale DNA sequence data available to researchers. The database includes whole-genome sequence data from 5,000 subjects with Alzheimer's disease and cognitively normal controls from diverse ethnic backgrounds.
Research suggests that reproductive factors, including number of children, miscarriages, age at first menstrual period, and reproductive period, may contribute to dementia risk in women. Women who had three or more children were found to have a lower risk of dementia, while those with earlier onset of menstruation or shorter reproducti...
The new National Strategy for Recruitment and Participation in Alzheimer's Disease Clinical Research aims to increase enrollment of underrepresented groups, including African Americans. The strategy focuses on local outreach, awareness, and incentives to facilitate participation and addresses physical, fiscal, and psychological barriers.
A virtual reality learning program is being used to prepare high school students to interact with older adults with Alzheimer's disease. The program aims to increase empathy and reduce negative attitudes towards people with dementia.
Researchers at the University of Toronto have identified a mechanism that recreates vivid sensory experiences from memory using smell. The findings shed light on how sensory-rich memories are created and stored in our brains, and could explain why loss of smell is recognized as an early symptom of Alzheimer's disease.
Researchers can now access eight new mouse models carrying genetic mutations found in patients with late-onset Alzheimer's disease. These models express variants at genetic loci associated with the disease but not yet proven to be causative, offering a significant advancement in AD research.
Research reveals that genetic copy-and-paste activity is increased in fruit fly models of tauopathies, leading to neuron death. Lamivudine, an anti-retroviral drug, decreases gene copying and reduces brain cell death.
The recommendations aim to improve timely and accurate diagnosis of Alzheimer's disease by emphasizing a multidisciplinary evaluation approach. The guidelines also focus on compassionate communication with patients and caregivers, and establishing a structured assessment process.
The study found significant rates of depression, hypertension, stroke, and cardiovascular disease among sexual minority older adults, contributing to the level of dementia. The prevalence of dementia increases with age, even in 'oldest old', and survival time for people with dementia is six years regardless of age.
Researchers at Tohoku University found that whole-brain low-intensity pulsed ultrasound (LIPUS) therapy improved cognitive dysfunction in mice with vascular dementia and Alzheimer's disease. The treatment was shown to enhance blood vessel formation, nerve cell regeneration, and protein expression without serious side effects.
A study found that women with a history of pregnancy, particularly those giving birth to five or more children, may be at higher risk for developing Alzheimer's disease. Incomplete pregnancies were also shown to reduce the likelihood of Alzheimer's development.
Researchers found α-band power reduction and decreased EEG complexity in mild cognitive impairment (MCI) and subjective cognitive impairment (SCI). Nonlinear EEG analysis during cognitive tasks highlights potential early markers of Alzheimer's disease (AD).
Researchers developed a 3D super-resolution nanoscope that provides unprecedented detail of brain molecules, shedding light on Alzheimer's disease progression. The instrument helped understand the structure of amyloid plaques, pinpointing their characteristics responsible for damage, and revealed their interactions with surrounding cells.
Researchers have developed a new method to directly measure synaptic loss in individuals with Alzheimer's disease, using PET imaging technology. The study found that participants with Alzheimer's disease had a 41% reduction in synaptic density compared to those with normal cognition.
Researchers at Jackson Laboratory explore APOEε4 mutation role in Alzheimer's disease, interacting with up to 20 other implicated genes. The study uses diverse mouse populations to understand complex genetic mechanisms underlying the disease.
Scientists have discovered a specific sulfate pattern on the cell's surface that allows misfolded tau protein to enter cells, leading to neurodegenerative diseases like Alzheimer's and Parkinson's. Understanding this process could lead to new therapies to halt disease progression.
Researchers found that repeated testing in middle-age men produced a practice effect, obscuring true cognitive decline and delaying detection of mild cognitive impairment (MCI). This has significant clinical consequences, as it can lead to misdiagnosis and delayed treatment for Alzheimer's disease (AD).
A study published in Neurology found that higher blood pressure in later life is associated with signs of brain aging and brain lesions, including infarcts and tangles linked to Alzheimer's disease. The risk of brain lesions increases by 46% for those with one standard deviation above the average systolic blood pressure.
A Finnish study found a link between a gene variation and increased risk of Alzheimer's disease in the elderly, particularly those with job-related exhaustion in shift workers. The research suggests that genetic predisposition combined with lifestyle disruptions can increase Alzheimer's risk.
A recent Penn Medicine study found that nearly all major neurodegenerative diseases share common 'proteinopathies' present in varying degrees across different diseases, expanding the potential for combination therapy targeting multiple disease proteins.
Researchers at McGill University used sMRI and PET scans to track brain degeneration in early-stage Alzheimer's disease, revealing a link between cholinergic neurons and cortical regions. The study suggests that combining PET with sMRI may be a powerful tool for diagnosing Alzheimer's before cognitive symptoms appear.
