Articles tagged with Alzheimer Disease
The initiative will enroll 800 people across five years, including normal elderly, diagnosed AD patients, and mild cognitive disorder individuals. Researchers aim to develop a standard imaging method for clinical trials, improve imaging methods, and validate imaging data.
The study aims to develop new treatments and monitor their effectiveness by tracking cognitive changes associated with MCI and AD. Researchers will use neuroimaging, biological, and clinical information from over 800 participants to identify critical biomarkers that respond to treatments.
A new anti-cholesterol drug, CP-113,818, has shown promise in treating Alzheimer's disease by reducing amyloid plaque accumulation and improving learning and memory in mice. Treatment with the drug resulted in a significant reduction of cholesterol storage in the brain, as well as improved performance on cognitive tests.
A study of 162 Japanese patients with mild to moderate Alzheimer's disease and high blood pressure found that brain-penetrating ACE inhibitors slowed cognitive decline. The medications declined thinking and memory skills by only 0.6 points, compared to 4.9 points for calcium channel blockers.
A review article suggests that age-associated executive function decline is due to frontal-striatal circuit changes, while medial temporal lobe memory system decline is more closely linked to Alzheimer's disease. Changes in white matter and neurotransmitter depletion also play a role.
A study published in Clinical Nutrition found that the use of high-contrast colored tableware increased food intake by 24.6% and liquid intake by 83.7% in individuals with severe Alzheimer's disease. The study, led by Boston University researchers, suggests that visual impairment may be a contributing factor to weight loss in AD patients.
Research finds that age-related testosterone depletion promotes Alzheimer's disease in men by protecting neurons from injury and reducing beta-amyloid protein levels. The study suggests that understanding the link between testosterone loss and Alzheimer's is crucial for identifying those at risk.
Researchers at Rush University Medical Center are exploring a new gene transfer technique that uses CERE-110 to deliver nerve growth factor to specific areas of the brain affected by Alzheimer's disease. The goal is to prevent cell death and reverse cell atrophy, which may have a widespread effect on the entire brain.
A recent study by a U.Va researcher found that walking regularly is associated with benefits for cognitive function later in life. Men who walked over two miles per day had significantly lower dementia risk compared to those who walked less than a quarter mile per day.
A recent study found that people with mild Alzheimer's disease are more likely to make driving errors during a route-following task, including wrong turns and safety errors. However, those familiar with the area drove safely, suggesting that familiar routes may be exempt from restrictions for drivers with early dementia.
A UCLA study found that a diet rich in DHA, an omega-3 fatty acid, dramatically reduces the impact of the Alzheimer's gene and prevents synaptic brain damage. Consuming more DHA can be easily controlled through food choices such as fish, eggs, or supplements.
Research in mice shows that dietary depletion of essential fatty acid DHA accelerates Alzheimer's disease, but supplementation protects against damage to dendrites and cognitive decline. The study supports increased DHA intake as a potential neuroprotective strategy for AD.
Researchers found that scores of patients with a shunt stayed stable, while those without declined by 20% after 12 months. Isoprostane levels were reduced by 50% compared to standard anti-Alzheimer medications.
Researchers found that people with Alzheimer's had less mentally stimulating careers than those without the disease. Engaging in mentally stimulating occupations and activities during younger years may help maintain a 'reserve' of brain cells that resists Alzheimer's effects.
Research suggests that mentally demanding jobs may protect against Alzheimer's disease by increasing brain cell activity and maintaining cognitive reserve. However, the exact link between job demands and Alzheimer's is not fully understood, and other factors such as socioeconomic status and environmental exposures may also play a role.
The study reveals that tau protein undergoes a stepwise folding and truncation process in the formation of neurofibrillary tangles in Alzheimer's disease. Dr. Binder's research contributes to diagnostic and therapeutic strategies for AD patients, marking an important milestone in understanding the disease.
A recent study suggests that antipsychotic medication quetiapine does not increase the risk of stroke or transient ischemic attack in people with Alzheimer's disease. The research, which pooled data from two studies, followed 684 institutionalized patients with dementia and found an incidence rate of 0.3% for quetiapine.
Researchers assessed the effectiveness of quetiapine in reducing agitation symptoms in Alzheimer's patients. A study also found a possible link between HIV treatment and increased risk of Alzheimer's disease due to abnormal protein deposits. An animal model has been developed to study tau protein tangles, a hallmark of Alzheimer's path...
African Americans bear a disproportionate burden of Alzheimer's disease, with early symptoms striking years before white peers. Studies reveal successful methods for involving minority communities in research to combat this growing public health threat.
Researchers have developed strategies to target beta-amyloid, a substance thought to kill brain cells in Alzheimer's. Preliminary success has been achieved with a drug candidate that appears safe and effective in reducing amyloid levels.
