Articles tagged with Alzheimer Disease
Researchers found that resveratrol, a compound in red wine, significantly reduces amyloid-beta peptide levels in cells. The compound is believed to stimulate the degradation of these peptides by the proteasome, a multi-protein complex. However, it remains unclear whether eating grapes can effectively prevent Alzheimer's disease.
Researchers have discovered that inflammation in the brain can cause toxic nerve impulses that inflict injury on neurons and disrupt function. Chemical preconditioning, induced by small amounts of stress, may be able to prevent this damage and preserve neurologic function, offering a new path for treating neurodegenerative diseases.
Researchers have found that mice lacking iNOS live twice as long and develop fewer brain lesions than those with iNOS. This could lead to a new treatment approach for Alzheimer's disease, which currently only temporarily improves cognitive function.
A special issue of The Gerontologist investigates quality of life for people with dementia in assisted living and nursing homes. The research aims to enhance care and improve lives through the Alzheimer's Association Campaign for Quality Residential Care.
A new study reveals that targeting the brain chemical methionine enkephalin (Met-Enk) with antisense molecules can alter brain function and increase alcohol consumption in mice. This breakthrough could lead to a new class of drugs for treating Alzheimer's disease and possibly even alcoholism.
Scientists found that P-glycoprotein accelerates clearance of amyloid beta from the brain, potentially reducing Alzheimer's risk. The study suggests that pharmaceuticals affecting Pgp activity levels may also influence Alzheimer's risk.
A study published in the Journal of Clinical Investigation found that P-glycoprotein plays a critical role in transporting amyloid-beta (Abeta) from the brain to the blood via the blood-brain barrier. The research suggests that altering P-glycoprotein function due to chronic drug treatment could increase Abeta deposition and risk of de...
Researchers pinpoint CD36 as the first candidate for detecting fatty acids in the oral cavity, influencing digestive physiology and potentially increasing obesity risk. The study also reveals an alteration in the fat perception system may impact HIV transmission through human milk.
Research reveals that accumulation of amyloid-beta (Aβ) peptides depletes key memory proteins in specific brain regions, worsening disease progression. Increasing Fyn activity further exacerbates this effect, highlighting a potential therapeutic target for Alzheimer's treatment.
Researchers found that a high fat, low carbohydrate diet can improve Alzheimer's disease in mice by regulating insulin and promoting ketone body production. This study suggests that dietary components may influence the metabolic state of key aspects of Alzheimer's disease.
The inaugural issue of Alzheimer's & Dementia focuses on the link between a high-folate diet and lower Alzheimer's disease risk, with studies showing a 55% reduction in risk for older adults. The journal will publish quarterly, offering valuable resources for professionals in the field.
A study published in Journal of Nuclear Medicine found that PET imaging with FDG has significantly higher accuracy than genetic screening for predicting Alzheimer's disease in mild cognitive impairment (MCI) patients. Most MCI patients who showed abnormalities in their original PET scan developed dementia within 16 months.
Regular leisure-time physical activity in midlife can lower the odds of developing dementia and Alzheimer's disease by 50-60%. The study found that individuals with genetic susceptibility to AD who engaged in regular physical activity experienced more pronounced effects against developing the condition.
Researchers aim to identify genes underlying Alzheimer's disease to develop drugs for treatment or prevention. The study will focus on protein amyloid production and processing, a known factor in the disease.
A study published in Neurology found that people who lost approximately one unit of BMI per year had a 35% greater risk of developing Alzheimer's disease. The researchers also found a similar relationship between changes in BMI and rate of cognitive decline, which is the clinical hallmark of AD.
Researchers have developed more sensitive tests to predict Alzheimer's disease and cognitive decline. These implicit-memory tests outperform the commonly used Mini Mental exam, which is mainly sensitive to episodic memory. The new tests are strong predictors of Alzheimer's diagnosis two years early.
Researchers silenced a normally functioning gene using RNA interference, reducing amyloid plaque formation and cognitive decline in mice. Within a month of treatment, impaired mice recovered memory functions.
A study by USF researchers found that green tea's epigallocatechin-3-gallate (EGCG) decreases production of the Alzheimer's-related protein beta-amyloid, leading to a 54% reduction in brain-clogging plaques. EGCG may be effective in preventing and treating Alzheimer's disease through dietary supplementation.
A study published in PLoS Medicine found that people with Alzheimer's disease have difficulty suppressing irrelevant brain activity, which can lead to cognitive impairments. This defective focusing process is characterized by reduced cross-modal inhibition, where auditory and visual processing areas are not properly deactivated.
Research suggests that docosahexaenoic acid (DHA) can decrease levels of pathogenic Abeta peptides associated with Alzheimer's disease in human brain cells. The synthesis of neuroprotectin D1 (NPD1), an endogenous DHA-derived messenger, is also upregulated and inhibits apoptosis triggered by Abeta peptides.