Research suggests that low-dose aspirin regimens could decrease amyloid plaque pathology in mice by stimulating lysosomes. Activating cellular waste removal mechanisms is a promising strategy for slowing disease progression.
A study found that impairing glucose conversion in ApoE4 brains may lead to reduced risk or delayed disease onset. The research highlights the potential therapeutic strategy of promoting brain energy conversion to mitigate Alzheimer's risk.
A study published in The Journal of Neuroscience found that low-dose aspirin may reduce plaques in the brain by stimulating lysosomes and increasing the activity of TFEB, a protein responsible for waste removal. This could lead to improved treatment options for Alzheimer's disease.
A novel stem cell-based model system mimics human brain tissue and reproduces features of Alzheimer's disease, indicating that modulating the immune system can trigger neuronal repair processes. The study suggests a potential approach to therapy by unlocking the potential of neural stem cells to build new neurons.
Scientists found microRNA changes detectable in mice before symptoms of Alzheimer's disease appear. The study suggests microRNA-142 may be a key biomarker for the condition.
A high-fat, high-sugar diet that leads to obesity may contribute to the development of Alzheimer's disease when paired with normal aging. The study found significant differences in inflammation and insulin resistance markers between obese and healthy mice.
Researchers identified exosomes as the main vehicle for spreading toxic proteins that trigger Alzheimer's Disease. Exosomes carrying oligomer amyloid-beta facilitate brain cell death, and their measurement could serve as a diagnostic tool.
New study by Drexel University researchers suggests that tau protein allows microtubules to grow and remain dynamic. This challenges the widely-held theory that tau stabilizes microtubules, which is critical for cognitive function.
Researchers found that extra copies of genes on chromosome 21 increase Alzheimer's-like brain pathology in a mouse model of Down syndrome. The study could lead to future medicines to prevent early onset Alzheimer's disease in people with Down syndrome.
Immune cells called microglia are precision cleaning machines protecting the central nervous system from damage. By understanding their role, scientists can develop new treatments tailored to individual patients' needs.
Researchers analyzing brain data from people with and without Alzheimer's disease found evidence that viral species may play a role in the disease. The study suggests a complex interplay between viral and host genetic factors, adding to our understanding of Alzheimer's biology.
Research found that human herpesvirus 6A and 7 are present in Alzheimer's brains at higher levels than in those without the disease. The study identified previously unknown gene networks that could reveal novel targets for new drugs, and may help prevent or arrest the progression of the disease.
Researchers identify chemically reduced iron species in brains affected by Alzheimer's, including a magnetic iron oxide called magnetite, which may contribute to disease toxicity. The study suggests that understanding these metals could lead to more effective therapies for Alzheimer's disease.
Researchers analyzed data from three major brain banks and found that human herpesvirus DNA and RNA were more abundant in the brains of Alzheimer's patients. The study suggests that viruses may be involved in regulating genes associated with increased Alzheimer's risk, and could offer potential new paths for treatment.
A new study implicates viral presence in the brain as a risk factor for Alzheimer's disease. Researchers found high levels of human herpesvirus 6A and 7 in brain samples from individuals with AD neuropathology, suggesting potential triggers and targets for treatment.
Researchers have found that participants over the age of 65 experience a slower progression of Alzheimer's disease when treated with Deep Brain Stimulation (DBS-f), regardless of when their device was turned on. This suggests that DBS could be a potential treatment for mild, late-onset Alzheimer's disease.
Exosomes in brains affected by Alzheimer's disease contain toxic aggregates of amyloid beta and tau proteins, spreading the disease to new neurons. The study opens up the possibility of diagnosing Alzheimer's disease and developing drugs that could prevent the spreading.
Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
Researchers from Kumamoto University analyzed over 107 Alzheimer's patients and found that face-saving responses are a common communication pattern in the disease. The study suggests that these responses may indicate conflicted feelings about questions that patients cannot answer correctly.
A tailored lighting intervention has been shown to improve sleep quality and reduce symptoms of depression and agitation in Alzheimer's patients. The study found that the lighting intervention significantly decreased sleep disturbances, with a significant improvement seen in sleep quality.
Researchers found a strong link between Tau protein accumulation and genomic instability, which may lead to cell death in Alzheimer's disease. The study identified activated transposable elements as a potential trigger for this process.
Research reveals that alcohol impairs microglial cells' ability to clear amyloid beta, contributing to Alzheimer's disease development. The study found altered gene expression for 312 genes under alcohol exposure.
Researchers have discovered that a compound found in green tea can break up potentially dangerous protein plaques in the blood vessels, which can reduce the flow of blood to the heart and brain. This discovery could lead to new medicines to treat heart attack and stroke.
A single molecule expressed in the brain affects how we learn new tasks and acquire new memories. Mice with a mutated Arc protein showed cognitive inflexibility, highlighting the importance of proteins being switched on and off at the correct times.
Researchers found that APOE4 promotes beta amyloid protein accumulation, leading to Alzheimer's pathology. They also discovered that editing the gene can eliminate signs of Alzheimer's in brain cells.