Research suggests that genetics studies demonstrate a significant impact of environment on Alzheimer's disease. Low levels of education are also found to be a risk factor for all groups, including identical twins. Additionally, disclosing an Alzheimer susceptibility gene does not increase anxiety about developing the disease.
Recent advances in brain imaging may allow early diagnosis of Alzheimer's and other dementias, as well as improved assessment of treatment effectiveness. Researchers have developed new PET technologies to visualize abnormal protein accumulations in the brain, which may help differentiate between Alzheimer's and other forms of dementia.
Research suggests that managing blood pressure, cholesterol, blood sugar levels, and body weight can promote healthier aging and reduce Alzheimer's risk. Studies found a consistent increase in cognitive health with higher HDL (good) cholesterol levels and some hypertension medications associated with reduced Alzheimer's risk.
Researchers at Washington University School of Medicine presented multiple studies highlighting the relationship between stress and Alzheimer's disease severity, as well as identifying predictive brain changes. These findings may lead to improved treatments and early detection methods for the devastating disease.
The study found that LR11 plays a crucial role in regulating beta amyloid levels, suggesting its potential as a therapeutic target for Alzheimer's disease. The Emory researchers used lentiviruses to selectively reduce and enhance LR11 expression in mouse brains and cultured cells.
Eating spinach and broccoli may slow cognitive decline; green leafy vegetables are associated with better brain health; complex leisure activities combining social, mental, and physical activity can prevent dementia.
The cost of care for those with Alzheimer's is projected to rise dramatically, with direct costs alone increasing by 60-200% as the disease progresses, and reaching $50 billion in less than 10 years.
A randomized study compared vitamin E and donepezil to placebo for delaying progression to Alzheimer's disease in patients with mild cognitive impairment. Patients treated with donepezil showed a modest delay in disease progression, but this effect was short-term.
Researchers are using primate behavioral memory tasks and infrared eye-tracking technology to identify patients with mild cognitive impairment. The study aims to detect impaired memory in humans before major brain damage occurs.
The Alzheimer's Association and NIA are expediting prevention trials for Alzheimer's by developing more efficient tools, such as home-based testing. This will reduce costs and burdens on participants while gaining valuable information about the course of cognitive changes in late life.
Research on statins as a treatment for Alzheimer's disease has yielded conflicting results, with some studies showing improved cognitive function and others finding no benefit. Large-scale clinical trials are needed to resolve the questions raised by these studies.
A study by Emory University researchers found that patients with mild cognitive impairment (MCI) show compromised ability to perform instrumental activities of daily living (IADLs), a trend also observed in Alzheimer's disease. Early detection and treatment can help maintain independence for individuals with MCI.
A recent study demonstrated that a current Alzheimer drug may delay the transition from Mild Cognitive Impairment (MCI) to Alzheimer's disease, but only for the first 18 months. The treatment showed modest effects on progression to Alzheimer's, but more research is needed to confirm its efficacy.
The study found that participants on donepezil experienced a slower progression to Alzheimer's disease compared to those on placebo, with an average delay of 661 days. However, the effects were only observed during the first half of the study and further analyses are needed to confirm these findings.
Researchers used MRI to study myelin insulation in brain connections, finding they deteriorate three times faster in older adults with Alzheimer's disease. This breakdown disrupts brain function and leads to cognitive decline.
Researchers found that individuals with early AD who participated in a 3-to-4 month cognitive rehabilitation program showed significant improvements in face-name recognition, mental processing speeds, and time-place orientation. The study suggests that people with early AD can be taught techniques to help stay engaged in everyday life.
Scientists at the University of Rochester Medical Center created an Alzheimer's vaccine with a customizable immune response using a harmless form of the herpes virus. The modified vaccine proved safer while still causing a 20-percent decline in amyloid plaque in the brain, offering new hope for developing a safe and effective vaccine.
The new Center will integrate resources between clinical and basic research programs to enhance understanding of dementia, improve diagnostics, and develop new treatments. The Center will focus on both Alzheimer's disease and non-Alzheimer's forms of dementia.
A recent study found that cholinesterase inhibitors improved mental and functional ability in AD patients over the first two years of treatment. However, there was no significant delay in institutionalisation or progression of disability, casting doubt on their effectiveness.
Researchers found a moderate association between the APOE-2 gene and an increased risk of developing Parkinson's disease, with a 20% higher chance. In contrast, the APOE-4 gene was not linked to Parkinson's disease, contrary to its established role in Alzheimer's risk.
Researchers use 18F-FDDNP-PET to measure tangles and plaques in brain, providing valuable information on disease status. The technique accurately separates AD patients from control subjects, offering opportunities for early diagnosis and monitoring treatment effects.