Researchers found that the fatty acid DHA decreases levels of Abeta peptides associated with Alzheimer disease and upregulates neuroprotectin D1, an endogenous messenger inhibiting apoptosis triggered by these peptides. Additionally, studies revealed beryllium-specific T cells determine immune responses in exposed workers and apoptosis...
Researchers developed a nanoscale optical biosensor to detect amyloid ?-derived diffusible ligands (ADDLs), tiny proteins accumulating in brain tissue of individuals with Alzheimer's disease. The findings may enable early diagnosis of the condition, currently only possible after death.
A new dye, NIAD-4, has been developed to allow direct imaging of Alzheimer's plaques through a patient's skull without invasive procedures. The compound binds to amyloid brain plaques and fluoresces when exposed to near-infrared radiation, providing clear visual images.
Researchers have identified the Dido gene as a potential tumor suppressor in myelodysplastic/myeloproliferative diseases. Additionally, SOCS-7 has been found to regulate insulin signaling and enhance insulin action. Furthermore, aldose reductase expression has been linked to accelerated diabetic atherosclerosis in transgenic mice.
The study found that Apoer2, a receptor interacting with the NMDA receptor, plays a crucial role in regulating synaptic signaling and learning. Mutant mice lacking this receptor had difficulties with learning and memory tasks.
Researchers discovered that a vascular gene plays a crucial role in the growth of blood vessels in brain cells. Restoring its expression level stimulates new vessel formation and improves clearance of amyloid beta peptide, a toxin associated with Alzheimer's disease.
A major observational study suggests that a healthy diet rich in folates can significantly reduce the risk of Alzheimer's disease. The study, led by UC Irvine researchers, analyzed the diets of over 500 individuals and found that high folate intake was associated with a 55% lower risk of developing Alzheimer's.
UT Southwestern researchers discovered how a protein called nicastrin is involved in the production of beta-amyloid, a key suspect in Alzheimer's disease. By targeting just this portion of the enzyme, they hope to create treatments that block the formation of amyloid plaques without affecting other essential functions.
Researchers have solved a 72-year-old mystery surrounding cholesterol production, revealing that Insig proteins play a crucial role in regulating this process. The study found that mice lacking these proteins accumulate excessive cholesterol and fat in the liver, highlighting the importance of Insig in maintaining normal lipid metabolism.
Researchers have developed a new nasal vaccine that decreases Alzheimer's disease (AD) burden in mice by activating microglia to clear beta-amyloid from the brain. The vaccine combines an FDA-approved multiple sclerosis treatment, glatiramer acetate, with a safe and effective nasal adjuvant that has been tested in humans.
Research found moderate hyperinsulinemia increases CNS inflammatory markers, linking insulin resistance to AD risk. Insulin-induced inflammation may contribute to AD pathology in nondiabetic adults with obesity, impaired glucose tolerance, and hypertension.
Researchers have discovered that quinolinic acid neurotoxicity is present in all dementia patients' brains, leading to brain dysfunction and death. This finding may lead to the development of new treatments for Alzheimer's disease, which currently affects over 200,000 Australians.
A Swedish meta-analysis of 47 scientific studies found clear patterns across thousands of people who went on to be diagnosed with Alzheimer's. The study showed marked preclinical deficits in global cognitive ability, episodic memory, and executive functioning, but no impairment in primary memory.
Researchers discover that amyloid-β protein plaques attach to blood vessels, causing damage and leakage. This breakthrough understanding may lead to the development of treatments that promote plaque removal from the brain.
Researchers discover KDI tri-peptide can block glutamate's damage in degenerative brain diseases, potentially leading to paralysis reversal and nerve regeneration. Human clinical trials expected to begin next year, with no toxic side effects seen so far.
Researchers have identified three small molecules that can inhibit the enzyme CDK5, which contributes to the development of Alzheimer's disease. The discovery is promising news for the development of new treatments for the disease.
Researchers found that women have more global AD pathology due to neurofibrillary tangles and experience clinical symptoms of AD nearly 20 times more often than men. This suggests that Alzheimer's disease is stronger in women, potentially linked to estrogen deficiency or other protective factors.
Studies using transgenic mice reveal impaired amyloid-beta clearance leads to vascular damage and neuroinflammation in the brain. This process appears to contribute to the progression of Alzheimer's disease, suggesting novel therapeutic targets to reduce blood vessel-associated Aβ deposition.
Researchers created transgenic mice overproducing Ab40 and Ab42 to study their roles in AD pathology. The results showed that Ab42 mice accumulated extensive amyloid plaque and neural damage, while Ab40 mice showed little disease pathology. The study provides evidence for the critical role of Ab42 in initiating amyloid deposition.