Dr. Li-Huei Tsai's groundbreaking study reveals p25 protein's role in Alzheimer's disease, a key feature of which is the presence of beta amyloid plaques and neurofibrillary tangles. The research also suggests an intervention after stroke could lower or prevent additional risk of Alzheimer's
Scientists discovered that certain brain systems remain intact in individuals with Alzheimer's disease, enabling the retention of implicit memory capabilities. Structured training programs may be an effective approach to improving cognitive function.
Researchers found that older adults with Alzheimer's symptoms can still use implicit memory to perform tasks, similar to young adults. By training these individuals using repetition and practice, their performance can be improved, according to a new study.
Fetal imaging technologies like DTI and fMRI enable early diagnosis and treatment of brain abnormalities, improving outcomes for patients with epilepsy, autism, and Alzheimer's. Researchers presented advancements in detecting seizure origins and understanding autistic brain function through innovative imaging techniques.
Researchers found three to four times more antibodies in Alzheimer's patients than healthy individuals, indicating a possible autoimmunity component to the disease. This discovery may lead to an early diagnostic test and more targeted treatments.
Researchers discovered a protein that dissolves amyloid fibers in yeast cells, which could have implications for understanding protein folding processes and the role of environmental factors in evolution. The finding also sheds light on the natural biology of Sup35, a protein involved in genetic translation.
A study by Fox Chase Cancer Center researchers has identified the human ABCA2 transporter as a potential therapeutic target for Alzheimer's disease. The protein is also involved in cancer drug resistance and plays a role in cholesterol transport and myelination, which may contribute to the development of Alzheimer's disease.
A study using mouse models of Alzheimer's disease found that blocking the Fyn enzyme reduces amyloid protein damage to synapses and improves longevity. However, increasing Fyn levels worsens synaptic damage and shortens lifespan. The findings suggest that pharmacological modulation of Fyn may be beneficial in treating Alzheimer's.
Researchers from Rush University Medical Center have discovered that diabetics are at a significantly higher risk of developing Alzheimer's disease. The study, which followed over 800 Catholic nuns and priests for five years, found a 65% increase in the risk of AD among those with diabetes.
A long-term study found that people with diabetes are at a 65% increased risk of developing Alzheimer's disease compared to those without the condition. The study also showed that cognitive decline in perceptual speed was associated with diabetes, but not other cognitive systems.
A study on transmissible spongiform encephalopathies (TSEs) and prion protein PrPSc accumulation in muscle tissue of infected rodents found that the defective form of PrPSc is present prior to clinical symptoms. The accumulation of PrPSc is greatest after clinical symptoms are well established.
Researchers found that increased expression of ADAM10 reduced AB peptide formation and prevented plaque formation in an Alzheimer disease mouse model. This suggests that targeting alpha-secretase might be a useful therapeutic target for AD.
A team of scientists from Harbor Branch Oceanographic Institution and Florida Atlantic University are exploring never-before-seen sections of deepwater coral reefs off Florida's east coast and the Keys. They aim to discover marine creatures that produce chemicals with the potential to cure human diseases, including cancer and Alzheimer's.
Researchers at UT Southwestern Medical Center have identified a characteristic sign of Alzheimer's disease that can distinguish it from frontotemporal diseases, which are the second-leading cause of dementia in the elderly. SPECT testing measures brain blood flow and shows significant reductions in the posterior cingulate cortex, indic...
Researchers at University of Texas Southwestern Medical Center developed a new SPECT imaging test that can accurately diagnose Alzheimer's disease in its early stages. The test identifies reduced blood flow in the posterior cingulate cortex, allowing doctors to identify AD patients significantly sooner than current methods.
A study published in the American Journal of Psychiatry found that enhanced counseling, including individual and family therapy, reduced symptoms of depression among caregivers of loved ones with Alzheimer's disease. After one year, 29.8% of caregivers in the enhanced group showed significant improvement.
The Mayo Clinic researchers have invented a nontoxic molecular probe that targets the brain regions containing amyloid plaques, enabling high-resolution MRI images in live mice and potentially human patients. The probe may also be used to evaluate new Alzheimer's therapies and provide early diagnosis.
Researchers found that the rate of total brain volume loss can predict which mildly cognitively impaired individuals are at high risk of developing dementia. Combining this with hippocampus volume measurements provides a strong model for predicting cognitive outcomes.
A new study has found that the APOE-2 form of the gene increases the risk of developing Parkinson's disease by 20 percent compared to other forms of the gene. The study analyzed data from 22 studies and 9,988 participants, providing strong evidence for the link between the APOE gene and Parkinson's disease.