One-third of nursing home patients with Alzheimer's disease lack correct glasses, causing disorientation and falls. Regular eye exams can prevent this visual impairment, improving overall quality of life.
Researchers at U of MN successfully reversed memory loss in mice with dementia, using a transgene to halt disease progression and even increase tangles. This breakthrough study suggests that reversing effects of memory loss may be possible in humans.
Researchers Hideo Hara and Takeshi Tabira develop an effective oral vaccine treatment for Alzheimer's disease using AAV vector carrying Aß cDNA, which reduces side effects associated with traditional immunotherapy. The treatment has shown promising results in mice, indicating a potential therapeutic approach for the disease.
A large cohort study of over 2,798 participants aged 65 or older found no significant reduction in dementia risk among those who used statins. The authors suggest that statin exposure may need to occur earlier in adulthood or for longer periods to prevent dementia.
Researchers found no significant difference in tests for depression and anxiety between children of people with Alzheimer's disease who were tested and those who were not. Participants reported high satisfaction with the genetic risk assessment process, with 95% saying they would choose it again.
Researchers have discovered a new enzyme family that plays a role in Alzheimer's disease, generating toxic molecules called amyloid-beta peptides. The study uses genetically-engineered mice to show that the toxic activity of this enzyme can be separated from its other benign activities.
A German-developed expert system enhances the diagnostic accuracy of Alzheimer's disease using FDG PET scans. The system, which was tested in 150 cases, helps inexperienced physicians diagnose Alzheimer's and differentiate it from other dementia disorders.
A new computer program, HipMask, uses brain scans to predict future Alzheimer's disease, offering a possible tool for early screening. The technique measures metabolic activity in the hippocampus, which diminishes in size as Alzheimer's progresses.
Researchers at USC College of Letters, Arts and Sciences have found a link between early exposure to inflammatory diseases like gum disease and an increased risk of Alzheimer's. The study, which analyzed data from the Swedish Twin Registry, suggests that chronic gum disease may be a preventable risk factor for Alzheimer's, adding to th...
Researchers used a non-invasive MRI technique to distinguish between Alzheimer's disease and frontotemporal dementia. The study successfully differentiated between the two conditions using arterial spin labeling, which measures blood flow in the brain.
A recent study found that the APOE e2 allele is associated with a moderately increased risk for chronic kidney disease, whereas the e4 variant provides protection. The study involved 14,520 middle-aged participants and confirmed previous findings on the role of genetics in kidney disease.
Researchers discovered that macrophages in the innate immune system may play a role in Alzheimer's development. They found that healthy individuals can clear amyloid-beta, but Alzheimer's patients' macrophages struggle with this task.
Researchers at UCLA have discovered a 'molecular zipper' structure in proteins linked to Alzheimer's, Parkinson's and mad cow disease. The discovery provides a potential rational basis for developing drugs to fight these diseases.
A recent study published in Archives of Neurology suggests that variations in p-tau 231 levels can predict the structural progression of Alzheimer's disease. The biomarker has been shown to discriminate between AD patients and those with other neurodegenerative disorders, with high accuracy in detecting early-stage disease.
The National Institute on Aging has awarded the University of California, Irvine (UCI) $9 million to continue its research on Alzheimer's disease. Two key projects will focus on understanding age-related changes in the brain and the role of mitochondrial defects in causing Alzheimer's disease. These studies aim to advance our knowledge...
The discovery of CD147 reveals a new component regulating the production of A-beta peptides, which form amyloid plaques. The study highlights the importance of understanding membrane protein structures to combat Alzheimer's research.
A study found that patients with mild to moderate Alzheimer's disease who are aware of their diagnosis and symptoms can make competent decisions about their treatment. The Mini-Mental State Examination (MMSE) score can help predict decision-making abilities, with those scoring 24 or higher indicating competence.
Researchers found that patients who mounted an immune response against beta amyloid experienced improved memory performance and reduced brain size, suggesting the removal of built-up protein. The new trial aims to stimulate an immune attack without raising brain inflammation risk.
A small-scale trial of atorvastatin calcium found significant reductions in circulating cholesterol levels and potential benefits on cognitive function and behavior in patients with mild to moderate Alzheimer's disease. The results hold promise for the treatment of AD, but further multicenter trials are needed to confirm these findings.
A recent study suggests that US Latinos may develop Alzheimer's disease symptoms at a younger age than white, non-Latino individuals. The study found that Latino patients had a mean age of symptom onset that was 6.8 years earlier than Anglo patients with similar educational levels.
A new study found that exercise can delay the development of Alzheimer's-like brain changes in mice by decreasing beta-amyloid levels. Exercise was shown to improve learning and memory in mice with AD-like pathology, suggesting a potential mechanism for reducing cognitive decline.